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Issue 7, 2019
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Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

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Abstract

Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well as biologically relevant. This review will highlight those natural products, and focus on ergostane-derived seco- and abeo-steroids. Their isolation, structure elucidation, and biological properties are reported. A special emphasis of this review lies in their respective (and typically proposed) biosyntheses, to help guide future bio-inspired synthetic attempts.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

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Article information


Submitted
19 Sep 2018
Accepted
18 Oct 2018
First published
24 Oct 2018

Org. Biomol. Chem., 2019,17, 1624-1633
Article type
Review Article

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

F. L. Duecker, F. Reuß and P. Heretsch, Org. Biomol. Chem., 2019, 17, 1624
DOI: 10.1039/C8OB02325E

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