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Issue 10, 2017
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Recent advances in biomaterials for the treatment of diabetic foot ulcers

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Abstract

Diabetes mellitus is one of the most challenging epidemics facing the world today, with over 300 million patients affected worldwide. A significant complication associated with diabetes is hyperglycemia, which impairs wound healing. The rise in the diabetic patient population in recent years has precipitated an increase in the incidence and prevalence of chronic diabetic wounds, most commonly the diabetic foot ulcer. Although foot ulcers are difficult to treat due to their complicated pathology, outcomes have improved with the development of increasingly sophisticated biomaterials that accelerate healing. In this review, we describe recently developed biomaterials that elicit healing through cell–material interactions and/or the sustained delivery of drugs. These tunable therapeutic systems increase angiogenesis, collagen deposition, cell proliferation, and growth factors concentrations, while decreasing inflammation and enzymatic degradation of the extracellular matrix. As the field of biomaterials for wound healing continues to mature, we expect to witness a broader range of clinical options that will speed healing times and improve patient quality of life.

Graphical abstract: Recent advances in biomaterials for the treatment of diabetic foot ulcers

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Publication details

The article was received on 28 Mar 2017, accepted on 14 Aug 2017 and first published on 15 Aug 2017


Article type: Review Article
DOI: 10.1039/C7BM00264E
Citation: Biomater. Sci., 2017,5, 1962-1975
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    Recent advances in biomaterials for the treatment of diabetic foot ulcers

    L. N. Kasiewicz and K. A. Whitehead, Biomater. Sci., 2017, 5, 1962
    DOI: 10.1039/C7BM00264E

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