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Manipulating tumor hypoxia toward enhanced photodynamic therapy (PDT)

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Abstract

Photodynamic therapy (PDT) is considered a promising approach for the treatment of cancer and is achieved via the photosensitizer (PS)-mediated incomplete reduction of oxygen upon light irradiation, which generates high levels of reactive oxygen species (ROS) to induce potent vascular damage and to directly kill tumor cells. However, there is an undesirable impediment with this approach in that tumor tissues generally suffer from serious hypoxia, which significantly affects the efficiency of PDT. Additionally, PDT that consumes oxygen will further aggravate tumor hypoxia, thus potentially leading to multiple undesirable consequences, such as angiogenesis, tumor invasiveness, and tumor metastasis. This mini-review provides a comprehensive overview of the recent research progress on overcoming or utilizing tumor hypoxia to enhance the therapeutic efficacy of PDT.

Graphical abstract: Manipulating tumor hypoxia toward enhanced photodynamic therapy (PDT)

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Publication details

The article was received on 29 Apr 2017, accepted on 14 Jun 2017 and first published on 21 Jun 2017


Article type: Minireview
DOI: 10.1039/C7BM00392G
Citation: Biomater. Sci., 2017, Advance Article
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    Manipulating tumor hypoxia toward enhanced photodynamic therapy (PDT)

    J. Dang, H. He, D. Chen and L. Yin, Biomater. Sci., 2017, Advance Article , DOI: 10.1039/C7BM00392G

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