Themed collection Journal of Materials Chemistry B HOT Papers
Understanding the fate of DNA nanostructures inside the cell
DNA nanostructures are highly tunable and responsive materials for diagnostic and healthcare-related applications, but their intracellular fate remains largely unknown.
Cleaving DNA by nanozymes
Various nanomaterials can mimic the activities of nucleases for hydrolytic and oxidative DNA cleavage on different sites allowing interesting biomedical and bioanalytical applications.
Triggering specific chemical reactions in the disease microenvironment can produce species for disease treatment that have high theranostic performance and low side effects on healthy cells/tissues.
Supramolecular ensembles modified by near-infrared dyes and their biological applications
This review presents recently developed supramolecular ensembles modified by near-infrared dyes. We discussed the construction of these near-infrared dyes-based ensembles and their biological application.
Mimicking the electrophysiological microenvironment of bone tissue using electroactive materials to promote its regeneration
A timely and comprehensive account of electroactive biomaterials promoting bone regeneration is provided by reviewing their physicochemical and biological properties.
Bioreactivity of decellularized animal, plant, and fungal scaffolds: perspectives for medical applications
With the integrated evaluation of the scaffold profile in the living systems, the decellularized animal, plant, and fungal scaffolds will become essential instruments for safe and controllable biomedical applications.
Cationic dynamic covalent polymers for gene transfection
Dynamic covalent polymers have revealed strong potential in gene delivery, thanks to their versatile self-assembly, adaptive and responsive behaviors.
Inflammation and biomaterials: role of the immune response in bone regeneration by inorganic scaffolds
The design of inorganic scaffolds able to instruct the immune system, eliciting adequate feedback by tuning specific material properties, has become an emerging field of research.
Structural design and antimicrobial properties of polypeptides and saccharide–polypeptide conjugates
The development and progress of antimicrobial polypeptides and saccharide–polypeptide conjugates in regards to their structural design, biological functions and antimicrobial mechanism.
Harnessing biomolecules for bioinspired dental biomaterials
We review the range of biomolecules used across dental biomaterials to spur the design and implementation of bioinspired multifunctional materials.
Recent advances of near infrared inorganic fluorescent probes for biomedical applications
Near infrared (NIR)-excitable and NIR-emitting probes have fuelled advances in biomedical applications owing to their power in enabling deep tissue imaging, offering high image contrast and reducing phototoxicity.
Recent advances in bio-orthogonal and dynamic crosslinking of biomimetic hydrogels
This review highlights recent advances in bio-orthogonal and dynamic hydrogels crosslinked by irreversible click chemistry, enzymatic reactions, and covalent-adaptable network.
Three-dimensional scaffold-free microtissues engineered for cardiac repair
In this review article, we present the state-of-the-art approaches and recent advancements in the engineering of scaffold-free cardiac microtissues for myocardial repair.
Flexible electrochemical biosensors for healthcare monitoring
Flexible electrochemical biosensors are studied hugely because of tremendous advantages including the fast response, high sensitivity, inherent miniaturization, convenient operation, and portability which are suitable for wearable biosensors.
Biological applications of water-soluble polypeptides with ordered secondary structures
Herein, recent advances in the synthesis of the water-soluble polypeptides with ordered secondary structures via ring-opening polymerization of NCA/NTA and their biological applications are described.
Single plasmonic nanostructures for biomedical diagnosis
This work discusses prominent advantages and advances in single-nanoparticle characterization and synthesis, and gives an outlook on particle-based biomedical diagnosis.
Nanomaterial-based gas sensors used for breath diagnosis
Gas-sensing applications commonly use nanomaterials (NMs) because of their unique physicochemical properties, including a high surface-to-volume ratio, enormous number of active sites, controllable morphology, and potential for miniaturisation.
Advances in functional nucleic acid based paper sensors
This article provides an extensive review of paper-based sensors that utilize functional nucleic acids, particularly DNA aptamers and DNAzymes, as recognition elements.
Effect of elasticity on the phagocytosis of micro/nanoparticles
A broad range of investigation methods and frameworks are used to better study the elasticity of various micro/nanoparticles (MNPs) with different properties and to explore the effect of such properties on their interactions with biological species.
Substituted hydroxyapatite coatings of bone implants
This review is a comprehensive overview and analysis of the most important advances in the field of substituted hydroxyapatite coatings.
Biodegradable and bioabsorbable sensors based on two-dimensional materials
This review presents a broad overview of recent reports on the biocompatibility and biodegradability of two-dimensional materials and highlights recent progress in their biodegradable and bioabsorbable sensors for diagnostic and therapeutic applications.
Conjugated polymers as nanoparticle probes for fluorescence and photoacoustic imaging
In this review, the role of conjugated polymer nanoparticles (CPNs) in emerging bioimaging techniques is described.
Controlling the properties and self-assembly of helical nanofibrils by engineering zinc-binding β-hairpin peptides
The type and location of residues in the designed novel peptides that bind Zn2+ ions determine the properties of the fibrils.
Single-molecule DNA origami aptasensors for real-time biomarker detection
DNA nanostructures as platforms to monitor the inherent conformational changes of aptamers upon analyte binding, with single-molecule resolution and real-time capability.
High-performance non-enzymatic glucose detection: using a conductive Ni-MOF as an electrocatalyst
A glucose sensor based on a conductive Ni-MOF as an electrocatalyst exhibits a fast response time, low detection limit, and high sensitivity, and it can also be applied for the detection of glucose in blood serum samples.
Hydrogels toughened by biominerals providing energy-dissipative sacrificial bonds
Inspired from toughening mechanism of bone tissues, hydrogels, toughened by low crsytalline hydroxyapatite as sacrificial bonds, were created.
Silica nanoparticle coated perfluorooctyl bromide for ultrasensitive MRI
MRI with hyperpolarized 129Xe can achieve low-concentration detection.
Target-directed enzyme-free dual-amplification DNA circuit for rapid signal amplification
An enzyme-free, single-step and rapid signal amplification DNA circuit was developed by integrating target-directed entropy-driven catalysis and hybridization chain reaction for fluorescence analysis of nucleic acids and small molecules.
A carbazole functionalized semiconducting compound as a heavy atom free photosensitizer for phototherapy against lung cancer
Semiconducting compounds with high photostability and excellent photothermal ability are potential candidates for phototheranostics.
White light-triggered zwitterionic polymer nanoparticles based on an AIE-active photosensitizer for photodynamic antimicrobial therapy
Photodynamic antimicrobial therapy (PDAT) has received enormous attention due to its excellent spatiotemporal accuracy, non-invasiveness, and anti-multidrug resistance properties compared with chemotherapy.
Biomimetic epidermal sensors assembled from polydopamine-modified reduced graphene oxide/polyvinyl alcohol hydrogels for the real-time monitoring of human motions
A skin-matched soft strain/pressure sensor fabricated by fully physically crosslinked conductive PDA–rGO/PVA hydrogel is reported for sensitive healthcare monitoring and human-machine interaction.
Highly luminescent biocompatible CsPbBr3@SiO2 core–shell nanoprobes for bioimaging and drug delivery
A facile approach for the highly luminescent and biocompatible CsPbBr3@SiO2 core–shell PNCs was developed. The dual biological roles of these PNCs are demonstrated, offering new directions to the stable PNCs for a variety of biomedical applications.
Bioinspired tissue-compliant hydrogels with multifunctions for synergistic surgery–photothermal therapy
A multifunction hydrogel system was designed to ablate residual tumors in 4T1 tumor-bearing mice models after surgery via photothermal therapy.
Construction and bioimaging application of novel indole heptamethine cyanines containing functionalized tetrahydropyridine rings
IR780 as a commercially available dye with near-infrared emission has been extensively applied in fluorescent probes and bioimaging.
Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models
The selective fluorescent probe BCy-HOCl monitoring the HOCl in acute lung injury cell and mouse models.
Matrix metalloproteinase-initiated aggregation of melanin nanoparticles as highly efficient contrast agent for enhanced tumor accumulation and dual-modal imaging
MMP2-initiated size-changeable melanin nanoparticles significantly increase the T1-weighted MRI and PA signals in vivo due to enhanced tumor accumulations.
A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy
A biocompatible nanocomposite of mesoporous silica-coated gold nanorods is fabricated for synergistic tumor therapy.
A tumor-targeted theranostic nanomedicine with strong absorption in the NIR-II biowindow for image-guided multi-gradient therapy
Developing new strategies to enhance drug accumulation in the tumor and therapeutic efficacy is of great importance in the field of tumor therapy.
Block copolymer [(L-GluA-5-BE)-b-(L-AspA-4-BE)]-based nanoflower capsules with thermosensitive morphology and pH-responsive drug release for cancer therapy
Herein, the synthesis of an amino-acid-based di-block copolymer (di-BCP) in-between an L-glutamic acid-5-benzyl ester and L-aspartic acid-4-benzyl ester [(L-GluA-5-BE)-b-(L-AspA-4-BE)] has been reported.
Carbon nanodot decorated acellular dermal matrix hydrogel augments chronic wound closure
Impaired skin regeneration in chronic wounds like in diabetes corresponds to high oxidative stress, poor angiogenesis and insufficient collagen hyperplasia.
Particle-attachment crystallization facilitates the occlusion of micrometer-sized Escherichia coli in calcium carbonate crystals with stable fluorescence
Taking advantages of the crystallization by attachment of amorphous calcium carbonate nanoparticles, micrometer-sized GFP-E. coli can be efficiently incorporated into vaterite crystals, the artificial composites exhibit stable fluorescence more than six months.
Consecutive dephosphorylation by alkaline phosphatase-directed in situ formation of porous hydrogels of SF with nanocrystalline calcium phosphate ceramics for bone regeneration
A porous hydrogel of SF with nanocrystalline calcium phosphate ceramics for bone regeneration was prepared through consecutive dephosphorylation actions.
Application of graphene nanowalls in an intraocular pressure sensor
Combining crack mechanism in GNWs with the stretchability of PDMS, a contact lens sensor exhibits excellent sensitivity to intraocular pressure.
Effects of nanopores on the mechanical strength, osteoclastogenesis, and osteogenesis in honeycomb scaffolds
The nanopoers of honeycomb scaffolds affect mechanical strength, osteoclastogenesis, and osteogenesis. When the nanopore volume was 0.15 cm3 g−1, steady replacement of honeycomb scaffolds with new bone was achieved.
Delivery of amino acid oxidase via catalytic nanocapsules to enable effective tumor inhibition
Amino acid oxidase, the fundamental building blocks of proteins, is delivered via catalytic nanocapsules and combined with chemodynamic therapy for tumor treatment.
A cation exchange strategy to construct a targeting nanoprobe for enhanced T1-weighted MR imaging of tumors
Excellent imaging performance and good biocompatibility of contrast agents are considered as prerequisites for accurate tumor diagnosis.
Biodegradable pH-responsive amorphous calcium carbonate nanoparticles as immunoadjuvants for multimodal imaging and enhanced photoimmunotherapy
Development of bioresponsive theranostic nanoparticles to enhance cancer diagnostics and control cancer metastasis.
FeMn layered double hydroxides: an efficient bifunctional electrocatalyst for real-time tracking of cysteine in whole blood and dopamine in biological samples
A peculiar clock-regulated design of FeMn-LDHs (FMH) with specific physiochemical attributes has been developed and used for highly sensitive detection of cysteine (CySH) and dopamine (DA).
Photo-induced specific intracellular release EGFR inhibitor from enzyme/ROS-dual sensitive nano-platforms for molecular targeted-photodynamic combinational therapy of non-small cell lung cancer
Nanoparticles with active-targeting, enzyme and ROS sensitive features were fabricated to load AFT for molecular targeted- and photodynamic combinational therapy.
Near-infrared optically active Cu2−xS nanocrystals: sacrificial template-ligand exchange integration fabrication and chirality dependent autophagy effects
The sacrificial template-ligand exchange integration fabrication and chirality dependent autophagy effects of the near-infrared optically active Cu2−xS nanocrystals.
Evaluating platelet activation related to the degradation products of biomaterials using molecular markers
The spectra of platelet activation molecular markers were used to study the changes of platelet activation by degradation products.
Visualizing mitochondria and mouse intestine with a fluorescent complex of a naphthalene-based dipolar dye and serum albumin
A fluorophore–protein complex for the visualization of mitochondria and the mouse intestine was developed. The complex formation of a naphthalene-based dipolar dye and serum albumin was identified and its imaging applications were investigated.
Rational design of near-infrared platinum(II)-acetylide conjugated polymers for photoacoustic imaging-guided synergistic phototherapy under 808 nm irradiation
We have developed a novel near-infrared Pt-acetylide conjugated polymer CP3 with highly efficient photoconversion behaviors for synergistic cancer phototherapy.
Near-infrared photothermal liposomal nanoantagonists for amplified cancer photodynamic therapy
Near-infrared photothermal liposomal nanoantagonists with photo-controlled cargo release were developed for amplified cancer photodynamic therapy through inhibiting intracellular glutathione biosynthesis.
In vivo immunological response of exposure to PEGylated graphene oxide via intraperitoneal injection
2D PEGylated graphene oxide showed stealth-but-immune-activating capacity on macrophages, along with specific intraperitoneal immunological response in vivo.
A physiologically active interpenetrating collagen network that supports growth and migration of epidermal keratinocytes: zinc-polyP nanoparticles integrated into compressed collagen
It is demonstrated that polyphosphate, as a component in wound healing mats together with Zn2+, is essential for growth and migration of skin keratinocytes.
3D printing of cell-laden electroconductive bioinks for tissue engineering applications
Bioprinting is an emerging powerful fabrication method, which enables the rapid assembly of 3D bioconstructs with dispensing cell-laden bioinks in pre-designed locations.
Photoactivated polyprodrug nanoparticles for effective light-controlled Pt(IV) and siRNA codelivery to achieve synergistic cancer therapy
A photoactivatable polyprodrug nanoparticle system (PPNPsiRNA) was developed for efficient light-controlled codelivery of Pt(IV) and siRNA for synergistic cancer therapy.
Nanostructures based on vanadium disulfide growing on UCNPs: simple synthesis, dual-mode imaging, and photothermal therapy
A simple method was developed by using core–shell UCNPs as seeds and heterogeneously growing VS2 nanoshell directly on the surface. The final nanostructures with uniform and small sizes afford dual-mode imaging and photothermal therapy in vitro.
pH and singlet oxygen dual-responsive GEM prodrug micelles for efficient combination therapy of chemotherapy and photodynamic therapy
Nanocarriers have been an important strategy for enhancing the combination therapy of chemotherapy and photodynamic therapy (PDT) (Chem-PDT).
A circulating tumor cell-based digital assay for the detection of EGFR T790M mutation in advanced non-small cell lung cancer
A CTC-based digital assay to detect T790M mutation non-invasively, indicating peripheral arterial blood to be a more abundant CTC source.
Hexametaphosphate as a potential therapy for the dissolution and prevention of kidney stones
Hexametaphosphate prevents aggregation and dissolves kidney stones an order of magnitude more effectively than the current therapy, citrate.
Nanoengineering multifunctional hybrid interfaces using adhesive glycogen nanoparticles
Amphiphilic phytoglycogen nanoparticles are used as building blocks for engineering multifunctional hybrid films with catalytic and sensing properties.
Zwitterionic small molecule based fluorophores for efficient and selective imaging of bacterial endospores
Zwitterionic small molecule based fluorophores for efficient and selective imaging of bacterial endospores.
Lyophilization enabled disentanglement of polyethylenimine on rambutan-like silica nanoparticles for enhanced plasmid DNA delivery
Lyophilization affects the conformation of PEI chains modified on the surface of silica nanoparticles and enhances the plasmid DNA transfection performance.
Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling
Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling.
A waterborne polyurethane 3D scaffold containing PLGA with a controllable degradation rate and an anti-inflammatory effect for potential applications in neural tissue repair
3D connected porous LGPU scaffolds with adjustable degradation and a strong anti-inflammatory effect were prepared for neural tissue repair.
The phosphatase-like activity of zirconium oxide nanoparticles and their application in near-infrared intracellular imaging
The phosphatase-like activity of ZrO2 nanoparticles is reported, which has found applications in intracellular imaging.
A photoluminescence biosensor for the detection of N-acyl homoserine lactone using cysteamine functionalized ZnO nanoparticles for the early diagnosis of urinary tract infections
We report a PL biosensor using cysteamine functionalized ZnO nanoparticles for the detection of quorum sensing signals (N-acyl homoserine lactones).
Tumor microenvironment-responsive polydopamine-based core/shell nanoplatform for synergetic theranostics
A tannic acid–Fe3+ networks-functionalized polydopamine-based composite nanoparticle was constructed and demonstrated the promising application for T1/T2-weighted MR imaging-guided synergistic treatment of PTT and reductant/photothermal-enhanced CDT.
About this collection
This on-going web collection features all the articles published in Journal of Materials Chemistry B in 2020 marked as HOT, as recommended by referees. Congratulations to all the authors whose articles are featured!