Themed collection 2021 Organic Chemistry Frontiers Review-type Articles

82 items - Showing page 1 of 2
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Macrocyclic and acyclic supramolecular elements for co-precipitation of square-planar gold(III) tetrahalide complexes

Non-covalent interactions control the solid-state packing of AuX4 anions (yellow circles) co-precipitated with different supramolecular elements.

Graphical abstract: Macrocyclic and acyclic supramolecular elements for co-precipitation of square-planar gold(iii) tetrahalide complexes
Review Article

Three decades of unveiling the complex chemistry of C-nitroso species with computational chemistry

This review revisits the complex reactivity of C-nitroso derivatives through the synergistic combination of computational and synthetic organic chemistry, with an emphasis on the rationalization of mechanisms and selectivities.

Graphical abstract: Three decades of unveiling the complex chemistry of C-nitroso species with computational chemistry
Review Article

Recent advances in catalytic enantioselective direct C–H bond functionalization of electron-deficient N-containing heteroarenes

Catalytic enantioselective direct C–H bond functionalization of electron-deficient N-containing heteroarenes represents one of the most straightforward and powerful protocols to construct diverse enantioenriched highly functionalized N-heteroarenes.

Graphical abstract: Recent advances in catalytic enantioselective direct C–H bond functionalization of electron-deficient N-containing heteroarenes
Review Article

Recent advances in sustainable organic transformations using methanol: expanding the scope of hydrogen-borrowing catalysis

Recent progress relating to sustainable approaches using methanol as a C1-alkylating agent for C–Me and N–Me bond formation is discussed.

Graphical abstract: Recent advances in sustainable organic transformations using methanol: expanding the scope of hydrogen-borrowing catalysis
Review Article

Metal-hydride hydrogen atom transfer (MHAT) reactions in natural product synthesis

Functionalization of olefins has been an important transformation in synthetic chemistry. This review will focus on the natural product synthesis employing the MHAT reaction as the key strategy.

Graphical abstract: Metal-hydride hydrogen atom transfer (MHAT) reactions in natural product synthesis
Review Article

1,3-Difunctionalization of alkenes: state-of-the-art and future challenges

This review summarizes the advances in 1,3-difunctionalization of alkenes mediated by Pd-, Ni-, Fe-, and Cu-based catalysts, as well as under metal-free conditions, with an emphasis on the reaction mechanisms and factors governing regioselectivity.

Graphical abstract: 1,3-Difunctionalization of alkenes: state-of-the-art and future challenges
Review Article

Recent advances in the direct transformation of propargylic alcohols to allenes

This review summaries a view of the advances in the direct transformation of propargylic alcohols to functionalized allenes.

Graphical abstract: Recent advances in the direct transformation of propargylic alcohols to allenes
Open Access Review Article

Site-selective modification of peptide backbones

Exciting developments in the site-selective modification of peptide backbones are allowing an outstanding fine-tuning of peptide conformation, folding ability, and physico-chemical and biological properties.

Graphical abstract: Site-selective modification of peptide backbones
Review Article

Achievements in fluorination using variable reagents through a deoxyfluorination reaction

The application of fluorination reagent for the direct conversion of alcohols and phenols to fluorinated analogues.

Graphical abstract: Achievements in fluorination using variable reagents through a deoxyfluorination reaction
Review Article

Recent advances in cyclization reactions of isatins or thioisatins via C–N or C–S bond cleavage

This review summarizes recent developments on cyclization reactions induced by the C–N or C–S bond cleavage of isatins or thioisatins in the last 5 years, which produce fused products instead of spiro compounds.

Graphical abstract: Recent advances in cyclization reactions of isatins or thioisatins via C–N or C–S bond cleavage
Review Article

Generation of azolium dienolates as versatile nucleophilic synthons via N-heterocyclic carbene catalysis

The recent advances in N-heterocyclic carbene (NHC)-catalyzed generation of azolium dienolates from different precursors and their synthetic applications for the construction of various valuable molecules are summarized comprehensively in this review.

Graphical abstract: Generation of azolium dienolates as versatile nucleophilic synthons via N-heterocyclic carbene catalysis
Review Article

Advances in regioselective functionalization of 9-phenanthrenols

Various approaches are discussed for regioselective functionalization and transformation of 9-phenanthrenol and its ether derivatives, which are readily available from phenanthrene in coal tar.

Graphical abstract: Advances in regioselective functionalization of 9-phenanthrenols
Review Article

Visible light mediated functionalization of allenes

This review summarizes the visible light mediated strategies for the functionalization of allenes.

Graphical abstract: Visible light mediated functionalization of allenes
Review Article

Synthesis of diverse heterocyclic frameworks using cyclopentadienones via the Diels–Alder strategy

In this review article, we briefly summarize the versatility of Diels–Alder reactions of cyclopentadienones and concise routes to diverse hetero-atom bearing PAHs using cyclones as building blocks.

Graphical abstract: Synthesis of diverse heterocyclic frameworks using cyclopentadienones via the Diels–Alder strategy
Review Article

The Ugi three-component reaction and its variants

A broad variety of α-aminoamide-based compounds have been synthesized via the three-component version of the Ugi reaction (U-3CR) or by any of its variants (Ugi-Zhu-3CR, Orru-3CR, Ugi-4C-3CR, Ugi-Joullié-3CR, GBB-3CR, Ugi-Reissert-3CR, and so on).

Graphical abstract: The Ugi three-component reaction and its variants
Review Article

Synthetic applications of α,α-difluoroarylacetic acids and salts via decarboxylative functionalization

α,α-Difluoroarylacetic acids are stable, inexpensive and readily available building blocks which can be used to access various difluoromethylated aryl motifs via decarboxylative functionalization for the formation of carbon–carbon and carbon-heteroatom (F, O, S) bonds.

Graphical abstract: Synthetic applications of α,α-difluoroarylacetic acids and salts via decarboxylative functionalization
Review Article

Recent advances for the synthesis of chiral sulfones with the sulfone moiety directly connected to the chiral center

The recent development of strategies for the asymmetric synthesis of chiral sulfones with sulfone moieties directly connected to the stereocenters.

Graphical abstract: Recent advances for the synthesis of chiral sulfones with the sulfone moiety directly connected to the chiral center
Open Access Review Article

Direct synthetic routes to functionalised crown ethers

Modification of crown ethers via grafting of functional groups represents a convenient yet underexplored tool.

Graphical abstract: Direct synthetic routes to functionalised crown ethers
Review Article

Recent progress in the total synthesis of pyrrole-containing natural products (2011–2020)

This review discusses total syntheses of pyrrole-containing natural products over the last ten years, highlighting recent advances in the chemistry of pyrroles in the context of their innate reactivity, and their preparation in complex settings.

Graphical abstract: Recent progress in the total synthesis of pyrrole-containing natural products (2011–2020)
Open Access Review Article

Emerging computational approaches for the study of regio- and stereoselectivity in organic synthesis

Computational chemistry has become important in organic synthesis as it provides a detailed understanding of molecular structures and properties and detailed reaction mechanisms.

Graphical abstract: Emerging computational approaches for the study of regio- and stereoselectivity in organic synthesis
Review Article

Recent developments in the difunctionalization of alkenes with C–N bond formation

Various alkene difunctionalization reactions involving nitridization, diamination, azidation, oxyamination, carboamination, aminohalogenation, and nitration are introduced in this review.

Graphical abstract: Recent developments in the difunctionalization of alkenes with C–N bond formation
Review Article

1,2,4,5-Tetrazine derivatives as components and precursors of photo- and electroactive materials

Synthetic approaches to 3,6-disubstituted-1,2,4,5-tetrazine systems are analyzed, and their properties attractive to practical applications in photo- and electroactive materials are overviewed.

Graphical abstract: 1,2,4,5-Tetrazine derivatives as components and precursors of photo- and electroactive materials
Review Article

SOMOphilic alkynylation using acetylenic sulfones as functional reagents

Recent advancements in SOMOphilic alkynylation reactions by using acetylenic sulfones as functional reagents are summarized.

Graphical abstract: SOMOphilic alkynylation using acetylenic sulfones as functional reagents
Open Access Review Article

Green strategies for transition metal-catalyzed C–H activation in molecular syntheses

Sustainable strategies for the activation of inert C–H bonds towards improved resource-economy.

Graphical abstract: Green strategies for transition metal-catalyzed C–H activation in molecular syntheses
Review Article

Remote C(sp3)–H functionalization via catalytic cyclometallation: beyond five-membered ring metallacycle intermediates

Despite impressive recent momentum gained in C(sp3)–H activation, achieving high regioselectivity in molecules containing different C–H bonds with similar high energy without abusing tailored substitution remains as one of the biggest challenges.

Graphical abstract: Remote C(sp3)–H functionalization via catalytic cyclometallation: beyond five-membered ring metallacycle intermediates
Review Article

Hybrid phosphorus–viologen dendrimers as new soft nanoparticles: design and properties

Design of new families of dendritic soft nanoparticles constituted of phosphorus, viologen and carbosilane fragments and their properties as nanomaterials and applications in biology.

Graphical abstract: Hybrid phosphorus–viologen dendrimers as new soft nanoparticles: design and properties
Review Article

Keep glowing and going: recent progress in diketopyrrolopyrrole synthesis towards organic optoelectronic materials

Recent progress in the syntheses of DPP derivatives is summarized as well as the structure–property relationships of the derivatives, including the syntheses of DPP cores, N-functionalization reactions, and π-extensions on and along the DPP cores.

Graphical abstract: Keep glowing and going: recent progress in diketopyrrolopyrrole synthesis towards organic optoelectronic materials
Review Article

Recent advances of Ritter reaction and its synthetic applications

This review provides a comprehensive survey of Ritter reactions from 2014 to 2020.

Graphical abstract: Recent advances of Ritter reaction and its synthetic applications
Review Article

Recent advances in the functionalization of saturated cyclic amines

Functionalized cyclic amines are the essential structural moieties of numerous biologically active compounds. This review summarized the most recent advances in the C–H, C–N and C–C bond functionalization of saturated cyclic amines.

Graphical abstract: Recent advances in the functionalization of saturated cyclic amines
Review Article

Recent advances in multi-component reactions and their mechanistic insights: a triennium review

This review summarizes the recent developments in MCRs, incorporating different strategies along with their mechanistic aspects.

Graphical abstract: Recent advances in multi-component reactions and their mechanistic insights: a triennium review
Review Article

Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles

Catalytic asymmetric MCCRs for enantioselective synthesis of spirooxindoles by using chiral phosphoric acids, amines, bifunctional thiourea/squaramides and metal-based reagents as catalysts.

Graphical abstract: Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles
Review Article

Recent advances in the application of tetrabromomethane in organic synthesis

This review article covers the use of tetrabromomethane as mediator, catalyst and reagents for organic synthesis for the period from 2007 to 2020.

Graphical abstract: Recent advances in the application of tetrabromomethane in organic synthesis
Review Article

Covalent organic framework-based membranes for liquid separation

This review summarizes the synthesis and characterization methods of COF-based membranes in recent years and discusses their separation mechanism and application in liquid separation.

Graphical abstract: Covalent organic framework-based membranes for liquid separation
Review Article

Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis

Integration of chemical synthesis, NMR spectroscopy, and various analytical means is key to success in the structure elucidation of stereochemically complex marine macrolide natural products.

Graphical abstract: Structure determination, correction, and disproof of marine macrolide natural products by chemical synthesis
Review Article

Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides

This review highlights the recent advancements of carbamoyl chlorides in transition metal-catalyzed reactions to access various amide-containing molecules and heterocycles.

Graphical abstract: Recent advances in transition metal-catalyzed reactions of carbamoyl chlorides
Review Article

Recent advances of chromone-based reactants in the catalytic asymmetric domino annulation reaction

Chiral polycyclic chromanones are important heterocyclic frameworks that constitute the core structures of many natural products and bioactive molecules.

Graphical abstract: Recent advances of chromone-based reactants in the catalytic asymmetric domino annulation reaction
Review Article

Recent advance in the C–F bond functionalization of trifluoromethyl-containing compounds

The C–F bond is the strongest single bond in organic compounds.

Graphical abstract: Recent advance in the C–F bond functionalization of trifluoromethyl-containing compounds
Review Article

C–H hetero-functionalization of arenes through palladacyclopentane-type intermediates

In this review article, we summarized recent advances in C–H hetero-functionalization of arenes through palladacyclopentane-type intermediates.

Graphical abstract: C–H hetero-functionalization of arenes through palladacyclopentane-type intermediates
Review Article

Strategies and methodologies for the construction of spiro-γ-lactams: an update

This review gives an insight into the most recent synthetic methodologies towards spiro-γ-lactams, a class of compounds that are present in a wide range of synthetic bioactive and naturally occurring molecules.

Graphical abstract: Strategies and methodologies for the construction of spiro-γ-lactams: an update
Review Article

Photo-induced transition-metal and external photosensitizer-free organic reactions

Photoreactions have become powerful synthetic tools with a broad scope of applications. This review mainly focuses on photoreactions in the absence of transition-metals and photosensitizers, and highlights the mechanisms of such reactions.

Graphical abstract: Photo-induced transition-metal and external photosensitizer-free organic reactions
Review Article

Recent advances in annulation reactions based on zwitterionic π-allyl palladium and propargyl palladium complexes

Carbocyclic and heterocyclic compounds could be constructed through the palladium-catalyzed annulation reactions of zwitterionic π-allyl palladium or propargyl palladium complexes with unsaturated electrophiles.

Graphical abstract: Recent advances in annulation reactions based on zwitterionic π-allyl palladium and propargyl palladium complexes
Review Article

C(sp3)–H functionalization with isocyanides

This review highlights the state-of-the-art advances in C(sp3)–H functionalization involving isocyanides through the synergistic combination of isocyanide insertion and C(sp3)–H bond activation.

Graphical abstract: C(sp3)–H functionalization with isocyanides
Review Article

Recent advances in NHC–palladium catalysis for alkyne chemistry: versatile synthesis and applications

This review summarizes the recent developments in NHC–palladium catalysis for alkyne chemistry: versatile synthesis and applications.

Graphical abstract: Recent advances in NHC–palladium catalysis for alkyne chemistry: versatile synthesis and applications
Review Article

Sequential activation of thioglycosides enables one-pot glycosylation

This review describes recent developments in relative reactivity value (RRV) controlled sequential glycosylation, pre-activation based iterative glycosylation, and sulfoxide activation initiated one-pot glycosylation.

Graphical abstract: Sequential activation of thioglycosides enables one-pot glycosylation
Review Article

Cyanation: a photochemical approach and applications in organic synthesis

This review summarises the photocatalytic cyanation strategies to construct C(sp2)–CN, C(sp3)–CN and X–CN (X = N, S) bonds.

Graphical abstract: Cyanation: a photochemical approach and applications in organic synthesis
Review Article

The ammoxidation of alcohols over heterogeneous catalysts for the green synthesis of nitriles

This is the first review on the ammoxidation of alcohols over heterogeneous catalysts, in which issues and potential solutions are demonstrated.

Graphical abstract: The ammoxidation of alcohols over heterogeneous catalysts for the green synthesis of nitriles
Review Article

Recent advances in electrochemically driven radical fluorination and fluoroalkylation

Electrochemical fluorination (ECF) refers to the introduction of fluorine-containing moieties into organic molecules under electrochemical conditions.

Graphical abstract: Recent advances in electrochemically driven radical fluorination and fluoroalkylation
Review Article

Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group

The scope of this review is to summarize routine asymmetric synthetic methods which enable the effective and selective introduction of difluoromethyl groups into the desired compounds, providing a general introduction to this important research area.

Graphical abstract: Stereoselective synthetic strategies of stereogenic carbon centers featuring a difluoromethyl group
Review Article

Recent progress on the construction of axial chirality through transition-metal-catalyzed benzannulation

Useful chiral biaryls have been constructed through rhodium and gold complex-catalyzed asymmetric benzannulation strategies.

Graphical abstract: Recent progress on the construction of axial chirality through transition-metal-catalyzed benzannulation
Review Article

Benzannulation strategies for the synthesis of carbazoles, indolocarbazoles, benzocarbazoles, and carbolines

This review presents a critical and authoritative analysis of several exciting benzannulation approaches developed in the past decade for the construction of carbazoles, indolocarbazoles, benzocarbazoles, and carbolines.

Graphical abstract: Benzannulation strategies for the synthesis of carbazoles, indolocarbazoles, benzocarbazoles, and carbolines
Review Article

Recent advances in the synthesis and reactivity of quinoxaline

Quinoxalines are observed in several bioactive molecules and have been widely employed in designing molecules for DSSC's, optoelectronics, and sensing applications. Therefore, developing newer synthetic routes as well as novel ways for their functionalization is apparent.

Graphical abstract: Recent advances in the synthesis and reactivity of quinoxaline
Review Article

Advances in organocatalytic asymmetric reactions of vinylindoles: powerful access to enantioenriched indole derivatives

This review summarizes advances in vinylindole-based organocatalytic asymmetric reactions since 2008 and includes the applications of some methodologies in the total synthesis of natural products, points out remaining challenges in this research area.

Graphical abstract: Advances in organocatalytic asymmetric reactions of vinylindoles: powerful access to enantioenriched indole derivatives
Review Article

Recent advances in sustainable synthesis of N-heterocycles following acceptorless dehydrogenative coupling protocol using alcohols

In this review, we have summarized various aspects of homogeneous and heterogeneously catalyzed recent advancements in the synthesis of heterocycles following the ADC approach.

Graphical abstract: Recent advances in sustainable synthesis of N-heterocycles following acceptorless dehydrogenative coupling protocol using alcohols
Review Article

Recent progress in the synthesis of the furanosteroid family of natural products

This review focuses on an overview of recent advances in the synthesis of furanosteroids and illustrates their applications in medicinal chemistry over the period of 2005–present.

Graphical abstract: Recent progress in the synthesis of the furanosteroid family of natural products
Review Article

Catalytic asymmetric synthesis of monofluoroalkenes and gem-difluoroalkenes: advances and perspectives

The latest achievements in the catalytic asymmetric synthesis of both monofluoro- and gem-difluoroalkenes are discussed.

Graphical abstract: Catalytic asymmetric synthesis of monofluoroalkenes and gem-difluoroalkenes: advances and perspectives
Review Article

Recent advances on transition-metal-catalysed asymmetric reductive amination

This review focuses on the recent progress of homogeneous transition-metal-catalysed asymmetric reductive amination of ketones with diverse nitrogen sources.

Graphical abstract: Recent advances on transition-metal-catalysed asymmetric reductive amination
Review Article

Organocatalytic dimensions to the C–H functionalization of the carbocyclic core in indoles: a review update

A review highlighting important research findings in remote C–H activation processes using effectual organocatalytic perspectives. The challenging indole carbocyclic ring positions were successfully accessed with proper regio- and stereocontrols.

Graphical abstract: Organocatalytic dimensions to the C–H functionalization of the carbocyclic core in indoles: a review update
Review Article

Synthesis of enantioenriched α-heteroatom functionalised aldehydes by chiral organocatalysis and their synthetic applications

Asymmetric organocatalysis is a versatile method for the enantioselective α-functionalisation of aldehydes. The synthetic scope for chiral α-heteroatom substituted aldehydes is examined including their applications in synthesis.

Graphical abstract: Synthesis of enantioenriched α-heteroatom functionalised aldehydes by chiral organocatalysis and their synthetic applications
Review Article

Fluorination and fluoroalkylation of alkenes/alkynes to construct fluoro-containing heterocycles

This review summarize the established strategies through fluorination and fluoroalkylation of alkenes/alkynes for constructing fluoro-containing heterocycles. Reaction scopes, mechanisms and some shortcomings are also discussed.

Graphical abstract: Fluorination and fluoroalkylation of alkenes/alkynes to construct fluoro-containing heterocycles
Review Article

Structural characterisation of natural products by means of quantum chemical calculations of NMR parameters: new insights

In this review, we focus in all aspects of NMR simulation of natural products, from the fundamentals to the new computational toolboxes available, combining advanced quantum chemical calculations with upstream data processing and machine learning.

Graphical abstract: Structural characterisation of natural products by means of quantum chemical calculations of NMR parameters: new insights
Review Article

Recent advances in the synthesis of indole embedded heterocycles with 3-diazoindolin-2-imines

The preparations, reactivity and synthetic applications of 3-diazoindolin-2-imines, a valuable class of α-diazo amidines, are reviewed.

Graphical abstract: Recent advances in the synthesis of indole embedded heterocycles with 3-diazoindolin-2-imines
Review Article

Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products

The furo-pyranone framework is widely present in the molecular structure of various biologically potent natural products and un-natural small molecules, and it represents a valuable target in synthetic organic chemistry and medicinal chemistry.

Graphical abstract: Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products
Review Article

Recent advances in quinazolinones as an emerging molecular platform for luminescent materials and bioimaging

This review summarized recent advances relating to the luminescence properties of quinazolinones and their applications in fluorescent probes, biological imaging and luminescent materials. Their future outlook is also included.

Graphical abstract: Recent advances in quinazolinones as an emerging molecular platform for luminescent materials and bioimaging
Review Article

Photoexcited molecular probes for selective and revertible imaging of cellular reactive oxygen species

Redox homeostasis is key to maintaining the normal physiological status of living cells.

Graphical abstract: Photoexcited molecular probes for selective and revertible imaging of cellular reactive oxygen species
Review Article

The oxa-Michael reaction in the synthesis of 5- and 6-membered oxygen-containing heterocycles

In this review, we provide an updated account on the recent advances and applications of oxa-Michael reaction in the synthesis 5- and 6-membered monocyclic oxygen-containing heterocyclic compounds published in the literature since 2013 to date.

Graphical abstract: The oxa-Michael reaction in the synthesis of 5- and 6-membered oxygen-containing heterocycles
Review Article

Recent advances in cascade radical cyclization of radical acceptors for the synthesis of carbo- and heterocycles

This review is devoted to highlighting main achievements in the development of cascade radical cyclization of radical acceptors for the synthesis of carbo- and heterocycles.

Graphical abstract: Recent advances in cascade radical cyclization of radical acceptors for the synthesis of carbo- and heterocycles
Review Article

Recent advances in hydride transfer-involved C(sp3)–H activation reactions

This review summarizes the recent progresses (2016–2020) in the hydride transfer-enabled C(sp3)–H activation according to the reaction types, categorized into the intramolecular/intermolecular C(sp3)–H functionalization, and hydride reduction.

Graphical abstract: Recent advances in hydride transfer-involved C(sp3)–H activation reactions
Review Article

An electrochemical perspective on the roles of ligands in the merger of transition-metal catalysis and electrochemistry

A perspective on the roles of ligands in transition-metal catalysis under electrochemical conditions is provided.

Graphical abstract: An electrochemical perspective on the roles of ligands in the merger of transition-metal catalysis and electrochemistry
Open Access Review Article

Stereoselective synthesis and applications of spirocyclic oxindoles

This review summaries recent synthetic developments towards spirocyclic oxindoles and applications as valuable medicinal and synthetic targets.

Graphical abstract: Stereoselective synthesis and applications of spirocyclic oxindoles
Review Article

Recent advances in transition metal-catalyzed olefinic C–H functionalization

Recent advances during 2015–2020 in the field of metal-catalyzed olefinic C–H functionalization are organized according to the metal center of the catalyst, with an emphasis on the similarities and differences among different catalysts.

Graphical abstract: Recent advances in transition metal-catalyzed olefinic C–H functionalization
82 items - Showing page 1 of 2

About this collection

Critical reviews and highlight articles published in Organic Chemistry Frontiers during 2021 are collated as below for the benefit of readers.

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