Jump to main content
Jump to site search

Issue 8, 2017
Previous Article Next Article

Supramolecular surface functionalization via catechols for the improvement of cell–material interactions

Author affiliations

Abstract

Optimization of cell-material interactions is crucial for the success of synthetic biomaterials in guiding tissue regeneration. To do so, catechol chemistry is often used to introduce adhesiveness into biomaterials. Here, a supramolecular approach based on ureido-pyrimidinone (UPy) modified polymers is combined with catechol chemistry in order to achieve improved cellular adhesion onto supramolecular biomaterials. UPy-modified hydrophobic polymers with non-cell adhesive properties are developed that can be bioactivated via a modular approach using UPy-modified catechols. It is shown that successful formulation of the UPy-catechol additive with the UPy-polymer results in surfaces that induce cardiomyocyte progenitor cell adhesion, cell spreading, and preservation of cardiac specific extracellular matrix production. Hence, by functionalizing supramolecular surfaces with catechol functionalities, an adhesive supramolecular biomaterial is developed that allows for the possibility to contribute to biomaterial-based regeneration.

Graphical abstract: Supramolecular surface functionalization via catechols for the improvement of cell–material interactions

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 May 2017, accepted on 06 Jun 2017 and first published on 13 Jun 2017


Article type: Paper
DOI: 10.1039/C7BM00407A
Citation: Biomater. Sci., 2017,5, 1541-1548
  • Open access: Creative Commons BY license
  •   Request permissions

    Supramolecular surface functionalization via catechols for the improvement of cell–material interactions

    S. Spaans, P. P. K. H. Fransen, B. D. Ippel, D. F. A. de Bont, H. M. Keizer, N. A. M. Bax, C. V. C. Bouten and P. Y. W. Dankers, Biomater. Sci., 2017, 5, 1541
    DOI: 10.1039/C7BM00407A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements