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Themed collection Lab on a Chip Recent HOT Articles

34 items
Open Access Critical Review

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

This review critically analyzes the history, fundamental operating principles, limitations, applications, and emerging ideas related to microchannel-based capillary microfluidics.

Graphical abstract: Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits
From the themed collection: Lab on a Chip Recent HOT Articles
Critical Review

Microfabricated devices for oral drug delivery

Oral administration of drugs is most convenient for patients and therefore the ultimate goal when developing new medication.

Graphical abstract: Microfabricated devices for oral drug delivery
From the themed collection: Lab on a Chip Recent HOT Articles
Communication

Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

A microfluidics-enabled strategy for the controllable synthesis of immunomagnetic nanomaterials was developed, and the shape-dependent screening efficiency of CTCs was investigated.

Graphical abstract: Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy
From the themed collection: Personalised Medicine: Liquid Biopsy
Communication

Cell-free extract based optimization of biomolecular circuits with droplet microfluidics

We combine cell-free protein expression systems with droplet microfluidics to enable ultrahigh-throughput parameter space exploration of synthetic biocircuits.

Graphical abstract: Cell-free extract based optimization of biomolecular circuits with droplet microfluidics
From the themed collection: Lab on a Chip Recent HOT Articles
Communication

Frequency tuning allows flow direction control in microfluidic networks with passive features

A bidirectional pump created by rectifying oscillating flow driven at engineered fluidic series and parallel resonance frequencies.

Graphical abstract: Frequency tuning allows flow direction control in microfluidic networks with passive features
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation

We report here a 96 well-plate based pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation.

Graphical abstract: Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Natural gas vaporization in a nanoscale throat connected model of shale: multi-scale, multi-component and multi-phase

Production of hydrocarbons from shale is a complex process that necessitates the extraction of multi-component hydrocarbons trapped in multi-scale nanopores.

Graphical abstract: Natural gas vaporization in a nanoscale throat connected model of shale: multi-scale, multi-component and multi-phase
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Versatile platform for performing protocols on a chip utilizing surface acoustic wave (SAW) driven mixing

We present a dextrous microfluidic device which features a reaction chamber with volume flexibility and acoustic mixing.

Graphical abstract: Versatile platform for performing protocols on a chip utilizing surface acoustic wave (SAW) driven mixing
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Microfluidic bead encapsulation above 20 kHz with triggered drop formation

Bead-triggered breakup of a fluid jet into monodispersed droplets improves the throughput of bead-based droplet workflows, enabling the analysis of large populations and the detection of rare events.

Graphical abstract: Microfluidic bead encapsulation above 20 kHz with triggered drop formation
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Extraction of electrokinetically separated analytes with on-demand encapsulation

On-demand two-phase encapsulation of electrokinetically separated analytes decouples electrokinetic separations from downstream analytical processes.

Graphical abstract: Extraction of electrokinetically separated analytes with on-demand encapsulation
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Selective assembly and functionalization of miniaturized redox capacitor inside microdevices for microbial toxin and mammalian cell cytotoxicity analyses

We report a novel strategy for bridging information transfer between electronics and biological systems within microdevices.

Graphical abstract: Selective assembly and functionalization of miniaturized redox capacitor inside microdevices for microbial toxin and mammalian cell cytotoxicity analyses
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Determining the lipid specificity of insoluble protein transmembrane domains

Overcoming solubility of membrane protein transmembrane domains to study their specificity to lipid compositions.

Graphical abstract: Determining the lipid specificity of insoluble protein transmembrane domains
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Novel devices for studying acute and chronic mechanical stress in retinal pigment epithelial cells

Replicating mechanical stress using two novel devices revealed that mechanical stress in retinal pigment epithelial cells induces choroidal neovascularization.

Graphical abstract: Novel devices for studying acute and chronic mechanical stress in retinal pigment epithelial cells
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Measurement and mitigation of free convection in microfluidic gradient generators

Microfluidic gradient generators are used to study the movement of living cells, lipid vesicles, and colloidal particles in response to spatial variations in their local chemical environment.

Graphical abstract: Measurement and mitigation of free convection in microfluidic gradient generators
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Integrated measurement of intracellular proteins and transcripts in single cells

Single cell coupled proteomic and transcriptomic measurements are captured on a scalable microfluidic device.

Graphical abstract: Integrated measurement of intracellular proteins and transcripts in single cells
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy.

Graphical abstract: 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

A microfluidic approach to study the effect of mechanical stress on erythrocytes in sickle cell disease

This work presents a microfluidic device to challenge the deformability of normal and pathological red cells and their resistance to lysis upon mechanical stress.

Graphical abstract: A microfluidic approach to study the effect of mechanical stress on erythrocytes in sickle cell disease
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Localized mechanical stimulation of single cells with engineered spatio-temporal profile

We introduce a new platform for mechanobiology based on active substrates, made of Fe-coated polymeric micropillars, capable to apply mechanical stimuli with tunable spatio-temporal profile on a cell culture.

Graphical abstract: Localized mechanical stimulation of single cells with engineered spatio-temporal profile
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Automated microfluidic droplet sampling with integrated, mix-and-read immunoassays to resolve endocrine tissue secretion dynamics

A fully automated droplet generation and analysis device based on pressure driven push-up valves for precise pumping of fluid and volumetric metering has been developed for high resolution hormone secretion sampling and measurement.

Graphical abstract: Automated microfluidic droplet sampling with integrated, mix-and-read immunoassays to resolve endocrine tissue secretion dynamics
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Detecting miRNA biomarkers from extracellular vesicles for cardiovascular disease with a microfluidic system

A novel microfluidic platform for extracellular vesicle extraction, microRNA isolation and detection with field-effect transistors for early detection of cardiovascular diseases.

Graphical abstract: Detecting miRNA biomarkers from extracellular vesicles for cardiovascular disease with a microfluidic system
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Micro-droplet arrays for micro-compartmentalization using an air/water interface

Here we present a water-in-air droplet platform for micro-compartmentalization for single molecule guided synthesis and analysis consisting of a flow-system hosting dense arrays of aqueous microdroplets on a glass surface surrounded by air.

Graphical abstract: Micro-droplet arrays for micro-compartmentalization using an air/water interface
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles

Microphysiological tissue engineering models of human skeletal muscle (myobundles) in series with a calibrated elastic membrane provide a platform to investigate the mechanism of muscle diseases and to study the response to drugs and toxins in vitro.

Graphical abstract: A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells

Tissues are increasingly being analyzed at this single cell level. We present a simple and inexpensive microfluidic filter device that can rapidly and effectively improve the quality of single cell suspensions obtained from digested tissue samples.

Graphical abstract: Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for microphysiological systems

UniChip enables recirculating unidirectional perfusion with gravity-driven flow, facilitating reliable and cost-effective integration of shear stress-sensitive tissues into microphysiological systems.

Graphical abstract: UniChip enables long-term recirculating unidirectional perfusion with gravity-driven flow for microphysiological systems
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Engineering cell heterogeneity into organs-on-a-chip

To improve predictive efficacy of organ-on-a-chip devices, developers must consider cell heterogeneity.

Graphical abstract: Engineering cell heterogeneity into organs-on-a-chip
From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Paper

Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays

This platform utilizes functionalized hydrogel posts contained within isolated nanoliter well reactors for quantitative and multiplex microRNA assays directly from unprocessed cell samples without needing prior nucleic acid extraction.

Graphical abstract: Quantitative and multiplex microRNA assays from unprocessed cells in isolated nanoliter well arrays
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans

NemaFlex measures a behavior- and gait-independent measure of C. elegans strength analogous to maximum voluntary force in humans.

Graphical abstract: NemaFlex: a microfluidics-based technology for standardized measurement of muscular strength of C. elegans
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Microstructure guided multi-scale liquid patterning on an open surface

A simple and fast multi-scale microliquid patterning on an open surface is demonstrated.

Graphical abstract: Microstructure guided multi-scale liquid patterning on an open surface
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions

A system for perfusing and interacting tumor fragments and immune cells and testing drug response with image analytics is reported.

Graphical abstract: A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Isolation and genome sequencing of individual circulating tumor cells using hydrogel encapsulation and laser capture microdissection

Single CTC sequencing workflow using biophysical enrichment and single cell isolation by laser capture microdissection.

Graphical abstract: Isolation and genome sequencing of individual circulating tumor cells using hydrogel encapsulation and laser capture microdissection
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Double-sided 3D printing on paper towards mass production of three-dimensional paper-based microfluidic analytical devices (3D-μPADs)

Recently, much effort has been focused on developing three-dimensional, paper-based microfluidic analytical devices (3D-μPADs) targeting in vitro diagnostics.

Graphical abstract: Double-sided 3D printing on paper towards mass production of three-dimensional paper-based microfluidic analytical devices (3D-μPADs)
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Multiparameter cell-tracking intrinsic cytometry for single-cell characterization

We introduce a multiparameter intrinsic cytometry approach for single-cell characterization that combines ≥2 label-free measurement techniques onto the same platform.

Graphical abstract: Multiparameter cell-tracking intrinsic cytometry for single-cell characterization
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Injection molded lab-on-a-disc platform for screening of genetically modified E. coli using liquid–liquid extraction and surface enhanced Raman scattering

We present an injection molded lab-on-a-disc enabling quantification of bacterial metabolites in E. coli supernatant.

Graphical abstract: Injection molded lab-on-a-disc platform for screening of genetically modified E. coli using liquid–liquid extraction and surface enhanced Raman scattering
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Engineering reaction–diffusion networks with properties of neural tissue

The application of soft lithography to create reaction–diffusion networks capable of generating spatiotemporal patterns analogous to biological central pattern generators.

Graphical abstract: Engineering reaction–diffusion networks with properties of neural tissue
From the themed collection: Lab on a Chip Recent HOT Articles
34 items

About this collection

Here is a collection of recent Lab on a Chip articles which have been classified as ‘HOT articles’ due to receiving particularly high scores at peer review.

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