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Themed collection Chemical biology in OBC

352 items - Showing page 1 of 6
Perspective

From pirates and killers: does metabolite diversity drive bacterial competition?

This article discusses interspecies competition by sets of closely related metabolites with significantly different biological activities.

Graphical abstract: From pirates and killers: does metabolite diversity drive bacterial competition?
From the themed collection: Chemical biology in OBC
Review Article

Stabilization of the triple helix in collagen mimicking peptides

The review classifies existing chemical approaches towards stronger triple helical assemblies in peptides.

Graphical abstract: Stabilization of the triple helix in collagen mimicking peptides
From the themed collection: Chemical biology in OBC
Review Article

Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose

A review of recent advances towards synthetic ADP-ribosylated proteins and oligo-ADP-ribose chains.

Graphical abstract: Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose
Review Article

Synthetic strategies for fluorination of carbohydrates

Different synthetic strategies for accomplishing regio- and stereoselective fluorinations of carbohydrate scaffolds are discussed in light of the biological implications arising from such substitutions.

Graphical abstract: Synthetic strategies for fluorination of carbohydrates
From the themed collection: Chemical biology in OBC
Review Article

Synthesis of carbohydrate building blocks via regioselective uniform protection/deprotection strategies

Scope 1: sugar is uniformly protected leaving only one (or two) free hydroxyl group; scope 2: uniformly protected sugar is deprotected to liberate only one (or two) hydroxyl group.

Graphical abstract: Synthesis of carbohydrate building blocks via regioselective uniform protection/deprotection strategies
Review Article

Chemical composition of DNA-encoded libraries, past present and future

We discuss here the chemical composition of DNA-encoded libraries likely to be made in the near future.

Graphical abstract: Chemical composition of DNA-encoded libraries, past present and future
Review Article

Versatility of glycals in synthetic organic chemistry: coupling reactions, diversity oriented synthesis and natural product synthesis

Versatility of glycals in the stereoselective synthesis of natural products.

Graphical abstract: Versatility of glycals in synthetic organic chemistry: coupling reactions, diversity oriented synthesis and natural product synthesis
From the themed collection: Total synthesis in OBC
Review Article

Saturated bioisosteres of benzene: where to go next?

Saturated bioisosteres for ortho- and meta-substituted benzenes remain a current challenge for chemists.

Graphical abstract: Saturated bioisosteres of benzene: where to go next?
From the themed collection: Chemical biology in OBC
Review Article

The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

Tailoring enzymes decorate diketopiperazines to yield unique structures and biological functions.

Graphical abstract: The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases
Review Article

Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials

Peptide–oligonucleotide conjugates (POCs) are covalent constructs that link a molecule like DNA to a synthetic peptide sequences.

Graphical abstract: Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials
From the themed collection: Chemical biology in OBC
Review Article

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Rearranged ergostane-type natural products are structurally intriguing and exhibit biologically relevant properties.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
Review Article

One-pot multi-segment condensation strategies for chemical protein synthesis

This paper describes recent advances of one-pot multi-segment condensation strategies based on kinetically controlled strategies and/or protecting group-removal strategies in chemical protein synthesis.

Graphical abstract: One-pot multi-segment condensation strategies for chemical protein synthesis
Open Access Review Article

Fluorogenic probes for super-resolution microscopy

Fluorogenic probes efficiently reduce non-specific background signals, which often results in highly improved signal-to-noise ratios.

Graphical abstract: Fluorogenic probes for super-resolution microscopy
Review Article

Azobenzene-based small molecular photoswitches for protein modulation

This review highlights the design strategies of azobenzene photoswitches as well as their applications in the manipulation of biological systems.

Graphical abstract: Azobenzene-based small molecular photoswitches for protein modulation
From the themed collection: Chemical biology in OBC
Review Article

Lasso peptides: chemical approaches and structural elucidation

The diverse functionality and the extraordinary stability of lasso peptides make these molecules attractive scaffolds for drug discovery. The ability to generate lasso peptides chemically remains a challenging endeavor.

Graphical abstract: Lasso peptides: chemical approaches and structural elucidation
From the themed collection: Chemical biology in OBC
Review Article

Biosynthesis of the teleocidin-type terpenoid indole alkaloids

Teleocidin B is a terpenoid indole alkaloid with unique structures including indolactam and cyclic terpenoid, and is a strong protein kinase C activator. In this review, we describe the isolation and biosynthetic studies of teleocidins.

Graphical abstract: Biosynthesis of the teleocidin-type terpenoid indole alkaloids
From the themed collection: Chemical biology in OBC
Review Article

The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions

Nucleic acids, phospholipids and other organic phosphates play central roles in biological pathways.

Graphical abstract: The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions
From the themed collection: Chemical biology in OBC
Review Article

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer

Participation of Z DNA in normal and disease related biological processes.

Graphical abstract: C8-Guanine modifications: effect on Z-DNA formation and its role in cancer
From the themed collection: Chemical biology in OBC
Review Article

Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals

C-Glycosylation has found widespread use in the synthesis of biomedically important natural products and pharmaceuticals.

Graphical abstract: Recent progress of C-glycosylation methods in the total synthesis of natural products and pharmaceuticals
From the themed collection: Chemical biology in OBC
Review Article

Target specificity of mammalian DNA methylation and demethylation machinery

We review here the molecular mechanisms employed by DNMTs and TET enzymes that are responsible for shaping the DNA methylation pattern of a mammalian cell.

Graphical abstract: Target specificity of mammalian DNA methylation and demethylation machinery
From the themed collection: Chemical biology in OBC
Review Article

The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches

Within a decade of Merrifield's seminal description of solid-phase peptide synthesis, the synergies between solid-phase approaches and flow synthesis were noted by a number of groups.

Graphical abstract: The renascence of continuous-flow peptide synthesis – an abridged account of solid and solution-based approaches
From the themed collection: Chemical biology in OBC
Open Access Review Article

Negishi cross-couplings in the synthesis of amino acids

The application of the Negishi cross-coupling reaction in the synthesis of amino acids is reviewed.

Graphical abstract: Negishi cross-couplings in the synthesis of amino acids
From the themed collection: Chemical biology in OBC
Review Article

25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science

This review highlights the synthesis, biophysical properties, and wide range of applications of oligonucleotides modified with 2′-O-(pyren-1-yl)methyl-RNA monomers reported over the past 25 years.

Graphical abstract: 25 years and still going strong: 2′-O-(pyren-1-yl)methylribonucleotides – versatile building blocks for applications in molecular biology, diagnostics and materials science
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Communication

Solvent- and catalyst-free transamidation reaction of unprotected glycosyl carboxamides.

From the themed collection: Chemical biology in OBC
Communication

Real-time monitoring of a photoactivated hydrogen persulfide donor for biological entities

A visible light responsive H2S2 donor based on the ESIPT mechanism with real-time monitoring ability using a non-invasive fluorescence technique.

Graphical abstract: Real-time monitoring of a photoactivated hydrogen persulfide donor for biological entities
From the themed collection: Chemical biology in OBC
Communication

Recognition of mixed-sequence DNA targets using spermine-modified Invader probes

Invader probes are additionally activated for recognition of mixed-sequence DNA targets upon incorporation of spermine bulges.

Graphical abstract: Recognition of mixed-sequence DNA targets using spermine-modified Invader probes
From the themed collection: Chemical biology in OBC
Communication

Chemoenzymatic reduction of citreorosein and its implications on aloe-emodin and rugulosin C (bio)synthesis

We report the first chemoenzymatic reduction of citreorosein to putative biosynthetic intermediates which will have implications on aloe-emodin and rugulosin C (bio)synthesis.

Graphical abstract: Chemoenzymatic reduction of citreorosein and its implications on aloe-emodin and rugulosin C (bio)synthesis
From the themed collection: Chemical biology in OBC
Communication

Synthesis and application of light-switchable arylazopyrazole rapamycin analogs

The first photoswitchable rapamycin analogs were synthesized and evaluated in split-enzyme assays using FKBP/FRB fusion, revealing configurational specificity of the system.

Graphical abstract: Synthesis and application of light-switchable arylazopyrazole rapamycin analogs
From the themed collection: Chemical biology in OBC
Communication

Triflic acid-mediated synthesis of thioglycosides

Examples include all common hexoses, aminosugars, sialic acids, and disaccharides.

Graphical abstract: Triflic acid-mediated synthesis of thioglycosides
From the themed collection: Synthetic methodology in OBC
Communication

The secondary structure of a heptapeptide containing trifluoromethyl-λ6-tetrafluorosulfanyl substituted amino acids

The polar hydrophobic trifluoromethyl-λ6-tetrafluorosulfanyl (CF3SF4) group effectively induces secondary structure in a heptapeptide in both polar and non-polar solvents.

Graphical abstract: The secondary structure of a heptapeptide containing trifluoromethyl-λ6-tetrafluorosulfanyl substituted amino acids
From the themed collection: Chemical biology in OBC
Communication

Compatibility of 5-ethynyl-2′F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers

A nucleoside triphosphate bearing modifications at both the sugar and the nucleobase level was shown to be compatible with combinatorial methods of in vitro selection.

Graphical abstract: Compatibility of 5-ethynyl-2′F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers
From the themed collection: Chemical biology in OBC
Open Access Communication

Optimised approach to albumin–drug conjugates using monobromomaleimide-C-2 linkers

Monobromomaleimides with C-2-PEG linkers offer an optimised platform for site-selective albumin conjugation, offering efficient conjugation and accelerated stabilising hydrolysis which prevents loss of drug during construction.

Graphical abstract: Optimised approach to albumin–drug conjugates using monobromomaleimide-C-2 linkers
From the themed collection: Chemical biology in OBC
Open Access Communication

Distortion of mannoimidazole supports a B2,5 boat transition state for the family GH125 α-1,6-mannosidase from Clostridium perfringens

Enzyme transition-state mimics can act as powerful inhibitors and allow structural studies that report on the conformation of the transition-state.

Graphical abstract: Distortion of mannoimidazole supports a B2,5 boat transition state for the family GH125 α-1,6-mannosidase from Clostridium perfringens
From the themed collection: Chemical biology in OBC
Open Access Communication

Microcalorimetry and fluorescence show stable peptide nucleic acid (PNA) duplexes in high organic content solvent mixtures

Peptide nucleic acid (PNA) hybridisation is highly tolerant to the addition of organic solvent. This finding suggests that PNA could enable the use of a range of water-sensitive chemistries in nucleic acid templating applications.

Graphical abstract: Microcalorimetry and fluorescence show stable peptide nucleic acid (PNA) duplexes in high organic content solvent mixtures
From the themed collection: Chemical biology in OBC
Communication

Production of a photohexapeptide library from entomopathogenic Photorhabdus asymbiotica PB68.1

A library of new peptides named photohexapeptides was identified from entomopathogenic Photorhabdus asymbiotica PB68.1 after the NRPS-encoding gene phpS was activated via promoter exchange.

Graphical abstract: Production of a photohexapeptide library from entomopathogenic Photorhabdus asymbiotica PB68.1
From the themed collection: Chemical biology in OBC
Communication

Formation of i-motifs from acyclic (L)-threoninol nucleic acids

Acyclic (L)-threoninol nucleic acids ((L)-aTNA) containing poly-cytosines are prepared and investigated at various pH values, revealing the formation of a highly stable structure at lower pH that have the characteristics of an i-motif.

Graphical abstract: Formation of i-motifs from acyclic (l)-threoninol nucleic acids
From the themed collection: Chemical biology in OBC
Communication

Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide

The oligosaccharide of the tumor-associated antigen DSGb5 was synthesized in a chemoenzymatic manner by exploiting the mammalian glycosyl transferases ST3Gal1 and ST6GalNAc5, and its binding with Siglec-7 was investigated by glycan microarray technology.

Graphical abstract: Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide
From the themed collection: Chemical biology in OBC
Communication

Hydantoin analogs inhibit the fully assembled ClpXP protease without affecting the individual peptidase and chaperone domains

A new class of non-covalent inhibitors attenuates ClpXP turnover, neither impairing chaperone nor peptidase activity.

Graphical abstract: Hydantoin analogs inhibit the fully assembled ClpXP protease without affecting the individual peptidase and chaperone domains
Communication

Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

An extended scaffold is the key to facile glucuronidation for the synthesis of prodrugs.

Graphical abstract: Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs
From the themed collection: Chemical biology in OBC
Communication

A novel chemiluminescent probe for hydrazine detection in water and HeLa cells

A novel chemiluminescent probe based on intramolecular cyclization for hydrazine detection in living cells.

Graphical abstract: A novel chemiluminescent probe for hydrazine detection in water and HeLa cells
From the themed collection: Chemical biology in OBC
Communication

Stereoselective synthesis of unnatural (2S,3S)-6-hydroxy-4-sphingenine-containing sphingolipids

Concise total synthesis of unnatural (2S,3S)-6-hydroxy-4-sphingenine containing sphingolipids using a hydrozirconationtransmetalation reaction and an unusual three-step-one-pot deprotection sequence.

Graphical abstract: Stereoselective synthesis of unnatural (2S,3S)-6-hydroxy-4-sphingenine-containing sphingolipids
From the themed collection: Chemical biology in OBC
Communication

Synthesis and evaluation of photo-activatable β-diarylsydnone-L-alanines for fluorogenic photo-click cyclization of peptides

β-Diarylsydnone-L-alanines were designed and introduced into peptides allowing photo-cyclization only in phosphate containing buffer with concomitant fluorescence generation in live cells.

Graphical abstract: Synthesis and evaluation of photo-activatable β-diarylsydnone-l-alanines for fluorogenic photo-click cyclization of peptides
From the themed collection: Chemical biology in OBC
Communication

Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging

Fluorescent-labeled neopeltolide derivatives were rationally designed for cell imaging to elucidate their localization in the mitochondria and the endoplasmic reticulum.

Graphical abstract: Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging
From the themed collection: Chemical biology in OBC
Communication

Gold(I)-promoted α-selective sialylation of glycosyl ortho-hexynylbenzoates for the latent-active synthesis of oligosialic acids

A gold(I)-promoted α-selective glycosylation approach with sialyl ortho-hexynylbenzoates as donors is developed for the latent-active synthesis of α-(2 → 9)-linked oligosialic acids.

Graphical abstract: Gold(i)-promoted α-selective sialylation of glycosyl ortho-hexynylbenzoates for the latent-active synthesis of oligosialic acids
From the themed collection: Chemical biology in OBC
Communication

Photoaffinity palladium reagents for capture of protein–protein interactions

A straightforward strategy using palladium-mediated reagents to reliably incorporate different photoaffinity groups into peptides/proteins for crosslinking of interacting partners is described.

Graphical abstract: Photoaffinity palladium reagents for capture of protein–protein interactions
From the themed collection: Chemical biology in OBC
Communication

Rational design of a function-based selection method for genetically encoding acylated lysine derivatives

Genetic code expansion depends on the directed evolution of aaRS to recognize non-canonical amino acids. Herein, we reported a function-based method that enables rapidly evolving aaRS for acylated lysine derivatives.

Graphical abstract: Rational design of a function-based selection method for genetically encoding acylated lysine derivatives
From the themed collection: Chemical biology in OBC
Communication

Clostrindolin is an antimycobacterial pyrone alkaloid from Clostridium beijerinckii

A novel antimycobacterial natural product, clostroindolin, was discovered from the anaerobic bacterium Clostridium beijerinckii.

Graphical abstract: Clostrindolin is an antimycobacterial pyrone alkaloid from Clostridium beijerinckii
From the themed collection: Chemical biology in OBC
Communication

The structure-based traceless specific fluorescence labeling of the smoothened receptor

Inspired by recent progress in structural studies of the smoothened receptor (SMO), a group of affinity probes were developed to specifically light up SMO by grafting a small fluorescent group at the specific residue K395.

Graphical abstract: The structure-based traceless specific fluorescence labeling of the smoothened receptor
From the themed collection: Chemical biology in OBC
Communication

Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases

Synthesis of LacNAc with reversible GalTs.

Graphical abstract: Enzymatic synthesis of N-acetyllactosamine from lactose enabled by recombinant β1,4-galactosyltransferases
From the themed collection: Chemical biology in OBC
Communication

Copper-mediated anomeric O-arylation with organoboron reagents

Copper-mediated couplings of boroxines with glycosyl hemiacetals generate O-aryl glycosides via Csp2–O bond formation.

Graphical abstract: Copper-mediated anomeric O-arylation with organoboron reagents
From the themed collection: Chemical biology in OBC
Communication

Importance of the main chain of lysine for histone lysine methyltransferase catalysis

Enzymatic and computational studies on the simplest lysine analogues that possess a modified main chain demonstrate that the lysine's backbone contributes significantly to functional KMT binding and catalysis.

Graphical abstract: Importance of the main chain of lysine for histone lysine methyltransferase catalysis
From the themed collection: Chemical biology in OBC
Communication

Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy

A simple-to-operate and highly efficient strategy for the epimerization-free synthesis of C-terminal Cys-containing peptide acids, which avoids the use of derivatization reagents for resin modification, is developed.

Graphical abstract: Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy
From the themed collection: Chemical biology in OBC
Open Access Communication

Lacto-N-tetraose synthesis by wild-type and glycosynthase variants of the β-N-hexosaminidase from Bifidobacterium bifidum

Enzymatic lacto-N-biose transfer from lacto-N-biose 1,2-oxazoline to lactose by wild-type and glycosynthase variants of Bifidobacterium bifidum β-N-hexosaminidase yielded lacto-N-tetraose in a single-step, highly regioselective transformation.

Graphical abstract: Lacto-N-tetraose synthesis by wild-type and glycosynthase variants of the β-N-hexosaminidase from Bifidobacterium bifidum
From the themed collection: Chemical biology in OBC
Communication

The one-pot nonhydrolysis Staudinger reaction and Staudinger or SPAAC ligation

The one-pot nonhydrolysis Staudinger reaction and Staudinger or SPAAC ligation were used for producing a FRET-based dyad in living cells as a proof-of-concept study.

Graphical abstract: The one-pot nonhydrolysis Staudinger reaction and Staudinger or SPAAC ligation
From the themed collection: Chemical biology in OBC
Communication

Experimental and numerical evaluation of a genetically engineered M13 bacteriophage with high sensitivity and selectivity for 2,4,6-trinitrotoluene

This study includes the experimental results of a sensitive M13 bacteriophage-based sensor system that are well matched with the quantum mechanics calculation.

Graphical abstract: Experimental and numerical evaluation of a genetically engineered M13 bacteriophage with high sensitivity and selectivity for 2,4,6-trinitrotoluene
Communication

Design of S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake

The S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID) was synthesised to identify the binding sites in bovin serum albumin (BSA).

Graphical abstract: Design of S–S bond containing maleimide-conjugated closo-dodecaborate (SSMID): identification of unique modification sites on albumin and investigation of intracellular uptake
From the themed collection: Chemical biology in OBC
Communication

Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi

A highly reducing polyketide synthase (HR-PKS) collaborates with a type III PKS to produce alkylresorcinols via unusual biosynthetic machinery.

Graphical abstract: Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi
From the themed collection: Chemical biology in OBC
Open Access Communication

Development of ergosterol peroxide probes for cellular localisation studies

Cell-permeable ergosterol peroxide probes were synthesized to advance their biological understanding and therapeutic potential.

Graphical abstract: Development of ergosterol peroxide probes for cellular localisation studies
From the themed collection: Chemical biology in OBC
Open Access Communication

TuPPL: Tub-tag mediated C-terminal protein–protein-ligation using complementary click-chemistry handles

We introduce a chemoenzymatic strategy for straightforward in vitro generation of C-terminally linked fusion proteins.

Graphical abstract: TuPPL: Tub-tag mediated C-terminal protein–protein-ligation using complementary click-chemistry handles
From the themed collection: Chemical biology in OBC
Communication

β-Glucuronidase triggers extracellular MMAE release from an integrin-targeted conjugate

A non-internalizing conjugate targeting αvβ3 integrin inhibits the proliferation of integrin-expressing cancer cells in the presence of β-glucuronidase.

Graphical abstract: β-Glucuronidase triggers extracellular MMAE release from an integrin-targeted conjugate
Communication

Pyrrolidine ring puckering and prolyl amide bond configurations of 2-methyl-allo-hydroxyproline-based dipeptides

Synthesis and conformational studies of C-2 methylated D- and L-allo-hydroxyproline containing dipeptides are described.

Graphical abstract: Pyrrolidine ring puckering and prolyl amide bond configurations of 2-methyl-allo-hydroxyproline-based dipeptides
From the themed collection: Chemical biology in OBC
Communication

A cell-permeant small molecule for the super-resolution imaging of the endoplasmic reticulum in live cells

A simple BODIPY-based small molecule has been identified to selectively label the endoplasmic reticulum for high-resolution imaging with negligible cytotoxicity.

Graphical abstract: A cell-permeant small molecule for the super-resolution imaging of the endoplasmic reticulum in live cells
From the themed collection: Chemical biology in OBC
Open Access Communication

Poloxin-2HT+: changing the hydrophobic tag of Poloxin-2HT increases Plk1 degradation and apoptosis induction in tumor cells

Hydrophobically-tagged Poloxin-2HT+ selectively degrades the tumor target Plk1 and induces apoptosis in tumor cells with higher potency than Poloxin-2HT.

Graphical abstract: Poloxin-2HT+: changing the hydrophobic tag of Poloxin-2HT increases Plk1 degradation and apoptosis induction in tumor cells
From the themed collection: Chemical biology in OBC
Communication

Modular synthesis and immunological evaluation of suspected allergenic galactooligosaccharides

The synthesis of suspected GOS-related allergens using a flexible modular approach and their immunological evaluation are reported.

Graphical abstract: Modular synthesis and immunological evaluation of suspected allergenic galactooligosaccharides
From the themed collection: Chemical biology in OBC
Communication

Glycoconjugate synthesis using chemoselective ligation

Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker.

Graphical abstract: Glycoconjugate synthesis using chemoselective ligation
From the themed collection: Chemical biology in OBC
Communication

One- and two-photon responsive sulfur dioxide (SO2) donors: a combinatorial drug delivery for improved antibiotic therapy

Light-activated sulfur dioxide donors have been developed and explored their applicability for combinatorial antibiotic therapy with self-monitoring ability.

Graphical abstract: One- and two-photon responsive sulfur dioxide (SO2) donors: a combinatorial drug delivery for improved antibiotic therapy
From the themed collection: Chemical biology in OBC
Communication

Cytosporins A–D, novel benzophenone derivatives from the endophytic fungus Cytospora rhizophorae A761

Cytosporins A–D (1–4), hemiterpene-conjugated phenolics with an unprecedented benzo[b][1,5]dioxocane skeleton, were isolated from Cytospora rhizophorae A761.

Graphical abstract: Cytosporins A–D, novel benzophenone derivatives from the endophytic fungus Cytospora rhizophorae A761
From the themed collection: Chemical biology in OBC
Open Access Communication

Stereoselective C-terminal peptide elongation from Chan–Lam–Evans reaction generated isopropenyl esters

Peptide isoprenyl esters were made via the Cu-mediated Chan–Lam–Evans reaction and elongated via pyrazole/DMEP-catalysed aminolysis.

Graphical abstract: Stereoselective C-terminal peptide elongation from Chan–Lam–Evans reaction generated isopropenyl esters
From the themed collection: Chemical biology in OBC
Communication

Abinukitrine A, a unique 17,18-cyclolanostane triterpenoid from Abies nukiangensis

Abinukitrine A was isolated from Abies nukiangensis as the first example of 17,18-cyclolanostane. It showed a potent anti-hepatitis C virus effect.

Graphical abstract: Abinukitrine A, a unique 17,18-cyclolanostane triterpenoid from Abies nukiangensis
From the themed collection: Chemical biology in OBC
Communication

DNA triplex-based fluorescence turn-on sensors for adenosine using a fluorescent molecular rotor 5-(3-methylbenzofuran-2-yl) deoxyuridine

Fluorescence turn-on detection of adenosine based on microenvironmental and conformational changes of a fluorescent molecular rotor in the DNA triplex is reported.

Graphical abstract: DNA triplex-based fluorescence turn-on sensors for adenosine using a fluorescent molecular rotor 5-(3-methylbenzofuran-2-yl) deoxyuridine
From the themed collection: Chemical biology in OBC
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The latest articles published in Organic and Biomolecular Chemistry related to chemical biology research.

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