Issue 65, 2022
From the journal:

Chemical Communications

Rationally designed Ru(ii) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer†

Le Tu,‡ab   Chonglu Li,‡b   Chang Liu,‡b   Suya Bai,b   Jingfang Yang,b   Xian Zhang,b   Liying Xu,*c   Xiaoxing Xiong*a  and  Yao Sun ORCID logo *b  

* Corresponding authors

a Department of Neurosurgery, Remin Hospital of Wuhan University, Wuhan 430079, P. R. China
E-mail: xiaoxingxiong@whu.edu.cn

b Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
E-mail: sunyaogbasp@ccnu.edu.cn

c Zhongnan Hospital of Wuhan University, Wuhan 430062, P. R. China
E-mail: aying0923@foxmail.com

Abstract

Herein, we construct a series of Ru(II) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru(II) metallacycles in biomedicine.

Graphical abstract: Rationally designed Ru(ii) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer

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Article information

DOI
https://doi.org/10.1039/D2CC03118C
Article type
Communication
Submitted
02 Jun 2022
Accepted
19 Jul 2022
First published
20 Jul 2022

Chem. Commun., 2022,58, 9068-9071

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Rationally designed Ru(II) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer

L. Tu, C. Li, C. Liu, S. Bai, J. Yang, X. Zhang, L. Xu, X. Xiong and Y. Sun, Chem. Commun., 2022, 58, 9068 DOI: 10.1039/D2CC03118C

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