Issue 8, 2017

Glutathione-responsive paclitaxel dimer nanovesicles with high drug content

Abstract

Paclitaxel dimer-based nanovesicles, with an ultrahigh drug content, have been prepared through a nanoprecipitation method. The as-formed nanovesicles exhibit improved paclitaxel solubility, prominent colloid stability, GSH-triggered disassembly, effective cellular uptake and comparable cytotoxicity to Taxol.

Graphical abstract: Glutathione-responsive paclitaxel dimer nanovesicles with high drug content

Supplementary files

Article information

Article type
Communication
Submitted
18 Jan 2017
Accepted
02 Feb 2017
First published
13 Feb 2017

Biomater. Sci., 2017,5, 1517-1521

Glutathione-responsive paclitaxel dimer nanovesicles with high drug content

Q. Pei, X. Hu, J. Zhou, S. Liu and Z. Xie, Biomater. Sci., 2017, 5, 1517 DOI: 10.1039/C7BM00052A

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