Automated access to well-defined ionic oligosaccharides
Automated Glycan Assembly grants access to ionic oligosaccharides for structural studies.
Photo-induced glycosylation using a diaryldisulfide as an organo-Lewis photoacid catalyst
Photo-induced glycosylations of several acceptors with trichloroacetimidate donors using bis(2-naphthyl)disulfide as an organo-Lewis photoacid (LPA) catalyst proceeded effectively to give the corresponding glycosides in good to high yields.
A hybrid polymer to target blood group dependence of cholera toxin
New hybrid glycopolymers were synthesized that contain two epitopes blocking GM1- and fucose-based intoxication modes of the cholera toxin.
α-Selective glycosylations using glycosyl N-(ortho-methoxyphenyl)trifluoroacetimidates
β-Selective acetimidate formation followed by α-selective catalytic activation.
Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)2 3,6Galβ1 → 4Glc
The first chemical synthesis of lacto-N-neohexaose (LNnH) has been completed using a convergent synthetic strategy.
C-2 auxiliaries for stereoselective glycosylation based on common additive functional groups
The stereoselective introduction of the glycosidic bond is one of the main challenges in chemical oligosaccharide synthesis.
L. pneumophila CMP-5,7-di-N-acetyllegionaminic acid synthetase (LpCLS)-involved chemoenzymatic synthesis of sialosides and analogues
A bacterial CMP-5,7-di-N-acetyllegionaminic acid synthetase was characterized and used in one-pot multienzyme systems for efficient synthesis of Leg5,7Ac2-glycosides and analogs.
Exploring a glycosylation methodology for the synthesis of hydroxamate-modified alginate building blocks
Mixed sequence, C6-hydroxamate-modified alginate disaccharides are prepared using NIS/TMSOTf glycosylation.
Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes of Burkholderia pseudomallei and Burkholderia mallei O-antigens
Tetrasaccharides mimicking Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens were synthesized and found to be highly reactive with Thai melioidosis patient serum, highlighting their potential as vaccine candidates.
About this collection
Glycosylation: New methodologies for oligosaccharide and glycoconjugate synthesis and their applications
This themed collection, Guest Edited by Professors M. Carmen Galan, Sabine Flitsch and Antony Fairbanks, is to highlight the exciting work being carried out by carbohydrate researchers at the forefront of their field. The scope of this collection includes reactions of the anomeric centre, di- and oligosaccharide synthesis, and the development of synthetic methodology for the production of glycoconjugates for biological, biophysical or other study.
Articles in this themed collection will be added below as soon as possible after they are published.
Please return to this page frequently to see the collection grow.