Issue 2, 2017

10 nm deep, sub-nanoliter fluidic nanochannels on germanium for attenuated total reflection infrared (ATR-IR) spectroscopy

Abstract

The fabrication of sub-nanoliter fluidic channels is demonstrated, with merely 10 nm depth on germanium, using conventional semiconductor device fabrication methods and a polymer assisted room-temperature sealing method. As a first application, an ultralow volume (650 pL) was studied by ATR-IR spectroscopy. A detection limit of ∼7.9 × 1010 molecules of human serum albumin (HSA) (∼0.2 mM) in D2O was achieved with highly specific ATR-IR spectroscopy.

Graphical abstract: 10 nm deep, sub-nanoliter fluidic nanochannels on germanium for attenuated total reflection infrared (ATR-IR) spectroscopy

Article information

Article type
Communication
Submitted
27 Jul 2016
Accepted
14 Nov 2016
First published
14 Nov 2016
This article is Open Access
Creative Commons BY-NC license

Analyst, 2017,142, 273-278

10 nm deep, sub-nanoliter fluidic nanochannels on germanium for attenuated total reflection infrared (ATR-IR) spectroscopy

K. K. Sriram, S. Nayak, S. Pengel, C. Chou and A. Erbe, Analyst, 2017, 142, 273 DOI: 10.1039/C6AN01699E

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