Issue 24, 2016
From the journal:

Organic & Biomolecular Chemistry

anti-Selective aminofluorination of alkenes with amidines mediated by hypervalent iodine(iii) reagents†

Hui Chen,a   Atsushi Kagaa  and  Shunsuke Chiba*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
E-mail: shunsuke@ntu.edu.sg
Fax: +65-67911961

Abstract

anti-Selective aminofluorination of alkenes with amidines was enabled by hypervalent iodine(III) reagents, affording 4-fluoroalkyl-2-imidazolines. Further reductive ring-opening of the 2-imidazoline moiety could deliver highly functionalized 3-fluoropropane-1,2-diamine derivatives.

Graphical abstract: anti-Selective aminofluorination of alkenes with amidines mediated by hypervalent iodine(iii) reagents

  • This article is part of the themed collection: New Talent
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Article information

DOI
https://doi.org/10.1039/C5OB01854D
Article type
Communication
Submitted
05 Sep 2015
Accepted
24 Sep 2015
First published
24 Sep 2015

Org. Biomol. Chem., 2016,14, 5481-5485

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anti-Selective aminofluorination of alkenes with amidines mediated by hypervalent iodine(III) reagents

H. Chen, A. Kaga and S. Chiba, Org. Biomol. Chem., 2016, 14, 5481 DOI: 10.1039/C5OB01854D

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