Themed collection 2022 Pioneering Investigators
Targeting chemokine receptors from the inside-out: discovery and development of small-molecule intracellular antagonists
Intracellular, allosteric antagonists for chemokine receptors hold great promise for the therapeutic modulation of chemokine responses.
d–sp orbital hybridization: a strategy for activity improvement of transition metal catalysts
This article highlights the recent progress of d–sp hybridization catalysts, and emphasizes d–sp orbital hybridization as a unique strategy to regulate the electronic structures and catalytic performances of transition metals.
Gaining control over conjugated polymer morphology to improve the performance of organic electronics
Conjugated polymer (CP) microstructure plays a crucial role in determining the characteristics of a target device. Here, we provide an overview of the key aspects of the CP microstructure-property relationship carried out in our group.
Molecular polymer bottlebrushes in nanomedicine: therapeutic and diagnostic applications
Molecular polymer bottlebrushes offer a comprehensive toolbox for nanomaterials design. Their tuneable and multifunctional architecture has accelerated their use in nano-bio research and nanomedicine applications.
Understanding the reactivity of frustrated Lewis pairs with the help of the activation strain model–energy decomposition analysis method
This Feature article presents recent representative applications of the combination of the Activation Strain Model of reactivity and the Energy Decomposition Analysis methods to understand the reactivity of Frustrated Lewis Pairs (FLPs).
Understanding PEDOT doped with tosylate
The conducting polymer of PEDOT doped with tosylate has properties and behaviour making it interesting for use in conformable electronic devices. Understanding this material is of research interest.
Gold-catalysed rearrangement of unconventional cyclopropane-tethered 1,5-enynes
The synthesis of particular cyclopropane-tethered 1,5-enynes, namely 6-alkynyl-4-alkylidenebicyclo[3.1.0]hex-2-enes, enabled the discovery of unprecedented gold-catalyzed rearrangment to indenes.
A chiral 3D silver(I)–benzenedithiolate coordination polymer exhibiting photoemission and non-linear optical response
A neutral coordination polymer made of Ag(I) and 1,3-benzenedithiolate, [Ag2(1,3-BDT)]n, displays both photoluminescence properties and a second harmonic generation signal.
Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues
A novel multivalent platform of NHS-activated acrylates was developed for the site-selective chemical appendage of multiple functionalities on native peptides, a highly demanding and complex tool of modern chemical biology.
Highly Dispersed Silica-Supported Iridium and Iridium-Aluminium Catalysts for Methane Activation Prepared via Surface Organometallic Chemistry
Defect engineering in two-dimensional perovskite nanowire arrays by europium(III) doping towards high-performance photodetection
We demonstrate high-performance photodetectors based on Eu-doped 2D perovskite nanowire arrays. Thanks to the efficient carrier transport and suppressed trap density, the optimized Eu-doped photodetectors show an excellent responsivity of 6.24 A W−1.
Nickel-Catalyzed Decarboxylative Cross-Coupling of Indole-3-acetic Acids with Aryl Bromides by Convergent Paired Electrolysis
Microemulsions for the covalent patterning of graphene
Emulsions are used as templates to pattern graphene covalently. When exposing graphene to a microemulsion, some regions are in contact with the aqueous phase which contains the reagent, while the rest are exposed to the oil phase and do not react.
Enolate SNAr of unactivated arenes via [(η6-arene)RuCp]+ intermediates
SNAr of unactivated arenes with enolate nucleophiles is facilitated by π-coordination to Ru and subsequent product release by photolysis.
Hydride state accumulation in native [FeFe]-hydrogenase with the physiological reductant H2 supports its catalytic relevance
Studies of enzymatic catalysis often rely on non-biological reagents, which may affect catalytic intermediates and produce off-cycle states. Here the influence of buffer and reductant on key intermediates of [FeFe]-hydrogenase are explored.
Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide
We describe a new approach to target non-canonical DNA 3-Way Junctions (3WJs) that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.
Triazine-pyridine chemistry for protein labelling on tyrosine
Herein, we discover the new reactivity of the 1,3,5-triazine moiety reacting with a phenol group and report the development of biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labelling under physiological conditions and profiling in the whole proteome.
Semiconducting silicon–phosphorus frameworks for caging exotic polycations
Silicon phosphides with a new structure have been synthesized. These salt inclusion materials contain exotic polycations such as [Ba6Cl]11+. The structure and properties are investigated.
Mechanistic insights of molecular metal polyselenides for catalytic hydrogen generation
Exploration of efficient molecular metal–selenide HER catalysts and identification of the mechanistic implications induced by the type of incorporated chalcogen.
Self-assembled benzoselenadiazole-capped tripeptide hydrogels with inherent in vitro anti-cancer and anti-inflammatory activity
Heterocyclic aromatic benzoselenadiazole (BSe)-capped tripeptides self-assemble to form hydrogels and exhibit in vitro anti-cancer and anti-inflammatory activities.
Metal–organic cage incorporating thin-film nanocomposite membranes with antifouling properties
Incorporation of functional water-stable metal–organic cages (MOCs) in the reverse osmosis membrane changes the membrane morphology and hydrophilicity to achieve better antifouling properties.
Tuning the photophysical properties of luminescent lanthanide complexes through regioselective antenna fluorination
Carbostyrils monofluorinated in the 3, 5, or 6 positions were synthesised via a photochemical isomerisation-cyclisation route, and incorporated into octadentate cyclen triacetate ligands that formed luminescent Tb(III) and Eu(III) complexes.
Air-stable plasmonic bubbles as a versatile three-dimensional surface-enhanced Raman scattering platform for bi-directional gas sensing
‘Plasmonic bubbles’ as a versatile, air-stable, centimetre-sized 3D SERS platform with bi-directional gas sensing capabilities.
AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity
We have designed and synthesized a new PKC ligand with a novel skeleton based on alotaketals through in silico screening, docking analysis, and molecular dynamics simulation. The new ligand has a higher affinity for PKCα-C1A than for PKCδ-C1B.
Decoupling the metal–insulator transition temperature and hysteresis of VO2 using Ge alloying and oxygen vacancies
Ge alloying enables independent control of forward and reverse metal–insulator transitions in VO2, enabling decoupling of transformation-temperature and hysteresis.
Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity
The development of multifunctional modulators by curating the metal chelating properties of bipyridine and biomolecular auxiliaries to ameliorate the multifaceted amyloid toxicity.
Chelation-activated ultralong room-temperature phosphorescence and thermo-/excitation-dependent persistent luminescence
Chelation-activated tunable room-temperature phosphorescence in molecule-based metal complexes.
Mechanistic insight into rapid oxygen-atom transfer from a calix-functionalized polyoxovanadate
Accelerated rates of O-atom vacancy formation in calix-substituted POV–alkoxide clusters. Mechanisms if OAT dependent on surface ligand substitution patterns.
Post-synthetic ligand cyclization in metal–organic frameworks through functional group connection with regioisomerism
Novel post-synthetic ligand cyclization (PSLC) strategy for metal–organic frameworks (MOFs) bearing regioisomeric functional groups has been developed to install benzo-fused heterocycles in MOFs.
Dual-photofunctional organogermanium compound based on donor–acceptor–donor architecture
A dual-photofunctional organogermanium compound based on a donor–acceptor–donor architecture that exhibits thermally activated delayed fluorescence and mechano-responsive luminochromism has been developed.
High capacity ammonia adsorption in a robust metal–organic framework mediated by reversible host–guest interactions
To understand the exceptional adsorption of NH3 in MFM-300(Sc), we report a full study of the mechanism of adsorption by in situ neutron diffraction, inelastic neutron scattering, synchrotron infrared microspectroscopy, and 45Sc NMR spectroscopy.
Mixed molecular orientations promote charge transport in bulk heterojunction solar cells
This study reveals that a mixture of face-on and edge-on molecular orientations can be favorable for out-of-plane charge transport in solution processed bulk heterojunction organic solar cell active layers.
A microfluidic organic transistor for reversible and real-time monitoring of H2O2 at ppb/ppt levels in ultrapure water
A microfluidic organic transistor functionalized with phenyboronic acid could monitor not only a reversible boronate anion with H2O2 but also an irreversible conversion into a phenol structure by a continuous flow.
Hundred-gram scale fabrication of few-layered silicene by a continuous vapor-dealloying strategy for high-performance lithium storage
A continuous vapor de-alloying strategy for a hundred-gram scale fabrication of silicene with high-performance Li storage capability.
Aromatic foldamers as molecular springs in network polymers
Aromatic foldamer based networks are developed, where the foldamer unit acts as a molecular spring. Energy dissipation increases with the number of turns in the foldamer, consistent with mechanical unfolding of the molecular spring.
Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
A novel kind of controlled delivery triggered by hydrogen sulfide has been developed. It is based on the dynamic chemistry of tetrazines, and it allows selective dual release in colon cancer cells.
UV degradation of poly(lactic acid) materials through copolymerisation with a sugar-derived cyclic xanthate
A bioderived cyclic xanthate monomer has been synthesised from tri-O-acetyl-D-glucal. Through copolymerisation with lactide, UV-degradable poly(lactic acid) materials are obtained.
Stereospecific reaction of sulfonimidoyl fluorides with Grignard reagents for the synthesis of enantioenriched sulfoximines
Highly enantioenriched sulfoximines can be prepared from sulfonimidoyl fluorides in a stereospecific reaction with a broad range of Grignard reagents.
Surfactant-modified Zn nanosheets on carbon paper for electrochemical CO2 reduction to CO
Hexadecyl trimethyl ammonium bromide favors CO2 surface diffusion and inhibits excessive proton accumulation on Zn electrodes.
Migratory insertion of copper-allenylidene from propargyl ester
The highly efficient homo-dimerization and cross-coupling of propargyl esters via migratory insertion of the copper-allenylidenes have been developed to give various 1-en-3,5-diynes, cumulenes and 1,3-diynes with moderate to excellent yields.
A photochromic carbazolyl-imidazolyl radical complex
A carbazole-incorporated photochromic radical complex is synthesized.
Aryl-substituted-indanone end-capped nonfullerene acceptors for organic solar cells with a low nonradiative loss
An aryl-substituted terminal group enables considerably low nonradiative energy loss (ΔEnr) of 0.15 eV and thus high open-circuit voltage (Voc) of 0.99 V.
Synthesis and disassembly of an organometallic polymer comprising redox-active Co4S4 clusters and Janus biscarbene linkers
Discrete Co4S4 clusters can be reversibly crosslinked into redox-active frameworks using Janus bis-N-heterocyclic carbene (NHC) ligands.
Transition structures for the oxy–ene reaction
Can this occur naturally? This study offers the theoretical background of an overlooked pericyclic reaction.
Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles
A sustainable flow strategy for the alkylation of heterocycles via the in situ generation of alkyl zinc sulfinates is presented.
Mechanochemical activation and oxidation of U(IV)O2
Mechanochemical impact induces oxidation of U(IV)O2 in presence of alkali metal peroxides Li2O2 and Na2O2 during liquid-assisted grinding, resulting in respective alkali U(VI) triperoxide phases (e.g. Na4[UO2(O2)3]·9H2O).
Amphipathic poly-β-peptides for intracellular protein delivery
We design amphipathic poly-β-peptides for intracellular protein delivery and find that protein loading and delivery efficiency are positively correlated with molecular weight and hydrophobic contents.
A non-natural biosynthesis pathway toward 2-methylisoborneol
The biosynthesis of 2-methylisoborneol was reconstituted by elongation of dimethylallyl diphosphate (DMAPP) with (S)- and (R)-2-methylisopentenyl diphosphate (2-Me-IPP) using farnesyl diphosphate synthase (FPPS), followed by terpene cyclisation.
Total synthesis of streptovertidione and bioinspired transformation to streptovertidine A and formicapyridine A
We report herein a concise total synthesis of streptovertidione, and its transformation to streptovertidine A and formicapyridine A through a bioinspired pyridination.
Synthesis of polycyclic aminal heterocycles via decarboxylative cyclisation of dipeptide derivatives
A convenient synthesis of structurally diverse N-fused aminal heterocycles from easily accessed dipeptides using the hypervalent iodine reagent PIDA in combination with BF3·OEt2 is described.
A pressure-induced ratiometric signalling chemosensor: a case of helical anthracenes
A helical anthracene-based chemosensor that shows ratiometric fluorescence signalling upon hydrostatic pressurization was newly constructed, in which a contraction behavior of the helical pitch plays a pivotal role.
Alkali metal ion binding using cyclic polyketones
Cyclic polyketones composed of acetylacetone analogues showed crown ether-like alkali metal ion binding in less polar solvents. Their cation-binding properties were used for the Finkelstein reaction and the design of new cation-binding hosts.
Strain-release arylations for the bis-functionalization of azetidines
Introducing azetidine-linkers between two aryl moieties is made possible through strain-release strategies.
Hemicubane topological analogs of the oxygen-evolving complex of photosystem II mediating water-assisted propylene carbonate oxidation
A series of Ca–Mn hemicubane clusters with topological analogy to the biological oxygen evolving complex are prepared. Those with closest structural analogy are active in the electrochemical activation of water in the decomposition of propylene carbonate.
Glycan shields for penetrating peptides
We here describe the synthesis and biological evaluation of glycan shields for cell penetrating peptides.
Templated synthesis of zirconium(IV)-based metal–organic layers (MOLs) with accessible chelating sites
A two-step templating/delamination strategy can provide access to metal–organic layers with accessible chelating sites poised for quantitative post-synthetic metalation.
Cation–π interactions enabling hard/soft Ti/Ag heterobimetallic cooperativity in lactide ring-opening polymerisation
Hard/soft Ti/Ag metal cooperativity in lactide ring-opening polymerization.
About this collection
ChemComm is here to support researchers throughout their careers. To complement our annual Emerging Investigators collection, this brand new special collection showcases high quality research being carried out by international researchers who are more established in their independent careers and have been recognised as making a significant contribution to their field.
New articles will be added to this collection as they are published.