Themed collection 2021 Organic Chemistry Frontiers Review-type Articles

Non-covalent interactions control the solid-state packing of AuX₄⁻ anions (yellow circles) co-precipitated with different supramolecular elements.

This review revisits the complex reactivity of C-nitroso derivatives through the synergistic combination of computational and synthetic organic chemistry, with an emphasis on the rationalization of mechanisms and selectivities.

Catalytic enantioselective direct C–H bond functionalization of electron-deficient N-containing heteroarenes represents one of the most straightforward and powerful protocols to construct diverse enantioenriched highly functionalized N-heteroarenes.

Recent progress relating to sustainable approaches using methanol as a C1-alkylating agent for C–Me and N–Me bond formation is discussed.

Functionalization of olefins has been an important transformation in synthetic chemistry. This review will focus on the natural product synthesis employing the MHAT reaction as the key strategy.

This review summarizes the advances in 1,3-difunctionalization of alkenes mediated by Pd-, Ni-, Fe-, and Cu-based catalysts, as well as under metal-free conditions, with an emphasis on the reaction mechanisms and factors governing regioselectivity.

This review summaries a view of the advances in the direct transformation of propargylic alcohols to functionalized allenes.

Exciting developments in the site-selective modification of peptide backbones are allowing an outstanding fine-tuning of peptide conformation, folding ability, and physico-chemical and biological properties.

The application of fluorination reagent for the direct conversion of alcohols and phenols to fluorinated analogues.

This review summarizes recent developments on cyclization reactions induced by the C–N or C–S bond cleavage of isatins or thioisatins in the last 5 years, which produce fused products instead of spiro compounds.

The recent advances in N-heterocyclic carbene (NHC)-catalyzed generation of azolium dienolates from different precursors and their synthetic applications for the construction of various valuable molecules are summarized comprehensively in this review.

Various approaches are discussed for regioselective functionalization and transformation of 9-phenanthrenol and its ether derivatives, which are readily available from phenanthrene in coal tar.

This review summarizes the visible light mediated strategies for the functionalization of allenes.

In this review article, we briefly summarize the versatility of Diels–Alder reactions of cyclopentadienones and concise routes to diverse hetero-atom bearing PAHs using cyclones as building blocks.

A broad variety of α-aminoamide-based compounds have been synthesized via the three-component version of the Ugi reaction (U-3CR) or by any of its variants (Ugi-Zhu-3CR, Orru-3CR, Ugi-4C-3CR, Ugi-Joullié-3CR, GBB-3CR, Ugi-Reissert-3CR, and so on).

α,α-Difluoroarylacetic acids are stable, inexpensive and readily available building blocks which can be used to access various difluoromethylated aryl motifs via decarboxylative functionalization for the formation of carbon–carbon and carbon-heteroatom (F, O, S) bonds.

The recent development of strategies for the asymmetric synthesis of chiral sulfones with sulfone moieties directly connected to the stereocenters.

Modification of crown ethers via grafting of functional groups represents a convenient yet underexplored tool.

This review discusses total syntheses of pyrrole-containing natural products over the last ten years, highlighting recent advances in the chemistry of pyrroles in the context of their innate reactivity, and their preparation in complex settings.

Computational chemistry has become important in organic synthesis as it provides a detailed understanding of molecular structures and properties and detailed reaction mechanisms.

Various alkene difunctionalization reactions involving nitridization, diamination, azidation, oxyamination, carboamination, aminohalogenation, and nitration are introduced in this review.

Synthetic approaches to 3,6-disubstituted-1,2,4,5-tetrazine systems are analyzed, and their properties attractive to practical applications in photo- and electroactive materials are overviewed.

Recent advancements in SOMOphilic alkynylation reactions by using acetylenic sulfones as functional reagents are summarized.

Sustainable strategies for the activation of inert C–H bonds towards improved resource-economy.

Despite impressive recent momentum gained in C(sp³)–H activation, achieving high regioselectivity in molecules containing different C–H bonds with similar high energy without abusing tailored substitution remains as one of the biggest challenges.

Design of new families of dendritic soft nanoparticles constituted of phosphorus, viologen and carbosilane fragments and their properties as nanomaterials and applications in biology.

Recent progress in the syntheses of DPP derivatives is summarized as well as the structure–property relationships of the derivatives, including the syntheses of DPP cores, N-functionalization reactions, and π-extensions on and along the DPP cores.

This review provides a comprehensive survey of Ritter reactions from 2014 to 2020.

Functionalized cyclic amines are the essential structural moieties of numerous biologically active compounds. This review summarized the most recent advances in the C–H, C–N and C–C bond functionalization of saturated cyclic amines.

This review summarizes the recent developments in MCRs, incorporating different strategies along with their mechanistic aspects.

Catalytic asymmetric MCCRs for enantioselective synthesis of spirooxindoles by using chiral phosphoric acids, amines, bifunctional thiourea/squaramides and metal-based reagents as catalysts.

This review article covers the use of tetrabromomethane as mediator, catalyst and reagents for organic synthesis for the period from 2007 to 2020.

This review summarizes the synthesis and characterization methods of COF-based membranes in recent years and discusses their separation mechanism and application in liquid separation.

Integration of chemical synthesis, NMR spectroscopy, and various analytical means is key to success in the structure elucidation of stereochemically complex marine macrolide natural products.

This review highlights the recent advancements of carbamoyl chlorides in transition metal-catalyzed reactions to access various amide-containing molecules and heterocycles.

Chiral polycyclic chromanones are important heterocyclic frameworks that constitute the core structures of many natural products and bioactive molecules.

The C–F bond is the strongest single bond in organic compounds.

In this review article, we summarized recent advances in C–H hetero-functionalization of arenes through palladacyclopentane-type intermediates.

This review gives an insight into the most recent synthetic methodologies towards spiro-γ-lactams, a class of compounds that are present in a wide range of synthetic bioactive and naturally occurring molecules.

Photoreactions have become powerful synthetic tools with a broad scope of applications. This review mainly focuses on photoreactions in the absence of transition-metals and photosensitizers, and highlights the mechanisms of such reactions.

Carbocyclic and heterocyclic compounds could be constructed through the palladium-catalyzed annulation reactions of zwitterionic π-allyl palladium or propargyl palladium complexes with unsaturated electrophiles.

This review highlights the state-of-the-art advances in C(sp³)–H functionalization involving isocyanides through the synergistic combination of isocyanide insertion and C(sp³)–H bond activation.

This review summarizes the recent developments in NHC–palladium catalysis for alkyne chemistry: versatile synthesis and applications.

This review describes recent developments in relative reactivity value (RRV) controlled sequential glycosylation, pre-activation based iterative glycosylation, and sulfoxide activation initiated one-pot glycosylation.

This review summarises the photocatalytic cyanation strategies to construct C(sp²)–CN, C(sp³)–CN and X–CN (X = N, S) bonds.

This is the first review on the ammoxidation of alcohols over heterogeneous catalysts, in which issues and potential solutions are demonstrated.

Electrochemical fluorination (ECF) refers to the introduction of fluorine-containing moieties into organic molecules under electrochemical conditions.

The scope of this review is to summarize routine asymmetric synthetic methods which enable the effective and selective introduction of difluoromethyl groups into the desired compounds, providing a general introduction to this important research area.

Useful chiral biaryls have been constructed through rhodium and gold complex-catalyzed asymmetric benzannulation strategies.

This review presents a critical and authoritative analysis of several exciting benzannulation approaches developed in the past decade for the construction of carbazoles, indolocarbazoles, benzocarbazoles, and carbolines.

Quinoxalines are observed in several bioactive molecules and have been widely employed in designing molecules for DSSC's, optoelectronics, and sensing applications. Therefore, developing newer synthetic routes as well as novel ways for their functionalization is apparent.

This review summarizes advances in vinylindole-based organocatalytic asymmetric reactions since 2008 and includes the applications of some methodologies in the total synthesis of natural products, points out remaining challenges in this research area.

In this review, we have summarized various aspects of homogeneous and heterogeneously catalyzed recent advancements in the synthesis of heterocycles following the ADC approach.

This review focuses on an overview of recent advances in the synthesis of furanosteroids and illustrates their applications in medicinal chemistry over the period of 2005–present.

The latest achievements in the catalytic asymmetric synthesis of both monofluoro- and gem-difluoroalkenes are discussed.

This review focuses on the recent progress of homogeneous transition-metal-catalysed asymmetric reductive amination of ketones with diverse nitrogen sources.

A review highlighting important research findings in remote C–H activation processes using effectual organocatalytic perspectives. The challenging indole carbocyclic ring positions were successfully accessed with proper regio- and stereocontrols.

Asymmetric organocatalysis is a versatile method for the enantioselective α-functionalisation of aldehydes. The synthetic scope for chiral α-heteroatom substituted aldehydes is examined including their applications in synthesis.

This review summarize the established strategies through fluorination and fluoroalkylation of alkenes/alkynes for constructing fluoro-containing heterocycles. Reaction scopes, mechanisms and some shortcomings are also discussed.

In this review, we focus in all aspects of NMR simulation of natural products, from the fundamentals to the new computational toolboxes available, combining advanced quantum chemical calculations with upstream data processing and machine learning.

The preparations, reactivity and synthetic applications of 3-diazoindolin-2-imines, a valuable class of α-diazo amidines, are reviewed.

The furo-pyranone framework is widely present in the molecular structure of various biologically potent natural products and un-natural small molecules, and it represents a valuable target in synthetic organic chemistry and medicinal chemistry.

This review summarized recent advances relating to the luminescence properties of quinazolinones and their applications in fluorescent probes, biological imaging and luminescent materials. Their future outlook is also included.

Redox homeostasis is key to maintaining the normal physiological status of living cells.

In this review, we provide an updated account on the recent advances and applications of oxa-Michael reaction in the synthesis 5- and 6-membered monocyclic oxygen-containing heterocyclic compounds published in the literature since 2013 to date.

This review is devoted to highlighting main achievements in the development of cascade radical cyclization of radical acceptors for the synthesis of carbo- and heterocycles.

This review summarizes the recent progresses (2016–2020) in the hydride transfer-enabled C(sp³)–H activation according to the reaction types, categorized into the intramolecular/intermolecular C(sp³)–H functionalization, and hydride reduction.

A perspective on the roles of ligands in transition-metal catalysis under electrochemical conditions is provided.

This review summaries recent synthetic developments towards spirocyclic oxindoles and applications as valuable medicinal and synthetic targets.

Recent advances during 2015–2020 in the field of metal-catalyzed olefinic C–H functionalization are organized according to the metal center of the catalyst, with an emphasis on the similarities and differences among different catalysts.