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Biological applications of water-soluble polypeptides with ordered secondary structures

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Abstract

Water-soluble polypeptides are a class of synthetic polymers with peptide bond frameworks imitating natural proteins and have broad prospects in biological applications. The regulation and dynamic transition of the secondary structures of water-soluble polypeptides have a great impact on their physio-chemical properties and biological functions. In this review article, we briefly introduce the current strategies to synthesize polypeptides and modulate their secondary structures. We then discuss the factors affecting the conformational stability/transition of polypeptides and the potential impact of side-chain functionalization on the ordered secondary structures, such as α-helix and β-sheet. We then summarize the biological applications of water-soluble polypeptides such as cell penetration, gene delivery, and antimicrobial treatment, highlighting the important roles of ordered secondary structures therein.

Graphical abstract: Biological applications of water-soluble polypeptides with ordered secondary structures

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Article information


Submitted
05 Apr 2020
Accepted
21 May 2020
First published
27 May 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Review Article

Biological applications of water-soluble polypeptides with ordered secondary structures

C. Ge, H. Ye, F. Wu, J. Zhu, Z. Song, Y. Liu and L. Yin, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00902D

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