Themed collection Injectable Hydrogels

32 items
Editorial

An introduction to injectable hydrogels

Julieta Paez and Khoon Lim introduce the Journal of Materials Chemistry B and Biomaterials Science themed collection on injectable hydrogels.

Graphical abstract: An introduction to injectable hydrogels
From the themed collection: Injectable Hydrogels
Perspective

Injectable organo-hydrogels influenced by click chemistry as a paramount stratagem in the conveyor belt of pharmaceutical revolution

Injectable hydrogels emerging as a significant breakthrough in the myriad of biomedical applications and paving a path towards clinical advancements.

Graphical abstract: Injectable organo-hydrogels influenced by click chemistry as a paramount stratagem in the conveyor belt of pharmaceutical revolution
From the themed collection: Injectable Hydrogels
Review Article

Injectable hydrogels as emerging drug-delivery platforms for tumor therapy

This review summarizes composition and preparation methodologies of injectable hydrogels and highlights the delivery mechanisms of drugs for tumor therapy, along with discussion on the optimal therapeutic efficiency of drugs and provides perspective on challenges and solutions in applications.

Graphical abstract: Injectable hydrogels as emerging drug-delivery platforms for tumor therapy
From the themed collection: Injectable Hydrogels
Review Article

Recent advances in fabricating injectable hydrogels via tunable molecular interactions for bio-applications

Fabricating injectable hydrogels via tunable molecular interactions for bio-applications.

Graphical abstract: Recent advances in fabricating injectable hydrogels via tunable molecular interactions for bio-applications
From the themed collection: Injectable Hydrogels
Review Article

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

This review makes a comprehensive summary on the cross-linking mechanism, optimization of mechanical properties, drug loading and release modalities, and recent biological applications of CD-based supramolecular hydrogels.

Graphical abstract: Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications
From the themed collection: Injectable Hydrogels
Review Article

Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

The synergistic integration of natural and synthetic materials, capitalizing on their respective advantages and mitigating their weaknesses, represents a rational strategy for the development of an ideal injectable smart stimuli-responsive hydrogel.

Graphical abstract: Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications
From the themed collection: Injectable Hydrogels
Review Article

Cell or cell derivative-laden hydrogels for myocardial infarction therapy: from the perspective of cell types

Injectable hydrogels and cell-based myocardial infarction (MI) therapy mutually enhance each other. This review focuses on recent studies using hydrogel to deliver cell or cell-derived preparations for MI treatment.

Graphical abstract: Cell or cell derivative-laden hydrogels for myocardial infarction therapy: from the perspective of cell types
From the themed collection: Injectable Hydrogels
Open Access Review Article

Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics

Multifunctional hydrogels play a pivotal role against infections, inflammation, and oxidative stress, especially for endodontics and periodontics treatment.

Graphical abstract: Advances in antimicrobial hydrogels for dental tissue engineering: regenerative strategies for endodontics and periodontics
From the themed collection: Injectable Hydrogels
Open Access Review Article

Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial photothermal therapy

Injectable hydrogels intended for cancer combinatorial-photothermal therapy bring forward the possibility of attaining multifunctional systems for an improved and selective treatment for this disease.

Graphical abstract: Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial photothermal therapy
From the themed collection: Injectable Hydrogels
Paper

Photocrosslinkable microgels derived from human platelet lysates: injectable biomaterials for cardiac cell culture

Human-derived methacryloyl platelet lysates (PLMA) have been employed for constructing full human-based 3D cell culture matrices and demonstrated potential for xeno-free applications.

Graphical abstract: Photocrosslinkable microgels derived from human platelet lysates: injectable biomaterials for cardiac cell culture
From the themed collection: Injectable Hydrogels
Paper

An injectable hydrogel dressing for controlled release of hydrogen sulfide pleiotropically mediates the wound microenvironment

In this work, a hydrogel dressing for controlled release of hydrogen sulfide is developed for the repair of scalded wounds. It exhibits a responsive release of H2S based on ROS concentration, allowing precise modulation of the wound microenvironment.

Graphical abstract: An injectable hydrogel dressing for controlled release of hydrogen sulfide pleiotropically mediates the wound microenvironment
From the themed collection: Injectable Hydrogels
Open Access Paper

Tissue-specific gelatin bioink as a rheology modifier for high printability and adjustable tissue properties

This study introduces gelatinized dECM, a tissue-specific rheological modifier, enabling high-resolution printing of flexible tissue constructs with enhanced resilience.

Graphical abstract: Tissue-specific gelatin bioink as a rheology modifier for high printability and adjustable tissue properties
From the themed collection: Injectable Hydrogels
Paper

Engineering sulfated polysaccharides and silk fibroin based injectable IPN hydrogels with stiffening and growth factor presentation abilities for cartilage tissue engineering

In this study, we combined the β-sheet mediated self-stiffening ability of silk with growth factor presenting ability of sulphated carboxymethyl cellulose in an injectable interpenetrating network hydrogel for repair of articular cartilage defects.

Graphical abstract: Engineering sulfated polysaccharides and silk fibroin based injectable IPN hydrogels with stiffening and growth factor presentation abilities for cartilage tissue engineering
From the themed collection: Injectable Hydrogels
Paper

Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications

Injectable thermosensitive hydrogels based on hyaluronic acid (HA) grafted with lower critical solution temperature (LCST) polyoxazoline (copolymers of poly(isopropyl-co-butyl oxazoline)) or P(iPrOx-co-BuOx) have been elaborated with tunable solution/gel temperature transitions and gel state elastic modulus.

Graphical abstract: Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications
From the themed collection: Injectable Hydrogels
Paper

Facilely printed silk fibroin hydrogel microparticles as injectable long-lasting fillers

A regenerated silk fibroin hydrogel is facilely printed by a screen to obtain injectable microparticles. The microparticles possess desirable biocompatibility and lasting filling effects and have great potential for facial rejuvenation.

Graphical abstract: Facilely printed silk fibroin hydrogel microparticles as injectable long-lasting fillers
From the themed collection: Injectable Hydrogels
Paper

Photothermal synergistic nitric oxide controlled release injectable self-healing adhesive hydrogel for biofilm eradication and wound healing

A novel injectable self-healing adhesive hydrogel with specific bacteria capture capability and inherent contact antimicrobial activity for mild photothermal therapy and NO controlled release to synergically eliminate biofilm infections and promote wound healing.

Graphical abstract: Photothermal synergistic nitric oxide controlled release injectable self-healing adhesive hydrogel for biofilm eradication and wound healing
From the themed collection: Injectable Hydrogels
Paper

A thermosensitive hydrogel formulation of phage and colistin combination for the management of multidrug-resistant Acinetobacter baumannii wound infections

Unlocking the power of synergy: PAS-loaded thermosensitive hydrogel for enhanced skin wound infection management.

Graphical abstract: A thermosensitive hydrogel formulation of phage and colistin combination for the management of multidrug-resistant Acinetobacter baumannii wound infections
From the themed collection: Injectable Hydrogels
Paper

Antibacterial, antioxidant and injectable hydrogels constructed using CuS and curcumin co-loaded micelles for NIR-enhanced infected wound healing

A CuS–curcumin hybrid hydrogel with good biocompatibility, NIR-enhanced antibacterial, antioxidant, anti-inflammatory, and angiogenesis properties has been developed for infected wound healing.

Graphical abstract: Antibacterial, antioxidant and injectable hydrogels constructed using CuS and curcumin co-loaded micelles for NIR-enhanced infected wound healing
From the themed collection: Injectable Hydrogels
Paper

Combining biomimetic collagen/hyaluronan hydrogels with discogenic growth factors promotes mesenchymal stroma cell differentiation into Nucleus Pulposus like cells

The combination of discogenic factors with biomimetic collagen/hyaluronan hydrogels is promising for disc regeneration; a high content of hyaluronan is responsible for the BM-MSC differentiation into NP like cells.

Graphical abstract: Combining biomimetic collagen/hyaluronan hydrogels with discogenic growth factors promotes mesenchymal stroma cell differentiation into Nucleus Pulposus like cells
From the themed collection: Injectable Hydrogels
Paper

Injectable spontaneously formed asymmetric adhesive hydrogel with controllable removal for wound healing

The mechanism and characteristics of injectable asymmetric hydrogel for large-scale skin trauma repair.

Graphical abstract: Injectable spontaneously formed asymmetric adhesive hydrogel with controllable removal for wound healing
From the themed collection: Injectable Hydrogels
Paper

A photocrosslinked methacrylated carboxymethyl chitosan/oxidized locust bean gum double network hydrogel for cartilage repair

Studies in vivo demonstrated that the MCOAC hydrogel exhibited superior performance in promoting cartilage tissue growth in articular cartilage defects. The MCOAC hydrogel is a promising cartilage repair hydrogel with potential for clinical use.

Graphical abstract: A photocrosslinked methacrylated carboxymethyl chitosan/oxidized locust bean gum double network hydrogel for cartilage repair
From the themed collection: Injectable Hydrogels
Paper

A nanozyme-reinforced injectable photodynamic hydrogel for combating biofilm infection

Here, an oxygen self-supplying nanozyme-based injectable hydrogel is constructed. Both in vitro and in vivo results indicate that the MTC gel has excellent antibiofilm ability with no side effects on normal tissues.

Graphical abstract: A nanozyme-reinforced injectable photodynamic hydrogel for combating biofilm infection
From the themed collection: Injectable Hydrogels
Paper

Etamsylate loaded oxidized Konjac glucomannan-ε-polylysine injectable hydrogels for rapid hemostasis and wound healing

Konjac glucomannan was oxidized using NaIO4 and subsequently reacted with ε-polylysine to form a drug-loaded adhesive hydrogel. The hydrogel was then utilized as a hemostatic dressing.

Graphical abstract: Etamsylate loaded oxidized Konjac glucomannan-ε-polylysine injectable hydrogels for rapid hemostasis and wound healing
From the themed collection: Injectable Hydrogels
Paper

Osteoimmunity-regulating nanosilicate-reinforced hydrogels for enhancing osseointegration

Schematic illustration of osteoimmunity-regulating injectable SA/MMT/HM hydrogel composites for enhanced bone regeneration via M2 macrophage polarization.

Graphical abstract: Osteoimmunity-regulating nanosilicate-reinforced hydrogels for enhancing osseointegration
From the themed collection: Injectable Hydrogels
Paper

An advanced biphasic porous and injectable scaffold displays a fine balance between mechanical strength and remodeling capabilities essential for cartilage regeneration

An important challenge in tissue engineering is the regeneration of functional articular cartilage (AC).

Graphical abstract: An advanced biphasic porous and injectable scaffold displays a fine balance between mechanical strength and remodeling capabilities essential for cartilage regeneration
From the themed collection: Injectable Hydrogels
Paper

Biomechanical characterization of a fibrinogen–blood hydrogel for human dental pulp regeneration

Biomechanical characterization of a fibrinogen–blood hydrogel for human dental pulp regeneration.

Graphical abstract: Biomechanical characterization of a fibrinogen–blood hydrogel for human dental pulp regeneration
From the themed collection: Injectable Hydrogels
Paper

Prodrug-loaded semiconducting polymer hydrogels for deep-tissue sono-immunotherapy of orthotopic glioblastoma

A novel sono-activatable prodrug hydrogel was developed to achieve deep-tissue sono-immunotherapy of orthotopic glioblastoma.

Graphical abstract: Prodrug-loaded semiconducting polymer hydrogels for deep-tissue sono-immunotherapy of orthotopic glioblastoma
From the themed collection: Injectable Hydrogels
Paper

A biodegradable injectable fluorescent polyurethane-oxidized dextran hydrogel for non-invasive monitoring

An injectable fluorescent hydrogel was successfully prepared by fluorescent polyurethane emulsion cross-linked with oxidized dextran for non-invasive monitoring.

Graphical abstract: A biodegradable injectable fluorescent polyurethane-oxidized dextran hydrogel for non-invasive monitoring
From the themed collection: Injectable Hydrogels
Paper

3D printable, injectable amyloid-based composite hydrogel of bovine serum albumin and aloe vera for rapid diabetic wound healing

Protein-based biomaterials, particularly amyloids, have sparked considerable scientific interest in recent years due to their exceptional mechanical strength, excellent biocompatibility and bioactivity.

Graphical abstract: 3D printable, injectable amyloid-based composite hydrogel of bovine serum albumin and aloe vera for rapid diabetic wound healing
From the themed collection: Injectable Hydrogels
Paper

Injectable, antibacterial, and oxygen-releasing chitosan-based hydrogel for multimodal healing of bacteria-infected wounds

This study introduces a novel antibacterial multifunctional hydrogel with synergistic chemodynamic and photothermal features for wound healing applications.

Graphical abstract: Injectable, antibacterial, and oxygen-releasing chitosan-based hydrogel for multimodal healing of bacteria-infected wounds
From the themed collection: Injectable Hydrogels
Paper

Engineering a platelet-rich plasma-based multifunctional injectable hydrogel with photothermal, antibacterial, and antioxidant properties for skin regeneration

This study presents a novel photothermally active hydrogel that contains platelet-rich plasma for infected wound healing. The hydrogel showed antibacterial, antioxidant, and hemostatic properties, as well as sustained growth factor release.

Graphical abstract: Engineering a platelet-rich plasma-based multifunctional injectable hydrogel with photothermal, antibacterial, and antioxidant properties for skin regeneration
From the themed collection: Injectable Hydrogels
Paper

An injectable supramolecular hydrogel as a self-drug-delivery system for local chemoimmunotherapy against melanoma

A unique self-drug-delivery approach providing chemoimmunotherapy in combating deadly melanoma has been developed from a Zn(II)-coordination complex-based hydrogel; M1-macrophages for activating T cells triggering apoptosis was confirmed in in vivo.

Graphical abstract: An injectable supramolecular hydrogel as a self-drug-delivery system for local chemoimmunotherapy against melanoma
From the themed collection: Injectable Hydrogels
32 items

About this collection

Injectable hydrogels have emerged as intelligent and versatile materials that have been proven to possess huge potential for many biomedical applications including drug delivery, tissue engineering, and regenerative medicine. Hydrogels are a class of polymers with highly hydrated 3D networks that have microenvironmental properties such as oxygen/nutrient permeability that are similar to the native extracellular matrix. In addition to possessing the typical advantages of conventional hydrogels, injectable hydrogels offer an extra unique feature, which enables minimally invasive injectability and durability for irregularly shaped sites. As such, there has been a growing interest of using injectable hydrogels as scaffolds/carriers for therapeutic agents, including but not limited to drugs, cells, proteins, and bioactive molecules, targeted to treat chronic diseases including cancer, but also to facilitate the repair and regeneration of damaged organs/tissues.

This themed collection across Journal of Materials Chemistry B and Biomaterials Science, Guest Edited by Dr Khoon Lim (University of Sydney, Australia) and Dr Julieta Paez (University of Twente, The Netherlands), aims at providing a platform for recent developments in this rapidly evolving field of injectable hydrogels and aims to inspire future research in this area.


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