Themed collection 2022 Pioneering Investigators

57 items
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Targeting chemokine receptors from the inside-out: discovery and development of small-molecule intracellular antagonists

Intracellular, allosteric antagonists for chemokine receptors hold great promise for the therapeutic modulation of chemokine responses.

Graphical abstract: Targeting chemokine receptors from the inside-out: discovery and development of small-molecule intracellular antagonists
From the themed collection: 2022 Pioneering Investigators
Feature Article

d–sp orbital hybridization: a strategy for activity improvement of transition metal catalysts

This article highlights the recent progress of d–sp hybridization catalysts, and emphasizes d–sp orbital hybridization as a unique strategy to regulate the electronic structures and catalytic performances of transition metals.

Graphical abstract: d–sp orbital hybridization: a strategy for activity improvement of transition metal catalysts
From the themed collection: 2022 Pioneering Investigators
Open Access Feature Article

Gaining control over conjugated polymer morphology to improve the performance of organic electronics

Conjugated polymer (CP) microstructure plays a crucial role in determining the characteristics of a target device. Here, we provide an overview of the key aspects of the CP microstructure-property relationship carried out in our group.

Graphical abstract: Gaining control over conjugated polymer morphology to improve the performance of organic electronics
From the themed collection: 2022 Pioneering Investigators
Feature Article

Molecular polymer bottlebrushes in nanomedicine: therapeutic and diagnostic applications

Molecular polymer bottlebrushes offer a comprehensive toolbox for nanomaterials design. Their tuneable and multifunctional architecture has accelerated their use in nano-bio research and nanomedicine applications.

Graphical abstract: Molecular polymer bottlebrushes in nanomedicine: therapeutic and diagnostic applications
From the themed collection: 2022 Pioneering Investigators
Feature Article

Understanding the reactivity of frustrated Lewis pairs with the help of the activation strain model–energy decomposition analysis method

This Feature article presents recent representative applications of the combination of the Activation Strain Model of reactivity and the Energy Decomposition Analysis methods to understand the reactivity of Frustrated Lewis Pairs (FLPs).

Graphical abstract: Understanding the reactivity of frustrated Lewis pairs with the help of the activation strain model–energy decomposition analysis method
From the themed collection: Chemical Communications HOT Articles 2022
Feature Article

Understanding PEDOT doped with tosylate

The conducting polymer of PEDOT doped with tosylate has properties and behaviour making it interesting for use in conformable electronic devices. Understanding this material is of research interest.

Graphical abstract: Understanding PEDOT doped with tosylate
From the themed collection: 2022 Pioneering Investigators
Communication

Gold-catalysed rearrangement of unconventional cyclopropane-tethered 1,5-enynes

The synthesis of particular cyclopropane-tethered 1,5-enynes, namely 6-alkynyl-4-alkylidenebicyclo[3.1.0]hex-2-enes, enabled the discovery of unprecedented gold-catalyzed rearrangment to indenes.

Graphical abstract: Gold-catalysed rearrangement of unconventional cyclopropane-tethered 1,5-enynes
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

A chiral 3D silver(I)–benzenedithiolate coordination polymer exhibiting photoemission and non-linear optical response

A neutral coordination polymer made of Ag(I) and 1,3-benzenedithiolate, [Ag2(1,3-BDT)]n, displays both photoluminescence properties and a second harmonic generation signal.

Graphical abstract: A chiral 3D silver(i)–benzenedithiolate coordination polymer exhibiting photoemission and non-linear optical response
From the themed collection: 2022 Pioneering Investigators
Communication

Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues

A novel multivalent platform of NHS-activated acrylates was developed for the site-selective chemical appendage of multiple functionalities on native peptides, a highly demanding and complex tool of modern chemical biology.

Graphical abstract: Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues
From the themed collection: 2022 Pioneering Investigators
Open Access Accepted Manuscript - Communication

Highly Dispersed Silica-Supported Iridium and Iridium-Aluminium Catalysts for Methane Activation Prepared via Surface Organometallic Chemistry

From the themed collection: 2022 Pioneering Investigators
Communication

Defect engineering in two-dimensional perovskite nanowire arrays by europium(III) doping towards high-performance photodetection

We demonstrate high-performance photodetectors based on Eu-doped 2D perovskite nanowire arrays. Thanks to the efficient carrier transport and suppressed trap density, the optimized Eu-doped photodetectors show an excellent responsivity of 6.24 A W−1.

Graphical abstract: Defect engineering in two-dimensional perovskite nanowire arrays by europium(iii) doping towards high-performance photodetection
From the themed collection: 2022 Pioneering Investigators
Accepted Manuscript - Communication

Nickel-Catalyzed Decarboxylative Cross-Coupling of Indole-3-acetic Acids with Aryl Bromides by Convergent Paired Electrolysis

From the themed collection: Chemical Communications HOT Articles 2022
Communication

Microemulsions for the covalent patterning of graphene

Emulsions are used as templates to pattern graphene covalently. When exposing graphene to a microemulsion, some regions are in contact with the aqueous phase which contains the reagent, while the rest are exposed to the oil phase and do not react.

Graphical abstract: Microemulsions for the covalent patterning of graphene
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Enolate SNAr of unactivated arenes via [(η6-arene)RuCp]+ intermediates

SNAr of unactivated arenes with enolate nucleophiles is facilitated by π-coordination to Ru and subsequent product release by photolysis.

Graphical abstract: Enolate SNAr of unactivated arenes via [(η6-arene)RuCp]+ intermediates
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Hydride state accumulation in native [FeFe]-hydrogenase with the physiological reductant H2 supports its catalytic relevance

Studies of enzymatic catalysis often rely on non-biological reagents, which may affect catalytic intermediates and produce off-cycle states. Here the influence of buffer and reductant on key intermediates of [FeFe]-hydrogenase are explored.

Graphical abstract: Hydride state accumulation in native [FeFe]-hydrogenase with the physiological reductant H2 supports its catalytic relevance
From the themed collection: 2022 Pioneering Investigators
Communication

Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

We describe a new approach to target non-canonical DNA 3-Way Junctions (3WJs) that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.

Graphical abstract: Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide
From the themed collection: 2022 Pioneering Investigators
Communication

Triazine-pyridine chemistry for protein labelling on tyrosine

Herein, we discover the new reactivity of the 1,3,5-triazine moiety reacting with a phenol group and report the development of biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labelling under physiological conditions and profiling in the whole proteome.

Graphical abstract: Triazine-pyridine chemistry for protein labelling on tyrosine
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Semiconducting silicon–phosphorus frameworks for caging exotic polycations

Silicon phosphides with a new structure have been synthesized. These salt inclusion materials contain exotic polycations such as [Ba6Cl]11+. The structure and properties are investigated.

Graphical abstract: Semiconducting silicon–phosphorus frameworks for caging exotic polycations
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Mechanistic insights of molecular metal polyselenides for catalytic hydrogen generation

Exploration of efficient molecular metal–selenide HER catalysts and identification of the mechanistic implications induced by the type of incorporated chalcogen.

Graphical abstract: Mechanistic insights of molecular metal polyselenides for catalytic hydrogen generation
From the themed collection: 2022 Pioneering Investigators
Communication

Self-assembled benzoselenadiazole-capped tripeptide hydrogels with inherent in vitro anti-cancer and anti-inflammatory activity

Heterocyclic aromatic benzoselenadiazole (BSe)-capped tripeptides self-assemble to form hydrogels and exhibit in vitro anti-cancer and anti-inflammatory activities.

Graphical abstract: Self-assembled benzoselenadiazole-capped tripeptide hydrogels with inherent in vitro anti-cancer and anti-inflammatory activity
From the themed collection: 2022 Pioneering Investigators
Communication

Metal–organic cage incorporating thin-film nanocomposite membranes with antifouling properties

Incorporation of functional water-stable metal–organic cages (MOCs) in the reverse osmosis membrane changes the membrane morphology and hydrophilicity to achieve better antifouling properties.

Graphical abstract: Metal–organic cage incorporating thin-film nanocomposite membranes with antifouling properties
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Tuning the photophysical properties of luminescent lanthanide complexes through regioselective antenna fluorination

Carbostyrils monofluorinated in the 3, 5, or 6 positions were synthesised via a photochemical isomerisation-cyclisation route, and incorporated into octadentate cyclen triacetate ligands that formed luminescent Tb(III) and Eu(III) complexes.

Graphical abstract: Tuning the photophysical properties of luminescent lanthanide complexes through regioselective antenna fluorination
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Air-stable plasmonic bubbles as a versatile three-dimensional surface-enhanced Raman scattering platform for bi-directional gas sensing

‘Plasmonic bubbles’ as a versatile, air-stable, centimetre-sized 3D SERS platform with bi-directional gas sensing capabilities.

Graphical abstract: Air-stable plasmonic bubbles as a versatile three-dimensional surface-enhanced Raman scattering platform for bi-directional gas sensing
From the themed collection: 2022 Pioneering Investigators
Communication

AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity

We have designed and synthesized a new PKC ligand with a novel skeleton based on alotaketals through in silico screening, docking analysis, and molecular dynamics simulation. The new ligand has a higher affinity for PKCα-C1A than for PKCδ-C1B.

Graphical abstract: AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity
From the themed collection: 2022 Pioneering Investigators
Communication

Decoupling the metal–insulator transition temperature and hysteresis of VO2 using Ge alloying and oxygen vacancies

Ge alloying enables independent control of forward and reverse metal–insulator transitions in VO2, enabling decoupling of transformation-temperature and hysteresis.

Graphical abstract: Decoupling the metal–insulator transition temperature and hysteresis of VO2 using Ge alloying and oxygen vacancies
From the themed collection: 2022 Pioneering Investigators
Communication

Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity

The development of multifunctional modulators by curating the metal chelating properties of bipyridine and biomolecular auxiliaries to ameliorate the multifaceted amyloid toxicity.

Graphical abstract: Multifunctional molecules with a bipyridyl core ameliorate multifaceted amyloid toxicity
From the themed collection: 2022 Pioneering Investigators
Communication

Chelation-activated ultralong room-temperature phosphorescence and thermo-/excitation-dependent persistent luminescence

Chelation-activated tunable room-temperature phosphorescence in molecule-based metal complexes.

Graphical abstract: Chelation-activated ultralong room-temperature phosphorescence and thermo-/excitation-dependent persistent luminescence
From the themed collection: 2022 Pioneering Investigators
Communication

Mechanistic insight into rapid oxygen-atom transfer from a calix-functionalized polyoxovanadate

Accelerated rates of O-atom vacancy formation in calix-substituted POV–alkoxide clusters. Mechanisms if OAT dependent on surface ligand substitution patterns.

Graphical abstract: Mechanistic insight into rapid oxygen-atom transfer from a calix-functionalized polyoxovanadate
From the themed collection: 2022 Pioneering Investigators
Communication

Post-synthetic ligand cyclization in metal–organic frameworks through functional group connection with regioisomerism

Novel post-synthetic ligand cyclization (PSLC) strategy for metal–organic frameworks (MOFs) bearing regioisomeric functional groups has been developed to install benzo-fused heterocycles in MOFs.

Graphical abstract: Post-synthetic ligand cyclization in metal–organic frameworks through functional group connection with regioisomerism
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Dual-photofunctional organogermanium compound based on donor–acceptor–donor architecture

A dual-photofunctional organogermanium compound based on a donor–acceptor–donor architecture that exhibits thermally activated delayed fluorescence and mechano-responsive luminochromism has been developed.

Graphical abstract: Dual-photofunctional organogermanium compound based on donor–acceptor–donor architecture
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

High capacity ammonia adsorption in a robust metal–organic framework mediated by reversible host–guest interactions

To understand the exceptional adsorption of NH3 in MFM-300(Sc), we report a full study of the mechanism of adsorption by in situ neutron diffraction, inelastic neutron scattering, synchrotron infrared microspectroscopy, and 45Sc NMR spectroscopy.

Graphical abstract: High capacity ammonia adsorption in a robust metal–organic framework mediated by reversible host–guest interactions
From the themed collection: 2022 Pioneering Investigators
Communication

Mixed molecular orientations promote charge transport in bulk heterojunction solar cells

This study reveals that a mixture of face-on and edge-on molecular orientations can be favorable for out-of-plane charge transport in solution processed bulk heterojunction organic solar cell active layers.

Graphical abstract: Mixed molecular orientations promote charge transport in bulk heterojunction solar cells
From the themed collection: 2022 Pioneering Investigators
Communication

A microfluidic organic transistor for reversible and real-time monitoring of H2O2 at ppb/ppt levels in ultrapure water

A microfluidic organic transistor functionalized with phenyboronic acid could monitor not only a reversible boronate anion with H2O2 but also an irreversible conversion into a phenol structure by a continuous flow.

Graphical abstract: A microfluidic organic transistor for reversible and real-time monitoring of H2O2 at ppb/ppt levels in ultrapure water
From the themed collection: 2022 Pioneering Investigators
Communication

Hundred-gram scale fabrication of few-layered silicene by a continuous vapor-dealloying strategy for high-performance lithium storage

A continuous vapor de-alloying strategy for a hundred-gram scale fabrication of silicene with high-performance Li storage capability.

Graphical abstract: Hundred-gram scale fabrication of few-layered silicene by a continuous vapor-dealloying strategy for high-performance lithium storage
From the themed collection: 2022 Pioneering Investigators
Communication

Aromatic foldamers as molecular springs in network polymers

Aromatic foldamer based networks are developed, where the foldamer unit acts as a molecular spring. Energy dissipation increases with the number of turns in the foldamer, consistent with mechanical unfolding of the molecular spring.

Graphical abstract: Aromatic foldamers as molecular springs in network polymers
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines

A novel kind of controlled delivery triggered by hydrogen sulfide has been developed. It is based on the dynamic chemistry of tetrazines, and it allows selective dual release in colon cancer cells.

Graphical abstract: Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

UV degradation of poly(lactic acid) materials through copolymerisation with a sugar-derived cyclic xanthate

A bioderived cyclic xanthate monomer has been synthesised from tri-O-acetyl-D-glucal. Through copolymerisation with lactide, UV-degradable poly(lactic acid) materials are obtained.

Graphical abstract: UV degradation of poly(lactic acid) materials through copolymerisation with a sugar-derived cyclic xanthate
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Stereospecific reaction of sulfonimidoyl fluorides with Grignard reagents for the synthesis of enantioenriched sulfoximines

Highly enantioenriched sulfoximines can be prepared from sulfonimidoyl fluorides in a stereospecific reaction with a broad range of Grignard reagents.

Graphical abstract: Stereospecific reaction of sulfonimidoyl fluorides with Grignard reagents for the synthesis of enantioenriched sulfoximines
From the themed collection: 2022 Pioneering Investigators
Communication

Surfactant-modified Zn nanosheets on carbon paper for electrochemical CO2 reduction to CO

Hexadecyl trimethyl ammonium bromide favors CO2 surface diffusion and inhibits excessive proton accumulation on Zn electrodes.

Graphical abstract: Surfactant-modified Zn nanosheets on carbon paper for electrochemical CO2 reduction to CO
From the themed collection: 2022 Pioneering Investigators
Communication

Migratory insertion of copper-allenylidene from propargyl ester

The highly efficient homo-dimerization and cross-coupling of propargyl esters via migratory insertion of the copper-allenylidenes have been developed to give various 1-en-3,5-diynes, [5]cumulenes and 1,3-diynes with moderate to excellent yields.

Graphical abstract: Migratory insertion of copper-allenylidene from propargyl ester
From the themed collection: Chemical Communications HOT Articles 2022
Communication

A photochromic carbazolyl-imidazolyl radical complex

A carbazole-incorporated photochromic radical complex is synthesized.

Graphical abstract: A photochromic carbazolyl-imidazolyl radical complex
From the themed collection: 2022 Pioneering Investigators
Communication

Aryl-substituted-indanone end-capped nonfullerene acceptors for organic solar cells with a low nonradiative loss

An aryl-substituted terminal group enables considerably low nonradiative energy loss (ΔEnr) of 0.15 eV and thus high open-circuit voltage (Voc) of 0.99 V.

Graphical abstract: Aryl-substituted-indanone end-capped nonfullerene acceptors for organic solar cells with a low nonradiative loss
From the themed collection: 2022 Pioneering Investigators
Communication

Synthesis and disassembly of an organometallic polymer comprising redox-active Co4S4 clusters and Janus biscarbene linkers

Discrete Co4S4 clusters can be reversibly crosslinked into redox-active frameworks using Janus bis-N-heterocyclic carbene (NHC) ligands.

Graphical abstract: Synthesis and disassembly of an organometallic polymer comprising redox-active Co4S4 clusters and Janus biscarbene linkers
From the themed collection: 2022 Pioneering Investigators
Communication

Transition structures for the oxy–ene reaction

Can this occur naturally? This study offers the theoretical background of an overlooked pericyclic reaction.

Graphical abstract: Transition structures for the oxy–ene reaction
From the themed collection: 2022 Pioneering Investigators
Communication

Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles

A sustainable flow strategy for the alkylation of heterocycles via the in situ generation of alkyl zinc sulfinates is presented.

Graphical abstract: Continuous-flow synthesis of alkyl zinc sulfinates for the direct photofunctionalization of heterocycles
From the themed collection: 2022 Pioneering Investigators
Communication

Mechanochemical activation and oxidation of U(IV)O2

Mechanochemical impact induces oxidation of U(IV)O2 in presence of alkali metal peroxides Li2O2 and Na2O2 during liquid-assisted grinding, resulting in respective alkali U(VI) triperoxide phases (e.g. Na4[UO2(O2)3]·9H2O).

Graphical abstract: Mechanochemical activation and oxidation of U(iv)O2
From the themed collection: 2022 Pioneering Investigators
Communication

Amphipathic poly-β-peptides for intracellular protein delivery

We design amphipathic poly-β-peptides for intracellular protein delivery and find that protein loading and delivery efficiency are positively correlated with molecular weight and hydrophobic contents.

Graphical abstract: Amphipathic poly-β-peptides for intracellular protein delivery
From the themed collection: 2022 Pioneering Investigators
Communication

A non-natural biosynthesis pathway toward 2-methylisoborneol

The biosynthesis of 2-methylisoborneol was reconstituted by elongation of dimethylallyl diphosphate (DMAPP) with (S)- and (R)-2-methylisopentenyl diphosphate (2-Me-IPP) using farnesyl diphosphate synthase (FPPS), followed by terpene cyclisation.

Graphical abstract: A non-natural biosynthesis pathway toward 2-methylisoborneol
From the themed collection: 2022 Pioneering Investigators
Communication

Total synthesis of streptovertidione and bioinspired transformation to streptovertidine A and formicapyridine A

We report herein a concise total synthesis of streptovertidione, and its transformation to streptovertidine A and formicapyridine A through a bioinspired pyridination.

Graphical abstract: Total synthesis of streptovertidione and bioinspired transformation to streptovertidine A and formicapyridine A
From the themed collection: 2022 Pioneering Investigators
Communication

Synthesis of polycyclic aminal heterocycles via decarboxylative cyclisation of dipeptide derivatives

A convenient synthesis of structurally diverse N-fused aminal heterocycles from easily accessed dipeptides using the hypervalent iodine reagent PIDA in combination with BF3·OEt2 is described.

Graphical abstract: Synthesis of polycyclic aminal heterocycles via decarboxylative cyclisation of dipeptide derivatives
From the themed collection: 2022 Pioneering Investigators
Communication

A pressure-induced ratiometric signalling chemosensor: a case of helical anthracenes

A helical anthracene-based chemosensor that shows ratiometric fluorescence signalling upon hydrostatic pressurization was newly constructed, in which a contraction behavior of the helical pitch plays a pivotal role.

Graphical abstract: A pressure-induced ratiometric signalling chemosensor: a case of helical anthracenes
From the themed collection: 2022 Pioneering Investigators
Communication

Alkali metal ion binding using cyclic polyketones

Cyclic polyketones composed of acetylacetone analogues showed crown ether-like alkali metal ion binding in less polar solvents. Their cation-binding properties were used for the Finkelstein reaction and the design of new cation-binding hosts.

Graphical abstract: Alkali metal ion binding using cyclic polyketones
From the themed collection: Chemical Communications HOT Articles 2022
Communication

Strain-release arylations for the bis-functionalization of azetidines

Introducing azetidine-linkers between two aryl moieties is made possible through strain-release strategies.

Graphical abstract: Strain-release arylations for the bis-functionalization of azetidines
From the themed collection: 2022 Pioneering Investigators
Communication

Hemicubane topological analogs of the oxygen-evolving complex of photosystem II mediating water-assisted propylene carbonate oxidation

A series of Ca–Mn hemicubane clusters with topological analogy to the biological oxygen evolving complex are prepared. Those with closest structural analogy are active in the electrochemical activation of water in the decomposition of propylene carbonate.

Graphical abstract: Hemicubane topological analogs of the oxygen-evolving complex of photosystem II mediating water-assisted propylene carbonate oxidation
From the themed collection: 2022 Pioneering Investigators
Communication

Glycan shields for penetrating peptides

We here describe the synthesis and biological evaluation of glycan shields for cell penetrating peptides.

Graphical abstract: Glycan shields for penetrating peptides
From the themed collection: 2022 Pioneering Investigators
Communication

Templated synthesis of zirconium(IV)-based metal–organic layers (MOLs) with accessible chelating sites

A two-step templating/delamination strategy can provide access to metal–organic layers with accessible chelating sites poised for quantitative post-synthetic metalation.

Graphical abstract: Templated synthesis of zirconium(iv)-based metal–organic layers (MOLs) with accessible chelating sites
From the themed collection: 2022 Pioneering Investigators
Open Access Communication

Cation–π interactions enabling hard/soft Ti/Ag heterobimetallic cooperativity in lactide ring-opening polymerisation

Hard/soft Ti/Ag metal cooperativity in lactide ring-opening polymerization.

Graphical abstract: Cation–π interactions enabling hard/soft Ti/Ag heterobimetallic cooperativity in lactide ring-opening polymerisation
From the themed collection: 2022 Pioneering Investigators
57 items

About this collection

ChemComm is here to support researchers throughout their careers. To complement our annual Emerging Investigators collection, this brand new special collection showcases high quality research being carried out by international researchers who are more established in their independent careers and have been recognised as making a significant contribution to their field.

New articles will be added to this collection as they are published.


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