Themed collection Journal of Materials Chemistry B Emerging Investigators

41 items
Open Access Perspective

Fluidic enabled bioelectronic implants: opportunities and challenges

Fluidics are enabling new possibilities in bioelectronic medicine and research.

Graphical abstract: Fluidic enabled bioelectronic implants: opportunities and challenges
Open Access Perspective

The importance of water content on the conductivity of biomaterials and bioelectronic devices

Water content derived from the environment is as an important a variable as temperature for affecting the conductivity and for understanding the charge transport mechanisms within conductive biomaterials as well as bioelectronic devices.

Graphical abstract: The importance of water content on the conductivity of biomaterials and bioelectronic devices
Perspective

Active nanomotors surpass passive nanomedicines: current progress and challenges

We summarise the superiorities of nanomotors over traditional nanomedicines, state-of-the-art applications and current challenges of using nanomotors in the biomedical field.

Graphical abstract: Active nanomotors surpass passive nanomedicines: current progress and challenges
Accepted Manuscript - Review Article

Nanomaterials Integrated 3D Printing for Biomedical Application

Review Article

Nucleic acid paranemic structures: a promising building block for functional nanomaterials in biomedical and bionanotechnological applications

This review highlights the PX-based DNA nanostructures in biological systems, dynamic systems, and biomedical contexts.

Graphical abstract: Nucleic acid paranemic structures: a promising building block for functional nanomaterials in biomedical and bionanotechnological applications
Open Access Review Article

Emerging approaches for preventing cytokine release syndrome in CAR-T cell therapy

Strategies for reducing CRS in CAR-T cells capitalize on the specificity between CAR-T cells, cytokines, and their receptors, the role of macrophages in cytokine release, and genetic constructs to ablate CAR-T function reversibly and irreversibly.

Graphical abstract: Emerging approaches for preventing cytokine release syndrome in CAR-T cell therapy
Review Article

Recent advances in nanotechnology mediated mitochondria-targeted imaging

Mitochondria play a critical role in cell growth and metabolism.

Graphical abstract: Recent advances in nanotechnology mediated mitochondria-targeted imaging
Open Access Review Article

Molecularly imprinted polymers in diagnostics: accessing analytes in biofluids

Bio-applied molecularly imprinted polymers (MIPs) are biomimetic materials with tailor-made synthetic recognition sites, mimicking biological counterparts known for their sensitive and selective analyte detection.

Graphical abstract: Molecularly imprinted polymers in diagnostics: accessing analytes in biofluids
Review Article

Recent advances in biomedical applications of bacterial outer membrane vesicles

This review comprehensively covers the extraction, characterization, functionalization and biomedical applications of bacterial outer membrane vesicles (OMVs).

Graphical abstract: Recent advances in biomedical applications of bacterial outer membrane vesicles
Review Article

Membrane-fusogenic biomimetic particles: a new bioengineering tool learned from nature

This review aims to highlight the recent advances, key limitations, and future directions of membrane-fusogenic biomimetic particles for biomedical applications.

Graphical abstract: Membrane-fusogenic biomimetic particles: a new bioengineering tool learned from nature
Review Article

Emerging nanobiotechnology-encoded relaxation tuning establishes new MRI modes to localize, monitor and predict diseases

Tumor microenvironment-activated longitudinal or transverse relaxation tuning shows highly promising applications. Smart MRI contrast agents exhibit high potential for tracking cancer progression and evolution and monitoring treatment process.

Graphical abstract: Emerging nanobiotechnology-encoded relaxation tuning establishes new MRI modes to localize, monitor and predict diseases
Review Article

Latest on biomaterial-based therapies for topical treatment of psoriasis

Biomaterials demonstrate great potential in the treatment of psoriasis.

Graphical abstract: Latest on biomaterial-based therapies for topical treatment of psoriasis
Review Article

Recent progress of nanomedicine in secreted phospholipase A2 as a potential therapeutic target

This paper systematically reviews recent studies on nanomedicines targeting sPLA2 overexpression in many inflammatory diseases and various types of cancer during the past few years.

Graphical abstract: Recent progress of nanomedicine in secreted phospholipase A2 as a potential therapeutic target
Review Article

Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends

Chitosan has been widely used to assemble different types of oral colon-targeted delivery systems, which attract great attention in the delivery of polyphenols to the colon for the treatment of colon and non-colon diseases.

Graphical abstract: Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends
Review Article

Conjugated polymer-based luminescent probes for ratiometric detection of biomolecules

We summarize the recent research progress concerning conjugated polymer-based luminescent probes for ratiometric detection of biomolecules.

Graphical abstract: Conjugated polymer-based luminescent probes for ratiometric detection of biomolecules
Review Article

Electrospun nanofibers for manipulating soft tissue regeneration

By integrating multiple types of guidance cues, electrospun nanofiber scaffolds can be used to manipulate cell behaviors and thus facilitate soft tissue regeneration, including nerves, skin, heart, blood vessels, and cornea.

Graphical abstract: Electrospun nanofibers for manipulating soft tissue regeneration
Review Article

Design of hydrogel-based wearable EEG electrodes for medical applications

We are in the evolution of continuous monitoring of neural activity with non-invasive wearable EEGs. The development of hydrogel electrodes technology is important for home-use systems for long-term EEG monitoring and diagnostics of disease.

Graphical abstract: Design of hydrogel-based wearable EEG electrodes for medical applications
Review Article

Hemostatic biomaterials to halt non-compressible hemorrhage

This review covers the design principles of hemostatic biomaterials based on biochemical and mechanical mechanisms, and discusses the remaining challenges and immediate opportunities to manage non-compressible hemorrhage with biomaterials.

Graphical abstract: Hemostatic biomaterials to halt non-compressible hemorrhage
Review Article

Cell membrane-engineered nanoparticles for cancer therapy

This review mainly summarizes the research progress of cell membrane extraction and coating technology, with an emphasis on the treatment of cancer with cell membrane-engineered nanoparticles from various sources.

Graphical abstract: Cell membrane-engineered nanoparticles for cancer therapy
From the themed collection: Journal of Materials Chemistry B HOT Papers
Review Article

Rational construction of polycystine-based nanoparticles for biomedical applications

This review summarizes the development of reduction-responsive disulfide-crosslinked PCys2-based nanoparticles through one-pot polymerization, post-polymerization modification, and post-polymerization self-assembly for biomedical applications.

Graphical abstract: Rational construction of polycystine-based nanoparticles for biomedical applications
From the themed collection: Journal of Materials Chemistry B HOT Papers
Review Article

Recent advances in biomaterial-assisted cell therapy

This review summarizes the recent research progress in various cell therapies and surveys the biomaterials developed to assist cell-based therapeutics for wide applications in diverse disease treatments.

Graphical abstract: Recent advances in biomaterial-assisted cell therapy
Review Article

Thioether-based ROS responsive polymers for biomedical applications

Thioether-based reactive oxygen species (ROS) responsive polymers and polypeptides, with the ability to self-assemble in aqueous media and disassemble or being transformed in the presence of ROS, are ideal candidates for target biomedical therapies.

Graphical abstract: Thioether-based ROS responsive polymers for biomedical applications
Review Article

Magnetomechanical force: an emerging paradigm for therapeutic applications

Magnetomechanical force for therapeutic applications.

Graphical abstract: Magnetomechanical force: an emerging paradigm for therapeutic applications
Review Article

Biofunctionalized metal–organic frameworks and host–guest interactions for advanced biomedical applications

With highly favorable properties such as enormous internal surface areas, high porosity and large flexibility, metal–organic frameworks (MOFs) have emerged as promising materials for applications such as gas storage and separation, catalysis, wastewater filtration, etc.

Graphical abstract: Biofunctionalized metal–organic frameworks and host–guest interactions for advanced biomedical applications
Review Article

Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management

This review provides the recent progress, intrinsic interactions between structures and bioactive performances, current limitations and future directions of bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management.

Graphical abstract: Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management
From the themed collection: Journal of Materials Chemistry B HOT Papers
Review Article

Recent advances in flexible and wearable chemo- and bio-sensors based on two-dimensional transition metal carbides and nitrides (MXenes)

Due to their excellent hydrophilicity, outstanding conductivity, unique structures, and physicochemical properties, MXenes have become a potential candidate material for flexible and wearable chemo- and bio-sensors.

Graphical abstract: Recent advances in flexible and wearable chemo- and bio-sensors based on two-dimensional transition metal carbides and nitrides (MXenes)
Review Article

Supramolecular biomaterials for enhanced cancer immunotherapy

Supramolecular self-assembly offers the possibility for modulating nanostructures and reprogramming immunological properties, paving the way for enhanced cancer immunotherapy.

Graphical abstract: Supramolecular biomaterials for enhanced cancer immunotherapy
Open Access Communication

Nanoscale patterning of polymers on DNA origami

Structurally precise biohybrid nanomaterials were created by grafting various polymers to DNA with high conversions under ambient conditions. They are patterned onto DNA origami nanostructures to form customizable surface contours.

Graphical abstract: Nanoscale patterning of polymers on DNA origami
Paper

Cationic lipopolymeric nanoplexes containing the CRISPR/Cas9 ribonucleoprotein for genome surgery

sgRNA/Cas9 ribonucleoproteins (RNPs) provide a site-specific robust gene-editing.

Graphical abstract: Cationic lipopolymeric nanoplexes containing the CRISPR/Cas9 ribonucleoprotein for genome surgery
Paper

A Cu-based nanoplatform for near-infrared light amplified multi-mode prostate cancer specific therapy

We report that Cu-MNCS-AIPH@PAA with high biocompatibility can be used for highly efficient therapy of PCa through the cooperative effect of PTT, CDT, and alkyl radical generation triggered by the photothermal effect.

Graphical abstract: A Cu-based nanoplatform for near-infrared light amplified multi-mode prostate cancer specific therapy
Paper

Photovoltaic molecules with ultra-high light energy utilization for near-infrared laser triggered synergetic photodynamic and photothermal therapy

The obtained IEICO NPs possess a high 1O2 quantum yield (11%) and PCE (85.4%) with an ultra-high light energy utilization efficacy of 96.4%, and therefore can be applied for near-infrared laser triggered synergetic photodynamic and photothermal therapy.

Graphical abstract: Photovoltaic molecules with ultra-high light energy utilization for near-infrared laser triggered synergetic photodynamic and photothermal therapy
Paper

Biosafety evaluation of dual-responsive neutrobots

Neutrobots carrying antitumor drugs facilitate considerable safety in vivo upon intravenous administration with high dose.

Graphical abstract: Biosafety evaluation of dual-responsive neutrobots
From the themed collection: Journal of Materials Chemistry B HOT Papers
Paper

Protein precoating modulates biomolecular coronas and nanocapsule–immune cell interactions in human blood

We demonstrate the effects of protein precoating on biomolecular corona formation and immune cell interactions of metal–phenolic network nanocapsules using proteomics analyses and human blood assays.

Graphical abstract: Protein precoating modulates biomolecular coronas and nanocapsule–immune cell interactions in human blood
Open Access Paper

Metal-phenolic networks as tuneable spore coat mimetics

Bacillus subtilis are probiotic microbes that are difficult to formulate when they are not in their spore form. Using self-assembling coatings, these cells were successfully protected during the freeze-drying process.

Graphical abstract: Metal-phenolic networks as tuneable spore coat mimetics
Paper

Repurposing pinacol esters of boronic acids for tuning viscoelastic properties of glucose-responsive polymer hydrogels: effects on insulin release kinetics

Injectable hydrogels capable of releasing the desired amount of insulin under hyperglycemic conditions will significantly advance smart insulin development. We report glucose-responsive hydrogels with programmable insulin release properties.

Graphical abstract: Repurposing pinacol esters of boronic acids for tuning viscoelastic properties of glucose-responsive polymer hydrogels: effects on insulin release kinetics
Paper

A polymer-based chemical tongue for the non-invasive monitoring of osteogenic stem-cell differentiation by pattern recognition of serum-supplemented spent media

A biomimetic ‘chemical-tongue’ combining polymeric probes with pattern-recognition techniques is presented, which can generate fluorescence-response patterns from serum-supplemented culture media to non-invasively monitor stem cell differentiation.

Graphical abstract: A polymer-based chemical tongue for the non-invasive monitoring of osteogenic stem-cell differentiation by pattern recognition of serum-supplemented spent media
Paper

A multi-functional SiO32−-releasing hydrogel with bioinspired mechanical properties and biodegradability for vascularized skeletal muscle regeneration

A SiO32−-releasing hydrogel (SRH) demonstrates multiple functions for skeletal muscle regeneration. The SRH with bioinspired biodegradation behavior enhances vascularized muscle regeneration.

Graphical abstract: A multi-functional SiO32−-releasing hydrogel with bioinspired mechanical properties and biodegradability for vascularized skeletal muscle regeneration
Paper

An antioxidant nanodrug protects against hepatic ischemia–reperfusion injury by attenuating oxidative stress and inflammation

CeO2 and MnO2 nanocomposites, with advantages of high biocompatibility, passive liver-targeting and short-term metabolic excretion, have the capacity to scavenge ROS and regulate the inflammation to alleviate hepatic ischemia–reperfusion injury.

Graphical abstract: An antioxidant nanodrug protects against hepatic ischemia–reperfusion injury by attenuating oxidative stress and inflammation
Paper

Carboxy-functionalized pH responsive capsule polymer particles fabricated by particulate interfacial photocrosslinking

Carboxy-functionalized capsule polymer particles possessing neutral-alkali pH responsive controlled release capability were newly fabricated by interfacial photocrosslinking of spherical photoreactive polymer particles.

Graphical abstract: Carboxy-functionalized pH responsive capsule polymer particles fabricated by particulate interfacial photocrosslinking
Paper

Multi-layered stimuli responsive DNA micelles for the stepwise controlled release of small molecules

DNA functionalized Multi layered Surface Crosslinked Micelles (mlSCMs) can compartmentalize two small molecule cargo in distinct layers. In response to the appropriate trigger, mlSCMs can release cargo for chemical and biochemical applications.

Graphical abstract: Multi-layered stimuli responsive DNA micelles for the stepwise controlled release of small molecules
Paper

Illuminating the biochemical interaction of antimicrobial few-layer black phosphorus with microbial cells using synchrotron macro-ATR-FTIR

Black phosphorus (BP) nanoflakes have shown high antimicrobial activity. The interaction of microbial cells and black phosphorus nanoflakes was investigated using microscopic techniques and synchrotron source ATR-FTIR spectroscopy.

Graphical abstract: Illuminating the biochemical interaction of antimicrobial few-layer black phosphorus with microbial cells using synchrotron macro-ATR-FTIR
41 items

About this collection

Journal of Materials Chemistry B is pleased to present this themed issue highlighting the rising stars of materials chemistry research in 2022. This issue showcases the very best work from materials chemists in the early stages of their independent career.

Each contributor was recommended by experts in their fields as carrying out work with the potential to influence future directions in materials chemistry with applications in biology and medicine. Congratulations to all the outstanding researchers featured.

See also:

Journal of Materials Chemistry A Emerging Investigators

Journal of Materials Chemistry C Emerging Investigators

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