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The effect of elasticity on the phagocytosis of micro/nanoparticles

Abstract

A broad range of investigation methods and frameworks aims at better studying the elasticity of various micro/nanoparticles (MNPs) with different properties and exploring the effect of such properties on their interactions with biological species. Specifically, the elasticity of MNPs serves as a key influencing factor with respect to important aspects of phagocytosis, such as the clathrin-mediated phagocytosis, caveolae-mediated phagocytosis, macrocytosis, and cell membrane fusion. Achieving a clear understanding of the relationships that exist between the elasticity of MNPs and their phagocytic processes is essential to improve their performance in drug delivery, which is related to aspects, such as circulation lifetime in blood, accumulation time in tissues, and resistance to metabolism, but at the same time very challenging. Resolving such aspects is very challenging, and requires using the right tools/methods, which are not always very easy to identify. This review facilitates this, by summarizing and comparing different cells phagocytosis pathways, while considering various MNPs with different shapes, elastic properties, and their effect on phagocytosis. We conducted an overview of the advantages exhibited by different MNPs with respect to both in vitro and in vivo, taking computer simulation and experimental results into account. This study will provide a guide on how to investigate the specific MNPs with elasticity properties and their biomedical effects that rely on phagocytosis.

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Article information


Submitted
21 Dec 2019
Accepted
03 Feb 2020
First published
03 Feb 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Review Article

The effect of elasticity on the phagocytosis of micro/nanoparticles

A. Wu, C. Yao, O. Akakuru, S. Stanciu, N. Hampp, Y. Jin, J. Zheng, G. Chen and F. Yang, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/C9TB02902H

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