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Themed collection Chemical biology in OBC

493 items - Showing page 1 of 8
Perspective

From pirates and killers: does metabolite diversity drive bacterial competition?

This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.

Graphical abstract: From pirates and killers: does metabolite diversity drive bacterial competition?
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Review Article

The Curious Yellow Colouring Matter of the Iceland Poppy

From the themed collection: Chemical biology in OBC
Review Article

Chemical methods for modification of proteins

The field of protein bioconjugation draws attention from stakeholders in chemistry, biology, and medicine. This review provides an overview of the present status, challenges, and opportunities for organic chemists.

Graphical abstract: Chemical methods for modification of proteins
From the themed collection: Chemical biology in OBC
Review Article

TLR2 agonists and their structure–activity relationships

We review the structure–activity relationships and synthetic studies of TLR2 agonists – important chemical targets in immunotherapy.

Graphical abstract: TLR2 agonists and their structure–activity relationships
From the themed collection: Chemical biology in OBC
Review Article

Recent development in the synthesis of C-glycosides involving glycosyl radicals

C-Glycosylation involving glycosyl radical intermediates is a particularly effective approach to access C-glycosides, which are core units of a great number of natural products, bioactive compounds and marketed drugs.

Graphical abstract: Recent development in the synthesis of C-glycosides involving glycosyl radicals
From the themed collection: Chemical biology in OBC
Review Article

Enzymatic glycosylation involving fluorinated carbohydrates

This contribution reviews the enzymatic synthesis, including optimisation efforts, of fluorinated carbohydrates involving fluorinated donors and/or acceptors, as well as the enzymatic activation of the fluorinated donors.

Graphical abstract: Enzymatic glycosylation involving fluorinated carbohydrates
From the themed collection: Chemical biology in OBC
Review Article

Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms

Advances in the synthesis of multiphosphorylated peptides and peptide libraries: tools for studying the effects of phosphorylation patterns on protein function and regulation.

Graphical abstract: Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms
From the themed collection: Chemical biology in OBC
Review Article

Recent advances in β-L-rhamnosylation

This review describes various methodologies for the stereoselective 1,2-cis glycosylation of L-rhamnose leading to β-L-rhamnosides and their applications in oligosaccharide synthesis.

Graphical abstract: Recent advances in β-l-rhamnosylation
From the themed collection: Chemical biology in OBC
Review Article

Synthesis of trehalose glycolipids

Chemical synthesis of trehalose glycolipids such as DAT, TDM, SL-1, SL-3, and Ac2SGL from MTb, emmyguyacins from fungi, succinoyl trehalose from rhodococcus, and maradolipids from worms, as well as mycobacterial oligosaccharides is reviewed.

Graphical abstract: Synthesis of trehalose glycolipids
From the themed collection: Chemical biology in OBC
Review Article

Structure elucidation of bacterial nonribosomal lipopeptides

We provide a summary of the tools, which allow elucidate the structures of nonribosomal lipopetides.

Graphical abstract: Structure elucidation of bacterial nonribosomal lipopeptides
From the themed collection: Chemical biology in OBC
Review Article

Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme

The review examines functional knowledge gathered over two decades of research on the 8-17 DNAzyme, focusing on three aspects: the structural requirements for catalysis, the role of metal ions and the participation of general acid-base catalysis.

Graphical abstract: Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme
From the themed collection: Chemical biology in OBC
Review Article

Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective

This review surveys known structures of staphylococcal polysaccharides and summarizes all synthetic efforts to obtain these sequences.

Graphical abstract: Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective
Review Article

Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)

The nonulosonic acid sugar pseudaminic acid, Pse5Ac7Ac, is present on the surface of a number of human pathogens, herein we review the mechanistic and structural characterisation of the enzymes responsible for its biosynthesis in bacteria.

Graphical abstract: Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)
From the themed collection: Chemical biology in OBC
Review Article

G-quadruplexes as versatile scaffolds for catalysis

This review summarizes the beginning, progress, and prospects of non-canonical DNA-based hybrid catalysts focusing on G-quadruplexes as versatile scaffolds for catalysis.

Graphical abstract: G-quadruplexes as versatile scaffolds for catalysis
From the themed collection: Chemical biology in OBC
Review Article

Stabilization of the triple helix in collagen mimicking peptides

The review classifies existing chemical approaches towards stronger triple helical assemblies in peptides.

Graphical abstract: Stabilization of the triple helix in collagen mimicking peptides
From the themed collection: Chemical biology in OBC
Open Access Review Article

Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose

A review of recent advances towards synthetic ADP-ribosylated proteins and oligo-ADP-ribose chains.

Graphical abstract: Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose
From the themed collection: Chemical biology in OBC
Review Article

Synthetic strategies for fluorination of carbohydrates

Different synthetic strategies for accomplishing regio- and stereoselective fluorinations of carbohydrate scaffolds are discussed in light of the biological implications arising from such substitutions.

Graphical abstract: Synthetic strategies for fluorination of carbohydrates
From the themed collection: Chemical biology in OBC
Review Article

Synthesis of carbohydrate building blocks via regioselective uniform protection/deprotection strategies

Scope 1: sugar is uniformly protected leaving only one (or two) free hydroxyl group; scope 2: uniformly protected sugar is deprotected to liberate only one (or two) hydroxyl group.

Graphical abstract: Synthesis of carbohydrate building blocks via regioselective uniform protection/deprotection strategies
From the themed collection: Chemical biology in OBC
Review Article

Chemical composition of DNA-encoded libraries, past present and future

We discuss here the chemical composition of DNA-encoded libraries likely to be made in the near future.

Graphical abstract: Chemical composition of DNA-encoded libraries, past present and future
From the themed collection: Chemical biology in OBC
Review Article

Versatility of glycals in synthetic organic chemistry: coupling reactions, diversity oriented synthesis and natural product synthesis

Versatility of glycals in the stereoselective synthesis of natural products.

Graphical abstract: Versatility of glycals in synthetic organic chemistry: coupling reactions, diversity oriented synthesis and natural product synthesis
From the themed collection: Total synthesis in OBC
Review Article

Saturated bioisosteres of benzene: where to go next?

Saturated bioisosteres for ortho- and meta-substituted benzenes remain a current challenge for chemists.

Graphical abstract: Saturated bioisosteres of benzene: where to go next?
From the themed collection: Chemical biology in OBC
Review Article

The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

Tailoring enzymes decorate diketopiperazines to yield unique structures and biological functions.

Graphical abstract: The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases
From the themed collection: Chemical biology in OBC
Review Article

Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials

Peptide–oligonucleotide conjugates (POCs) are covalent constructs that link a molecule like DNA to a synthetic peptide sequences.

Graphical abstract: Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials
From the themed collection: Chemical biology in OBC
Review Article

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Rearranged ergostane-type natural products are structurally intriguing and exhibit biologically relevant properties.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
From the themed collection: Chemical biology in OBC
Review Article

One-pot multi-segment condensation strategies for chemical protein synthesis

This paper describes recent advances of one-pot multi-segment condensation strategies based on kinetically controlled strategies and/or protecting group-removal strategies in chemical protein synthesis.

Graphical abstract: One-pot multi-segment condensation strategies for chemical protein synthesis
From the themed collection: Chemical biology in OBC
Open Access Review Article

Fluorogenic probes for super-resolution microscopy

Fluorogenic probes efficiently reduce non-specific background signals, which often results in highly improved signal-to-noise ratios.

Graphical abstract: Fluorogenic probes for super-resolution microscopy
From the themed collection: Chemical biology in OBC
Review Article

Azobenzene-based small molecular photoswitches for protein modulation

This review highlights the design strategies of azobenzene photoswitches as well as their applications in the manipulation of biological systems.

Graphical abstract: Azobenzene-based small molecular photoswitches for protein modulation
From the themed collection: Chemical biology in OBC
Review Article

Lasso peptides: chemical approaches and structural elucidation

The diverse functionality and the extraordinary stability of lasso peptides make these molecules attractive scaffolds for drug discovery. The ability to generate lasso peptides chemically remains a challenging endeavor.

Graphical abstract: Lasso peptides: chemical approaches and structural elucidation
From the themed collection: Chemical biology in OBC
Review Article

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. In this review, we describe the isolation and biosynthetic studies of teleocidins.

Graphical abstract: Biosynthesis of the teleocidin-type terpenoid indole alkaloids
From the themed collection: Chemical biology in OBC
Review Article

The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions

Nucleic acids, phospholipids and other organic phosphates play central roles in biological pathways.

Graphical abstract: The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions
From the themed collection: Chemical biology in OBC
Review Article

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Participation of Z DNA in normal and disease related biological processes.

Graphical abstract: C8-Guanine modifications: effect on Z-DNA formation and its role in cancer
From the themed collection: Chemical biology in OBC
Review Article

Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals

C-Glycosylation has found widespread use in the synthesis of biomedically important natural products and pharmaceuticals.

Graphical abstract: Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals
From the themed collection: Chemical biology in OBC
Review Article

Target specificity of mammalian DNA methylation and demethylation machinery

We review here the molecular mechanisms employed by DNMTs and TET enzymes that are responsible for shaping the DNA methylation pattern of a mammalian cell.

Graphical abstract: Target specificity of mammalian DNA methylation and demethylation machinery
From the themed collection: Chemical biology in OBC
Review Article

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

Within a decade of Merrifield's seminal description of solid-phase peptide synthesis, the synergies between solid-phase approaches and flow synthesis were noted by a number of groups.

Graphical abstract: The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches
From the themed collection: Chemical biology in OBC
Open Access Review Article

Negishi cross-couplings in the synthesis of amino acids

The application of the Negishi cross-coupling reaction in the synthesis of amino acids is reviewed.

Graphical abstract: Negishi cross-couplings in the synthesis of amino acids
From the themed collection: Chemical biology in OBC
Review Article

25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science

This review highlights the synthesis, biophysical properties, and wide range of applications of oligonucleotides modified with 2′-O-(pyren-1-yl)methyl-RNA monomers reported over the past 25 years.

Graphical abstract: 25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science
From the themed collection: Chemical biology in OBC
Open Access Communication

Efficient and selective antibody modification with functionalised divinyltriazines

We have developed a highly efficient disulfide rebridging strategy for the modification of antibodies with substituted divinyltriazine linkers.

Graphical abstract: Efficient and selective antibody modification with functionalised divinyltriazines
From the themed collection: Chemical biology in OBC
Open Access Communication

A [Pd2L4]4+ cage complex for n-octyl-β-D-glycoside recognition

A Pd2L4 coordination cage with improved solubility properties was prepared and used to bind n-octyl glycosides, showing a preference for the all equatorial n-octyl glucoside.

Graphical abstract: A [Pd2L4]4+ cage complex for n-octyl-β-d-glycoside recognition
From the themed collection: Chemical biology in OBC
Communication

Comparison of disaccharide donors for heparan sulfate synthesis: uronic acids vs. their pyranose equivalents

Disaccharide glycosyl donors were synthesised and directly compared in glycosylations to assess their potential for heparan sulfate oligosaccharide synthesis.

Graphical abstract: Comparison of disaccharide donors for heparan sulfate synthesis: uronic acids vs. their pyranose equivalents
From the themed collection: Chemical biology in OBC
Communication

Disulphide-mediated site-directed modification of proteins

Site-directed addition of a single thiols handle to proteins by means of temporary disulphide rebridging of solvent exposed disulphides is obtained with a new labelling reagent.

Graphical abstract: Disulphide-mediated site-directed modification of proteins
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Communication

Genetic dereplication driven discovery of a tricinoloniol acid biosynthetic pathway in Trichoderma hypoxylon

From the themed collection: Chemical biology in OBC
Communication

Aldol sensor-inspired fluorescent probes for measuring protein citrullination

Inspired by aldol sensors, a novel series of fluorescent probes were developed for measuring and capturing protein citrullination.

Graphical abstract: Aldol sensor-inspired fluorescent probes for measuring protein citrullination
From the themed collection: Chemical biology in OBC
Communication

Isocoumarin formation by heterologous gene expression and modification by host enzymes

The polyketide synthase product was converted to its methylated and hydroxylated derivatives by host endogenous enzymes.

Graphical abstract: Isocoumarin formation by heterologous gene expression and modification by host enzymes
From the themed collection: Chemical biology in OBC
Communication

Sesquiterpene synthases for bungoene, pentalenene and epi-isozizaene from Streptomyces bungoensis

A sesquiterpene synthase from Streptomyces bungoensis was characterised and produces the new compound bungoene.

Graphical abstract: Sesquiterpene synthases for bungoene, pentalenene and epi-isozizaene from Streptomyces bungoensis
From the themed collection: Chemical biology in OBC
Communication

Synthesis of paenipeptin C′ analogues employing solution-phase CLipPA chemistry

Thiol–ene CLipPA reaction of a vinyl ester and thiolated peptide for generation of an S-lipidated paenipeptin C′ analogue with broad spectrum antibacterial activity.

Graphical abstract: Synthesis of paenipeptin C′ analogues employing solution-phase CLipPA chemistry
From the themed collection: Chemical biology in OBC
Communication

Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein–protein interactions

Homo-oligomers are difficult drug targets. Here, Differential Scanning Fluorimetry (DSF) is introduced as a method to identify inhibitors of these systems, by discriminating between oligomers and monomers based on their thermal stability.

Graphical abstract: Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein–protein interactions
From the themed collection: Chemical biology in OBC
Communication

Modular control of L-tryptophan isotopic substitution via an efficient biosynthetic cascade

Facile biocatalytic synthesis of isotopically substituted tryptophans.

Graphical abstract: Modular control of l-tryptophan isotopic substitution via an efficient biosynthetic cascade
From the themed collection: Chemical biology in OBC
Communication

Synthesis of aryl ethers of carbohydrates via reaction with arynes: selective O-arylation of trans-vicinal dihydroxyl groups in carbohydrates

A new method for the O-arylation of carbohydrates under transition metal-free conditions using arynes as an aryl source has been developed.

Graphical abstract: Synthesis of aryl ethers of carbohydrates via reaction with arynes: selective O-arylation of trans-vicinal dihydroxyl groups in carbohydrates
From the themed collection: Chemical biology in OBC
Open Access Communication

Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation

A genetically incorporated ThrK unnatural amino acid can undergo rapid periodate oxidation to reveal a reactive internal α-oxo aldehyde.

Graphical abstract: Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation
From the themed collection: Chemical biology in OBC
Communication

Conjugating pyrene onto PNA-based fluorescent probes for improved detection selectivity toward double-stranded siRNA

PNA-based fluorescent probes conjugated with the pyrene unit exhibited the improved detection selectivity for double-stranded siRNA.

Graphical abstract: Conjugating pyrene onto PNA-based fluorescent probes for improved detection selectivity toward double-stranded siRNA
From the themed collection: Chemical biology in OBC
Communication

NBD-based fluorescent probes for separate detection of cysteine and biothiols via different reactivities

A NBD-based fluorescent probe is developed to seperately detect Cys and all biothiols via different reactivity.

Graphical abstract: NBD-based fluorescent probes for separate detection of cysteine and biothiols via different reactivities
From the themed collection: Chemical biology in OBC
Communication

A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe

A carbapenem-based fluorogenic reagent has been developed to detect the activity of carbapenemases, exhibiting high specificity to all carbapenemases, including both metallo carbapenemases and serine carbapenemases, over other β-lactamases.

Graphical abstract: A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe
From the themed collection: Chemical biology in OBC
Communication

A laccase-catalysed tyrosine click reaction

The tyrosine click reaction of peptides/proteins with the tyrosine modification reagent, N-methyl luminol, was catalysed by a laccase in the presence of molecular oxygen (O2) at 37 °C.

Graphical abstract: A laccase-catalysed tyrosine click reaction
From the themed collection: Chemical biology in OBC
Communication

Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8

N-Methyltransferase TsnB8 was demonstrated to catalyze successive methyltransfer reactions in the biosynthesis of trichostatin.

Graphical abstract: Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8
From the themed collection: Chemical biology in OBC
Communication

The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function

We achieved the first synthesis of phosphatidylinositol mannoside Ac1PIM1, and a very potent agonist of an innate immune receptor DCAR is demonstrated.

Graphical abstract: The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function
From the themed collection: Chemical biology in OBC
Communication

Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides

A major current issue in medicinal chemistry is the design of small peptide analogues resistant to proteolysis and able to adopt preferential conformations, while preserving the selectivity and efficiency of natural peptides.

Graphical abstract: Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides
From the themed collection: Chemical biology in OBC
Communication

Direct recognition and sensitive detection of circular RNA with ligation-based PCR

A sensitive and specific method for circRNA detection is developed through the direct ligation of two ingeniously designed DNA probes.

Graphical abstract: Direct recognition and sensitive detection of circular RNA with ligation-based PCR
From the themed collection: Chemical biology in OBC
Communication

Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates

An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.

Graphical abstract: Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates
From the themed collection: Chemical biology in OBC
Communication

Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination

The practical synthesis of pseudo-enantiomeric carbohydrate-based NHC–Rh complexes bearing C1 or C3 sterically differentiated positions is reported. We show that steric bulk at either C1 or C3 leads to enantiotopic discrimination in the hydrosilylation of acetophenone.

Graphical abstract: Pseudo-enantiomeric carbohydrate-based N-heterocyclic carbenes as promising chiral ligands for enantiotopic discrimination
From the themed collection: Chemical biology in OBC
Communication

Peptide precursors that acquire denatured collagen-hybridizing ability by O-to-N acyl migration at physiological pH

Collagen-like peptides containing Gly-Ser O-acyl isopeptide units without self-assembling propensity serve as precursors for collagen-detecting agents.

Graphical abstract: Peptide precursors that acquire denatured collagen-hybridizing ability by O-to-N acyl migration at physiological pH
From the themed collection: Chemical biology in OBC
Communication

Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina

Genome mining and heterologous biosynthesis led to the discovery of a 12 membered macrolide from Macrophomina phaseolina.

Graphical abstract: Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina
From the themed collection: Chemical biology in OBC
Communication

Spontaneous oxidative cyclisations of 1,3-dihydroxy-4-dimethylallylnaphthalene to tricyclic derivatives

Radical-involved spontaneous oxidative cyclisations of 1,3-dihydroxy-4-dimethylallylnaphthalene are reported.

Graphical abstract: Spontaneous oxidative cyclisations of 1,3-dihydroxy-4-dimethylallylnaphthalene to tricyclic derivatives
From the themed collection: Chemical biology in OBC
Communication

Metal-free synthesis of imino-disaccharides and calix-iminosugars by photoinduced radical thiol–ene coupling (TEC)

Deprotected iminosugar alkenes were subjected to thiol–ene coupling with deprotected sugar thiols to afford new imino-disaccharides. Two thiol–ene couplings converted these alkenes into iminosugar thiols and then multivalent iminosugars.

Graphical abstract: Metal-free synthesis of imino-disaccharides and calix-iminosugars by photoinduced radical thiol–ene coupling (TEC)
From the themed collection: Chemical biology in OBC
Communication

18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain

Dihydromethidine (DHM) labeled with 18F at the para position of the benzene ring has been developed as a positron emission tomography (PET) radiotracer for non-invasive imaging of reactive oxygen species (ROS).

Graphical abstract: 18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain
From the themed collection: Chemical biology in OBC
Communication

Photosensitised biphotonic chemistry of pyrimidine derivatives

Biphotonic chemistry of pyrimidines is produced using a 355 nm laser and 2-methoxyacetophenone as photosensitiser.

Graphical abstract: Photosensitised biphotonic chemistry of pyrimidine derivatives
From the themed collection: Chemical biology in OBC
Communication

Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis

More than 500 siderophores are known to date, but only three were identified to be aryl-containing hydroxamate siderophores, legonoxamines A and B from Streptomyces sp. MA37, and aryl ferrioxamine 2 from Micrococcus luteus KLE1011.

Graphical abstract: Characterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis
From the themed collection: Chemical biology in OBC
Open Access Communication

Functionalised thermally induced phase separation (TIPS) microparticles enabled for “click” chemistry

In this study we describe a novel platform for generating functionalised TIPS microparticles for “click” conjugation to various active compounds.

Graphical abstract: Functionalised thermally induced phase separation (TIPS) microparticles enabled for “click” chemistry
From the themed collection: Chemical biology in OBC
Communication

Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

A sequential oxidative coupling and oxime or hydrazone ligation method allows construction of bifunctional N-terminal bioconjugates.

Graphical abstract: Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates
From the themed collection: Chemical biology in OBC
Open Access Communication

Automated access to well-defined ionic oligosaccharides

Automated Glycan Assembly grants access to ionic oligosaccharides for structural studies.

Graphical abstract: Automated access to well-defined ionic oligosaccharides
Communication

The effect of spermidine on guanine decomposition via photoinduced electron transfer in DNA

The addition of spermidine caused the attenuation of guanine decomposition via photoinduced electron transfer in pyrene-modified DNA, and higher added concentrations of spermidine resulted in the promotion of decomposition in condensed DNA.

Graphical abstract: The effect of spermidine on guanine decomposition via photoinduced electron transfer in DNA
From the themed collection: Chemical biology in OBC
493 items - Showing page 1 of 8

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