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Themed collection Emerging Investigators 2017

36 items
Editorial

Biomaterials Science Emerging Investigators 2017

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Graphical abstract: Biomaterials Science Emerging Investigators 2017
From the themed collection: Emerging Investigators 2017
Minireview

Manipulating tumor hypoxia toward enhanced photodynamic therapy (PDT)

This mini-review summarizes various methods for overcoming or utilizing hypoxia for enhanced PDT.

Graphical abstract: Manipulating tumor hypoxia toward enhanced photodynamic therapy (PDT)
From the themed collection: Emerging Investigators 2017
Minireview

Viscoelastic hydrogels for 3D cell culture

This mini-review discusses newly developed approaches to tuning hydrogel viscoelasticity and recent studies demonstrating an impact of viscoelasticity on cells.

Graphical abstract: Viscoelastic hydrogels for 3D cell culture
From the themed collection: Emerging Investigators 2017
Minireview

Emerging strategies in near-infrared light triggered drug delivery using organic nanomaterials

Near-infrared light has significant advantages for light-triggered drug delivery systems within deep tissues.

Graphical abstract: Emerging strategies in near-infrared light triggered drug delivery using organic nanomaterials
From the themed collection: Emerging Investigators 2017
Minireview

Multicellular tumor invasion and plasticity in biomimetic materials

Collective and individual cancer cell invasion can be investigated in vitro and ex vivo using microfabricated devices and hydrogels.

Graphical abstract: Multicellular tumor invasion and plasticity in biomimetic materials
From the themed collection: Emerging Investigators 2017
Minireview

Peptide and antibody ligands for renal targeting: nanomedicine strategies for kidney disease

This review presents key peptide and antibody based kidney-targeting ligands, with a focus on use in nanoparticle systems.

Graphical abstract: Peptide and antibody ligands for renal targeting: nanomedicine strategies for kidney disease
From the themed collection: Emerging Investigators 2017
Review Article

Recent advances in biomaterials for the treatment of diabetic foot ulcers

Diabetes mellitus is one of the most challenging epidemics facing the world today, with over 300 million patients affected worldwide.

Graphical abstract: Recent advances in biomaterials for the treatment of diabetic foot ulcers
From the themed collection: Emerging Investigators 2017
Review Article

From molecules to macrostructures: recent development of bioinspired hard tissue repair

This review summarizes the bioinspired strategies for hard tissue repair, ranging from molecule-induced mineralization, to microscale assembly to macroscaffold fabrication.

Graphical abstract: From molecules to macrostructures: recent development of bioinspired hard tissue repair
From the themed collection: Emerging Investigators 2017
Review Article

Recent progress in nanomedicine-based combination cancer therapy using a site-specific co-delivery strategy

This review article highlights the recent progresses in nanomedicine-based combination cancer therapy via site-specific co-delivery strategies.

Graphical abstract: Recent progress in nanomedicine-based combination cancer therapy using a site-specific co-delivery strategy
From the themed collection: Emerging Investigators 2017
Open Access Review Article

Using biomaterials to rewire the process of wound repair

This review discusses recent advances in using biomaterials to actively modulate various stages of wound healing from haemostasis through resolution.

Graphical abstract: Using biomaterials to rewire the process of wound repair
From the themed collection: Emerging Investigators 2017
Review Article

Recent advances in nanomedicines for the treatment of rheumatoid arthritis

Schematic illustration of inflammatory microenvironment in inflamed joints and events occurring in rheumatoid arthritis.

Graphical abstract: Recent advances in nanomedicines for the treatment of rheumatoid arthritis
From the themed collection: Emerging Investigators 2017
Review Article

Bioapplications of renal-clearable luminescent metal nanoparticles

This review summarizes the recent synthetic strategies of the renal-clearable luminescent metal nanoparticles, and discusses the biological behaviors and current disease-related applications of this type of biomaterials in tumor targeting, kidney disease and antimicrobial investigations.

Graphical abstract: Bioapplications of renal-clearable luminescent metal nanoparticles
From the themed collection: Emerging Investigators 2017
Review Article

The scaffold microenvironment for stem cell based bone tissue engineering

Bone tissue engineering uses the principles and methods of engineering and life sciences to study bone structure, function and growth mechanism for the purposes of repairing, maintaining and improving damaged bone tissue.

Graphical abstract: The scaffold microenvironment for stem cell based bone tissue engineering
From the themed collection: Emerging Investigators 2017
Communication

Glycocalyx scaffolding with synthetic nanoscale glycomaterials

A cell surface engineering method allows for building glycan complexity with control over nanoscale presentation.

Graphical abstract: Glycocalyx scaffolding with synthetic nanoscale glycomaterials
From the themed collection: Emerging Investigators 2017
Communication

Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy

In this work, sinoporphyrin sodium was loaded into RGD-modified ferritin (R-Fn) nanocages by a rapid, scalable and versatile approach for imaging guided photodynamic and photothermal co-therapy.

Graphical abstract: Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy
From the themed collection: Emerging Investigators 2017
Communication

The influence of tumor-induced immune dysfunction on the immune cell distribution of gold nanoparticles in vivo

Tumor-induced immune dysfunction has been observed in tumor bearing mice. The nanoparticle cellular distribution is significantly affected by the immune dysfunction, compared with tumor free mice.

Graphical abstract: The influence of tumor-induced immune dysfunction on the immune cell distribution of gold nanoparticles in vivo
From the themed collection: Emerging Investigators 2017
Communication

Self-assembly of amphiphilic tripeptides with sequence-dependent nanostructure

Sequence variation in short self-assembled peptides enables creation of a diversity of nanostructures and biomaterials.

Graphical abstract: Self-assembly of amphiphilic tripeptides with sequence-dependent nanostructure
From the themed collection: Emerging Investigators 2017
Communication

Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer

An oxaliplatin prodrug liposome with an extremely high drug loading ratio (>27%) was reported for treatment of triple-negative breast cancer.

Graphical abstract: Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer
From the themed collection: Emerging Investigators 2017
Communication

Glutathione-responsive paclitaxel dimer nanovesicles with high drug content

Paclitaxel dimers containing mono thioether linkers can self-assemble into hollow nanovesicles that exhibit comparable cytotoxicity to Taxol.

Graphical abstract: Glutathione-responsive paclitaxel dimer nanovesicles with high drug content
From the themed collection: Emerging Investigators 2017
Paper

Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages

The ability of octadecylamine-functionalized nanodiamond to promote anti-inflammatory behaviour in macrophages suggests its potential to act as an anti-inflammatory therapeutic.

Graphical abstract: Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages
From the themed collection: Emerging Investigators 2017
Paper

Alginate-based hydrogels functionalised at the nanoscale using layer-by-layer assembly for potential cartilage repair

Articular cartilage injuries are frequently difficult to repair because of the poor regenerative capacity of this tissue.

Graphical abstract: Alginate-based hydrogels functionalised at the nanoscale using layer-by-layer assembly for potential cartilage repair
From the themed collection: Emerging Investigators 2017
Paper

Anisotropic microfibrous scaffolds enhance the organization and function of cardiomyocytes derived from induced pluripotent stem cells

Engineering of myocardial tissue constructs is a promising approach for treatment of coronary heart disease.

Graphical abstract: Anisotropic microfibrous scaffolds enhance the organization and function of cardiomyocytes derived from induced pluripotent stem cells
From the themed collection: Emerging Investigators 2017
Paper

Spatiotemporal presentation of exogenous SDF-1 with PLGA nanoparticles modulates SDF-1/CXCR4 signaling axis in the rodent cortex

Temporal control over SDF-1 release via PLGA nanoparticles differentially affects the SDF-1/CXCR4 signaling axis across the adult cortex.

Graphical abstract: Spatiotemporal presentation of exogenous SDF-1 with PLGA nanoparticles modulates SDF-1/CXCR4 signaling axis in the rodent cortex
From the themed collection: Emerging Investigators 2017
Paper

Surgical suture releasing macrophage-targeted drug-loaded nanoparticles for an enhanced anti-inflammatory effect

An anti-inflammatory nanoparticle-coated suture reduces inflammation and pain at the wound site.

Graphical abstract: Surgical suture releasing macrophage-targeted drug-loaded nanoparticles for an enhanced anti-inflammatory effect
From the themed collection: Emerging Investigators 2017
Paper

Electrospun poly(N-isopropyl acrylamide)/poly(caprolactone) fibers for the generation of anisotropic cell sheets

Cell alignment in muscle, nervous tissue, and cartilage is requisite for proper tissue function; however, cell sheeting techniques using the thermosensitive polymer poly(N-isopropyl acrylamide) can only produce anisotropic cell sheets with resource-intensive modifications.

Graphical abstract: Electrospun poly(N-isopropyl acrylamide)/poly(caprolactone) fibers for the generation of anisotropic cell sheets
From the themed collection: Emerging Investigators 2017
Paper

Tubulogenesis of co-cultured human iPS-derived endothelial cells and human mesenchymal stem cells in fibrin and gelatin methacrylate gels

Here, we investigate the tubulogenic potential of commercially-sourced iPS-ECs with and without supporting commercially-sourced hMSCs within 3D natural fibrin or semi-synthetic gelatin methacrylate (GelMA) hydrogels.

Graphical abstract: Tubulogenesis of co-cultured human iPS-derived endothelial cells and human mesenchymal stem cells in fibrin and gelatin methacrylate gels
From the themed collection: Emerging Investigators 2017
Open Access Paper

Supramolecular surface functionalization via catechols for the improvement of cell–material interactions

Bioactivation of non-cell adhesive hydrophobic polymers was achieved by employing mussel-inspired chemistry in combination with a supramolecular and modular approach.

Graphical abstract: Supramolecular surface functionalization via catechols for the improvement of cell–material interactions
From the themed collection: Emerging Investigators 2017
Paper

Stretch-dependent changes in molecular conformation in fibronectin nanofibers

Engineered fibronectin nanofibers reveal a nodular to fibrillar transformation in molecular conformation during 7-fold extension.

Graphical abstract: Stretch-dependent changes in molecular conformation in fibronectin nanofibers
From the themed collection: Emerging Investigators 2017
Open Access Paper

Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules

The generation of microgel capsules with a photo-crosslinkable polymer shell and FITC-dextran encapsulation. Scale bars: 100 μm.

Graphical abstract: Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules
From the themed collection: Emerging Investigators 2017
Paper

A specific environment-sensitive near-infrared fluorescent turn-on probe for synergistic enhancement of anticancer activity of a chemo-drug

A near-infrared fluorescent turn-on probe has been reported for specific HER2 imaging and synergistic enhancement of anticancer activity of doxorubicin.

Graphical abstract: A specific environment-sensitive near-infrared fluorescent turn-on probe for synergistic enhancement of anticancer activity of a chemo-drug
From the themed collection: Emerging Investigators 2017
Paper

A micellar cisplatin prodrug simultaneously eliminates both cancer cells and cancer stem cells in lung cancer

Cancer stem cells and bulk cancer cells can be simultaneously targeted when using nanomedicine.

Graphical abstract: A micellar cisplatin prodrug simultaneously eliminates both cancer cells and cancer stem cells in lung cancer
From the themed collection: Emerging Investigators 2017
Paper

Intracellular accumulation and immunological responses of lipid modified magnetic iron nanoparticles in mouse antigen processing cells

Lipid modified magnetic nanoparticles could enhance the intracellular accumulation and immune responses of mouse antigen processing cells.

Graphical abstract: Intracellular accumulation and immunological responses of lipid modified magnetic iron nanoparticles in mouse antigen processing cells
From the themed collection: Emerging Investigators 2017
Paper

Skin-safe photothermal therapy enabled by responsive release of acid-activated membrane-disruptive polymer from polydopamine nanoparticle upon very low laser irradiation

How to ablate tumor without damaging skin is a challenge for photothermal therapy.

Graphical abstract: Skin-safe photothermal therapy enabled by responsive release of acid-activated membrane-disruptive polymer from polydopamine nanoparticle upon very low laser irradiation
From the themed collection: Emerging Investigators 2017
Paper

Enhancing MRI of liver metastases with a zwitterionized biodegradable dendritic contrast agent

The MRI enhanced by a zwitterionized dendritic contrast agent clearly indicates metastatic tumors in the liver.

Graphical abstract: Enhancing MRI of liver metastases with a zwitterionized biodegradable dendritic contrast agent
From the themed collection: Emerging Investigators 2017
Paper

Macrophage infiltration of electrospun polyester fibers

Ibuprofen (IBU)-loaded fibrous PLA membranes can prevent peritendinous adhesion/granuloma formation and inflammation by reducing macrophage infiltration.

Graphical abstract: Macrophage infiltration of electrospun polyester fibers
From the themed collection: Emerging Investigators 2017
Paper

Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index

A Pt(IV)-backboned prodrug-like polymer was synthesized and formulated to a phosphatase-responsive polyion complex for cell-selective delivery.

Graphical abstract: Phosphatase-triggered cell-selective release of a Pt(iv)-backboned prodrug-like polymer for an improved therapeutic index
From the themed collection: Emerging Investigators 2017
36 items

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