New directions of activity-based sensing for in vivo NIR imaging
In vivo imaging is a powerful approach to study biological processes. Beyond cellular methods, in vivo studies allow for biological stimuli (small molecules or proteins) to be studied in their native environment. This has the potential to aid in the discovery of new biology and guide the development of diagnostics and therapies for diseases. To ensure selectivity and an observable readout, the probe development field is shifting towards activity-based sensing (ABS) approaches and near-infrared (NIR) imaging modalities. This perspective will highlight recent in vivo ABS applications that utilize NIR imaging platforms.
- This article is part of the themed collections: Most popular 2021 chemical biology articles, Chemical Science Recent Perspective articles and Near-infrared (NIR) luminescent probes for bioimaging and biosensing