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Glycocalyx scaffolding with synthetic nanoscale glycomaterials

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Abstract

We report a method for programming complexity into the glycocalyx of live cells. Via a combination of glycomaterial synthesis and membrane remodeling, we have engineered cells to display native-like, mixed sialoglycan populations, while confining the activity of each glycan into a specific nanoscale presentation.

Graphical abstract: Glycocalyx scaffolding with synthetic nanoscale glycomaterials

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Publication details

The article was received on 31 Mar 2017, accepted on 06 Jun 2017 and first published on 08 Jun 2017


Article type: Communication
DOI: 10.1039/C7BM00289K
Citation: Biomater. Sci., 2017, Advance Article
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    Glycocalyx scaffolding with synthetic nanoscale glycomaterials

    M. L. Huang, S. C. Purcell, S. Verespy III, Y. Wang and K. Godula, Biomater. Sci., 2017, Advance Article , DOI: 10.1039/C7BM00289K

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