Themed collection Near-infrared (NIR) luminescent probes for bioimaging and biosensing
Near-infrared luminescent probes for bioimaging and biosensing
Fan Zhang and Ben Zhong Tang introduce the Chemical Science themed issue on Near-infrared luminescent probes for bioimaging and biosensing.
Fluorescent small organic probes for biosensing
Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity and sensitivity, whilst being non-invasive, and suitable for real-time analysis of living systems.
New directions of activity-based sensing for in vivo NIR imaging
In vivo imaging is a powerful approach to study biological processes.
Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases
Near-infrared fluorescent molecular probes with improved imaging depth and optimized biodistribution have been reviewed, showing great potential for diagnosis of nephro-urological diseases.
Activatable fluorescence sensors for in vivo bio-detection in the second near-infrared window
Fluorescence imaging in the second near-infrared (NIR-II, 1000–1700 nm) window has exhibited advantages of high optical resolution at deeper penetration (ca. 5–20 mm) in bio-tissues owing to the reduced photon scattering and tissue autofluorescence.
Near-infrared fluorescent probes: a next-generation tool for protein-labeling applications
This minireview describes the development of NIR chemical probes for various protein-tag systems.
Structural and process controls of AIEgens for NIR-II theranostics
Structural and process controls of NIR-II AIEgens realize manipulating of radiative (R) and nonradiative (NR) decay for precise theranostics.
A facile way to obtain near-infrared room-temperature phosphorescent soft materials based on Bodipy dyes
Near-infrared room-temperature phosphorescence was achieved by employing iodine substituted Bodipy into amorphous polymers. The self-healable gels were also obtained with the incorporation of a crosslinker and quadruple hydrogen bond based moieties.
An aggregation-induced emission dye-powered afterglow luminogen for tumor imaging
An aggregation-induced emission (AIE) dye-powered afterglow luminogen has been designed for in vivo tumor imaging. The underlying afterglow mechanism can be described as a closed-loop of “photon–1O2–SP intermediates–photon”.
Far-red/near-infrared emitting, two-photon absorbing, and bio-stable amino-Si-pyronin dyes
Far-red/NIR emitting, two-photon absorbing, biostable aminosilapyronin dyes (ASiPj) and their derivatives (NIR-ASiPj) offer novel (ratiometric) bioimaging platforms.
Near-infrared fluorescein dyes containing a tricoordinate boron atom
Tricoordinate boron imparts near-infrared absorption/emission and unusual multi-stage changes in the photophysical properties to fluorescein dyes.
A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging
A molecular design strategy is established to access diverse enzyme-activated probes that are excitable and emit in the NIR (I and II) region with favorable Stokes shifts, enabling targeted cancer imaging by real-time monitoring enzyme activities.
A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum(II) metallacycle for efficient cancer imaging and therapy
A novel NIR-II theranostic nanoprobe, PSY (∼110 nm), was concisely developed, which demonstrated excellent photostability, high tumor uptake, superior S/N ratios and more efficient cancer treatment with minimal side effects than cisplatin.
Light emission enhancement by supramolecular complexation of chemiluminescence probes designed for bioimaging
Chemiluminescence offers advantages over fluorescence for bioimaging, since an external light source is unnecessary with chemiluminescent agents.
In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe
In this work, a novel NIR two-photon fluorescence probe DCM-APN is reported for tracking APN in vitro and in vivo.
Chemiluminescence-initiated and in situ-enhanced photoisomerization for tissue-depth-independent photo-controlled drug release
Tissue-penetration-depth-independent self-luminescence is highly expected to perform photoisomerization-related bioapplications in vivo to overcome the limitation of shallow tissue-penetration from external photoexcitation.
Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging
Novel biocompatible NIR-II aggregation-induced emission dots are facilely assembled and used for NIR-II biomedical fluorescence imaging.
Molecular design of near-infrared fluorescent Pdots for tumor targeting: aggregation-induced emission versus anti-aggregation-caused quenching
This article presents the first work to fundamentally study the effect of steric hindrance in Pdot systems.
Covalent organic nanosheets for bioimaging
Non-toxic covalent organic nanosheet-based fluorescent nuclear stains.
ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy
Aptamer conjugated porphyrinic metal–organic framework (MOF) achieved target-induced bioimaging and photodynamic therapy.
Tricarbocyanine N-triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo
Tricarbocyanine N-triazoles are first described as rationally-designed structures to overcome the limitations of NIR dyes for long-term in vivo imaging.
Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis
Development of molecular probes for the detection of reactive oxygen and nitrogen species (RONS) is important for the pathology and diagnosis of keloid diseases.
Detection of analytes in mitochondria without interference from other sites based on an innovative ratiometric fluorophore
A new strategy that integrates the targeting group and response moiety together for the preparation of mitochondrial probe was developed. Bioimaging studies have shown that for the first time, the newly designed probe HDFL-Cys can first accumulate in mitochondria and then react with the analyte.
Intense near-infrared-II luminescence from NaCeF4:Er/Yb nanoprobes for in vitro bioassay and in vivo bioimaging
We report the controlled synthesis of monodisperse NaCeF4:Er/Yb nanoprobes that exhibit intense NIR-II emission for in vitro bioassay and in vivo bioimaging.
Highly luminescent, biocompatible ytterbium(III) complexes as near-infrared fluorophores for living cell imaging
We report three synthetic methods to prepare biocompatible Yb3+ complexes, which displayed high NIR luminescence with quantum yields up to 13% in aqueous media. This renders β-fluorinated Yb3+ porphyrinoids a new class of NIR probes for living cell imaging including time-resolved fluorescence lifetime imaging.
Design, synthesis, and time-gated cell imaging of carbon-bridged triangulenium dyes with long fluorescence lifetime and red emission
Introduction of an isopropyl bridge in the triangulenium skeleton leads to a new series of redshifted triangulenium dyes with high fluorescence quantum yields and remarkable long fluorescence lifetime allowing for time-gated cell imaging.
Bioresponsive and near infrared photon co-enhanced cancer theranostic based on upconversion nanocapsules
A yolk-like nanocapsule with responsiveness to tumor microenvironment and NIR photons was invented by integrating a tumor-responsive photothermal agent on Mn-doped UCNPs@mSiO2 nanospheres for multiple imaging guided thermo-chemotherapy.
Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery
PDFT1032, a new semiconducting polymer possessing a favorable absorption peak (1032 nm) and outstanding biocompatibility, may be widely applicable in clinical imaging and the surgical treatment of malignancy.
Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration
A successful strategy for the design of ultrabright red luminogens with aggregation-induced emission (AIE) features is reported. The AIE dots can be utilized as efficient fluorescent probes for in vivo deep-tissue imaging with high penetration depth and high contrast.
About this collection
Near-infrared (NIR) fluorescence imaging (wavelength range: 650–1700 nm) is one of the remarkable imaging modalities for improved bioimaging and biosensing in both fundamental research and clinical applications, owing to its high spatiotemporal resolution and noninvasiveness. It has been a growing research topic for decades and will continue to flourish in the coming years. In this themed issue, selected studies focused on NIR bioimaging and biosensing published in Chemical Science in the past 18 months have been collected. Through this themed issue, we aim to call on the research community to strengthen cooperation with scientists among diverse research fields, such as chemistry, biology and biomedicine.