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Themed collection Chemical biology in OBC

145 items - Showing page 1 of 3
Perspective

From pirates and killers: does metabolite diversity drive bacterial competition?

This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.

Graphical abstract: From pirates and killers: does metabolite diversity drive bacterial competition?
Review Article

Azobenzene-based small molecular photoswitches for protein modulation

This review highlights the design strategies of azobenzene photoswitches as well as their applications in the manipulation of biological systems.

Graphical abstract: Azobenzene-based small molecular photoswitches for protein modulation
From the themed collection: Chemical biology in OBC
Review Article

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Rearranged ergostane-type natural products are structurally intriguing and exhibit biologically relevant properties.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
From the themed collection: New Talent
Review Article

Lasso peptides: chemical approaches and structural elucidation

The diverse functionality and the extraordinary stability of lasso peptides make these molecules attractive scaffolds for drug discovery. The ability to generate lasso peptides chemically remains a challenging endeavor.

Graphical abstract: Lasso peptides: chemical approaches and structural elucidation
From the themed collection: Chemical biology in OBC
Review Article

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. In this review, we describe the isolation and biosynthetic studies of teleocidins.

Graphical abstract: Biosynthesis of the teleocidin-type terpenoid indole alkaloids
From the themed collection: Chemical biology in OBC
Review Article

The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions

Nucleic acids, phospholipids and other organic phosphates play central roles in biological pathways.

Graphical abstract: The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions
From the themed collection: Chemical biology in OBC
Review Article

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Participation of Z DNA in normal and disease related biological processes.

Graphical abstract: C8-Guanine modifications: effect on Z-DNA formation and its role in cancer
From the themed collection: Chemical biology in OBC
Review Article

Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals

C-Glycosylation has found widespread use in the synthesis of biomedically important natural products and pharmaceuticals.

Graphical abstract: Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals
From the themed collection: Chemical biology in OBC
Review Article

Target specificity of mammalian DNA methylation and demethylation machinery

We review here the molecular mechanisms employed by DNMTs and TET enzymes that are responsible for shaping the DNA methylation pattern of a mammalian cell.

Graphical abstract: Target specificity of mammalian DNA methylation and demethylation machinery
From the themed collection: Chemical biology in OBC
Review Article

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

Within a decade of Merrifield's seminal description of solid-phase peptide synthesis, the synergies between solid-phase approaches and flow synthesis were noted by a number of groups.

Graphical abstract: The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches
From the themed collection: Chemical biology in OBC
Open Access Review Article

Negishi cross-couplings in the synthesis of amino acids

The application of the Negishi cross-coupling reaction in the synthesis of amino acids is reviewed.

Graphical abstract: Negishi cross-couplings in the synthesis of amino acids
From the themed collection: Chemical biology in OBC
Review Article

25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science

This review highlights the synthesis, biophysical properties, and wide range of applications of oligonucleotides modified with 2′-O-(pyren-1-yl)methyl-RNA monomers reported over the past 25 years.

Graphical abstract: 25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Communication

Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA

From the themed collection: New Talent
Communication

Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect

PEGylation + stapling contributes more to conformational stability when the two linked sites are close in tertiary structure but far apart in primary sequence.

Graphical abstract: Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect
From the themed collection: Chemical biology in OBC
Communication

Iron(III) chloride-catalyzed activation of glycosyl chlorides

Glycosyl chlorides can be readily activated with 20 mol% of FeCl3.

Graphical abstract: Iron(iii) chloride-catalyzed activation of glycosyl chlorides
From the themed collection: Chemical biology in OBC
Communication

Synthesis and potassium KV7 channel opening activity of thioether analogues of the analgesic flupirtine

Benign by design: active sulfide-analogues of potassium channel opener flupirtine do not form reactive oxidation products in vitro.

Graphical abstract: Synthesis and potassium KV7 channel opening activity of thioether analogues of the analgesic flupirtine
From the themed collection: Chemical biology in OBC
Communication

Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides

A squaramide derivative bearing a coumarin fluorophore and a morpholinyl group was synthesized and found to be able to target and efficiently deacidify lysosomes.

Graphical abstract: Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides
From the themed collection: Chemical biology in OBC
Communication

Fluorogenic “photoclick” labelling of DNA using a Cy3 dye

Two 2′-deoxyuridines as new building blocks for automated DNA synthesis carry a small aryltetrazole as a “photoclickable” group at their 5-positions.

Graphical abstract: Fluorogenic “photoclick” labelling of DNA using a Cy3 dye
From the themed collection: Chemical biology in OBC
Communication

Synthesis of the β-linked GalNAc-Kdo disaccharide antigen of the capsular polysaccharide of Kingella kingae KK01

TfOH-catalyzed glycosylation with D-galactosaminyl N-phenyl trifluoroacetimidate as the donor was developed for the construction of the challenging β-(1 → 5)-linked GalNAc-Kdo disaccharide antigen from Kingella kingae KK01.

Graphical abstract: Synthesis of the β-linked GalNAc-Kdo disaccharide antigen of the capsular polysaccharide of Kingella kingae KK01
From the themed collection: Chemical biology in OBC
Communication

Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential

We present the functional characterization of GlbB, a lysine 4-hydroxylase from the glidobactin biosynthetic gene cluster.

Graphical abstract: Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential
From the themed collection: New Talent
Communication

Azlactone-based heterobifunctional linkers with orthogonal clickable groups: efficient tools for bioconjugation with complete atom economy

New azlactone-based heterobifunctional linkers that proceed in orthogonal click-like reactions for chemical ligations in biologically relevant medium without releasing any byproduct.

Graphical abstract: Azlactone-based heterobifunctional linkers with orthogonal clickable groups: efficient tools for bioconjugation with complete atom economy
From the themed collection: Chemical biology in OBC
Open Access Communication

A pendant peptide endows a sunscreen with water-resistance

A small-molecule UV-filter with a pendant collagen mimetic peptide anneals to a collagen-laden surface and protects against UV radiation.

Graphical abstract: A pendant peptide endows a sunscreen with water-resistance
Open Access Communication

The study of multivalent carbohydrate–protein interactions by bio-layer interferometry

Bio-layer interferometry is an excellent method to evaluate multivalent carbohydrate–protein interactions.

Graphical abstract: The study of multivalent carbohydrate–protein interactions by bio-layer interferometry
From the themed collection: Chemical biology in OBC
Communication

Stereoselective synthesis of sugar-fused (or 1,2-annulated) isochromans and isochromanones by using oxa-Pictet–Spengler reaction

We report the utility of the oxa-Pictet–Spengler reaction in carbohydrates for stereoselective synthesis of sugar fused 1,2-annulated isochromans in good to excellent yields.

Graphical abstract: Stereoselective synthesis of sugar-fused (or 1,2-annulated) isochromans and isochromanones by using oxa-Pictet–Spengler reaction
From the themed collection: Chemical biology in OBC
Communication

Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry

Two novel cyclic quaternary amine crosslinking probes are synthesized for structural mass spectrometry of protein complexes in solution and for analysis of protein interactions in organellar and whole cell extracts.

Graphical abstract: Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry
From the themed collection: Chemical biology in OBC
Communication

Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors

The synthesis of novel disaccharide nucleoside analogues that resemble the central motif of poly(ADP-ribose) was developed and it was found that some of them show inhibitory effects on human poly(ADP-ribose) polymerase-1.

Graphical abstract: Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors
From the themed collection: Chemical biology in OBC
Communication

Two-step activity-based protein profiling of diacylglycerol lipase

Diacylglycerol lipases (DAGL) produce the endocannabinoid 2-arachidonoylglycerol, a key modulator of neurotransmitter release.

Graphical abstract: Two-step activity-based protein profiling of diacylglycerol lipase
Communication

Sterically shielded tetrazoles for a fluorogenic photoclick reaction: tuning cycloaddition rate and product fluorescence

We report the reactivity and fluorescence studies of a panel of sterically shielded tetrazoles with different N-aryl groups in the fluorogenic photoclick reaction with spiro[2.3]hex-1-ene.

Graphical abstract: Sterically shielded tetrazoles for a fluorogenic photoclick reaction: tuning cycloaddition rate and product fluorescence
From the themed collection: Chemical biology in OBC
Communication

Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition.

Graphical abstract: Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89
From the themed collection: Chemical biology in OBC
Communication

The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε

The first example of a counterintuitive freezing-induced peptide ligation was discovered during the total synthesis of human interferon-ε (187 amino acids) which blocks HIV infection through unique mechanisms.

Graphical abstract: The discovery of a freezing-induced peptide ligation during the total chemical synthesis of human interferon-ε
From the themed collection: Chemical biology in OBC
Communication

Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens

Highly efficient streamlined total synthesis of complex prioritized gangliosides was achieved chemoenzymatically by sequential one-pot multienzyme (OPME) reactions with facile C18 cartridge purification schemes followed by high-yield acylation.

Graphical abstract: Streamlined chemoenzymatic total synthesis of prioritized ganglioside cancer antigens
From the themed collection: Chemical biology in OBC
Communication

Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu.

Graphical abstract: Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites
From the themed collection: Chemical biology in OBC
Communication

In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product

A new bilirubin degradation end product was isolated and characterized.

Graphical abstract: In vivo and in vitro identification of Z-BOX C – a new bilirubin oxidation end product
Communication

Secondary amine salt catalyzed controlled activation of 2-deoxy sugar lactols towards alpha-selective dehydrative glycosylation

An organocatalytic alpha-selective dehydrative glycosylation method for the synthesis of 2-deoxyglycosides.

Graphical abstract: Secondary amine salt catalyzed controlled activation of 2-deoxy sugar lactols towards alpha-selective dehydrative glycosylation
From the themed collection: Chemical biology in OBC
Communication

Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA

In this paper, we report the development of a new G-4 alkylating molecule and the evaluation of the properties of the alkylated G-4 DNA.

Graphical abstract: Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA
From the themed collection: Chemical biology in OBC
Communication

A double-click approach to the protecting group free synthesis of glycoconjugates

The use of a bi-functional linker, containing an alkyne and an alkene, allows the protecting group free conjugation of reducing sugars to thiols via a double click process.

Graphical abstract: A double-click approach to the protecting group free synthesis of glycoconjugates
From the themed collection: Chemical biology in OBC
Communication

Can strand displacement take place in DNA triplexes?

Toehold-mediated strand displacement can take place in the context of DNA triplexes, slowly.

Graphical abstract: Can strand displacement take place in DNA triplexes?
From the themed collection: Chemical biology in OBC
Communication

An intramolecular tryptophan-condensation approach for peptide stapling

Stapled peptides are gaining tremendous interest as next-generation therapeutic agents to target protein–protein interactions. Herein, we report an intramolecular peptide stapling method which links two tryptophan residues at C2 position of the indole moieties via acid-mediated condensation with an aldehyde.

Graphical abstract: An intramolecular tryptophan-condensation approach for peptide stapling
From the themed collection: Chemical biology in OBC
Communication

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability

Different ways to get peptides into cells.

Graphical abstract: Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability
From the themed collection: Chemical biology in OBC
Communication

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities.

Graphical abstract: Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries
From the themed collection: Chemical biology in OBC
Open Access Communication

Automated glycan assembly of galactosylated xyloglucan oligosaccharides and their recognition by plant cell wall glycan-directed antibodies

Automated glycan assembly enabled the synthesis of galactosylated xyloglucan oligosaccharides from the plant cell wall. The synthetic glycans were differentially recognized by a number of xyloglucan-directed antibodies.

Graphical abstract: Automated glycan assembly of galactosylated xyloglucan oligosaccharides and their recognition by plant cell wall glycan-directed antibodies
From the themed collection: Chemical biology in OBC
Paper

Compatibility between the cysteine-cyclopentenedione reaction and the copper(I)-catalyzed azide–alkyne cycloaddition

The cysteine-cyclopentenedione reaction and CuAAC can be combined for double conjugation provided that the former is carried out firstly.

Graphical abstract: Compatibility between the cysteine-cyclopentenedione reaction and the copper(i)-catalyzed azide–alkyne cycloaddition
From the themed collection: Chemical biology in OBC
Paper

pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism

PKS dehydratases utilize a one-base mechanism.

Graphical abstract: pH-Rate profiles establish that polyketide synthase dehydratase domains utilize a single-base mechanism
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Paper

Identification of Thienopyridine Carboxamides as Selective Binders of HIV-1 Trans Activation Response (TAR) and Rev Response Element (RRE) RNAs

From the themed collection: Chemical biology in OBC
Accepted Manuscript - Paper

Syntheses and in vitro biological evaluation of new S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primate

From the themed collection: Chemical biology in OBC
Paper

New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus

Chemical investigation of Aspergillus terreus resulted in the identification of terreusterpenes A–D with potential BACE1 and AchE inhibitory activities.

Graphical abstract: New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus
From the themed collection: Chemical biology in OBC
Paper

Covalent capture of OGT's active site using engineered human-E. coli chimera and intrastrand DNA cross-links

Intrastrand crosslinked DNA has been shown to react with an AGT variant to produce well-defined protein–DNA conjugates.

Graphical abstract: Covalent capture of OGT's active site using engineered human-E. coli chimera and intrastrand DNA cross-links
From the themed collection: Chemical biology in OBC
Paper

Porphyrin–ferrocene conjugates for photodynamic and chemodynamic therapy

Porphyrin–ferrocene conjugates were designed and synthesized for photodynamic and chemodynamic therapy.

Graphical abstract: Porphyrin–ferrocene conjugates for photodynamic and chemodynamic therapy
From the themed collection: Chemical biology in OBC
Paper

Expedient synthesis of trifunctional oligoethyleneglycol-amine linkers and their use in the preparation of PEG-based branched platforms

Reductive azide dimerization provides access to trifunctional OEG-amine linkers which were employed in coupling reactions to afford multifunctional discrete PEG-branched dendrons.

Graphical abstract: Expedient synthesis of trifunctional oligoethyleneglycol-amine linkers and their use in the preparation of PEG-based branched platforms
From the themed collection: Chemical biology in OBC
Paper

Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors

Gold glyconanoparticles (Au GNPs) decorated with the natural iminosugar DAB-1 at different densities are reported.

Graphical abstract: Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Paper

Aminoluciferin 4-Hydroxyphenyl Amide Enables Bioluminescence Detection of Endogenous Tyrosinase

From the themed collection: Chemical biology in OBC
Paper

Site-specific near-infrared fluorescent labelling of proteins on cysteine residues with meso-chloro-substituted heptamethine cyanine dyes

meso-Chloroheptamethine cyanine dyes react selectively with cysteine residues in proteins to give site-specifically labelled NIR fluorescent bioconjugates.

Graphical abstract: Site-specific near-infrared fluorescent labelling of proteins on cysteine residues with meso-chloro-substituted heptamethine cyanine dyes
From the themed collection: Chemical biology in OBC
Paper

RNA-based boronate internucleosidic linkages: an entry into reversible templated ligation and loop formation

The synthesis of a 5′-boronoribonucleotidic phosphoramidite building block has been achieved and incorporated at the 5′ extremities of RNA sequences for the templated assembly of RNA shortmers.

Graphical abstract: RNA-based boronate internucleosidic linkages: an entry into reversible templated ligation and loop formation
From the themed collection: Chemical biology in OBC
Paper

Synthesis and mass spectrometric analysis of disaccharides from methanolysis of heparan sulfate

Heparan sulfate (HS) disaccharides were synthesized to identify HS methanolysis products by LC-MS/MS with applications for mucopolysaccharidosis disorders.

Graphical abstract: Synthesis and mass spectrometric analysis of disaccharides from methanolysis of heparan sulfate
From the themed collection: Chemical biology in OBC
Paper

Potent anti-proliferative activities of organochalcogenocyanates towards breast cancer

The synthesis of benzylic and mesitylenic organochalcogenocyanates has been described and the compounds have been studied for their anti-proliferative activities in breast cancer cells (MDA-MB-231, MCF-7 and T-47D).

Graphical abstract: Potent anti-proliferative activities of organochalcogenocyanates towards breast cancer
From the themed collection: Chemical biology in OBC
Paper

Tetraphenylethylene-based glycoclusters with aggregation-induced emission (AIE) properties as high-affinity ligands of bacterial lectins

TPE-based glycoclusters are fluorescent through aggregation induced emission (AIE) in water.

Graphical abstract: Tetraphenylethylene-based glycoclusters with aggregation-induced emission (AIE) properties as high-affinity ligands of bacterial lectins
From the themed collection: Chemical biology in OBC
Paper

A novel peptide dendrimer LTP efficiently facilitates transfection of mammalian cells

An arginine-rich peptide dendrimer, LTP, is a new low-toxicity promising tool for intracellular gene delivery.

Graphical abstract: A novel peptide dendrimer LTP efficiently facilitates transfection of mammalian cells
From the themed collection: Chemical biology in OBC
Paper

Syntheses and anti-cancer activity of CO-releasing molecules with targeting galactose receptors

A series of CORMs based on carbohydrates were evaluated for their anti-tumor activities and the antitumor mechanism.

Graphical abstract: Syntheses and anti-cancer activity of CO-releasing molecules with targeting galactose receptors
From the themed collection: Chemical biology in OBC
Paper

Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum

Fifteen new polycyclic polyprenylated acylphloroglucinols with dual-targeted inhibitory activities for Alzheimer's disease, were isolated from Hypericum perforatum.

Graphical abstract: Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum
From the themed collection: Chemical biology in OBC
Open Access Paper

Non-invasive 19F NMR analysis of a protein-templated N-acylhydrazone dynamic combinatorial library

Dynamic combinatorial chemistry (DCC) is a powerful tool to identify ligands for biological targets.

Graphical abstract: Non-invasive 19F NMR analysis of a protein-templated N-acylhydrazone dynamic combinatorial library
From the themed collection: Chemical biology in OBC
Paper

Immune responses against Lewis Y tumor-associated carbohydrate antigen displayed densely on self-assembling nanocarriers

Immune responses against Lewis Y (LY) displayed at varying densities on the nanocarriers were studied.

Graphical abstract: Immune responses against Lewis Y tumor-associated carbohydrate antigen displayed densely on self-assembling nanocarriers
From the themed collection: Chemical biology in OBC
Open Access Paper

Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer

We present a highly-specific, rapidly activatable dual-FRET-smartprobe for the independent optical detection of metalloproteinases and thrombin in lung cancer tissue.

Graphical abstract: Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer
From the themed collection: Chemical biology in OBC
Paper

Anti-inflammatory fusicoccane-type diterpenoids from the phytopathogenic fungus Alternaria brassicicola

Eight undescribed fusicoccane-type diterpenoids (1–8), wherein 1 had a rare 16-nor-dicyclopenta[a,d]cyclooctane skeleton, were isolated from Alternaria brassicicola.

Graphical abstract: Anti-inflammatory fusicoccane-type diterpenoids from the phytopathogenic fungus Alternaria brassicicola
From the themed collection: Chemical biology in OBC
Paper

Self-assembled micro-fibres by oxime connection of linear peptide amphiphiles

The oxime connection between linear peptides and hydrophobic aldehydes affords amphiphiles that are excellent biocompatible scaffolds for the hierarchical self-assembly of nano and micro fibrillar structures in aqueous media.

Graphical abstract: Self-assembled micro-fibres by oxime connection of linear peptide amphiphiles
From the themed collection: Chemical biology in OBC
Paper

Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases

Xyloglucan (XyG) is a complex polysaccharide that is ubiquitous and often abundant in the cell walls of terrestrial plants.

Graphical abstract: Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases
From the themed collection: Chemical biology in OBC
Paper

Sulfono-γ-AA modified peptides that inhibit HIV-1 fusion

Peptide 4 with sulfono-γ-AA1 (γK) substitution and hydrocarbon stapling exhibited potent anti-HIV activity and improved biostability.

Graphical abstract: Sulfono-γ-AA modified peptides that inhibit HIV-1 fusion
From the themed collection: Chemical biology in OBC
Paper

A novel peptide conformation: the γ-bend ribbon

Conformational analysis of oligopeptides based on the repeating –(S)-(αMe)Aze-(S)-Ala– dyad allowed the characterization of a 3D-structure featuring multiple, non-consecutive γ-bends.

Graphical abstract: A novel peptide conformation: the γ-bend ribbon
From the themed collection: Chemical biology in OBC
Paper

Specific protein-labeling and ligand-binding position analysis with amidopyrene probes as LDI MS tags

Ligand-dissociation type amidopyrene probes, being useful for LDI MS, were developed for specific protein-labeling and ligand-binding position analysis.

Graphical abstract: Specific protein-labeling and ligand-binding position analysis with amidopyrene probes as LDI MS tags
From the themed collection: Chemical biology in OBC
Paper

Tetraphenylethylene conjugated p-hydroxyphenacyl: fluorescent organic nanoparticles for the release of hydrogen sulfide under visible light with real-time cellular imaging

Hydrogen sulfide (H2S) behaves like a two-edged sword, at low concentrations it has beneficial and cytoprotective effects, while at higher concentrations it exhibits toxicity.

Graphical abstract: Tetraphenylethylene conjugated p-hydroxyphenacyl: fluorescent organic nanoparticles for the release of hydrogen sulfide under visible light with real-time cellular imaging
From the themed collection: Chemical biology in OBC
Paper

A highly HDAC6-selective inhibitor acts as a fluorescent probe

HDAC6 receives great attention because of its therapeutic potential for the treatment of various diseases.

Graphical abstract: A highly HDAC6-selective inhibitor acts as a fluorescent probe
From the themed collection: Chemical biology in OBC
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The latest articles published in Organic and Biomolecular Chemistry related to chemical biology research.

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