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Issue 30, 2019
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A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging

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Abstract

The advance of cancer imaging requires innovations to establish novel fluorescent scaffolds that are excitable and emit in the near-infrared region with favorable Stokes shifts. Nevertheless, the lack of probes with these optimized optical properties presents a major bottleneck in targeted cancer imaging. By coupling of boron dipyrromethene platforms to enzymic substrates via a self-immolative benzyl thioether linker, we here report a strategy toward enzyme-activated fluorescent probes to satisfy these requirements. This strategy is applicable to generate various BODIPY-based probes across the NIR spectrum via introducing diverse electron-withdrawing substituents at the 3-position of the BODIPY core through a vinylene unit. As expected, such designed probes show advantages of two-channel ratiometric fluorescence and light-up NIR (I and II) emission with large Stokes shifts upon enzyme activation, enabling targeted cancer cell imaging and accurate tumor location by real-time monitoring of enzyme activities. This strategy is promising in engineering activatable molecular probes suitable for precision medicine.

Graphical abstract: A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging

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Publication details

The article was received on 28 Apr 2019, accepted on 12 Jun 2019 and first published on 14 Jun 2019


Article type: Edge Article
DOI: 10.1039/C9SC02093D
Chem. Sci., 2019,10, 7222-7227
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging

    R. Wang, J. Chen, J. Gao, J. Chen, G. Xu, T. Zhu, X. Gu, Z. Guo, W. Zhu and C. Zhao, Chem. Sci., 2019, 10, 7222
    DOI: 10.1039/C9SC02093D

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