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Issue 14, 2018
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Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

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Abstract

Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate system toward the screening and analysis of circulating tumor biomarkers.

Graphical abstract: Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

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Article information


Submitted
17 Mar 2018
Accepted
11 Jun 2018
First published
12 Jun 2018

Lab Chip, 2018,18, 1997-2002
Article type
Communication
Author version available

Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

N. Hao, Y. Nie, T. Shen and J. X. J. Zhang, Lab Chip, 2018, 18, 1997
DOI: 10.1039/C8LC00273H

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