Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 18, 2020
Previous Article Next Article

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Author affiliations

Abstract

The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria.

Graphical abstract: Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Back to tab navigation

Supplementary files

Article information


Submitted
05 Feb 2020
Accepted
08 Apr 2020
First published
30 Apr 2020

This article is Open Access

Org. Biomol. Chem., 2020,18, 3607-3612
Article type
Paper

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

H. L. Parker, R. M. F. Tomás, C. M. Furze, C. S. Guy and E. Fullam, Org. Biomol. Chem., 2020, 18, 3607
DOI: 10.1039/D0OB00253D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements