Themed collection Chemical Biology in OBC

724 items - Showing page 1 of 11
Perspective

From pirates and killers: does metabolite diversity drive bacterial competition?

This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.

Graphical abstract: From pirates and killers: does metabolite diversity drive bacterial competition?
From the themed collection: Chemical Biology in OBC
Review Article

Molecular platforms based on biocompatible photoreactions for photomodulation of biological targets

In this paper, we summarize molecular platforms based on ultraviolet (UV), visible (Vis) or near-infrared (NIR) photoreactions. Recent applications for spatiotemporal photomodulation of various biomolecules in living objects are also discussed.

Graphical abstract: Molecular platforms based on biocompatible photoreactions for photomodulation of biological targets
From the themed collection: Chemical Biology in OBC
Review Article

Photoaffinity labelling strategies for mapping the small molecule–protein interactome

We review the development of photoaffinity labeling (PAL) chemistries and the application of PAL to chemoproteomic target deconvolution for small molecules, lipids, and metabolites.

Graphical abstract: Photoaffinity labelling strategies for mapping the small molecule–protein interactome
From the themed collection: Chemical Biology in OBC
Review Article

Antitumor activity of tridentate pincer and related metal complexes

Pincer and related metal complexes containing tunable tridentate ligand frameworks display promising antitumor activity.

Graphical abstract: Antitumor activity of tridentate pincer and related metal complexes
From the themed collection: Synthetic methodology in OBC
Review Article

Optically superior fluorescent probes for selective imaging of cells, tumors, and reactive chemical species

Fluorescent probes with superior optical properties have been summarized along with the mechanisms used for their development and the challenges faced in their synthesis.

Graphical abstract: Optically superior fluorescent probes for selective imaging of cells, tumors, and reactive chemical species
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Asparaginyl endopeptidases: enzymology, applications and limitations

The potentials of using asparaginyl endopeptidases (AEP) as tools for polypeptide modifications have been discussed.

Graphical abstract: Asparaginyl endopeptidases: enzymology, applications and limitations
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Chemical probes targeting the kinase CK2: a journey outside the catalytic box

An up-to-date and comprehensive review on chemical probes targeting the important kinase CK2.

Graphical abstract: Chemical probes targeting the kinase CK2: a journey outside the catalytic box
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Approaches for peptide and protein cyclisation

Polypeptide cyclisation can enhance thermal stability, proteolytic resistance and membrane permeability. Cyclisation can be achieved by methods including chemical, enzyme and protein tag approaches. Each has strengths and limitations.

Graphical abstract: Approaches for peptide and protein cyclisation
From the themed collection: Chemical Biology in OBC
Review Article

Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions

This review summarizes the recent findings and developments in the emerging area of (chemo)-enzymatic cascades using MTases and AdoMet-generating enzymes.

Graphical abstract: Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Metabolic labeling probes for interrogation of the host–pathogen interaction

Metabolic labeling of intracellular pathogens can provide new methods of studying host pathogen interactions.

Graphical abstract: Metabolic labeling probes for interrogation of the host–pathogen interaction
From the themed collection: Chemical Biology in OBC
Review Article

Chemistry and biology of spiroacetals from myxobacteria

This review details the isolation, biosynthesis, biological activity and synthesis of spiroacetals from the myxobacterium Sorangium cellulosum.

Graphical abstract: Chemistry and biology of spiroacetals from myxobacteria
From the themed collection: Chemical Biology in OBC
Review Article

Artificial enzymes bringing together computational design and directed evolution

This manuscript reviews the combination of computational enzyme design and directed evolution and its advantages in the development of artificial enzymes.

Graphical abstract: Artificial enzymes bringing together computational design and directed evolution
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Silicon phthalocyanines: synthesis and resurgent applications

Their unique axial bonds and NIR optical properties have made silicon phthalocyanines (SiPcs) valuable compounds. Herein, we present key synthetic strategies and emerging applications of SiPcs over the past decade.

Graphical abstract: Silicon phthalocyanines: synthesis and resurgent applications
From the themed collection: Chemical Biology in OBC
Review Article

Recent advances in the direct O-arylation of carbohydrates

An emerging approach for the synthesis of O-aryl glycosides and carbohydrate-derived aryl ethers via C(sp2)–O bond formation is reviewed.

Graphical abstract: Recent advances in the direct O-arylation of carbohydrates
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Recent highlights of biosynthetic studies on marine natural products

Marine bacteria are excellent yet often underexplored sources of structurally unique bioactive natural products.

Graphical abstract: Recent highlights of biosynthetic studies on marine natural products
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Glycosyl disulfides: importance, synthesis and application to chemical and biological systems

This review explores methodologies for the preparation of glycosyl disulfides, their utility as intermediates in carbohydrate synthesis, and evaluates their biological impact in glycoscience and beyond.

Graphical abstract: Glycosyl disulfides: importance, synthesis and application to chemical and biological systems
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Tyrosine bioconjugation – an emergent alternative

A review of the heretofore less explored approach of tyrosine bioconjugation, which is rapidly becoming a constructive alternative/complement to the more well-established strategies, is provided.

Graphical abstract: Tyrosine bioconjugation – an emergent alternative
From the themed collection: Chemical Biology in OBC
Review Article

Recent advances in the synthesis of C-terminally modified peptides

A go-to compilation of recent strategies to access C-terminally modified peptides contextualized by a discussion of the major synthetic challenges that have historically hampered progress in this area.

Graphical abstract: Recent advances in the synthesis of C-terminally modified peptides
From the themed collection: Chemical Biology in OBC
Review Article

Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria

This review discusses the development of peptide-based quorum sensing modulators and their use as potential therapeutics.

Graphical abstract: Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria
From the themed collection: Chemical Biology in OBC
Review Article

Rational design of small molecule fluorescent probes for biological applications

Guidelines based on photophysical tuning, reactivity, isomerization, and energy transfer for rational design of synthetic fluorescent probes for biological systems.

Graphical abstract: Rational design of small molecule fluorescent probes for biological applications
From the themed collection: Chemical Biology in OBC
Review Article

Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation

This review summarizes the natural and synthetic glycan ligands of Siglecs and the growing body of knowledge for structural features governing sialic acid recognition.

Graphical abstract: Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation
From the themed collection: Chemical Biology in OBC
Review Article

The curious yellow colouring matter of the Iceland poppy

This account provides an chronological overview of the fascinating history of the pigment responsible for the yellow colour of the Iceland poppy (Papaver nudicaule).

Graphical abstract: The curious yellow colouring matter of the Iceland poppy
From the themed collection: Chemical Biology in OBC
Review Article

TLR2 agonists and their structure–activity relationships

We review the structure–activity relationships and synthetic studies of TLR2 agonists – important chemical targets in immunotherapy.

Graphical abstract: TLR2 agonists and their structure–activity relationships
From the themed collection: Chemical Biology in OBC
Review Article

Recent development in the synthesis of C-glycosides involving glycosyl radicals

C-Glycosylation involving glycosyl radical intermediates is a particularly effective approach to access C-glycosides, which are core units of a great number of natural products, bioactive compounds and marketed drugs.

Graphical abstract: Recent development in the synthesis of C-glycosides involving glycosyl radicals
From the themed collection: Chemical Biology in OBC
Review Article

Chemical methods for modification of proteins

The field of protein bioconjugation draws attention from stakeholders in chemistry, biology, and medicine. This review provides an overview of the present status, challenges, and opportunities for organic chemists.

Graphical abstract: Chemical methods for modification of proteins
From the themed collection: Chemical Biology in OBC
Review Article

Enzymatic glycosylation involving fluorinated carbohydrates

This contribution reviews the enzymatic synthesis, including optimisation efforts, of fluorinated carbohydrates involving fluorinated donors and/or acceptors, as well as the enzymatic activation of the fluorinated donors.

Graphical abstract: Enzymatic glycosylation involving fluorinated carbohydrates
From the themed collection: Chemical Biology in OBC
Review Article

Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms

Advances in the synthesis of multiphosphorylated peptides and peptide libraries: tools for studying the effects of phosphorylation patterns on protein function and regulation.

Graphical abstract: Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms
From the themed collection: Chemical Biology in OBC
Review Article

Recent advances in β-L-rhamnosylation

This review describes various methodologies for the stereoselective 1,2-cis glycosylation of L-rhamnose leading to β-L-rhamnosides and their applications in oligosaccharide synthesis.

Graphical abstract: Recent advances in β-l-rhamnosylation
From the themed collection: Chemical Biology in OBC
Review Article

Synthesis of trehalose glycolipids

Chemical synthesis of trehalose glycolipids such as DAT, TDM, SL-1, SL-3, and Ac2SGL from MTb, emmyguyacins from fungi, succinoyl trehalose from rhodococcus, and maradolipids from worms, as well as mycobacterial oligosaccharides is reviewed.

Graphical abstract: Synthesis of trehalose glycolipids
From the themed collection: Chemical Biology in OBC
Review Article

Structure elucidation of bacterial nonribosomal lipopeptides

We provide a summary of the tools, which allow elucidate the structures of nonribosomal lipopetides.

Graphical abstract: Structure elucidation of bacterial nonribosomal lipopeptides
From the themed collection: Chemical Biology in OBC
Review Article

Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme

The review examines functional knowledge gathered over two decades of research on the 8-17 DNAzyme, focusing on three aspects: the structural requirements for catalysis, the role of metal ions and the participation of general acid-base catalysis.

Graphical abstract: Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme
From the themed collection: Chemical Biology in OBC
Review Article

Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective

This review surveys known structures of staphylococcal polysaccharides and summarizes all synthetic efforts to obtain these sequences.

Graphical abstract: Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective
From the themed collection: Chemical Biology in OBC
Review Article

Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)

The nonulosonic acid sugar pseudaminic acid, Pse5Ac7Ac, is present on the surface of a number of human pathogens, herein we review the mechanistic and structural characterisation of the enzymes responsible for its biosynthesis in bacteria.

Graphical abstract: Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)
From the themed collection: Chemical Biology in OBC
Review Article

G-quadruplexes as versatile scaffolds for catalysis

This review summarizes the beginning, progress, and prospects of non-canonical DNA-based hybrid catalysts focusing on G-quadruplexes as versatile scaffolds for catalysis.

Graphical abstract: G-quadruplexes as versatile scaffolds for catalysis
From the themed collection: Chemical Biology in OBC
Review Article

Stabilization of the triple helix in collagen mimicking peptides

The review classifies existing chemical approaches towards stronger triple helical assemblies in peptides.

Graphical abstract: Stabilization of the triple helix in collagen mimicking peptides
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose

A review of recent advances towards synthetic ADP-ribosylated proteins and oligo-ADP-ribose chains.

Graphical abstract: Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose
From the themed collection: Chemical Biology in OBC
Review Article

Synthetic strategies for fluorination of carbohydrates

Different synthetic strategies for accomplishing regio- and stereoselective fluorinations of carbohydrate scaffolds are discussed in light of the biological implications arising from such substitutions.

Graphical abstract: Synthetic strategies for fluorination of carbohydrates
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis of carbohydrate building blocks via regioselective uniform protection/deprotection strategies

Scope 1: sugar is uniformly protected leaving only one (or two) free hydroxyl group; scope 2: uniformly protected sugar is deprotected to liberate only one (or two) hydroxyl group.

Graphical abstract: Synthesis of carbohydrate building blocks via regioselective uniform protection/deprotection strategies
From the themed collection: Chemical Biology in OBC
Review Article

Chemical composition of DNA-encoded libraries, past present and future

We discuss here the chemical composition of DNA-encoded libraries likely to be made in the near future.

Graphical abstract: Chemical composition of DNA-encoded libraries, past present and future
From the themed collection: Chemical Biology in OBC
Review Article

Versatility of glycals in synthetic organic chemistry: coupling reactions, diversity oriented synthesis and natural product synthesis

Versatility of glycals in the stereoselective synthesis of natural products.

Graphical abstract: Versatility of glycals in synthetic organic chemistry: coupling reactions, diversity oriented synthesis and natural product synthesis
From the themed collection: Chemical Biology in OBC
Review Article

Saturated bioisosteres of benzene: where to go next?

Saturated bioisosteres for ortho- and meta-substituted benzenes remain a current challenge for chemists.

Graphical abstract: Saturated bioisosteres of benzene: where to go next?
From the themed collection: Chemical Biology in OBC
Review Article

The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

Tailoring enzymes decorate diketopiperazines to yield unique structures and biological functions.

Graphical abstract: The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases
From the themed collection: Chemical Biology in OBC
Review Article

Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials

Peptide–oligonucleotide conjugates (POCs) are covalent constructs that link a molecule like DNA to a synthetic peptide sequences.

Graphical abstract: Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials
From the themed collection: Chemical Biology in OBC
Review Article

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Rearranged ergostane-type natural products are structurally intriguing and exhibit biologically relevant properties.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
From the themed collection: Chemical Biology in OBC
Review Article

One-pot multi-segment condensation strategies for chemical protein synthesis

This paper describes recent advances of one-pot multi-segment condensation strategies based on kinetically controlled strategies and/or protecting group-removal strategies in chemical protein synthesis.

Graphical abstract: One-pot multi-segment condensation strategies for chemical protein synthesis
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Fluorogenic probes for super-resolution microscopy

Fluorogenic probes efficiently reduce non-specific background signals, which often results in highly improved signal-to-noise ratios.

Graphical abstract: Fluorogenic probes for super-resolution microscopy
From the themed collection: Chemical Biology in OBC
Review Article

Azobenzene-based small molecular photoswitches for protein modulation

This review highlights the design strategies of azobenzene photoswitches as well as their applications in the manipulation of biological systems.

Graphical abstract: Azobenzene-based small molecular photoswitches for protein modulation
From the themed collection: Chemical Biology in OBC
Review Article

Lasso peptides: chemical approaches and structural elucidation

The diverse functionality and the extraordinary stability of lasso peptides make these molecules attractive scaffolds for drug discovery. The ability to generate lasso peptides chemically remains a challenging endeavor.

Graphical abstract: Lasso peptides: chemical approaches and structural elucidation
From the themed collection: Chemical Biology in OBC
Review Article

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. In this review, we describe the isolation and biosynthetic studies of teleocidins.

Graphical abstract: Biosynthesis of the teleocidin-type terpenoid indole alkaloids
From the themed collection: Chemical Biology in OBC
Review Article

The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions

Nucleic acids, phospholipids and other organic phosphates play central roles in biological pathways.

Graphical abstract: The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions
From the themed collection: Chemical Biology in OBC
Review Article

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Participation of Z DNA in normal and disease related biological processes.

Graphical abstract: C8-Guanine modifications: effect on Z-DNA formation and its role in cancer
From the themed collection: Chemical Biology in OBC
Review Article

Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals

C-Glycosylation has found widespread use in the synthesis of biomedically important natural products and pharmaceuticals.

Graphical abstract: Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals
From the themed collection: Chemical Biology in OBC
Communication

A comprehensive study on the effect of backbone stereochemistry of a cyclic hexapeptide on membrane permeability and microsomal stability

The effect of backbone stereochemistry of a cyclic hexapeptide on membrane permeability and metabolic stability was comprehensively evaluated. Besides, the effect of side chain structures on the pharmacokinetic properties was investigated.

Graphical abstract: A comprehensive study on the effect of backbone stereochemistry of a cyclic hexapeptide on membrane permeability and microsomal stability
From the themed collection: Chemical Biology in OBC
Communication

Synthesis, proteolytic stability, and in vitro evaluation of DOTA conjugated p160 peptide based radioconjugates: [177Lu]Lu–DOTA–p160

Synthesis, spectroscopic characterization, and in vitro biological evaluation of Lu-177 radiolabeled DOTA conjugated p160 peptide derivatives: potential candidates for breast tumor imaging and therapy.

Graphical abstract: Synthesis, proteolytic stability, and in vitro evaluation of DOTA conjugated p160 peptide based radioconjugates: [177Lu]Lu–DOTA–p160
From the themed collection: Chemical Biology in OBC
Communication

Pentacyclic spermidine alkaloids with radioprotective and anti-inflammatory activities from Orychophragmus violaceus

Two pairs of novel pentacyclic spermidine alkaloid enantiomers, (±)-orychoviolines A and B, were isolated from the seeds of Orychophragmus violaceus and represented the first example of a 2-piperidinone-fused hydrodibenzofuran skeleton.

Graphical abstract: Pentacyclic spermidine alkaloids with radioprotective and anti-inflammatory activities from Orychophragmus violaceus
From the themed collection: Chemical Biology in OBC
Open Access Communication

Automated glycan assembly of peptidoglycan backbone fragments

The automated glycan assembly of different oligosaccharide fragments of the bacterial peptidoglycan backbone is reported.

Graphical abstract: Automated glycan assembly of peptidoglycan backbone fragments
From the themed collection: Chemical Biology in OBC
Communication

Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.

Two new quassinoids, perforalactones D and E, from Harrisonia perforata, could promote the expression of lysosomal genes and induce lysosomal biogenesis.

Graphical abstract: Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.
From the themed collection: Chemical Biology in OBC
Communication

Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 are producers of the antibiotic nucleocidin and 4′-fluoroadenosine is identified as a co-product

Genome homologies led to the identification of Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 as producers of the antibiotic nucleocidin, and also 4’-fluoroadenosine.

Graphical abstract: Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 are producers of the antibiotic nucleocidin and 4′-fluoroadenosine is identified as a co-product
From the themed collection: Chemical Biology in OBC
Communication

Methyl to trifluoromethyl substitution as a strategy to increase the membrane permeability of short peptides

CH3 to CF3 substitution on a side chain of proteiogenic amino acids increases the membrane permeability of peptides.

Graphical abstract: Methyl to trifluoromethyl substitution as a strategy to increase the membrane permeability of short peptides
From the themed collection: Chemical Biology in OBC
Communication

Solitumergosterol A, a unique 6/6/6/6/5 steroid from the deep-sea-derived Penicillium solitum MCCC 3A00215

An unprecedented C30 steroid, solitumergosterol A (1), from the deep-sea-derived Penicillium solitum inhibited the proliferation of MB231 tumor cells by a RXRα-dependent mechanism.

Graphical abstract: Solitumergosterol A, a unique 6/6/6/6/5 steroid from the deep-sea-derived Penicillium solitum MCCC 3A00215
From the themed collection: Chemical Biology in OBC
Communication

Inhibition of efflux pumps aids small-molecule probe-based fluorescence labeling and imaging in the Gram-negative bacterium Escherichia coli

We describe a novel strategy for small-molecule probe-based fluorescence protein labeling and imaging in the Gram-negative bacterium Escherichia coli, which involves inhibition of efflux pumps.

Graphical abstract: Inhibition of efflux pumps aids small-molecule probe-based fluorescence labeling and imaging in the Gram-negative bacterium Escherichia coli
From the themed collection: Chemical Biology in OBC
Communication

Tightly linked morpholino-nucleoside chimeras: new, compact cationic oligonucleotide analogues

The synthesis of oligonucleotide analogues consisting of morpholino and a ribo- or deoxyribonucleoside in which the 5'-amino group of the nucleoside unit provides the nitrogen to the morpholine ring is described.

Graphical abstract: Tightly linked morpholino-nucleoside chimeras: new, compact cationic oligonucleotide analogues
From the themed collection: Chemical Biology in OBC
Communication

Stereochemical characterisation of the non-canonical α-humulene synthase from Acremonium strictum

The stereochemical course of the non-canonical α-humulene synthase from Acremonium strictum was investigated in isotopic labelling experiments.

Graphical abstract: Stereochemical characterisation of the non-canonical α-humulene synthase from Acremonium strictum
From the themed collection: Chemical Biology in OBC
Communication

Pyrrovobasine, hybrid alkylated pyrraline monoterpene indole alkaloid pseudodimer discovered using a combination of mass spectral and NMR-based machine learning annotations

The MS2-guided phytochemical investigation of Voacanga africana stem bark resulted in the isolation of pyrrovobasine, the first pyrraline-containing MIA.

Graphical abstract: Pyrrovobasine, hybrid alkylated pyrraline monoterpene indole alkaloid pseudodimer discovered using a combination of mass spectral and NMR-based machine learning annotations
From the themed collection: Chemical Biology in OBC
Communication

A silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection

In this report, we introduce a novel building block for Fmoc/tBu solid phase peptide synthesis (SPPS) of β-linked O-GlcNAcylated peptides.

Graphical abstract: A silyl ether-protected building block for O-GlcNAcylated peptide synthesis to enable one-pot acidic deprotection
From the themed collection: Chemical Biology in OBC
Communication

A triple-targeting delivery system carrying two anticancer agents

To improve tumor selectivity, we prepared a new triple-targeting delivery system bearing two anticancer agents. Both anticancer agents in this system are released in the presence of both H2O2 and cathepsin B which are highly produced in cancer cells.

Graphical abstract: A triple-targeting delivery system carrying two anticancer agents
From the themed collection: Chemical Biology in OBC
Communication

Protecting carbohydrates with ethers, acetals and orthoesters under basic conditions

Chlorinated ethyl and vinyl ethers are introduced at various positions of carbohydrates and gives access to acetals and ortho-esters under basic conditions.

Graphical abstract: Protecting carbohydrates with ethers, acetals and orthoesters under basic conditions
From the themed collection: Chemical Biology in OBC
Open Access Communication

Controlled density glycodendron microarrays for studying carbohydrate–lectin interactions

Density depended binding and selectivity is studied on glycodendron microarray with defined valency, which were prepared by on-chip synthesis and analysed by in situ MALDI-TOF MS.

Graphical abstract: Controlled density glycodendron microarrays for studying carbohydrate–lectin interactions
From the themed collection: Chemical Biology in OBC
Communication

Rational design and development of a lit-active photoswitchable inhibitor targeting CENP-E

Lit-active (cis-active) photoswitchable inhibitor targeting centromere-associated protein E (CENP-E) was developed through the rational design.

Graphical abstract: Rational design and development of a lit-active photoswitchable inhibitor targeting CENP-E
From the themed collection: Chemical Biology in OBC
Communication

Synthesis of enantiopure α-Tfm-proline and α-Tfm-pipecolic acid from oxazolo-pyrrolidines and -piperidines

Scalable synthesis of enantiopure (R) and (S)-α-Tfm-proline and α-Tfm-pipecolic acid.

Graphical abstract: Synthesis of enantiopure α-Tfm-proline and α-Tfm-pipecolic acid from oxazolo-pyrrolidines and -piperidines
From the themed collection: Chemical Biology in OBC
724 items - Showing page 1 of 11

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The latest articles published in Organic and Biomolecular Chemistry related to chemical biology research.

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