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Themed collection Lab on a Chip Recent HOT Articles

61 items
Open Access Critical Review

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

This review critically analyzes the history, fundamental operating principles, limitations, applications, and emerging ideas related to microchannel-based capillary microfluidics.

Graphical abstract: Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits
From the themed collection: Recent Open Access Articles
Critical Review

Microfabricated devices for oral drug delivery

Oral administration of drugs is most convenient for patients and therefore the ultimate goal when developing new medication.

Graphical abstract: Microfabricated devices for oral drug delivery
From the themed collection: Lab on a Chip Recent HOT Articles
Communication

Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

A microfluidics-enabled strategy for the controllable synthesis of immunomagnetic nanomaterials was developed, and the shape-dependent screening efficiency of CTCs was investigated.

Graphical abstract: Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy
From the themed collection: Personalised Medicine: Liquid Biopsy
Communication

Cell-free extract based optimization of biomolecular circuits with droplet microfluidics

We combine cell-free protein expression systems with droplet microfluidics to enable ultrahigh-throughput parameter space exploration of synthetic biocircuits.

Graphical abstract: Cell-free extract based optimization of biomolecular circuits with droplet microfluidics
From the themed collection: Lab on a Chip Recent HOT Articles
Communication

Frequency tuning allows flow direction control in microfluidic networks with passive features

A bidirectional pump created by rectifying oscillating flow driven at engineered fluidic series and parallel resonance frequencies.

Graphical abstract: Frequency tuning allows flow direction control in microfluidic networks with passive features
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Microfluidic bead encapsulation above 20 kHz with triggered drop formation

Bead-triggered breakup of a fluid jet into monodispersed droplets improves the throughput of bead-based droplet workflows, enabling the analysis of large populations and the detection of rare events.

Graphical abstract: Microfluidic bead encapsulation above 20 kHz with triggered drop formation
From the themed collection: Recent Open Access Articles
Paper

Extraction of electrokinetically separated analytes with on-demand encapsulation

On-demand two-phase encapsulation of electrokinetically separated analytes decouples electrokinetic separations from downstream analytical processes.

Graphical abstract: Extraction of electrokinetically separated analytes with on-demand encapsulation
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Selective assembly and functionalization of miniaturized redox capacitor inside microdevices for microbial toxin and mammalian cell cytotoxicity analyses

We report a novel strategy for bridging information transfer between electronics and biological systems within microdevices.

Graphical abstract: Selective assembly and functionalization of miniaturized redox capacitor inside microdevices for microbial toxin and mammalian cell cytotoxicity analyses
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Determining the lipid specificity of insoluble protein transmembrane domains

Overcoming solubility of membrane protein transmembrane domains to study their specificity to lipid compositions.

Graphical abstract: Determining the lipid specificity of insoluble protein transmembrane domains
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Novel devices for studying acute and chronic mechanical stress in retinal pigment epithelial cells

Replicating mechanical stress using two novel devices revealed that mechanical stress in retinal pigment epithelial cells induces choroidal neovascularization.

Graphical abstract: Novel devices for studying acute and chronic mechanical stress in retinal pigment epithelial cells
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Measurement and mitigation of free convection in microfluidic gradient generators

Microfluidic gradient generators are used to study the movement of living cells, lipid vesicles, and colloidal particles in response to spatial variations in their local chemical environment.

Graphical abstract: Measurement and mitigation of free convection in microfluidic gradient generators
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Integrated measurement of intracellular proteins and transcripts in single cells

Single cell coupled proteomic and transcriptomic measurements are captured on a scalable microfluidic device.

Graphical abstract: Integrated measurement of intracellular proteins and transcripts in single cells
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy.

Graphical abstract: 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

A microfluidic approach to study the effect of mechanical stress on erythrocytes in sickle cell disease

This work presents a microfluidic device to challenge the deformability of normal and pathological red cells and their resistance to lysis upon mechanical stress.

Graphical abstract: A microfluidic approach to study the effect of mechanical stress on erythrocytes in sickle cell disease
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Localized mechanical stimulation of single cells with engineered spatio-temporal profile

We introduce a new platform for mechanobiology based on active substrates, made of Fe-coated polymeric micropillars, capable to apply mechanical stimuli with tunable spatio-temporal profile on a cell culture.

Graphical abstract: Localized mechanical stimulation of single cells with engineered spatio-temporal profile
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Automated microfluidic droplet sampling with integrated, mix-and-read immunoassays to resolve endocrine tissue secretion dynamics

A fully automated droplet generation and analysis device based on pressure driven push-up valves for precise pumping of fluid and volumetric metering has been developed for high resolution hormone secretion sampling and measurement.

Graphical abstract: Automated microfluidic droplet sampling with integrated, mix-and-read immunoassays to resolve endocrine tissue secretion dynamics
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Detecting miRNA biomarkers from extracellular vesicles for cardiovascular disease with a microfluidic system

A novel microfluidic platform for extracellular vesicle extraction, microRNA isolation and detection with field-effect transistors for early detection of cardiovascular diseases.

Graphical abstract: Detecting miRNA biomarkers from extracellular vesicles for cardiovascular disease with a microfluidic system
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Micro-droplet arrays for micro-compartmentalization using an air/water interface

Here we present a water-in-air droplet platform for micro-compartmentalization for single molecule guided synthesis and analysis consisting of a flow-system hosting dense arrays of aqueous microdroplets on a glass surface surrounded by air.

Graphical abstract: Micro-droplet arrays for micro-compartmentalization using an air/water interface
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles

Microphysiological tissue engineering models of human skeletal muscle (myobundles) in series with a calibrated elastic membrane provide a platform to investigate the mechanism of muscle diseases and to study the response to drugs and toxins in vitro.

Graphical abstract: A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells

Tissues are increasingly being analyzed at this single cell level. We present a simple and inexpensive microfluidic filter device that can rapidly and effectively improve the quality of single cell suspensions obtained from digested tissue samples.

Graphical abstract: Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for microphysiological systems

UniChip enables recirculating unidirectional perfusion with gravity-driven flow, facilitating reliable and cost-effective integration of shear stress-sensitive tissues into microphysiological systems.

Graphical abstract: UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for microphysiological systems
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Engineering cell heterogeneity into organs-on-a-chip

To improve predictive efficacy of organ-on-a-chip devices, developers must consider cell heterogeneity.

Graphical abstract: Engineering cell heterogeneity into organs-on-a-chip
From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Paper

Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays

This platform utilizes functionalized hydrogel posts contained within isolated nanoliter well reactors for quantitative and multiplex microRNA assays directly from unprocessed cell samples without needing prior nucleic acid extraction.

Graphical abstract: Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays
From the themed collection: Recent Open Access Articles
Paper

NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans

NemaFlex measures a behavior- and gait-independent measure of C. elegans strength analogous to maximum voluntary force in humans.

Graphical abstract: NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Microstructure guided multi-scale liquid patterning on an open surface

A simple and fast multi-scale microliquid patterning on an open surface is demonstrated.

Graphical abstract: Microstructure guided multi-scale liquid patterning on an open surface
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions

A system for perfusing and interacting tumor fragments and immune cells and testing drug response with image analytics is reported.

Graphical abstract: A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Isolation and genome sequencing of individual circulating tumor cells using hydrogel encapsulation and laser capture microdissection

Single CTC sequencing workflow using biophysical enrichment and single cell isolation by laser capture microdissection.

Graphical abstract: Isolation and genome sequencing of individual circulating tumor cells using hydrogel encapsulation and laser capture microdissection
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Double-sided 3D printing on paper towards mass production of three-dimensional paper-based microfluidic analytical devices (3D-μPADs)

Recently, much effort has been focused on developing three-dimensional, paper-based microfluidic analytical devices (3D-μPADs) targeting in vitro diagnostics.

Graphical abstract: Double-sided 3D printing on paper towards mass production of three-dimensional paper-based microfluidic analytical devices (3D-μPADs)
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Multiparameter cell-tracking intrinsic cytometry for single-cell characterization

We introduce a multiparameter intrinsic cytometry approach for single-cell characterization that combines ≥2 label-free measurement techniques onto the same platform.

Graphical abstract: Multiparameter cell-tracking intrinsic cytometry for single-cell characterization
From the themed collection: Recent Open Access Articles
Paper

Injection molded lab-on-a-disc platform for screening of genetically modified E. coli using liquid–liquid extraction and surface enhanced Raman scattering

We present an injection molded lab-on-a-disc enabling quantification of bacterial metabolites in E. coli supernatant.

Graphical abstract: Injection molded lab-on-a-disc platform for screening of genetically modified E. coli using liquid–liquid extraction and surface enhanced Raman scattering
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Engineering reaction–diffusion networks with properties of neural tissue

The application of soft lithography to create reaction–diffusion networks capable of generating spatiotemporal patterns analogous to biological central pattern generators.

Graphical abstract: Engineering reaction–diffusion networks with properties of neural tissue
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

An ultra-small, multi-point, and multi-color photo-detection system with high sensitivity and high dynamic range

Fluorescence from four emission points is collimated by four lenses, split into four-color fluxes by four dichroic mirrors, and directly input into the image sensor.

Graphical abstract: An ultra-small, multi-point, and multi-color photo-detection system with high sensitivity and high dynamic range
From the themed collection: Recent Open Access Articles
Open Access Paper

Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing

An asymmetric nanofluidic grating is shown to enable simple, robust, and fully differential measurements of refractive index or of surface-adsorbed layers of biomolecules through interferometry.

Graphical abstract: Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing
From the themed collection: Recent Open Access Articles
Paper

Persistent drought monitoring using a microfluidic-printed electro-mechanical sensor of stomata in planta

Stomatal function can be used effectively to monitor plant hydraulics, photosensitivity, and gas exchange.

Graphical abstract: Persistent drought monitoring using a microfluidic-printed electro-mechanical sensor of stomata in planta
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Optofluidic marine phosphate detection with enhanced absorption using a Fabry–Pérot resonator

An optofluidic phosphate analysis chip combined with a resonator has been created with enhanced absorption and real-time monitoring. It overcomes the obstacles of traditional methods with macroscale absorption cells, and low representative and time-sensitive detection results.

Graphical abstract: Optofluidic marine phosphate detection with enhanced absorption using a Fabry–Pérot resonator
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Microfluidic diafiltration-on-chip using an integrated magnetic peristaltic micropump

A novel magnetically-driven peristaltic pump can be used to drive cyclic on-chip flow for small volume (50 μL) diafiltration.

Graphical abstract: Microfluidic diafiltration-on-chip using an integrated magnetic peristaltic micropump
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules

A chip design inspired by the “Snakes-and-Ladders” boardgame was used to deposit a bilayer of polyelectrolytes onto magnetic droplets within 30 seconds.

Graphical abstract: On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Reproducible fiber optofluidic laser for disposable and array applications

This paper describes a low-cost fiber optofluidic laser for disposable and array applications using a microstructured optical fiber.

Graphical abstract: Reproducible fiber optofluidic laser for disposable and array applications
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis

We have developed a microchip platform that combines fast, magnetic micropore based negative selection (>10 mL h−1) with rapid on-chip in situ RNA profiling.

Graphical abstract: A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles

A microfluidic co-flow of Newtonian (water or PBS) and viscoelastic fluids (PEO) is presented for the size-dependent separation of microparticles.

Graphical abstract: Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Label-free ferrohydrodynamic cell separation of circulating tumor cells

A size-based ferrohydrodynamic cell separation (FCS) device capable of enriching intact circulating tumor cells with high throughput and high recovery rate.

Graphical abstract: Label-free ferrohydrodynamic cell separation of circulating tumor cells
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Custom 3D printer and resin for 18 μm × 20 μm microfluidic flow channels

We demonstrate that 3D printing can consistently fabricate truly microfluidic features (18 μm × 20 μm cross sectional area) by creating a custom 3D printer and a low-cost custom resin.

Graphical abstract: Custom 3D printer and resin for 18 μm × 20 μm microfluidic flow channels
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices

A variety of therapeutic and/or diagnostic nanoparticles (NPs), or nanomedicines, have been formulated for improved drug delivery and imaging applications.

Graphical abstract: Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Studying blood clotting in stereolithography 3D-printed microfluidic chips with endothelialised vascular structures.

Graphical abstract: Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

An automated optofluidic biosensor platform combining interferometric sensors and injection moulded microfluidics

This work presents an on-chip valve-based microfluidic automation module, capable of performing the complex fluid handling required for photonic biosensors.

Graphical abstract: An automated optofluidic biosensor platform combining interferometric sensors and injection moulded microfluidics
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Multicomponent diffusion coefficients from microfluidics using Raman microspectroscopy

Microfluidic measurement of multicomponent diffusion coefficients using minimal number of experiments with high accuracy in short time.

Graphical abstract: Multicomponent diffusion coefficients from microfluidics using Raman microspectroscopy
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

On-chip cell sorting by high-speed local-flow control using dual membrane pumps

We achieved high-throughput on-chip sorting of large cells by using on-chip dual membrane pumps integrated with a high-rigidity microfluidic chip. In the case of Euglena gracilis sorting, the throughput was 23 kHz with 92.8% success rate, 95.8% purity, and 90.8% cell viability.

Graphical abstract: On-chip cell sorting by high-speed local-flow control using dual membrane pumps
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

3D printed conformal microfluidics for isolation and profiling of biomarkers from whole organs

3D printed conformal microfluidics provide a novel approach for isolation and profiling of biomarkers from whole organs.

Graphical abstract: 3D printed conformal microfluidics for isolation and profiling of biomarkers from whole organs
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Soft, skin-mounted microfluidic systems for measuring secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands

We introduce a skin-mounted microfluidic device for measuring the secretory pressure of sweat glands at the surface of the skin.

Graphical abstract: Soft, skin-mounted microfluidic systems for measuring secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Size-tunable microvortex capture of rare cells

A wide distribution of cell sizes can be selectively captured by tuning the flow rate in a micro-vortex flow.

Graphical abstract: Size-tunable microvortex capture of rare cells
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy

Machine-learning-assisted identification of platelet aggregation in human blood with label-free images.

Graphical abstract: Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion

A new microfluidic-integrated nanoplasmonic biosensor for the study of cell signaling in a label-free and real-time manner.

Graphical abstract: Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Using μ2rheology to quantify rheological properties during repeated reversible phase transitions of soft matter

A novel microfluidic design enables repeated phase transitions in a single sample by surrounding fluid exchange and microrheological characterization.

Graphical abstract: Using μ2rheology to quantify rheological properties during repeated reversible phase transitions of soft matter
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Integrated pretreatment and desalination by electrocoagulation (EC)–ion concentration polarization (ICP) hybrid

We integrated desalination and particle removal technologies into a single electrochemical system and demonstrated its operation on a microfluidic platform.

Graphical abstract: Integrated pretreatment and desalination by electrocoagulation (EC)–ion concentration polarization (ICP) hybrid
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation

We introduce a robust microfluidic platform for production of relatively homogenous microdroplets at generation frequency of up to 3.1 MHz, about three orders of magnitude higher than the production rate of a conventional microfluidic dropmaker.

Graphical abstract: A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

On-chip enzymatic microbiofuel cell-powered integrated circuits

A CMOS based digital circuit that is powered by an integrated on-chip enzymatic microbiofuelcell.

Graphical abstract: On-chip enzymatic microbiofuel cell-powered integrated circuits
From the themed collection: Recent Open Access Articles
Paper

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice

A biomimetic glomerulus-on-a-chip microdevice was created to recapitulate a disease model of diabetic nephropathy.

Graphical abstract: A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice
From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Paper

Device and programming abstractions for spatiotemporal control of active micro-particle swarms

We present a hardware setup and a set of executable commands for spatiotemporal programming and interactive control of a swarm of self-propelled microscopic agents (Euglena gracilis) inside a microfluidic chip.

Graphical abstract: Device and programming abstractions for spatiotemporal control of active micro-particle swarms
From the themed collection: Recent Open Access Articles
Paper

Dielectrowetting manipulation for digital microfluidics: creating, transporting, splitting, and merging of droplets

Fundamental and critical unit operations (creating, transporting, splitting and merging of droplets) for digital (droplet-based) microfluidic circuits have been established using dielectrowetting.

Graphical abstract: Dielectrowetting manipulation for digital microfluidics: creating, transporting, splitting, and merging of droplets
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

Pancreatic islets on a chip platform.

Graphical abstract: Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Brillouin flow cytometry for label-free mechanical phenotyping of the nucleus

A flow cytometry technique featuring the all-optical measurement of nuclear mechanical properties is developed by integrating Brillouin spectroscopy with microfluidics.

Graphical abstract: Brillouin flow cytometry for label-free mechanical phenotyping of the nucleus
From the themed collection: Lab on a Chip Recent HOT Articles
61 items

About this collection

Here is a collection of recent Lab on a Chip articles which have been classified as ‘HOT articles’ due to receiving particularly high scores at peer review.

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