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Themed collection Recent Open Access Articles

120 items - Showing page 1 of 2
Open Access Minireview

Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells

This review summarizes recent research progress in the development of micro/nanoelectrochemical probe and chip devices for the evaluation of three-dimensional (3D) cultured cells.

Graphical abstract: Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells
From the themed collection: Recent Review Articles
Open Access Minireview

Recent advances in the chemical imaging of human fingermarks (a review)

This review highlights the considerable advances in the chemical imaging of human fingermarks. Additional information about the donor can be obtained from the chemical composition of latent fingermarks besides the physical pattern, such as the age, gender, medical history and possible drug habits.

Graphical abstract: Recent advances in the chemical imaging of human fingermarks (a review)
From the themed collection: Recent Review Articles
Open Access Minireview

Recent advancements in ion concentration polarization

Advancements in ion concentration polarization made over the past three years are highlighted.

Graphical abstract: Recent advancements in ion concentration polarization
From the themed collection: Recent Review Articles
Open Access Minireview

Electrochemical hydrogen sulfide biosensors

Biological application of electrochemical hydrogen sulfide sensors.

Graphical abstract: Electrochemical hydrogen sulfide biosensors
From the themed collection: Recent Review Articles
Open Access Minireview

Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics

We present an overview of current isolation, detection, and characterization methods of extracellular vesicles and their applications and limitations as a potential emerging biomarker in cancer management and their clinical implementation.

Graphical abstract: Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics
From the themed collection: Recent Review Articles
Open Access Tutorial Review

Thin film depth profiling by ion beam analysis

The analysis of thin films is of central importance for functional materials, including the very large and active field of nanomaterials.

Graphical abstract: Thin film depth profiling by ion beam analysis
From the themed collection: Recent Review Articles
Open Access Tutorial Review

High spatial and temporal resolution cell manipulation techniques in microchannels

Reviewing latest developments on lab on chips for enhanced control of cells’ experiments.

Graphical abstract: High spatial and temporal resolution cell manipulation techniques in microchannels
From the themed collection: Recent Review Articles
Open Access Tutorial Review

Gold nanoparticles as sensitive optical probes

Recent advances in Au NP based optical sensing systems for various analytes based on absorption, fluorescence and SERS are summarized.

Graphical abstract: Gold nanoparticles as sensitive optical probes
From the themed collection: Recent Review Articles
Open Access Critical Review

Hybrid plasmonic–photonic whispering gallery mode resonators for sensing: a critical review

In this review we present the state of the art and the most recent advances in the field of optical sensing with hybrid plasmonic–photonic whispering gallery mode (WGM) resonators.

Graphical abstract: Hybrid plasmonic–photonic whispering gallery mode resonators for sensing: a critical review
From the themed collection: Recent Review Articles
Open Access Critical Review

A critical insight into the development pipeline of microfluidic immunoassay devices for the sensitive quantitation of protein biomarkers at the point of care

A critical review on the development of microfluidic tests capable of the high-sensitivity measurement of protein biomarkers at the point-of-care.

Graphical abstract: A critical insight into the development pipeline of microfluidic immunoassay devices for the sensitive quantitation of protein biomarkers at the point of care
From the themed collection: Recent Review Articles
Open Access Critical Review

Chemometrics for ion mobility spectrometry data: recent advances and future prospects

This is the first comprehensive review on chemometric techniques used in ion mobility spectrometry data analysis.

Graphical abstract: Chemometrics for ion mobility spectrometry data: recent advances and future prospects
From the themed collection: Recent Review Articles
Open Access Critical Review

Nanoparticles and intracellular applications of surface-enhanced Raman spectroscopy

Surface-enhanced Raman spectroscopy offers ultra-sensitive vibrational fingerprinting within biological cells.

Graphical abstract: Nanoparticles and intracellular applications of surface-enhanced Raman spectroscopy
From the themed collection: Recent Review Articles
Open Access Critical Review

Raman spectroscopy: an evolving technique for live cell studies

This review highlights some of the most recent advances in the development of Raman spectroscopy for live cell studies.

Graphical abstract: Raman spectroscopy: an evolving technique for live cell studies
From the themed collection: Recent Review Articles
Open Access Critical Review

Functionalization of metal nanoclusters for biomedical applications

Metal nanoclusters (NCs) are emerging as a new class of functional nanomaterials in the area of biological sensing, labelling, imaging and therapy due to their unique physical and chemical properties, such as ultrasmall size, HOMO–LUMO transition, strong luminescence together with good photostability and biocompatibility.

Graphical abstract: Functionalization of metal nanoclusters for biomedical applications
From the themed collection: Recent Review Articles
Open Access Critical Review

Micro-scale spatially offset Raman spectroscopy for non-invasive subsurface analysis of turbid materials

This article reviews a very recent field of noninvasive analysis of turbid media using micro-scale Spatially Offset Raman Spectroscopy – micro-SORS.

Graphical abstract: Micro-scale spatially offset Raman spectroscopy for non-invasive subsurface analysis of turbid materials
From the themed collection: Recent Review Articles
Open Access Critical Review

Biomarker detection technologies and future directions

Advancement in technologies which can provide highly selective and sensitive multiplex detection of biomarkers is inevitable for accurate disease prognosis, diagnosis, and treatment follow-up.

Graphical abstract: Biomarker detection technologies and future directions
From the themed collection: Recent Review Articles
Open Access Communication

Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers

The first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of methoxphenidine (MXP) and its regioisomers.

Graphical abstract: Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers
From the themed collection: Recent Open Access Articles
Open Access Communication

Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)

A novel analytical approach for the identification/quantification of the reduction products of platinum(IV) complexes is presented.

Graphical abstract: Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)
From the themed collection: Recent Open Access Articles
Open Access Communication

Bulk double emulsification for flow cytometric analysis of microfluidic droplets

We describe a simple bulk method to prepare double emulsions for high-throughput analysis and sorting with flow cytometers.

Graphical abstract: Bulk double emulsification for flow cytometric analysis of microfluidic droplets
From the themed collection: Recent Open Access Articles
Open Access Communication

10 nm deep, sub-nanoliter fluidic nanochannels on germanium for attenuated total reflection infrared (ATR-IR) spectroscopy

Nanoslits with a depth of ∼10 nm were manufactured on a germanium internal reflection element for attenuated internal reflection infrared spectroscopy.

Graphical abstract: 10 nm deep, sub-nanoliter fluidic nanochannels on germanium for attenuated total reflection infrared (ATR-IR) spectroscopy
From the themed collection: Recent Open Access Articles
Open Access Communication

Image analysis for a microfluidic paper-based analytical device using the CIE L*a*b* color system

A quantitative method based on image analysis of multiple color changes in microfluidic paper-based analytical devices using CIE L*a*b* color difference is presented.

Graphical abstract: Image analysis for a microfluidic paper-based analytical device using the CIE L*a*b* color system
From the themed collection: Recent Open Access Articles
Open Access Communication

Next generation of labeling reagents for quantitative and multiplexing immunoassays by the use of LA-ICP-MS

A novel labeling strategy – which results in one label per antibody molecule – was used for multiplex and quantitative immuno imaging by use of LA-ICP-MS.

Graphical abstract: Next generation of labeling reagents for quantitative and multiplexing immunoassays by the use of LA-ICP-MS
From the themed collection: Recent Open Access Articles
Open Access Communication

Advanced gas sensors based on substrate-integrated hollow waveguides and dual-color ring quantum cascade lasers

The first combination of a ring-shaped vertically emitting quantum cascade laser (riQCL) with a substrate-integrated hollow waveguide (iHWG) is presented.

Graphical abstract: Advanced gas sensors based on substrate-integrated hollow waveguides and dual-color ring quantum cascade lasers
From the themed collection: Recent Open Access Articles
Open Access Communication

Infrared spectroscopy via substrate-integrated hollow waveguides: a powerful tool in catalysis research

Monitoring catalyst performance via substrate-integrated hollow waveguide (iHWGs) assisted infrared spectroscopy.

Graphical abstract: Infrared spectroscopy via substrate-integrated hollow waveguides: a powerful tool in catalysis research
From the themed collection: Recent Open Access Articles
Open Access Communication

Measuring the effects of fractionated radiation therapy in a 3D prostate cancer model system using SERS nanosensors

Using Surface Enhanced Raman Spectroscopy to measure cell death caused by radiation in a 3D model of prostate cancer.

Graphical abstract: Measuring the effects of fractionated radiation therapy in a 3D prostate cancer model system using SERS nanosensors
From the themed collection: Recent Open Access Articles
Open Access Communication

A tunable Au core–Ag shell nanoparticle tip for tip-enhanced spectroscopy

A single Au nanoparticle (NP) with a diameter of 5 nm was transferred to the end of a Si-tip through a picking process, and an Ag shell with a controlled thickness was formed on the Au core.

Graphical abstract: A tunable Au core–Ag shell nanoparticle tip for tip-enhanced spectroscopy
From the themed collection: Recent Open Access Articles
Open Access Communication

Detection of prostate cancer using a voltammetric electronic tongue

A multivariate analysis of data from urine with an electronic voltammetric tongue to detect patients with prostate cancer.

Graphical abstract: Detection of prostate cancer using a voltammetric electronic tongue
From the themed collection: Recent Open Access Articles
Open Access Communication

Electrocatalytic monitoring of peptidic proton-wires

The transfer of protons or proton donor/acceptor abilities is an important phenomenon in many biomolecular systems.

Graphical abstract: Electrocatalytic monitoring of peptidic proton-wires
From the themed collection: Recent Open Access Articles
Open Access Communication

Signal enhancement in ligand–receptor interactions using dynamic polymers at quartz crystal microbalance sensors

The signal enhancement properties of QCM sensors based on dynamic, biotinylated poly(acrylic acid) brushes has been studied in interaction studies with an anti-biotin Fab fragment.

Graphical abstract: Signal enhancement in ligand–receptor interactions using dynamic polymers at quartz crystal microbalance sensors
From the themed collection: Recent Open Access Articles
Open Access Communication

NMR detection in biofluid extracts at sub-μM concentrations via para-H2 induced hyperpolarization

A combination of solid phase extraction, para-hydrogen induced hyperpolarization and selective NMR detection allows the quantitative determination of a doping substance at sub-μM concentrations in urine.

Graphical abstract: NMR detection in biofluid extracts at sub-μM concentrations via para-H2 induced hyperpolarization
From the themed collection: Recent Open Access Articles
Open Access Communication

The origin of the band at around 730 cm−1 in the SERS spectra of bacteria: a stable isotope approach

A stable isotope approach combined with SERS analysis of bacteria allows clarification of the origin of a pronounced band at 730 cm−1.

Graphical abstract: The origin of the band at around 730 cm−1 in the SERS spectra of bacteria: a stable isotope approach
From the themed collection: Recent Open Access Articles
Open Access Communication

Analytically useful blue chemiluminescence from a water-soluble iridium(III) complex containing a tetraethylene glycol functionalised triazolylpyridine ligand

The first highly water soluble, blue-luminescent iridium(III) complex for chemiluminescence detection is presented.

Graphical abstract: Analytically useful blue chemiluminescence from a water-soluble iridium(iii) complex containing a tetraethylene glycol functionalised triazolylpyridine ligand
From the themed collection: Recent Open Access Articles
Open Access Communication

Utilising copper screen-printed electrodes (CuSPE) for the electroanalytical sensing of sulfide

A mediatorless sulfide electrochemical sensing platform utilising a novel nanocopper-oxide screen-printed electrodes (CuSPE) is reported for the first time.

Graphical abstract: Utilising copper screen-printed electrodes (CuSPE) for the electroanalytical sensing of sulfide
From the themed collection: Recent Open Access Articles
Open Access Communication

A ratiometric fluorescent probe for detection of biogenic primary amines with nanomolar sensitivity

An ultrasensitive ratiometric fluorescent sensor made of an N,N-dimethylaminonaphthalene anhydride moiety for detection of aliphatic primary amines is reported.

Graphical abstract: A ratiometric fluorescent probe for detection of biogenic primary amines with nanomolar sensitivity
From the themed collection: Recent Open Access Articles
Open Access Paper

Simultaneous non-polar and polar lipid analysis by on-line combination of HILIC, RP and high resolution MS

Polar and non-polar lipids analysis in 15 min chromatographic run time was enabled by a novel instrumental setup using orthogonal HILIC and RP separation and effluent combination prior to high-resolution mass spectrometry.

Graphical abstract: Simultaneous non-polar and polar lipid analysis by on-line combination of HILIC, RP and high resolution MS
From the themed collection: Recent Open Access Articles
Open Access Paper

Collection of amino acids and DNA from fingerprints using hydrogels

We detail the use of cross-linkable solutions of dextran-methacrylate to form hydrogels capable of collecting amino acids and DNA from fingerprints, while allowing for their increased visualisation at a later stage.

Graphical abstract: Collection of amino acids and DNA from fingerprints using hydrogels
From the themed collection: Recent Open Access Articles
Open Access Paper

Fast selective trapping and release of picoliter droplets in a 3D microfluidic PDMS multi-trap system with bubbles

A surface acoustic wave (SAW) induces a bubble in a 3D designed multi-trap polydimethylsiloxane (PDMS) device for the selection, incubation and on-demand release of aqueous droplets from a continuous oil flow.

Graphical abstract: Fast selective trapping and release of picoliter droplets in a 3D microfluidic PDMS multi-trap system with bubbles
From the themed collection: Recent Open Access Articles
Open Access Paper

High temporal resolution delayed analysis of clinical microdialysate streams

This paper presents the use of tubing to store clinical microdialysis samples for delayed analysis with high temporal resolution, offering an alternative to traditional discrete offline microdialysis sampling. A model allowing optimal results is described.

Graphical abstract: High temporal resolution delayed analysis of clinical microdialysate streams
From the themed collection: Recent Open Access Articles
Open Access Paper

Kinetically-enhanced DNA detection via multiple-pass exonuclease III-aided target recycling

A multiple-pass, exonuclease III-mediated target recycling circuit is described for sensitive DNA detection with a shorter assay time.

Graphical abstract: Kinetically-enhanced DNA detection via multiple-pass exonuclease III-aided target recycling
From the themed collection: Recent Open Access Articles
Open Access Paper

Imaging of compartmentalised intracellular nitric oxide, induced during bacterial phagocytosis, using a metalloprotein–gold nanoparticle conjugate

Imaging of the in situ production of nitric oxide following phagocytosis of Escherichia coli bacteria using a NO nanobiosensor.

Graphical abstract: Imaging of compartmentalised intracellular nitric oxide, induced during bacterial phagocytosis, using a metalloprotein–gold nanoparticle conjugate
From the themed collection: Recent Open Access Articles
Open Access Paper

Cellulose ionics: switching ionic diode responses by surface charge in reconstituted cellulose films

Cellulose films as well as chitosan-modified cellulose films of approximately 5 μm thickness, reconstituted from ionic liquid media onto a poly(ethylene-terephthalate) (PET, 6 μm thickness) film with a 5, 10, 20, or 40 μm diameter laser-drilled microhole, show significant current rectification in aqueous NaCl.

Graphical abstract: Cellulose ionics: switching ionic diode responses by surface charge in reconstituted cellulose films
From the themed collection: Recent Open Access Articles
Open Access Paper

Titanium nanoparticles (TiO2)/graphene oxide nanosheets (GO): an electrochemical sensing platform for the sensitive and simultaneous determination of benzocaine in the presence of antipyrine

An effective electrochemical sensing platform for the simultaneous determination of benzocaine (BEN) and antipyrine (ANT).

Graphical abstract: Titanium nanoparticles (TiO2)/graphene oxide nanosheets (GO): an electrochemical sensing platform for the sensitive and simultaneous determination of benzocaine in the presence of antipyrine
From the themed collection: Recent Open Access Articles
Open Access Paper

Spatially offset Raman spectroscopy for photon migration studies in bones with different mineralization levels

This study provides a deeper understanding of bone's optical properties which is essential to the development of SORS-based diagnostic tools.

Graphical abstract: Spatially offset Raman spectroscopy for photon migration studies in bones with different mineralization levels
From the themed collection: Recent Open Access Articles
Open Access Paper

Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS

The metabolism of the anticancer thiosemicarbazone Triapine was investigated.

Graphical abstract: Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS
From the themed collection: Recent Open Access Articles
Open Access Paper

Influence of washing and quenching in profiling the metabolome of adherent mammalian cells: a case study with the metastatic breast cancer cell line MDA-MB-231

1 step of PBS wash followed by quenching with 60% methanol supplemented with 70 mM HEPES results in minimal metabolite leakage.

Graphical abstract: Influence of washing and quenching in profiling the metabolome of adherent mammalian cells: a case study with the metastatic breast cancer cell line MDA-MB-231
From the themed collection: Recent Open Access Articles
Open Access Paper

LILY-lipidome isotope labeling of yeast: in vivo synthesis of 13C labeled reference lipids for quantification by mass spectrometry

Quantification is an essential task in comprehensive lipidomics studies challenged by the high number of lipids, their chemical diversity and their dynamic range (up to 7 orders of magnitude) of the lipidome.

Graphical abstract: LILY-lipidome isotope labeling of yeast: in vivo synthesis of 13C labeled reference lipids for quantification by mass spectrometry
From the themed collection: Recent Open Access Articles
Open Access Paper

Time-resolved and temperature tuneable measurements of fluorescent intensity using a smartphone fluorimeter

A smartphone fluorimeter is demonstrated for steady-state and time-resolved fluorescence intensity measurements at tunable temperatures.

Graphical abstract: Time-resolved and temperature tuneable measurements of fluorescent intensity using a smartphone fluorimeter
From the themed collection: Recent Open Access Articles
Open Access Paper

In vitro field potential monitoring on a multi-microelectrode array for the electrophysiological long-term screening of neural stem cell maturation

Combining in vitro neuron cell models to automated electrophysiology monitoring allows the standardized identification of toxic and protective neuromodulators in pharmaceutical ingredient development.

Graphical abstract: In vitro field potential monitoring on a multi-microelectrode array for the electrophysiological long-term screening of neural stem cell maturation
From the themed collection: Recent Open Access Articles
Open Access Paper

Surfactant exfoliated 2D hexagonal Boron Nitride (2D-hBN) explored as a potential electrochemical sensor for dopamine: surfactants significantly influence sensor capabilities

The surfactant utilised in the exfoliated synthesis of 2D hexagonal Boron Nitride (2D-hBN) significantly influences sensor capabilities towards the detection of dopamine.

Graphical abstract: Surfactant exfoliated 2D hexagonal Boron Nitride (2D-hBN) explored as a potential electrochemical sensor for dopamine: surfactants significantly influence sensor capabilities
From the themed collection: Recent Open Access Articles
Open Access Paper

Implementation of MALDI MS profiling and imaging methods for the analysis of real crime scene fingermarks

First insights into MALDI MS based method's transition to operational casework involving fingermark analysis.

Graphical abstract: Implementation of MALDI MS profiling and imaging methods for the analysis of real crime scene fingermarks
From the themed collection: Recent Open Access Articles
Open Access Paper

Simultaneous viscosity and density measurement of small volumes of liquids using a vibrating microcantilever

An analytical model is derived to calculate the viscosity and density of small volumes of fluid from the resonance frequencies of an immersed microcantilever. Its accuracy is verified on simple and non-Newtonian fluids.

Graphical abstract: Simultaneous viscosity and density measurement of small volumes of liquids using a vibrating microcantilever
From the themed collection: Recent Open Access Articles
Open Access Paper

Detection of chemical warfare agent simulants and hydrolysis products in biological samples by paper spray mass spectrometry

Paper spray ionization was used to detect and quantitate chemical warfare simulants and hydrolysis products from whole blood and urine.

Graphical abstract: Detection of chemical warfare agent simulants and hydrolysis products in biological samples by paper spray mass spectrometry
From the themed collection: Recent Open Access Articles
Open Access Paper

Infrared spectral histopathology using haematoxylin and eosin (H&E) stained glass slides: a major step forward towards clinical translation

Infrared spectral histopathology has shown great promise as an important diagnostic tool, with the potential to complement current pathological methods.

Graphical abstract: Infrared spectral histopathology using haematoxylin and eosin (H&E) stained glass slides: a major step forward towards clinical translation
From the themed collection: Recent Open Access Articles
Open Access Paper

Specificity of SNP detection with molecular beacons is improved by stem and loop separation with spacers

Dissection of stem and loop regions in molecular beacons by nucleotide or non-nucleotide linkers minimizes nonspecific recognition in SNP discrimination.

Graphical abstract: Specificity of SNP detection with molecular beacons is improved by stem and loop separation with spacers
From the themed collection: Recent Open Access Articles
Open Access Paper

Covalent immobilisation of antibodies in Teflon-FEP microfluidic devices for the sensitive quantification of clinically relevant protein biomarkers

Antibodies immobilised covalently within Teflon-FEP microcapillary devices allow sensitive fluorescent enzyme immunoassay.

Graphical abstract: Covalent immobilisation of antibodies in Teflon-FEP microfluidic devices for the sensitive quantification of clinically relevant protein biomarkers
From the themed collection: Recent Open Access Articles
Open Access Paper

Photochemistry in a soft-glass single-ring hollow-core photonic crystal fibre

A single-ring hollow-core photonic crystal fibre (HC-PCF), guided by anti-resonant reflection, is investigated as a highly efficient and versatile microreactor for liquid-phase photochemistry and catalysis.

Graphical abstract: Photochemistry in a soft-glass single-ring hollow-core photonic crystal fibre
From the themed collection: Recent Open Access Articles
Open Access Paper

Detection of glycosylation and iron-binding protein modifications using Raman spectroscopy

We have used Raman spectroscopy and chemometrics to determine protein modification as a result of glycosylation and iron binding.

Graphical abstract: Detection of glycosylation and iron-binding protein modifications using Raman spectroscopy
From the themed collection: Recent Open Access Articles
Open Access Paper

Development of a full micro-scale spatially offset Raman spectroscopy prototype as a portable analytical tool

We present, for the first time, a portable full micro-Spatially Offset Raman Spectroscopy (micro-SORS) prototype permitting the in situ analysis of thin, highly turbid stratified layers at depths not accessible to conventional Raman microscopy.

Graphical abstract: Development of a full micro-scale spatially offset Raman spectroscopy prototype as a portable analytical tool
From the themed collection: Recent Open Access Articles
Open Access Paper

Label-free monitoring of tissue biochemistry following traumatic brain injury using Raman spectroscopy

Acute tissue biochemical response to traumatic brain injury is revealed using Raman spectroscopy.

Graphical abstract: Label-free monitoring of tissue biochemistry following traumatic brain injury using Raman spectroscopy
From the themed collection: Recent Open Access Articles
Open Access Paper

Acoustofluidic particle trapping, manipulation, and release using dynamic-mode cantilever sensors

Active and programmable mixing, trapping, separation, manipulation and release of suspended particles in liquids using dynamic-mode cantilever sensors.

Graphical abstract: Acoustofluidic particle trapping, manipulation, and release using dynamic-mode cantilever sensors
From the themed collection: Recent Open Access Articles
Open Access Paper

Role of micropillar arrays in cell rolling dynamics

In this study, we present a role of arrayed micropillar structures in cell rolling dynamics.

Graphical abstract: Role of micropillar arrays in cell rolling dynamics
From the themed collection: Recent Open Access Articles
Open Access Paper

A competitive immunoassay system for microfluidic paper-based analytical detection of small size molecules

A colorimetric competitive immunoassay system involving the catalytic oxidation of TMB by H2O2 was developed for the microfluidic paper-based detection of small size molecules.

Graphical abstract: A competitive immunoassay system for microfluidic paper-based analytical detection of small size molecules
From the themed collection: Recent Open Access Articles
Open Access Paper

Design of luciferase-displaying protein nanoparticles for use as highly sensitive immunoassay detection probes

In this study, we developed a protein nanoparticle-based immunoassay to detect cancer biomarkers using a bioluminescent fusion protein.

Graphical abstract: Design of luciferase-displaying protein nanoparticles for use as highly sensitive immunoassay detection probes
From the themed collection: Recent Open Access Articles
Open Access Paper

Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach

A rapid, low-cost and label-free method of cell analysis compares favorably to Annexin-V, MTT and trypan blue for assessment of apoptosis and IC50.

Graphical abstract: Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach
From the themed collection: Recent Open Access Articles
Open Access Paper

Real-time detection of carboplatin using a microfluidic system

A novel on-line microfluidic assay for the chemotherapy agent carboplatin will allow sensitive detection of the drug directly applied to the tumour as it emerges from the tumour into healthy tissue.

Graphical abstract: Real-time detection of carboplatin using a microfluidic system
From the themed collection: Recent Open Access Articles
Open Access Paper

Fiber enhanced Raman spectroscopic analysis as a novel method for diagnosis and monitoring of diseases related to hyperbilirubinemia and hyperbiliverdinemia

Fiber enhanced resonance Raman spectroscopy (FERS) is introduced for chemically selective and ultrasensitive analysis of the biomolecules hematin, hemoglobin, biliverdin, and bilirubin, as well as intact red blood cells.

Graphical abstract: Fiber enhanced Raman spectroscopic analysis as a novel method for diagnosis and monitoring of diseases related to hyperbilirubinemia and hyperbiliverdinemia
From the themed collection: Recent Open Access Articles
Open Access Paper

Quantitative surface-enhanced Raman spectroscopy for kinetic analysis of aldol condensation using Ag–Au core–shell nanocubes

Ag–Au core–shell nanocube-based surface-enhanced Raman scattering (SERS) probes utilizing internal standard calibration for quantitative kinetic analysis of the aldol condensation reaction.

Graphical abstract: Quantitative surface-enhanced Raman spectroscopy for kinetic analysis of aldol condensation using Ag–Au core–shell nanocubes
From the themed collection: Recent Open Access Articles
Open Access Paper

Designed miniaturization of microfluidic biosensor platforms using the stop-flow technique

Here, we present a novel approach to increase the degree of miniaturization as well as the sensitivity of biosensor platforms by the optimization of microfluidic stop-flow techniques independent of the applied detection technique (e.g. electrochemical or optical).

Graphical abstract: Designed miniaturization of microfluidic biosensor platforms using the stop-flow technique
From the themed collection: Recent Open Access Articles
Open Access Paper

Nano electrospray gas-phase electrophoretic mobility molecular analysis (nES GEMMA) of liposomes: applicability of the technique for nano vesicle batch control

Gas-phase electrophoresis of single-charged particles enables liposome characterization and finally the resulting vesicle encapsulation capacity determination.

Graphical abstract: Nano electrospray gas-phase electrophoretic mobility molecular analysis (nES GEMMA) of liposomes: applicability of the technique for nano vesicle batch control
From the themed collection: Recent Open Access Articles
Open Access Paper

An experimental study on the influence of trace impurities on ionization of atmospheric noble gas dielectric barrier discharges

Penning Ionisation of N2+ by collisions with of N2 with HeM and [C3H8]+ by collisions of C3H8 with ArM.

Graphical abstract: An experimental study on the influence of trace impurities on ionization of atmospheric noble gas dielectric barrier discharges
From the themed collection: Recent Open Access Articles
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