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Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy

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Abstract

In this work, a potent photosensitizer, sinoporphyrin sodium (DVDMS), was loaded into RGD-modified ferritin (R-Fn) nanocages by a rapid, scalable and versatile approach for imaging guided photodynamic and photothermal (PTT/PDT) co-therapy. The resulting nanocomposite formed a well-defined nanocage with a photosensitizer loading capacity as high as 66.67 wt%, which far exceeds those reported previously. The bioengineered protein nanocage-based nanotheranostics exhibits a remarkably improved tumor treatment effect over DVDMS with good biocompatibility and the potential of clinical translation.

Graphical abstract: Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy

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Publication details

The article was received on 04 Apr 2017, accepted on 31 May 2017 and first published on 01 Jun 2017


Article type: Communication
DOI: 10.1039/C7BM00302A
Citation: Biomater. Sci., 2017, Advance Article
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    Ultra-high loading of sinoporphyrin sodium in ferritin for single-wave motivated photothermal and photodynamic co-therapy

    C. Huang, C. Chu, X. Wang, H. Lin, J. Wang, Y. Zeng, W. Zhu, Y. J. Wang and G. Liu, Biomater. Sci., 2017, Advance Article , DOI: 10.1039/C7BM00302A

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