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Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose

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Abstract

ADP-ribosylation is an important post-translational modification that plays a pivotal role in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. Although chemical synthesis of mono- or poly-ADP-ribosylated biomolecules is extremely difficult due to the challenges in regio- and stereoselective glycosylation, suitable protective group manipulations and pyrophosphate construction, synthetic procedures towards these bio-related targets have been reported in recent years. Chemically synthesized well-defined ADP-ribose derivatives serve as useful tools in biological experiments aimed to further elucidate native ADP-ribosylation. In this review, we will discuss the synthetic studies on mono-ADP-ribosylated proteins and oligo-ADP-ribose chains. Future possible synthetic targets and upcoming new methods for the synthesis of these molecules are also included.

Graphical abstract: Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose

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Publication details

The article was received on 28 Feb 2019, accepted on 11 May 2019 and first published on 13 May 2019


Article type: Review Article
DOI: 10.1039/C9OB00501C
Org. Biomol. Chem., 2019, Advance Article

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    Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose

    Q. Liu, G. A. van der Marel and D. V. Filippov, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00501C

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