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Themed collection Chemical biology in OBC

199 items - Showing page 1 of 3
Perspective

From pirates and killers: does metabolite diversity drive bacterial competition?

This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.

Graphical abstract: From pirates and killers: does metabolite diversity drive bacterial competition?
From the themed collection: Chemical biology in OBC
Review Article

Saturated bioisosteres of benzene: where to go next?

Saturated bioisosteres for ortho- and meta-substituted benzenes remain a current challenge for chemists.

Graphical abstract: Saturated bioisosteres of benzene: where to go next?
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Review Article

The Expanding Spectrum of Diketopiperazine Natural Product Biosynthetic Pathways Containing Cyclodipeptide Synthases

From the themed collection: Biosynthesis
Review Article

Fluorogenic probes for super-resolution microscopy

Fluorogenic probes efficiently reduce non-specific background signals, which often results in highly improved signal-to-noise ratios.

Graphical abstract: Fluorogenic probes for super-resolution microscopy
From the themed collection: Chemical biology in OBC
Review Article

One-pot multi-segment condensation strategies for chemical protein synthesis

This paper describes recent advances of one-pot multi-segment condensation strategies based on kinetically controlled strategies and/or protecting group-removal strategies in chemical protein synthesis.

Graphical abstract: One-pot multi-segment condensation strategies for chemical protein synthesis
From the themed collection: Chemical biology in OBC
Review Article

Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials

Peptide–oligonucleotide conjugates (POCs) are covalent constructs that link a molecule like DNA to a synthetic peptide sequences.

Graphical abstract: Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials
From the themed collection: Chemical biology in OBC
Review Article

Azobenzene-based small molecular photoswitches for protein modulation

This review highlights the design strategies of azobenzene photoswitches as well as their applications in the manipulation of biological systems.

Graphical abstract: Azobenzene-based small molecular photoswitches for protein modulation
From the themed collection: Chemical biology in OBC
Review Article

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Rearranged ergostane-type natural products are structurally intriguing and exhibit biologically relevant properties.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
From the themed collection: Chemical biology in OBC
Review Article

Lasso peptides: chemical approaches and structural elucidation

The diverse functionality and the extraordinary stability of lasso peptides make these molecules attractive scaffolds for drug discovery. The ability to generate lasso peptides chemically remains a challenging endeavor.

Graphical abstract: Lasso peptides: chemical approaches and structural elucidation
From the themed collection: Chemical biology in OBC
Review Article

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. In this review, we describe the isolation and biosynthetic studies of teleocidins.

Graphical abstract: Biosynthesis of the teleocidin-type terpenoid indole alkaloids
From the themed collection: Chemical biology in OBC
Review Article

The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions

Nucleic acids, phospholipids and other organic phosphates play central roles in biological pathways.

Graphical abstract: The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions
From the themed collection: Chemical biology in OBC
Review Article

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Participation of Z DNA in normal and disease related biological processes.

Graphical abstract: C8-Guanine modifications: effect on Z-DNA formation and its role in cancer
From the themed collection: Chemical biology in OBC
Review Article

Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals

C-Glycosylation has found widespread use in the synthesis of biomedically important natural products and pharmaceuticals.

Graphical abstract: Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals
From the themed collection: Chemical biology in OBC
Review Article

Target specificity of mammalian DNA methylation and demethylation machinery

We review here the molecular mechanisms employed by DNMTs and TET enzymes that are responsible for shaping the DNA methylation pattern of a mammalian cell.

Graphical abstract: Target specificity of mammalian DNA methylation and demethylation machinery
From the themed collection: Chemical biology in OBC
Review Article

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

Within a decade of Merrifield's seminal description of solid-phase peptide synthesis, the synergies between solid-phase approaches and flow synthesis were noted by a number of groups.

Graphical abstract: The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches
From the themed collection: Chemical biology in OBC
Open Access Review Article

Negishi cross-couplings in the synthesis of amino acids

The application of the Negishi cross-coupling reaction in the synthesis of amino acids is reviewed.

Graphical abstract: Negishi cross-couplings in the synthesis of amino acids
From the themed collection: Chemical biology in OBC
Review Article

25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science

This review highlights the synthesis, biophysical properties, and wide range of applications of oligonucleotides modified with 2′-O-(pyren-1-yl)methyl-RNA monomers reported over the past 25 years.

Graphical abstract: 25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science
From the themed collection: Chemical biology in OBC
Communication

Seven-enzyme in vitro cascade to (3R)-3-hydroxybutyryl-CoA

Economical and environmentally-friendly routes to convert feedstock chemicals like acetate into valuable chiral products such as (R)-3-hydroxybutyrate are in demand.

Graphical abstract: Seven-enzyme in vitro cascade to (3R)-3-hydroxybutyryl-CoA
From the themed collection: Chemical biology in OBC
Communication

Biochemical studies of a β-1,4-rhamnoslytransferase from Streptococcus pneumonia serotype 23F

A new β-rhamnoslytransferase Cps23FT from Streptococcus pneumonia serotype 23F was functionally explored for the first time.

Graphical abstract: Biochemical studies of a β-1,4-rhamnoslytransferase from Streptococcus pneumonia serotype 23F
From the themed collection: Chemical biology in OBC
Open Access Communication

Development of a peptide-based fluorescent probe for biological heme monitoring

A prototype peptide-based probe has been developed for the determination of intracellular heme levels.

Graphical abstract: Development of a peptide-based fluorescent probe for biological heme monitoring
From the themed collection: Chemical biology in OBC
Communication

Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway

The biosynthetic pathway of the uridine-derived nucleoside antibiotic A-94964 was proposed via in silico analysis coupled with gene deletion experiments.

Graphical abstract: Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway
From the themed collection: Chemical biology in OBC
Communication

In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid

Four enzymes direct the biosynthesis of 3-hydroxypicolinic acid, an important building block of bacterial natural products.

Graphical abstract: In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Communication

Stereoselective synthesis of phosphonate pThr mimetic via palladium-catalyzed γ-C(sp3)-H activation for peptide assembling

From the themed collection: Chemical biology in OBC
Communication

HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease

HAP-01 was developed as an activity-based probe for A. oryzae acid protease important for production of sake, a Japanese rice wine.

Graphical abstract: HAP-01, the first chromogenic substrate for Aspergillus oryzae acid protease
From the themed collection: Chemical biology in OBC
Communication

ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

We report a high-affinity photoswitchable DNA binder, which displays different nucleosome-binding capacities upon visible-light irradiation.

Graphical abstract: ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light
From the themed collection: Chemical biology in OBC
Communication

Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A

Biosynthesis of a potent MptpB inhibitor asperterpenoid A by a sesterterpene cyclase AstC and a multifunctional P450 enzyme AstB.

Graphical abstract: Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A
From the themed collection: Biosynthesis
Communication

Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

Targeted gene knockout in Coprinopsis cinerea, yeast in vivo bioconversion and in vitro assays elucidated the lagopodin biosynthetic pathway, including a complexity-generating network of oxidation steps.

Graphical abstract: Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions
From the themed collection: Chemical biology in OBC
Communication

Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

A heterologous production of asperipin-2a and determination of its absolute structure revealed a sequential oxidative cyclization catalyzed by DUF3328 oxidase.

Graphical abstract: Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase
From the themed collection: Chemical biology in OBC
Communication

Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system

The amyloidogenic Aβ42 peptide was prepared in high purity and yield enabling biophysical characterisation studies using a double linker system and the incorporation of pseudoprolines.

Graphical abstract: Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system
From the themed collection: Chemical biology in OBC
Communication

Aldehydes can switch the chemoselectivity of electrophiles in protein labeling

The derivatization of an electrophile can switch its chemoselectivity. The aldehyde-conjugated epoxide and sulfonate ester provide the proof of principle and deliver N-terminus tagged proteins.

Graphical abstract: Aldehydes can switch the chemoselectivity of electrophiles in protein labeling
From the themed collection: Chemical biology in OBC
Communication

Ring-closing metathesis of unprotected peptides in water

RCM of unprotected peptides in water was achieved using a water-soluble Ru catalyst ‘AquaMet’.

Graphical abstract: Ring-closing metathesis of unprotected peptides in water
From the themed collection: Chemical biology in OBC
Communication

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Aurantizolicin and new compound 3 with improved bioactivity were generated highly effectively by heterologous expression of an engineered YM-216391 biosynthetic gene cluster.

Graphical abstract: Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system
From the themed collection: Chemical biology in OBC
Communication

A fluorogenic C4N4 probe for azide-based labelling

A new fluorogenic probe based on the recently identified 2,5-diaminopyrimidine (C4N4) fluorophore is introduced for azide-specific labelling.

Graphical abstract: A fluorogenic C4N4 probe for azide-based labelling
From the themed collection: New Talent
Communication

Radical SAM-dependent adenosylation catalyzed by L-tyrosine lyases

Tyrosine analogues containing an olefin moiety can be adenosylated by L-tyrosine lyases.

Graphical abstract: Radical SAM-dependent adenosylation catalyzed by l-tyrosine lyases
From the themed collection: New Talent
Communication

Posttranscriptional spin labeling of RNA by tetrazine-based cycloaddition

Spin labeling of in vitro transcribed RNA by iEDDA click chemistry is demonstrated. This allows the determination of distance distributions between two nitroxide spin labels by PELDOR in a self-complementary RNA duplex.

Graphical abstract: Posttranscriptional spin labeling of RNA by tetrazine-based cycloaddition
From the themed collection: Chemical biology in OBC
Communication

StnK2 catalysing a Pictet–Spengler reaction involved in the biosynthesis of the antitumor reagent streptonigrin

StnK2 is a new Pictet–Spenglerase specifically catalyzing a (1R,3S,4S)-tetrahydro-β-carboline scaffold as the biosynthetic intermediate of the antitumor reagent streptonigrin.

Graphical abstract: StnK2 catalysing a Pictet–Spengler reaction involved in the biosynthesis of the antitumor reagent streptonigrin
From the themed collection: Chemical biology in OBC
Communication

Iron(III) chloride-catalyzed activation of glycosyl chlorides

Glycosyl chlorides can be readily activated with 20 mol% of FeCl3.

Graphical abstract: Iron(iii) chloride-catalyzed activation of glycosyl chlorides
From the themed collection: Chemical biology in OBC
Communication

Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect

PEGylation + stapling contributes more to conformational stability when the two linked sites are close in tertiary structure but far apart in primary sequence.

Graphical abstract: Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect
From the themed collection: Chemical biology in OBC
Open Access Communication

The study of multivalent carbohydrate–protein interactions by bio-layer interferometry

Bio-layer interferometry is an excellent method to evaluate multivalent carbohydrate–protein interactions.

Graphical abstract: The study of multivalent carbohydrate–protein interactions by bio-layer interferometry
From the themed collection: Chemical biology in OBC
Communication

Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors

The synthesis of novel disaccharide nucleoside analogues that resemble the central motif of poly(ADP-ribose) was developed and it was found that some of them show inhibitory effects on human poly(ADP-ribose) polymerase-1.

Graphical abstract: Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors
From the themed collection: Chemical biology in OBC
Communication

Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA

A fluorescent peptide displacement assay combined with statistical analysis is used for screening small molecules against different RNA targets and profiling their affinity/selectivity patterns.

Graphical abstract: Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA
From the themed collection: Chemical biology in OBC
Communication

Synthesis and potassium KV7 channel opening activity of thioether analogues of the analgesic flupirtine

Benign by design: active sulfide-analogues of potassium channel opener flupirtine do not form reactive oxidation products in vitro.

Graphical abstract: Synthesis and potassium KV7 channel opening activity of thioether analogues of the analgesic flupirtine
From the themed collection: Chemical biology in OBC
Communication

Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides

A squaramide derivative bearing a coumarin fluorophore and a morpholinyl group was synthesized and found to be able to target and efficiently deacidify lysosomes.

Graphical abstract: Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides
From the themed collection: Chemical biology in OBC
Communication

Fluorogenic “photoclick” labelling of DNA using a Cy3 dye

Two 2′-deoxyuridines as new building blocks for automated DNA synthesis carry a small aryltetrazole as a “photoclickable” group at their 5-positions.

Graphical abstract: Fluorogenic “photoclick” labelling of DNA using a Cy3 dye
From the themed collection: Chemical biology in OBC
Communication

Synthesis of the β-linked GalNAc-Kdo disaccharide antigen of the capsular polysaccharide of Kingella kingae KK01

TfOH-catalyzed glycosylation with D-galactosaminyl N-phenyl trifluoroacetimidate as the donor was developed for the construction of the challenging β-(1 → 5)-linked GalNAc-Kdo disaccharide antigen from Kingella kingae KK01.

Graphical abstract: Synthesis of the β-linked GalNAc-Kdo disaccharide antigen of the capsular polysaccharide of Kingella kingae KK01
From the themed collection: Chemical biology in OBC
Communication

Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential

We present the functional characterization of GlbB, a lysine 4-hydroxylase from the glidobactin biosynthetic gene cluster.

Graphical abstract: Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential
From the themed collection: New Talent
Communication

Azlactone-based heterobifunctional linkers with orthogonal clickable groups: efficient tools for bioconjugation with complete atom economy

New azlactone-based heterobifunctional linkers that proceed in orthogonal click-like reactions for chemical ligations in biologically relevant medium without releasing any byproduct.

Graphical abstract: Azlactone-based heterobifunctional linkers with orthogonal clickable groups: efficient tools for bioconjugation with complete atom economy
From the themed collection: Chemical biology in OBC
Open Access Communication

A pendant peptide endows a sunscreen with water-resistance

A small-molecule UV-filter with a pendant collagen mimetic peptide anneals to a collagen-laden surface and protects against UV radiation.

Graphical abstract: A pendant peptide endows a sunscreen with water-resistance
From the themed collection: Chemical biology in OBC
Communication

Stereoselective synthesis of sugar-fused (or 1,2-annulated) isochromans and isochromanones by using oxa-Pictet–Spengler reaction

We report the utility of the oxa-Pictet–Spengler reaction in carbohydrates for stereoselective synthesis of sugar fused 1,2-annulated isochromans in good to excellent yields.

Graphical abstract: Stereoselective synthesis of sugar-fused (or 1,2-annulated) isochromans and isochromanones by using oxa-Pictet–Spengler reaction
From the themed collection: Chemical biology in OBC
Communication

Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry

Two novel cyclic quaternary amine crosslinking probes are synthesized for structural mass spectrometry of protein complexes in solution and for analysis of protein interactions in organellar and whole cell extracts.

Graphical abstract: Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry
From the themed collection: Chemical biology in OBC
Communication

Two-step activity-based protein profiling of diacylglycerol lipase

Diacylglycerol lipases (DAGL) produce the endocannabinoid 2-arachidonoylglycerol, a key modulator of neurotransmitter release.

Graphical abstract: Two-step activity-based protein profiling of diacylglycerol lipase
From the themed collection: Chemical biology in OBC
Communication

Sterically shielded tetrazoles for a fluorogenic photoclick reaction: tuning cycloaddition rate and product fluorescence

We report the reactivity and fluorescence studies of a panel of sterically shielded tetrazoles with different N-aryl groups in the fluorogenic photoclick reaction with spiro[2.3]hex-1-ene.

Graphical abstract: Sterically shielded tetrazoles for a fluorogenic photoclick reaction: tuning cycloaddition rate and product fluorescence
From the themed collection: Chemical biology in OBC
Communication

Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition.

Graphical abstract: Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89
From the themed collection: Chemical biology in OBC
Communication

The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε

The first example of a counterintuitive freezing-induced peptide ligation was discovered during the total synthesis of human interferon-ε (187 amino acids) which blocks HIV infection through unique mechanisms.

Graphical abstract: The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε
From the themed collection: Chemical biology in OBC
Communication

Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens

Highly efficient streamlined total synthesis of complex prioritized gangliosides was achieved chemoenzymatically by sequential one-pot multienzyme (OPME) reactions with facile C18 cartridge purification schemes followed by high-yield acylation.

Graphical abstract: Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens
From the themed collection: Chemical biology in OBC
Communication

Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu.

Graphical abstract: Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites
From the themed collection: Chemical biology in OBC
Communication

In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product

A new bilirubin degradation end product was isolated and characterized.

Graphical abstract: In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product
From the themed collection: Chemical biology in OBC
Communication

Secondary amine salt catalyzed controlled activation of 2-deoxy sugar lactols towards alpha-selective dehydrative glycosylation

An organocatalytic alpha-selective dehydrative glycosylation method for the synthesis of 2-deoxyglycosides.

Graphical abstract: Secondary amine salt catalyzed controlled activation of 2-deoxy sugar lactols towards alpha-selective dehydrative glycosylation
From the themed collection: Chemical biology in OBC
Communication

Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA

In this paper, we report the development of a new G-4 alkylating molecule and the evaluation of the properties of the alkylated G-4 DNA.

Graphical abstract: Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA
From the themed collection: Chemical biology in OBC
Communication

A double-click approach to the protecting group free synthesis of glycoconjugates

The use of a bi-functional linker, containing an alkyne and an alkene, allows the protecting group free conjugation of reducing sugars to thiols via a double click process.

Graphical abstract: A double-click approach to the protecting group free synthesis of glycoconjugates
From the themed collection: Chemical biology in OBC
Communication

Can strand displacement take place in DNA triplexes?

Toehold-mediated strand displacement can take place in the context of DNA triplexes, slowly.

Graphical abstract: Can strand displacement take place in DNA triplexes?
From the themed collection: Chemical biology in OBC
Communication

An intramolecular tryptophan-condensation approach for peptide stapling

Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at C2 position of the indole moieties via acid-mediated condensation with an aldehyde.

Graphical abstract: An intramolecular tryptophan-condensation approach for peptide stapling
From the themed collection: Chemical biology in OBC
Communication

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability

Different ways to get peptides into cells.

Graphical abstract: Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability
From the themed collection: Chemical biology in OBC
Communication

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities.

Graphical abstract: Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries
From the themed collection: Chemical biology in OBC
Open Access Communication

Automated glycan assembly of galactosylated xyloglucan oligosaccharides and their recognition by plant cell wall glycan-directed antibodies

Automated glycan assembly enabled the synthesis of galactosylated xyloglucan oligosaccharides from the plant cell wall. The synthetic glycans were differentially recognized by a number of xyloglucan-directed antibodies.

Graphical abstract: Automated glycan assembly of galactosylated xyloglucan oligosaccharides and their recognition by plant cell wall glycan-directed antibodies
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Paper

Identifying a novel anticancer agent with microtubule-stabilizing effects through computational cell-based bioactivity prediction models and bioassays

From the themed collection: Chemical biology in OBC
Accepted Manuscript - Paper

Mechanistic Characterization of Three Sesquiterpene Synthases from the Termite-Associated Fungus Termitomyces

From the themed collection: Biosynthesis
Accepted Manuscript - Paper

Characterization of the Flavin Monooxygenase Involved in Biosynthesis of the Antimalarial FR-900098

From the themed collection: Biosynthesis
Paper

DNA dumbbell tiles with uneven widths for 2D arrays

DNA dumbbell tiles of AO(E) and BO(E), with stem spans of 11 and 16 bp twisting two head loop motifs of each tile into parallel and antiparallel conformations respectively, were constructed to grow planar nanoribbon arrays and nanotubes as well.

Graphical abstract: DNA dumbbell tiles with uneven widths for 2D arrays
From the themed collection: Chemical biology in OBC
Paper

Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist

Through chemical synthesis we have designed out the toxicity associated with the powerful vaccine adjuvant α-GalCer.

Graphical abstract: Enhancing T cell responses and tumour immunity by vaccination with peptides conjugated to a weak NKT cell agonist
From the themed collection: Chemical biology in OBC
199 items - Showing page 1 of 3

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The latest articles published in Organic and Biomolecular Chemistry related to chemical biology research.

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