SCHEDULED MAINTENANCE
Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide†
Laura
Martínez-Castro, 
§b
Juan
Tolosa-Barrilero,
§cd
Ana
Alcalde-Ordóñez,
a
Soraya
Learte-Aymamí,
a
José L.
Mascareñas,
a
Joaquín C.
García-Martínez,
cd
José
Martínez-Costas,
e
Jean-Didier
Maréchal,
b
Miguel
Vázquez López
f
and
M. Eugenio
Vázquez
*a
§b
Juan
Tolosa-Barrilero,
§cd
Ana
Alcalde-Ordóñez,
a
Soraya
Learte-Aymamí,
a
José L.
Mascareñas,
a
Joaquín C.
García-Martínez,
cd
José
Martínez-Costas,
e
Jean-Didier
Maréchal,
b
Miguel
Vázquez López
f
and
M. Eugenio
Vázquez
*a
Abstract
Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.
- This article is part of the themed collection: 2022 Pioneering Investigators
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