Jump to main content
Jump to site search

Themed collection Glycosylation: New methodologies and applications

9 items
Open Access Communication

Automated access to well-defined ionic oligosaccharides

Automated Glycan Assembly grants access to ionic oligosaccharides for structural studies.

Graphical abstract: Automated access to well-defined ionic oligosaccharides
From the themed collection: Chemical biology in OBC
Communication

Photo-induced glycosylation using a diaryldisulfide as an organo-Lewis photoacid catalyst

Photo-induced glycosylations of several acceptors with trichloroacetimidate donors using bis(2-naphthyl)disulfide as an organo-Lewis photoacid (LPA) catalyst proceeded effectively to give the corresponding glycosides in good to high yields.

Graphical abstract: Photo-induced glycosylation using a diaryldisulfide as an organo-Lewis photoacid catalyst
From the themed collection: Synthetic methodology in OBC
Open Access Communication

A hybrid polymer to target blood group dependence of cholera toxin

New hybrid glycopolymers were synthesized that contain two epitopes blocking GM1- and fucose-based intoxication modes of the cholera toxin.

Graphical abstract: A hybrid polymer to target blood group dependence of cholera toxin
Paper

α-Selective glycosylations using glycosyl N-(ortho-methoxyphenyl)trifluoroacetimidates

β-Selective acetimidate formation followed by α-selective catalytic activation.

Graphical abstract: α-Selective glycosylations using glycosyl N-(ortho-methoxyphenyl)trifluoroacetimidates
Paper

Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)2 3,6Galβ1 → 4Glc

The first chemical synthesis of lacto-N-neohexaose (LNnH) has been completed using a convergent synthetic strategy.

Graphical abstract: Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)2 3,6Galβ1 → 4Glc
From the themed collection: Chemical biology in OBC
Open Access Paper

C-2 auxiliaries for stereoselective glycosylation based on common additive functional groups

The stereoselective introduction of the glycosidic bond is one of the main challenges in chemical oligosaccharide synthesis.

Graphical abstract: C-2 auxiliaries for stereoselective glycosylation based on common additive functional groups
From the themed collection: Chemical biology in OBC
Paper

L. pneumophila CMP-5,7-di-N-acetyllegionaminic acid synthetase (LpCLS)-involved chemoenzymatic synthesis of sialosides and analogues

A bacterial CMP-5,7-di-N-acetyllegionaminic acid synthetase was characterized and used in one-pot multienzyme systems for efficient synthesis of Leg5,7Ac2-glycosides and analogs.

Graphical abstract: L. pneumophila CMP-5,7-di-N-acetyllegionaminic acid synthetase (LpCLS)-involved chemoenzymatic synthesis of sialosides and analogues
Paper

Exploring a glycosylation methodology for the synthesis of hydroxamate-modified alginate building blocks

Mixed sequence, C6-hydroxamate-modified alginate disaccharides are prepared using NIS/TMSOTf glycosylation.

Graphical abstract: Exploring a glycosylation methodology for the synthesis of hydroxamate-modified alginate building blocks
Paper

Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes of Burkholderia pseudomallei and Burkholderia mallei O-antigens

Tetrasaccharides mimicking Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens were synthesized and found to be highly reactive with Thai melioidosis patient serum, highlighting their potential as vaccine candidates.

Graphical abstract: Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes of Burkholderia pseudomallei and Burkholderia mallei O-antigens
9 items

About this collection

Glycosylation: New methodologies for oligosaccharide and glycoconjugate synthesis and their applications

This themed collection, Guest Edited by Professors M. Carmen Galan, Sabine Flitsch and Antony Fairbanks, is to highlight the exciting work being carried out by carbohydrate researchers at the forefront of their field. The scope of this collection includes reactions of the anomeric centre, di- and oligosaccharide synthesis, and the development of synthetic methodology for the production of glycoconjugates for biological, biophysical or other study.

Articles in this themed collection will be added below as soon as possible after they are published.

Please return to this page frequently to see the collection grow.

Spotlight

Advertisements