Issue 67, 2022

Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture

Abstract

Dimeric boronic acids kill Mycobacterium tuberculosis (Mtb) by targeting mycobacterial specific extracellular glycans, removing the requirement for a therapeutic agent to permeate the complex cell envelope. Here we report the successful development and use of new ‘clickable’ boronic acid probes as a powerful method to enable the direct detection and visualisation of this unique class of cell-surface targeting antitubercular agents.

Graphical abstract: Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2022
Accepted
26 Jul 2022
First published
02 Aug 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 9361-9364

Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture

C. S. Guy, R. M. F. Tomás, Q. Tang, M. I. Gibson and E. Fullam, Chem. Commun., 2022, 58, 9361 DOI: 10.1039/D2CC02407A

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