Themed collection Lab on a Chip Recent Open Access Articles

124 items - Showing page 1 of 2
Open Access Perspective

Personalised organs-on-chips: functional testing for precision medicine

Organs-on-chips can be ‘personalised’ so they can be used as functional tests to inform clinical decision-making for specific patients.

Graphical abstract: Personalised organs-on-chips: functional testing for precision medicine
Open Access Perspective

Maximizing the impact of microphysiological systems with in vitroin vivo translation

The full impact of MPS technologies will be realized only when robust approaches for in vitroin vivo (MPS-to-human) translation are developed and utilized.

Graphical abstract: Maximizing the impact of microphysiological systems with in vitro–in vivo translation
From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Tutorial Review

Droplet microfluidics for the construction of compartmentalised model membranes

This tutorial review explores the use of droplet microfluidics to generate compartmentalised model membrane constructs that have potential applications as microreactors, as artificial cells in synthetic biology, as simplified cell models and as drug delivery vehicles.

Graphical abstract: Droplet microfluidics for the construction of compartmentalised model membranes
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Tutorial Review

Integration and application of optical chemical sensors in microbioreactors

This tutorial review explains the integration of optical chemical sensor formats for the purpose of monitoring oxygen, pH, carbon dioxide, glucose and temperature in microbioreactors.

Graphical abstract: Integration and application of optical chemical sensors in microbioreactors
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Rotating magnetic particles for lab-on-chip applications – a comprehensive review

Magnetic particles are widely used in lab-on-chip and biosensing applications, because they have a high surface-to-volume ratio, they can be actuated with magnetic fields and many biofunctionalization options are available. This review focuses on the use of rotating magnetic particles for lab-on-chip applications.

Graphical abstract: Rotating magnetic particles for lab-on-chip applications – a comprehensive review
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Increasing the functionalities of 3D printed microchemical devices by single material, multimaterial, and print-pause-print 3D printing

3D printing has emerged as a valuable approach for the fabrication of fluidic devices and may replace soft-lithography as the method of choice for rapid prototyping.

Graphical abstract: Increasing the functionalities of 3D printed microchemical devices by single material, multimaterial, and print-pause-print 3D printing
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Critical Review

Caring for cells in microsystems: principles and practices of cell-safe device design and operation

This review is geared towards device engineers, designers, and users who wish to establish “cell-friendly” technologies with utility to a broader scientific community.

Graphical abstract: Caring for cells in microsystems: principles and practices of cell-safe device design and operation
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

This review critically analyzes the history, fundamental operating principles, limitations, applications, and emerging ideas related to microchannel-based capillary microfluidics.

Graphical abstract: Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Microsensor systems for cell metabolism – from 2D culture to organ-on-chip

We discuss microsensors for cell culture monitoring from 2D culture to organ-on-chip systems, including sensor principles, fabrication and culture formats.

Graphical abstract: Microsensor systems for cell metabolism – from 2D culture to organ-on-chip
From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Critical Review

Wearable sensors: modalities, challenges, and prospects

Non-invasive wearable sensing technology extracts mechanical, electrical, optical, and chemical information from the human body.

Graphical abstract: Wearable sensors: modalities, challenges, and prospects
From the themed collection: Wearable and Implantable Sensors
Open Access Critical Review

Recent advances in microfluidic technologies for cell-to-cell interaction studies

Microfluidic cell cultures are ideally positioned to become the next generation of in vitro diagnostic tools for biomedical research, where key biological processes such as cell signalling and dynamic cell-to-cell interactions can be reliably analysed under reproducible physiological cell culture conditions.

Graphical abstract: Recent advances in microfluidic technologies for cell-to-cell interaction studies
From the themed collection: Immunotherapy
Open Access Critical Review

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

Breakthroughs in adapting microfluidic systems for exosome isolation, detection, and analysis are providing new tools to revolutionize personalized medicine.

Graphical abstract: Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine
From the themed collection: Personalised Medicine: Liquid Biopsy
Open Access Critical Review

Mobile microrobots for bioengineering applications

Untethered micron-scale mobile robots can navigate and non-invasively perform specific tasks inside unprecedented and hard-to-reach inner human body sites and inside enclosed organ-on-a-chip microfluidic devices with live cells.

Graphical abstract: Mobile microrobots for bioengineering applications
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

The lab-on-PCB approach: tackling the μTAS commercial upscaling bottleneck

Recent developments in the lab-on-PCB integration technology, highlighting its standardized industrial fabrication potential.

Graphical abstract: The lab-on-PCB approach: tackling the μTAS commercial upscaling bottleneck
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Advancements in microfluidics for nanoparticle separation

Nanoparticles have been widely implemented for healthcare and nanoscience industrial applications.

Graphical abstract: Advancements in microfluidics for nanoparticle separation
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Communication

Waveguide-based chemo- and biosensors: complex emulsions for the detection of caffeine and proteins

Emulsion waveguides: a new modular sensing approach in which complex emulsions serve as efficient transducers in optical evanescent field-based waveguide sensors is reported.

Graphical abstract: Waveguide-based chemo- and biosensors: complex emulsions for the detection of caffeine and proteins
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Communication

Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips

We present a novel extension of laminar flow patterning using Darcy flow within cured three-dimensional hydrogels for precise delivery of solutes.

Graphical abstract: Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Communication

Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer

Biomolecular recognition can be attained by using the self-assembled monolayer modification for capture of a target analyte on the nanowire surfaces instead of primary antibodies.

Graphical abstract: Biomolecular recognition on nanowire surfaces modified by the self-assembled monolayer
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Communication

A simple and low-cost chip bonding solution for high pressure, high temperature and biological applications

An adhesive-based strategy for the low-cost and reversible sealing of a wide range of materials used in microfluidics, requiring only the application of manually-achievable pressures.

Graphical abstract: A simple and low-cost chip bonding solution for high pressure, high temperature and biological applications
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Communication

On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale

Seamless on-chip integration of a micro reaction unit and an HPLC functionality coupled to MS allows to study stereo selective chemical transformations at the microscale.

Graphical abstract: On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Microfluidic centrifugation assisted precipitation based DNA quantification

A microfluidic centrifugation assisted precipitation method for rapid DNA visualization and quantification.

Graphical abstract: Microfluidic centrifugation assisted precipitation based DNA quantification
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

High-throughput single-particle detections using a dual-height-channel-integrated pore

We report a proof-of-principle demonstration of particle concentration to achieve high-throughput resistive pulse detections of bacteria using a microfluidic-channel-integrated micropore.

Graphical abstract: High-throughput single-particle detections using a dual-height-channel-integrated pore
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Multiparameter antibiotic resistance detection based on hydrodynamic trapping of individual E. coli

We present a single-bacteria hydrodynamic trapping platform to detect antibiotic susceptibility and resistance by simultaneously monitoring motility and morphology of individual E. coli.

Graphical abstract: Multiparameter antibiotic resistance detection based on hydrodynamic trapping of individual E. coli
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Overcoming transport limitations in miniaturized electrophoretic delivery devices

Combining experimental and theoretical approach, we demonstrate practical solutions to limiting currents in capillary-based electrophoretic delivery devices.

Graphical abstract: Overcoming transport limitations in miniaturized electrophoretic delivery devices
From the themed collection: Wearable and Implantable Sensors
Open Access Paper

Label-free separation of leukocyte subpopulations using high throughput multiplex acoustophoresis

Implementing a new designed cooling system for rigorous temperature control and minimal acoustic energy losses allows high-throughput multiplex acoustophoresis.

Graphical abstract: Label-free separation of leukocyte subpopulations using high throughput multiplex acoustophoresis
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells

The development of drugs to treat cancer is hampered by the inefficiency of translating pre-clinical in vitro monoculture and mouse studies into clinical benefit.

Graphical abstract: Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells
From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Paper

Array based real-time measurement of fluid viscosities and mass-densities to monitor biological filament formation

A membrane-based resonator detecting filament formation of biological samples in a label- and functionalization-free manner.

Graphical abstract: Array based real-time measurement of fluid viscosities and mass-densities to monitor biological filament formation
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Grooved step emulsification systems optimize the throughput of passive generation of monodisperse emulsions

A novel step emulsifier allows high throughput production of monodisperse emulsions. Additionally, different modes of droplet production are investigated.

Graphical abstract: Grooved step emulsification systems optimize the throughput of passive generation of monodisperse emulsions
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Inertial focusing with sub-micron resolution for separation of bacteria

Inertial focusing in curved channels is demonstrated for particles between 0.5 and 2.0 μm in diameter; a range of biological relevance since it comprises a multitude of bacteria and organelles of eukaryotic cells.

Graphical abstract: Inertial focusing with sub-micron resolution for separation of bacteria
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Lipid coated liquid crystal droplets for the on-chip detection of antimicrobial peptides

Lipid coated liquid crystal droplets have been trapped in a novel trap structure for the on-chip detection of a model antimicrobial peptide – Smp43, an α-helical peptide from Scorpion Venom.

Graphical abstract: Lipid coated liquid crystal droplets for the on-chip detection of antimicrobial peptides
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Gradient in the electric field for particle position detection in microfluidic channels

In this work a new method to track particles in microfluidic channels is presented.

Graphical abstract: Gradient in the electric field for particle position detection in microfluidic channels
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution

Generation of exact cell clusters in the CAGE chip allows for paracrine signaling studies in models of specific tissue niches.

Graphical abstract: Formation of precisely composed cancer cell clusters using a cell assembly generator (CAGE) for studying paracrine signaling at single-cell resolution
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Modular soft robotic microdevices for dexterous biomanipulation

We present a methodology for building biologically inspired, soft microelectromechanical systems (MEMS) devices.

Graphical abstract: Modular soft robotic microdevices for dexterous biomanipulation
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

A microfluidic platform for the characterisation of membrane active antimicrobials

We quantify the membranolytic activity of antimicrobial peptides on biomimetic lipid vesicles in a multilayer microfluidic total analysis system.

Graphical abstract: A microfluidic platform for the characterisation of membrane active antimicrobials
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Latchable microfluidic valve arrays based on shape memory polymer actuators

Latchable microfluidic valve arrays taking advantage of the shape memory polymer's multiple stable shapes and large change in stiffness for a small temperature variation.

Graphical abstract: Latchable microfluidic valve arrays based on shape memory polymer actuators
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Analysis and simulation of multiphase hydrodynamics in capillary microseparators

The capillary microseparator is an important microfluidic device for achieving the inline separation of biphasic segmented flows.

Graphical abstract: Analysis and simulation of multiphase hydrodynamics in capillary microseparators
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Ultra-high capacity microfluidic trapping of giant vesicles for high-throughput membrane studies

A high-capacity microfluidic platform designed to capture tens of thousands of giant vesicles for high-throughput membrane analysis.

Graphical abstract: Ultra-high capacity microfluidic trapping of giant vesicles for high-throughput membrane studies
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Parahydrogen based NMR hyperpolarisation goes micro: an alveolus for small molecule chemosensing

We implemented continuous-flow SABRE NMR spectroscopy on a chip, unlocking low-volume chemosensing of strongly diluted analytes.

Graphical abstract: Parahydrogen based NMR hyperpolarisation goes micro: an alveolus for small molecule chemosensing
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Acoustophoretic focusing effects on particle synthesis and clogging in microreactors

An acoustophoretic microreactor to manage particles in flow and to control the material synthesis process.

Graphical abstract: Acoustophoretic focusing effects on particle synthesis and clogging in microreactors
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

A lung/liver-on-a-chip platform for acute and chronic toxicity studies

A lung/liver-on-a-chip platform with metabolic capability over 28 days: a fit-for-purpose microfluidic system for toxicity assessment of pulmonary toxicants.

Graphical abstract: A lung/liver-on-a-chip platform for acute and chronic toxicity studies
From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Paper

Correlative light and electron microscopy for complex cellular structures on PDMS substrates with coded micro-patterns

A correlative light and electron microscopy system that utilizes PDMS substrates with coded micro-patterns has been developed.

Graphical abstract: Correlative light and electron microscopy for complex cellular structures on PDMS substrates with coded micro-patterns
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Microfluidic bead encapsulation above 20 kHz with triggered drop formation

Bead-triggered breakup of a fluid jet into monodispersed droplets improves the throughput of bead-based droplet workflows, enabling the analysis of large populations and the detection of rare events.

Graphical abstract: Microfluidic bead encapsulation above 20 kHz with triggered drop formation
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Screening of nutritional and genetic anemias using elastic light scattering

Elastic light scattering and machine learning accurately discriminates between healthy children, those with iron deficiency, and those with thalassemia minor.

Graphical abstract: Screening of nutritional and genetic anemias using elastic light scattering
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

An automated in vitro motility assay for high-throughput studies of molecular motors

Molecular motors, essential to force-generation and cargo transport within cells, are invaluable tools for powering nanobiotechnological lab-on-a-chip devices.

Graphical abstract: An automated in vitro motility assay for high-throughput studies of molecular motors
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Millifluidic culture improves human midbrain organoid vitality and differentiation

The use of millifluidics technology for human midbrain organoid cultures reduces central cell death and increases dopaminergic neuron differentiation.

Graphical abstract: Millifluidic culture improves human midbrain organoid vitality and differentiation
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy.

Graphical abstract: 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Effect of exercise on the plasma vesicular proteome: a methodological study comparing acoustic trapping and centrifugation

Improved reproducibility in seed particle mediated acoustic trapping of submicron particles enables clinical biomarker studies in extracellular vesicles.

Graphical abstract: Effect of exercise on the plasma vesicular proteome: a methodological study comparing acoustic trapping and centrifugation
From the themed collection: Personalised Medicine: Liquid Biopsy
Open Access Paper

Multi-parametric cell profiling with a CMOS quad-modality cellular interfacing array for label-free fully automated drug screening

A 1024-pixel CMOS quad-modality cellular interfacing array that enables multi-parametric cell profiling and holistic cellular characterization for drug development.

Graphical abstract: Multi-parametric cell profiling with a CMOS quad-modality cellular interfacing array for label-free fully automated drug screening
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Quantitative phase microscopy of red blood cells during planar trapping and propulsion

Here, we have combined quantitative phase microscopy and waveguide trapping techniques to study changes in RBC morphology during planar trapping and transportation.

Graphical abstract: Quantitative phase microscopy of red blood cells during planar trapping and propulsion
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

High-throughput single-molecule bioassay using micro-reactor arrays with a concentration gradient of target molecules

We developed micro-reactor arrays with a concentration gradient of target molecules for high-throughput single-molecule bioassay.

Graphical abstract: High-throughput single-molecule bioassay using micro-reactor arrays with a concentration gradient of target molecules
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Continuous removal of small nonviable suspended mammalian cells and debris from bioreactors using inertial microfluidics

We introduce a new application of spiral inertial microfluidics for removing small nonviable cells from a mammalian suspension culture.

Graphical abstract: Continuous removal of small nonviable suspended mammalian cells and debris from bioreactors using inertial microfluidics
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis

A novel technology for quantifying hormone secretion from tissues, with a single-cell resolution.

Graphical abstract: Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Acoustic formation of multicellular tumor spheroids enabling on-chip functional and structural imaging

Combining a protein repellent coating and ultrasonic standing waves in microwells enables on-chip formation and confocal microscopy of multicellular tumor spheroids.

Graphical abstract: Acoustic formation of multicellular tumor spheroids enabling on-chip functional and structural imaging
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays

This platform utilizes functionalized hydrogel posts contained within isolated nanoliter well reactors for quantitative and multiplex microRNA assays directly from unprocessed cell samples without needing prior nucleic acid extraction.

Graphical abstract: Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Sequencing of human genomes extracted from single cancer cells isolated in a valveless microfluidic device

Whole genome sequencing of single cancer cells isolated and lysed in an injection-moulded valveless microfluidic device.

Graphical abstract: Sequencing of human genomes extracted from single cancer cells isolated in a valveless microfluidic device
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

A universal platform for selection and high-resolution phenotypic screening of bacterial mutants using the nanowell slide

Dual selection, high-resolution phenotypic screening and genotypic analysis of single-derived bacterial nanocultures using a 672-nanowell slide.

Graphical abstract: A universal platform for selection and high-resolution phenotypic screening of bacterial mutants using the nanowell slide
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Enhanced ion transport using geometrically structured charge selective interfaces

A microfluidic platform containing charged hydrogels is used to investigate the effect of geometry on charge transport in electrodialysis applications.

Graphical abstract: Enhanced ion transport using geometrically structured charge selective interfaces
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions

Cell signalling and mechanics influence vascular pathophysiology and there is an increasing demand for in vitro model systems that enable examination of signalling between vascular cells under hemodynamic conditions.

Graphical abstract: A biomimetic microfluidic model to study signalling between endothelial and vascular smooth muscle cells under hemodynamic conditions
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Roll-to-roll fabrication of integrated PDMS–paper microfluidics for nucleic acid amplification

High-volume roll-to-roll manufacturing of PDMS–paper microfluidics.

Graphical abstract: Roll-to-roll fabrication of integrated PDMS–paper microfluidics for nucleic acid amplification
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Multiparameter cell-tracking intrinsic cytometry for single-cell characterization

We introduce a multiparameter intrinsic cytometry approach for single-cell characterization that combines ≥2 label-free measurement techniques onto the same platform.

Graphical abstract: Multiparameter cell-tracking intrinsic cytometry for single-cell characterization
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Electrically controlled mass transport into microfluidic droplets from nanodroplet carriers with application in controlled nanoparticle flow synthesis

Infuse chemical into microdroplets from nanodroplet carriers with rates and dosages controlled by electrical fields, and applications in nanoparticle synthesis.

Graphical abstract: Electrically controlled mass transport into microfluidic droplets from nanodroplet carriers with application in controlled nanoparticle flow synthesis
Open Access Paper

Inertial manipulation of bubbles in rectangular microfluidic channels

The position of bubbles in rectangular microchannels can be controlled by tuning the balance of forces acting on them.

Graphical abstract: Inertial manipulation of bubbles in rectangular microfluidic channels
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Microfluidic label-free selection of mesenchymal stem cell subpopulation during culture expansion extends the chondrogenic potential in vitro

A microfluidic cell sorting based selective culture expansion method for mesenchymal stem cell improves cell yield and chondrogenic potential.

Graphical abstract: Microfluidic label-free selection of mesenchymal stem cell subpopulation during culture expansion extends the chondrogenic potential in vitro
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications.

Graphical abstract: Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Flocculation on a chip: a novel screening approach to determine floc growth rates and select flocculating agents

A novel microfluidic flocculation screening tool to efficiently compare flocculating agents and rapidly find the best flocculating condition using in situ detection of flocculation growth rates.

Graphical abstract: Flocculation on a chip: a novel screening approach to determine floc growth rates and select flocculating agents
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

On-chip functional neuroimaging with mechanical stimulation in Caenorhabditis elegans larvae for studying development and neural circuits

New designs of microfluidic devices can facilitate recording of C. elegans larvae neuronal responses to precise mechanical stimuli, which reveal new understanding of development of mechanosensory neurons and circuits.

Graphical abstract: On-chip functional neuroimaging with mechanical stimulation in Caenorhabditis elegans larvae for studying development and neural circuits
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

Acoustically modulated biomechanical stimulation for human cartilage tissue engineering

The biomechanical environment in an acoustofluidic bioreactor is modified by controlling the acoustic driving conditions to promote human cartilage generation.

Graphical abstract: Acoustically modulated biomechanical stimulation for human cartilage tissue engineering
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement

Miniaturised conical measures for cell aggregates.

Graphical abstract: A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products

Single-layer lithography microfluidic devices for applying high and stable electric fields on chip.

Graphical abstract: On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products
From the themed collection: Lab on a Chip Recent Open Access Articles
Open Access Paper

An ultra-small, multi-point, and multi-color photo-detection system with high sensitivity and high dynamic range

Fluorescence from four emission points is collimated by four lenses, split into four-color fluxes by four dichroic mirrors, and directly input into the image sensor.

Graphical abstract: An ultra-small, multi-point, and multi-color photo-detection system with high sensitivity and high dynamic range
From the themed collection: Lab on a Chip Recent Open Access Articles
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