Jump to main content
Jump to site search

Themed collection Chemical Biology in OBC

644 items - Showing page 1 of 10
Perspective

From pirates and killers: does metabolite diversity drive bacterial competition?

This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.

Graphical abstract: From pirates and killers: does metabolite diversity drive bacterial competition?
From the themed collection: Chemical Biology in OBC
Review Article

Antitumor activity of tridentate pincer and related metal complexes

Pincer and related metal complexes containing tunable tridentate ligand frameworks display promising antitumor activity.

Graphical abstract: Antitumor activity of tridentate pincer and related metal complexes
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Asparaginyl endopeptidases: enzymology, applications and limitations

The potentials of using asparaginyl endopeptidases (AEP) as tools for polypeptide modifications have been discussed.

Graphical abstract: Asparaginyl endopeptidases: enzymology, applications and limitations
From the themed collection: Chemical Biology in OBC
Review Article

Optically superior fluorescent probes for selective imaging of cells, tumors, and reactive chemical species

Fluorescent probes with superior optical properties have been summarized along with the mechanisms used for their development and the challenges faced in their synthesis.

Graphical abstract: Optically superior fluorescent probes for selective imaging of cells, tumors, and reactive chemical species
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Chemical probes targeting the kinase CK2: a journey outside the catalytic box

An up-to-date and comprehensive review on chemical probes targeting the important kinase CK2.

Graphical abstract: Chemical probes targeting the kinase CK2: a journey outside the catalytic box
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Approaches for peptide and protein cyclisation

Polypeptide cyclisation can enhance thermal stability, proteolytic resistance and membrane permeability. Cyclisation can be achieved by methods including chemical, enzyme and protein tag approaches. Each has strengths and limitations.

Graphical abstract: Approaches for peptide and protein cyclisation
From the themed collection: Chemical Biology in OBC
Review Article

Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions

This review summarizes the recent findings and developments in the emerging area of (chemo)-enzymatic cascades using MTases and AdoMet-generating enzymes.

Graphical abstract: Harnessing methylation and AdoMet-utilising enzymes for selective modification in cascade reactions
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Metabolic labeling probes for interrogation of the host–pathogen interaction

Metabolic labeling of intracellular pathogens can provide new methods of studying host pathogen interactions.

Graphical abstract: Metabolic labeling probes for interrogation of the host–pathogen interaction
From the themed collection: Chemical Biology in OBC
Review Article

Chemistry and biology of spiroacetals from myxobacteria

This review details the isolation, biosynthesis, biological activity and synthesis of spiroacetals from the myxobacterium Sorangium cellulosum.

Graphical abstract: Chemistry and biology of spiroacetals from myxobacteria
From the themed collection: Chemical Biology in OBC
Review Article

Artificial enzymes bringing together computational design and directed evolution

This manuscript reviews the combination of computational enzyme design and directed evolution and its advantages in the development of artificial enzymes.

Graphical abstract: Artificial enzymes bringing together computational design and directed evolution
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Silicon phthalocyanines: synthesis and resurgent applications

Their unique axial bonds and NIR optical properties have made silicon phthalocyanines (SiPcs) valuable compounds. Herein, we present key synthetic strategies and emerging applications of SiPcs over the past decade.

Graphical abstract: Silicon phthalocyanines: synthesis and resurgent applications
From the themed collection: Chemical Biology in OBC
Review Article

Recent advances in the direct O-arylation of carbohydrates

An emerging approach for the synthesis of O-aryl glycosides and carbohydrate-derived aryl ethers via C(sp2)–O bond formation is reviewed.

Graphical abstract: Recent advances in the direct O-arylation of carbohydrates
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Recent highlights of biosynthetic studies on marine natural products

Marine bacteria are excellent yet often underexplored sources of structurally unique bioactive natural products.

Graphical abstract: Recent highlights of biosynthetic studies on marine natural products
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Glycosyl disulfides: importance, synthesis and application to chemical and biological systems

This review explores methodologies for the preparation of glycosyl disulfides, their utility as intermediates in carbohydrate synthesis, and evaluates their biological impact in glycoscience and beyond.

Graphical abstract: Glycosyl disulfides: importance, synthesis and application to chemical and biological systems
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Tyrosine bioconjugation – an emergent alternative

A review of the heretofore less explored approach of tyrosine bioconjugation, which is rapidly becoming a constructive alternative/complement to the more well-established strategies, is provided.

Graphical abstract: Tyrosine bioconjugation – an emergent alternative
From the themed collection: Chemical Biology in OBC
Review Article

Recent advances in the synthesis of C-terminally modified peptides

A go-to compilation of recent strategies to access C-terminally modified peptides contextualized by a discussion of the major synthetic challenges that have historically hampered progress in this area.

Graphical abstract: Recent advances in the synthesis of C-terminally modified peptides
From the themed collection: Chemical Biology in OBC
Review Article

Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria

This review discusses the development of peptide-based quorum sensing modulators and their use as potential therapeutics.

Graphical abstract: Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria
From the themed collection: Chemical Biology in OBC
Review Article

Rational design of small molecule fluorescent probes for biological applications

Guidelines based on photophysical tuning, reactivity, isomerization, and energy transfer for rational design of synthetic fluorescent probes for biological systems.

Graphical abstract: Rational design of small molecule fluorescent probes for biological applications
From the themed collection: Chemical Biology in OBC
Review Article

Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation

This review summarizes the natural and synthetic glycan ligands of Siglecs and the growing body of knowledge for structural features governing sialic acid recognition.

Graphical abstract: Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation
From the themed collection: Chemical Biology in OBC
Review Article

The curious yellow colouring matter of the Iceland poppy

This account provides an chronological overview of the fascinating history of the pigment responsible for the yellow colour of the Iceland poppy (Papaver nudicaule).

Graphical abstract: The curious yellow colouring matter of the Iceland poppy
From the themed collection: Chemical Biology in OBC
Review Article

TLR2 agonists and their structure–activity relationships

We review the structure–activity relationships and synthetic studies of TLR2 agonists – important chemical targets in immunotherapy.

Graphical abstract: TLR2 agonists and their structure–activity relationships
From the themed collection: Chemical Biology in OBC
Review Article

Recent development in the synthesis of C-glycosides involving glycosyl radicals

C-Glycosylation involving glycosyl radical intermediates is a particularly effective approach to access C-glycosides, which are core units of a great number of natural products, bioactive compounds and marketed drugs.

Graphical abstract: Recent development in the synthesis of C-glycosides involving glycosyl radicals
From the themed collection: Chemical Biology in OBC
Review Article

Chemical methods for modification of proteins

The field of protein bioconjugation draws attention from stakeholders in chemistry, biology, and medicine. This review provides an overview of the present status, challenges, and opportunities for organic chemists.

Graphical abstract: Chemical methods for modification of proteins
From the themed collection: Chemical Biology in OBC
Review Article

Enzymatic glycosylation involving fluorinated carbohydrates

This contribution reviews the enzymatic synthesis, including optimisation efforts, of fluorinated carbohydrates involving fluorinated donors and/or acceptors, as well as the enzymatic activation of the fluorinated donors.

Graphical abstract: Enzymatic glycosylation involving fluorinated carbohydrates
From the themed collection: Chemical Biology in OBC
Review Article

Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms

Advances in the synthesis of multiphosphorylated peptides and peptide libraries: tools for studying the effects of phosphorylation patterns on protein function and regulation.

Graphical abstract: Multiphosphorylated peptides: importance, synthetic strategies, and applications for studying biological mechanisms
From the themed collection: Chemical Biology in OBC
Review Article

Recent advances in β-L-rhamnosylation

This review describes various methodologies for the stereoselective 1,2-cis glycosylation of L-rhamnose leading to β-L-rhamnosides and their applications in oligosaccharide synthesis.

Graphical abstract: Recent advances in β-l-rhamnosylation
From the themed collection: Chemical Biology in OBC
Review Article

Synthesis of trehalose glycolipids

Chemical synthesis of trehalose glycolipids such as DAT, TDM, SL-1, SL-3, and Ac2SGL from MTb, emmyguyacins from fungi, succinoyl trehalose from rhodococcus, and maradolipids from worms, as well as mycobacterial oligosaccharides is reviewed.

Graphical abstract: Synthesis of trehalose glycolipids
From the themed collection: Chemical Biology in OBC
Review Article

Structure elucidation of bacterial nonribosomal lipopeptides

We provide a summary of the tools, which allow elucidate the structures of nonribosomal lipopetides.

Graphical abstract: Structure elucidation of bacterial nonribosomal lipopeptides
From the themed collection: Chemical Biology in OBC
Review Article

Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme

The review examines functional knowledge gathered over two decades of research on the 8-17 DNAzyme, focusing on three aspects: the structural requirements for catalysis, the role of metal ions and the participation of general acid-base catalysis.

Graphical abstract: Insights into DNA catalysis from structural and functional studies of the 8-17 DNAzyme
From the themed collection: Chemical Biology in OBC
Review Article

Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective

This review surveys known structures of staphylococcal polysaccharides and summarizes all synthetic efforts to obtain these sequences.

Graphical abstract: Staphylococcus aureus capsular polysaccharides: a structural and synthetic perspective
From the themed collection: Chemical Biology in OBC
Review Article

Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)

The nonulosonic acid sugar pseudaminic acid, Pse5Ac7Ac, is present on the surface of a number of human pathogens, herein we review the mechanistic and structural characterisation of the enzymes responsible for its biosynthesis in bacteria.

Graphical abstract: Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)
From the themed collection: Chemical Biology in OBC
Review Article

G-quadruplexes as versatile scaffolds for catalysis

This review summarizes the beginning, progress, and prospects of non-canonical DNA-based hybrid catalysts focusing on G-quadruplexes as versatile scaffolds for catalysis.

Graphical abstract: G-quadruplexes as versatile scaffolds for catalysis
From the themed collection: Chemical Biology in OBC
Review Article

Stabilization of the triple helix in collagen mimicking peptides

The review classifies existing chemical approaches towards stronger triple helical assemblies in peptides.

Graphical abstract: Stabilization of the triple helix in collagen mimicking peptides
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose

A review of recent advances towards synthetic ADP-ribosylated proteins and oligo-ADP-ribose chains.

Graphical abstract: Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose
From the themed collection: Chemical Biology in OBC
Review Article

Synthetic strategies for fluorination of carbohydrates

Different synthetic strategies for accomplishing regio- and stereoselective fluorinations of carbohydrate scaffolds are discussed in light of the biological implications arising from such substitutions.

Graphical abstract: Synthetic strategies for fluorination of carbohydrates
From the themed collection: Synthetic methodology in OBC
Review Article

Synthesis of carbohydrate building blocks via regioselective uniform protection/deprotection strategies

Scope 1: sugar is uniformly protected leaving only one (or two) free hydroxyl group; scope 2: uniformly protected sugar is deprotected to liberate only one (or two) hydroxyl group.

Graphical abstract: Synthesis of carbohydrate building blocks via regioselective uniform protection/deprotection strategies
From the themed collection: Chemical Biology in OBC
Review Article

Chemical composition of DNA-encoded libraries, past present and future

We discuss here the chemical composition of DNA-encoded libraries likely to be made in the near future.

Graphical abstract: Chemical composition of DNA-encoded libraries, past present and future
From the themed collection: Chemical Biology in OBC
Review Article

Versatility of glycals in synthetic organic chemistry: coupling reactions, diversity oriented synthesis and natural product synthesis

Versatility of glycals in the stereoselective synthesis of natural products.

Graphical abstract: Versatility of glycals in synthetic organic chemistry: coupling reactions, diversity oriented synthesis and natural product synthesis
From the themed collection: Chemical Biology in OBC
Review Article

Saturated bioisosteres of benzene: where to go next?

Saturated bioisosteres for ortho- and meta-substituted benzenes remain a current challenge for chemists.

Graphical abstract: Saturated bioisosteres of benzene: where to go next?
From the themed collection: Chemical Biology in OBC
Review Article

The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

Tailoring enzymes decorate diketopiperazines to yield unique structures and biological functions.

Graphical abstract: The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases
From the themed collection: Chemical Biology in OBC
Review Article

Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials

Peptide–oligonucleotide conjugates (POCs) are covalent constructs that link a molecule like DNA to a synthetic peptide sequences.

Graphical abstract: Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials
From the themed collection: Chemical Biology in OBC
Review Article

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Rearranged ergostane-type natural products are structurally intriguing and exhibit biologically relevant properties.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
From the themed collection: Chemical Biology in OBC
Review Article

One-pot multi-segment condensation strategies for chemical protein synthesis

This paper describes recent advances of one-pot multi-segment condensation strategies based on kinetically controlled strategies and/or protecting group-removal strategies in chemical protein synthesis.

Graphical abstract: One-pot multi-segment condensation strategies for chemical protein synthesis
From the themed collection: Chemical Biology in OBC
Open Access Review Article

Fluorogenic probes for super-resolution microscopy

Fluorogenic probes efficiently reduce non-specific background signals, which often results in highly improved signal-to-noise ratios.

Graphical abstract: Fluorogenic probes for super-resolution microscopy
From the themed collection: Chemical Biology in OBC
Review Article

Azobenzene-based small molecular photoswitches for protein modulation

This review highlights the design strategies of azobenzene photoswitches as well as their applications in the manipulation of biological systems.

Graphical abstract: Azobenzene-based small molecular photoswitches for protein modulation
From the themed collection: Chemical Biology in OBC
Review Article

Lasso peptides: chemical approaches and structural elucidation

The diverse functionality and the extraordinary stability of lasso peptides make these molecules attractive scaffolds for drug discovery. The ability to generate lasso peptides chemically remains a challenging endeavor.

Graphical abstract: Lasso peptides: chemical approaches and structural elucidation
From the themed collection: Chemical Biology in OBC
Review Article

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. In this review, we describe the isolation and biosynthetic studies of teleocidins.

Graphical abstract: Biosynthesis of the teleocidin-type terpenoid indole alkaloids
From the themed collection: Chemical Biology in OBC
Review Article

The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions

Nucleic acids, phospholipids and other organic phosphates play central roles in biological pathways.

Graphical abstract: The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions
From the themed collection: Chemical Biology in OBC
Review Article

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Participation of Z DNA in normal and disease related biological processes.

Graphical abstract: C8-Guanine modifications: effect on Z-DNA formation and its role in cancer
From the themed collection: Chemical Biology in OBC
Review Article

Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals

C-Glycosylation has found widespread use in the synthesis of biomedically important natural products and pharmaceuticals.

Graphical abstract: Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals
From the themed collection: Chemical Biology in OBC
Open Access Communication

A promiscuous glycosyltransferase generates poly-β-1,4-glucan derivatives that facilitate mass spectrometry-based detection of cellulolytic enzymes

Promiscuous activity of a glycosyltransferase was exploited to polymerise glucose from UDP-glucose via the generation of β-1,4-glycosidic linkages.

Graphical abstract: A promiscuous glycosyltransferase generates poly-β-1,4-glucan derivatives that facilitate mass spectrometry-based detection of cellulolytic enzymes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Preparation and characterization of glycopolymers with biphenyl spacers via Suzuki coupling reaction

Glycopolymers were prepared using living radical polymerization and catalytic reaction. Glycopolymers with biphenyl spacers had specific protein-binding ability and fluorescence.

Graphical abstract: Preparation and characterization of glycopolymers with biphenyl spacers via Suzuki coupling reaction
From the themed collection: Chemical Biology in OBC
Communication

Plasma induced acceleration and selectivity in strain-promoted azide–alkyne cycloadditions

We report the unexpected acceleration of strain-promoted azide–alkyne cycloaddition in human plasma compared to classical solvent systems. Besides fast kinetics, human plasma also allows for discrimination between two azides in competition reaction.

Graphical abstract: Plasma induced acceleration and selectivity in strain-promoted azide–alkyne cycloadditions
From the themed collection: Chemical Biology in OBC
Communication

Discovery of a new asymmetric dimer nenestatin B and implications of a dimerizing enzyme in a deep sea actinomycete

Isolation of NEN C from Δnes18 revealed the role of Nes18 in the biosynthesis of the asymmetric dimer NEN B.

Graphical abstract: Discovery of a new asymmetric dimer nenestatin B and implications of a dimerizing enzyme in a deep sea actinomycete
From the themed collection: Chemical Biology in OBC
Communication

A protecting group–free approach for synthesizing C-glycosides through glycosyl dithiocarbamates

The first protection/deprotection-free process for radical C-glycosylation has been achieved through one-step preparable glycosyl dithiocarbamates (GDTCs).

Graphical abstract: A protecting group–free approach for synthesizing C-glycosides through glycosyl dithiocarbamates
From the themed collection: Chemical Biology in OBC
Communication

An artificial ruthenium-containing β-barrel protein for alkene–alkyne coupling reaction

An artificial metalloprotein harboring an [(η5-pentamethylcyclopentadienyl)ruthenium(II)] catalyst for the alkene–alkyne coupling reaction was developed.

Graphical abstract: An artificial ruthenium-containing β-barrel protein for alkene–alkyne coupling reaction
From the themed collection: Chemical Biology in OBC
Communication

Selective alkylation of parallel G-quadruplex structure

We achieve selective alkylation of parallel G-quadruplex DNA using a conjugate of a macrocyclic hexaoxazole and a sulfoxide precursor to a vinyl-quinazolinone.

Graphical abstract: Selective alkylation of parallel G-quadruplex structure
From the themed collection: Chemical Biology in OBC
Communication

Investigating eosin Y as a photocatalyst for the radical-dependent activity-based probing of deubiquitinating enzymes

Assessment of the eosin Y initiated protein–protein thiol–ene reaction in a metal-free, oxygen-tolerant, visible-light mediated system.

Graphical abstract: Investigating eosin Y as a photocatalyst for the radical-dependent activity-based probing of deubiquitinating enzymes
From the themed collection: Chemical Biology in OBC
Communication

Cholesteryl glucosides signal through the carbohydrate recognition domain of the macrophage inducible C-type lectin (mincle)

H. pylori derived cholesteryl glycosides signal through the Carbohydrate Recognition Domain (CRD) of the Macrophage inducible C-type lectin (Mincle).

Graphical abstract: Cholesteryl glucosides signal through the carbohydrate recognition domain of the macrophage inducible C-type lectin (mincle)
From the themed collection: Chemical Biology in OBC
Communication

Genomics-driven discovery of a new cyclodepsipeptide from the guanophilic fungus Amphichorda guana

By genome mining and LC-MS analysis, a novel cyclodepsipeptide isaridin H (1) and seven known analogs were isolated and genetically identified from a guanophilic fungus Amphichorda guana.

Graphical abstract: Genomics-driven discovery of a new cyclodepsipeptide from the guanophilic fungus Amphichorda guana
From the themed collection: Chemical Biology in OBC
Communication

A DNA nanosensor for monitoring ligand-induced i-motif formation

A GNP-based DNA nanosensor has been developed that identifies i-motif inducing ligands at physiological pH from a chemical library.

Graphical abstract: A DNA nanosensor for monitoring ligand-induced i-motif formation
From the themed collection: Chemical Biology in OBC
Communication

Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications

We report the synthesis and initial biological assessment of a halogenated phenazine–erythromycin conjugate prodrug 5 aimed to treat bacterial infections.

Graphical abstract: Design, synthesis and biological evaluation of a halogenated phenazine-erythromycin conjugate prodrug for antibacterial applications
From the themed collection: Chemical Biology in OBC
Communication

Thermally reversible and irreversible interstrand photocrosslinking of 5-chloro-2′-deoxy-4-thiouridine modified DNA oligonucleotides

The interstrand photocrosslinking of a 5-chloro-2′-deoxy-4-thiouridine modified DNA oligonucleotide proceeds via a two-step photocascade involving the formation of a thermally reversible crosslink and its conversion to a stable fluorescent crosslink.

Graphical abstract: Thermally reversible and irreversible interstrand photocrosslinking of 5-chloro-2′-deoxy-4-thiouridine modified DNA oligonucleotides
From the themed collection: Chemical Biology in OBC
Communication

Clickable gold-nanoparticles as generic probe precursors for facile photoaffinity labeling application

Clickable photoreactive gold nanoparticles have been developed to facilitate one-step preparation of photoaffinity probes for bioactive small molecules and their application to target protein analysis.

Graphical abstract: Clickable gold-nanoparticles as generic probe precursors for facile photoaffinity labeling application
From the themed collection: Chemical Biology in OBC
Communication

Development and application of a high throughput assay system for the detection of Rieske dioxygenase activity

A new periodate-based reactive assay system enables the rapid evaluation of the cis-dihydroxylation activity of Rieske dioxygenase enzymes.

Graphical abstract: Development and application of a high throughput assay system for the detection of Rieske dioxygenase activity
From the themed collection: Chemical Biology in OBC
Communication

Synthesis and evaluation of sensitive coumarin-based fluorogenic substrates for discovery of α-N-acetyl galactosaminidases through droplet-based screening

Synthesis of sensitive coumarin α-GalNAc glycosides as substrates for droplet-based screening of GalNAcases.

Graphical abstract: Synthesis and evaluation of sensitive coumarin-based fluorogenic substrates for discovery of α-N-acetyl galactosaminidases through droplet-based screening
From the themed collection: Chemical Biology in OBC
Communication

Mechanistic divergence between (4S,7R)-germacra-(1(10)E,5E)-dien-11-ol synthases from Dictyostelium purpureum and Streptomyces coelicolor

The enzyme mechanism of germacradienol synthase DpTPS9 from Dictyostelium purpureum has been studied by labelling experiments and site-directed mutagenesis, and is different to the mechanism of geosmin synthase SCO6073 from Streptomyces coelicolor.

Graphical abstract: Mechanistic divergence between (4S,7R)-germacra-(1(10)E,5E)-dien-11-ol synthases from Dictyostelium purpureum and Streptomyces coelicolor
From the themed collection: Chemical Biology in OBC
Communication

Construction of an IMiD-based azide library as a kit for PROTAC research

As a promising protein degradation strategy, PROTAC technology is increasingly becoming a new star in cancer treatment.

Graphical abstract: Construction of an IMiD-based azide library as a kit for PROTAC research
From the themed collection: Chemical Biology in OBC
Communication

Structural elucidation, total synthesis, and cytotoxic activity of effphenol A

Effphenol A was isolated and elucidated through spectroscopic analysis together with single-crystal X-ray diffraction experiments and further confirmed by the first biomimetic total synthesis.

Graphical abstract: Structural elucidation, total synthesis, and cytotoxic activity of effphenol A
From the themed collection: Chemical Biology in OBC
Communication

Chemoselective activation of ethyl vs. phenyl thioglycosides: one-pot synthesis of oligosaccharides

Ethyl thioglycosides could be selectively activated in the presence of phenyl thioglycosides carrying the same or even more armed protecting group pattern.

Graphical abstract: Chemoselective activation of ethyl vs. phenyl thioglycosides: one-pot synthesis of oligosaccharides
From the themed collection: Chemical Biology in OBC
644 items - Showing page 1 of 10

About this collection

The latest articles published in Organic and Biomolecular Chemistry related to chemical biology research.

Spotlight

Advertisements