The effect of almond intake on anthropometric indices: a systematic review and meta-analysis
This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of almond intake on anthropometric indices in adult subjects.
Insights into the potential benefits of black soybean (Glycine max L.) polyphenols in lifestyle diseases
Black soybean (Glycine max L.), a cultivar containing abundant polyphenols in its seed coat such as anthocyanins and flavan-3-ols, has been reported to possess various health benefits toward lifestyle diseases.
An overview and update on the epidemiology of flavonoid intake and cardiovascular disease risk
Higher intakes of flavonoid-rich foods are associated with a lower risk of cardiovascular disease in prospective cohort studies.
The digestion of galactolipids and its ubiquitous function in Nature for the uptake of the essential α-linolenic acid
Galactolipases allow the digestion of galactolipids, the most abundant lipids on Earth and the main source of α-linolenic acid.
Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development
Diet could play a dual role in the production of the TMA/TMAO meta-organismal pathway since it provides TMA precursors, but also other dietary constituents that reduce endogenous TMAO or its damaging effects through different mechanisms.
Anti-stress effects of polyphenols: animal models and human trials
Relationship between “stressors” and “stress responses”, such as hormone secretion. Some polyphenols can prevent stress responses, which subsequently prevent stress-related health problems.
Protection against developing type 2 diabetes by coffee consumption: assessment of the role of chlorogenic acid and metabolites on glycaemic responses
Coffee chlorogenic acids do not affect carbohydrate digestion directly, but modulate glucose absorption/utilisation, the latter through endogenous/gut microbiota metabolites.
Impact of functional foods and nutraceuticals on high blood pressure with a special focus on meta-analysis: review from a public health perspective
In recent times many researchers are expressing immense interest in nutraceuticals and functional foods for combating various diseases or abnormal conditions, especially against hypertension (HT).
Sesamol: a powerful functional food ingredient from sesame oil for cardioprotection
Phytophenols are important bioactive food based chemical entities, largely present in several natural sources.
The impact of postharvest storage and cooking time on mineral bioaccessibility in common beans
Postharvest storage negatively influences the common bean mineral bioaccessibility which cannot be counteracted by adapting conventional processing variables. However, dehulling can lead to an improvement of mineral bioaccessibility.
Contents of key bioactive and detrimental compounds in health performance coffees compared to conventional types of coffees sold in the United States market
The contents of major bioactive compounds in health performance coffees and conventional coffees sold in the U.S. market were compared. Many health claims on the health performance coffee labels were unjustified.
A multi-targeting strategy to ameliorate high-fat-diet- and fructose-induced (western diet-induced) non-alcoholic fatty liver disease (NAFLD) with supplementation of a mixture of legume ethanol extracts
NAFLD (non-alcoholic fatty liver disease) is a multifactorial liver disease related to multiple causes or unhealthy conditions, including obesity and chronic inflammation.
Wheat germ-derived peptide ADWGGPLPH abolishes high glucose-induced oxidative stress via modulation of the PKCζ/AMPK/NOX4 pathway
This study explores the antioxidative effect of a specific wheat germ-derived peptide on high glucose-induced oxidative stress in vascular smooth muscle cells (VSMCs) and the underlying mechanisms.
Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise
Bone and energy metabolism are profoundly influenced by exercise.
Eugenol-loaded chitosan emulsion holds the texture of chilled hairtail (Trichiurus lepturus) better: mechanism exploration by proteomic analysis
Eugenol-loaded chitosan emulsion (ELCE) has been proved to have an excellent antibacterial property.
Peptidomic analysis of pilose antler and its inhibitory effect on triple-negative breast cancer at multiple sites
Pilose antler (PA) is a traditional Chinese functional food and 22 tumor-suppressing polypeptides was detected in its water extract. They inhibit the progression and metastasis of triple-negative 4T1 breast cancer at multiple key sites.
Roasting carob flour decreases the capacity to bind glycoconjugates of bile acids
Carob is the fruit obtained from Ceratonia siliqua L. and it is a source of bioactive compounds that have been linked to several health promoting effects, including lowering blood cholesterol concentration.
Commercial whey products promote intestinal barrier function with glycomacropeptide enhanced activity in downregulating bacterial endotoxin lipopolysaccharides (LPS)-induced inflammation in vitro
Commercial whey products promote healthy gut by upregulating barrier function related molecules with glycomacropeptide (GMP) having enhanced activity in protecting colon cells against inflammation.
Sacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats
We report that sacha inchi oil with plant-derived ω-3 PUFAs alleviates gut microbiota dysbiosis, prevents bile acid dysmetabolism, and ameliorates hepatic lipid dysmetabolism of glycerolipids, glycerophospholipids, and sphingolipids in HFD rats.
Effectiveness of Vigna unguiculata seed extracts in preventing colorectal cancer
Colorectal cancer (CRC) is one of the most common types of cancer, especially in Western countries, and its incidence rate is increasing every year.
Prebiotic galactooligosaccharides production from lactose and lactulose by Lactobacillus delbrueckii subsp. bulgaricus CRL450
Galactooligosaccharides (GOS) are useful dietary ingredients recognized worldwide as prebiotics.
Effect of mitochondrial quality control on the lycopene antagonizing DEHP-induced mitophagy in spermatogenic cells
This study provides new insights and indicates that LYC prevents DEHP-induced mitophagy of spermatogenic cells via the mitochondrial quality regulation, which may be the target molecule for future DEHP toxicity and the LYC effector mechanism.
Optimization of ergosterol extraction from Pleurotus mushrooms using response surface methodology
In this study, heat-assisted extraction (HAE) was used to optimise the extraction of ergosterol from Pleurotus ostreatus (PO) and Pleurotus eryngii (PE) using response surface methodology (RSM).
Tea polyphenols as a strategy to control starch digestion in bread: the effects of polyphenol type and gluten
Mechanisms to slow down starch digestion – tea polyphenols interact with α-amylase and starch during co-digestion of tea extract and bread.
Theoretical and experimental investigation of the antioxidative activity of monascin
The antioxidant activity of monascin characterized by both theoretical prediction and experimental validation via colorimetric and electron spin resonance (ESR) assays.
Gallic acid reduces the viscosity and water binding capacity of soluble dietary fibers
Water binding capacity and viscosity of soluble dietary fibers are known to be essential drivers of their nutritional benefits.
Lactic acid bacteria reduce diabetes symptoms in mice by alleviating gut microbiota dysbiosis and inflammation in different manners
LAB exhibiting hypoglycaemic effects reduced insulin resistance by contributing to the production of SCFAs and alleviation of inflammation. L. rhamnosus regulated blood lipid more efficiently than Bifidobacterium.
Citrus auraptene induces drug efflux transporter P-glycoprotein expression in human intestinal cells
Citrus phytochemical auraptene activates the drug efflux transporter P-glycoprotein gene (MDR1) promoter in human intestinal LS174T cells. Auraptene increases protein expression of P-glycoprotein. Auraptene can cause food–drug interactions.
Loss of allergy-protective capacity of raw cow's milk after heat treatment coincides with loss of immunologically active whey proteins
Whey proteins denaturing ≤65 °C are important for allergy protection by raw cow's milk.
Influence of type of dairy matrix micro- and macrostructure on in vitro lipid digestion
Recent research indicates that the food matrix can influence digestion kinetics and uptake of nutrients, thus affecting human health.
Milk protein complexation enhances post prandial vitamin D3 absorption in rats
This study investigated the effect of complexation with whey and casein protein, respectively, on post prandial absorption of vitamin D3.
Isolation and identification of cholesterol esterase and pancreatic lipase inhibitory peptides from brewer's spent grain by consecutive chromatography and mass spectrometry
New peptides with cholesterol esterase and pancreatic lipase inhibitory activities were identified from brewer's spent grain hydrolysate, providing added value to this by-product obtained from the beer industry.
Evaluation of the relationship between the peptide profiles and the lipid-lowering properties of olive seed hydrolysates as a tool for tuning hypocholesterolemic functionality
Olive processing generates large amounts of stones with high protein contents.
Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease
Flavanol intake positively influences cardiometabolic health in humans – evidence from in vitro nutrigenomic studies.
The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet
In our previous studies, Lactobacillus plantarum Y44 showed antioxidant activity and favorable gastric and intestinal transit tolerance.
Antioxidant and anti-aging effects of a sea cucumber protein hydrolyzate and bioinformatic characterization of its composing peptides
C. elegans-based activity guided and size-based isolation of antioxidant peptide fractions from a sea cucumber protein hydrolyzate and their bioinformatic characterization.
The chemopreventive effect of 5-demethylnobiletin, a unique citrus flavonoid, on colitis-driven colorectal carcinogenesis in mice is associated with its colonic metabolites
The inhibitory effect of dietary 5-demethylnobiletin on colitis-driven colorectal carcinogenesis and the potential roles of its colonic metabolites were reported.
Peptides obtained from edible mushrooms: Hericium erinaceus offers the ability to scavenge free radicals and induce apoptosis in lung cancer cells in humans
This research examined the antioxidant abilities of peptides derived from the Hericium erinaceus mushroom produced via three microbial proteases at varying concentrations.
Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition
Aberrant activation of inflammation and excess accumulation of lipids play pivotal roles in atherosclerosis (AS) progression.
Oral administration of Lactobacillus fermentum CRL1446 improves biomarkers of metabolic syndrome in mice fed a high-fat diet supplemented with wheat bran
This work evaluated the effect of oral administration of Lactobacillus fermentum CRL1446, feruloyl esterase producing, on metabolic biomarkers and intestinal microbiota of high fat diet-induced metabolic syndrome mice and supplemented with wheat bran.
Kinetic profile and urinary excretion of phenyl-γ-valerolactones upon consumption of cranberry: a dose–response relationship
Cranberries are a rich source of poly(phenols), mainly monomeric and oligomeric flavan-3-ols. The metabolism of their main colonic compounds has been assessed.
The effect of quercetin on endothelial cells is modified by heterocellular interactions
Single cell-type models are useful for determining mechanisms, but in vivo, cell–cell interactions are important, and neighbouring cells can impact endothelial cell function.
Targets and underlying mechanisms related to the sedative and hypnotic activities of saponin extracts from semen Ziziphus jujube
Semen Ziziphus jujube (SZJ) has been widely consumed because it is recognized as edible in China to treat insomnia disorders.
Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue
Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder in high-fat diet restored adiposity, glucose tolerance and insulin sensitivity in mice.
Analysis of β-lactoglobulin–epigallocatechin gallate interactions: the antioxidant capacity and effects of polyphenols under different heating conditions in polyphenolic–protein interactions
A β-Lg-EGCG covalent conjugate is formed by linking the amino group of a lysine residue and EGCG; the antioxidant capacity of EGCG induced by β-Lg–EGCG covalent conjugates causes a significant decrease.
Secoisolariciresinol diglucoside alleviates hepatic lipid metabolic misalignment involving the endoplasmic reticulum–mitochondrial axis
The potential mechanism of SDG against HFFD-induced insulin resistance and hepatic lipid metabolic disorders in mice.
Lysine inhibits apoptosis in satellite cells to govern skeletal muscle growth via the JAK2-STAT3 pathway
Apoptosis is programmed cell death that can be stimulated by external stress or nutrition restrictions.
Synbiotic supplementation containing Bifidobacterium infantis and xylooligosaccharides alleviates dextran sulfate sodium-induced ulcerative colitis
Synbiotics (Bifidobacterium infantis + xylooligosaccharides) had the strongest efficacy on colitis through inhibiting inflammation and oxidative stress and protecting epithelial integrity.
Number of galloyl moieties and molecular flexibility are both important in alpha-amylase inhibition by galloyl-based polyphenols
The inhibition of porcine pancreatic α-amylase (PPA) by 9 galloyl-based polyphenols was evaluated via initial digestion velocity, IC50, inhibition kinetics, fluorescence quenching and molecular docking studies.
A study on the protective effects of taxifolin on human umbilical vein endothelial cells and THP-1 cells damaged by hexavalent chromium: a probable mechanism for preventing cardiovascular disease induced by heavy metals
Taxifolin suppressed the toxicity and THP-1 cell adhesion to HUVECs induced by Cr(VI) via regulating the p38 MAPK and JNK pathways.
Selenoproteins and renal programming in metabolic syndrome-exposed rat offspring
Selenoprotein implication in oxidative stress-related renal programming alteration in MS pups.
A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice
A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice.
Alleviating effects of noni fruit polysaccharide on hepatic oxidative stress and inflammation in rats under a high-fat diet and its possible mechanisms
Non-alcoholic fatty liver disease is associated with gut microbiota, oxidative stress, and inflammation.
Metallic iron in cornflakes
Magnetometry and X-ray analysis show that the iron in cornflake-style cereals fortified with this essential element at levels up to 14 mg per 100 g, is micron-sized body-centred cubic metallic iron, partially soluble at stomach pH.
Dietary intake of Lycium ruthenicum Murray ethanol extract inhibits colonic inflammation in dextran sulfate sodium-induced murine experimental colitis
Lycium ruthenicum Murray extract protected experimental colitis by inhibiting pro-inflammatory cytokines production, inflammatory cell infiltration, inflammatory mediators activation and oxidative stress, and restored intestinal barrier integrity.
Black mulberry ethanol extract attenuates atherosclerosis-related inflammatory factors and downregulates PPARγ and CD36 genes in experimental atherosclerotic rats
Atherosclerosis (AS) is the pathological basis of various vascular diseases and currently is seriously affecting human health.
Cloning, expression and comparison of the properties of Scy p 9, a Scylla paramamosain allergen
This study investigated the properties of Scy p 9 in mud crab (Scylla paramamosain).
Integrated anti-hyperlipidemic bioactivity of whole Citrus grandis [L.] osbeck fruits—multi-action mechanism evidenced using animal and cell models
Multi- antihyperlipidemic mechanism revealed by the pomelo phytonutrients. Both the sterol synthesis and lipogenesis pathways are affected by the pomelo phytonutrients. Dotted line: from citation. Solid line: verified in this experiment.
Biogenic selenium nanoparticles synthesized by Lactobacillus casei ATCC 393 alleviate diquat-induced intestinal barrier dysfunction in C57BL/6 mice through their antioxidant activity
Biogenic SeNPs synthesized by Lactobacillus casei ATCC 393 reversed diquat-induced oxidative damage to the epithelium by activating the Nrf2 signaling pathway.
Nutritional value, physicochemical characterization and bioactive properties of the Brazilian quinoa BRS Piabiru
Quinoa is a very interesting food due to its nutritional and chemical composition, as well as its bioactive properties, such as antioxidant and antimicrobial activity.
Natural cordycepin induces apoptosis and suppresses metastasis in breast cancer cells by inhibiting the Hedgehog pathway
Cordycepin induces apoptosis and suppresses metastasis in breast cancer cells by regulating the Hedgehog pathway and its downstream pathways.
Enzymatic cross-linking of pectin in a high-pressure foaming process
This study demonstrates that integrating enzymatic cross-linking in a high-pressure foaming process is a viable option to increase foam stability when well aligning the relevant process parameters and process kinetics.
Engineering water-induced ceramide/lecithin oleogels: understanding the influence of water added upon pre- and post-nucleation
A mixture of ceramide (CER) and lecithin (LEC) at specific ratios was capable of forming oleogels in sunflower oil triggered by adding a trace amount of water.
Effects of collagen peptides from skate (Raja kenojei) skin on improvements of the insulin signaling pathway via attenuation of oxidative stress and inflammation
It has been well established that hepatic insulin signaling is significantly affected by the antioxidative status of the liver.
Pure omega 3 polyunsaturated fatty acids (EPA, DPA or DHA) are associated with increased plasma levels of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) in a short-term study in women
3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) is a metabolite of furan fatty acids found in plasma and urine. Our data show that purified EPA, DPA and DHA may also be precursors of CMPF; however the metabolic pathway(s) remain unclear.
Anti-Alzheimer's disease activity of secondary metabolites from Xanthoceras sorbifolia Bunge
Xanthoceras sorbifolia Bunge is an edible oil tree species peculiar to China and it has long been used as a traditional medicine for enuresis in children. In this paper, X. sorbifolia was found to have significant anti-Alzheimer's activity.
Rosmarinic acid alleviates ethanol-induced lipid accumulation by repressing fatty acid biosynthesis
Rosmarinic acid ameliorates ethanol-induced lipid accumulation by reducing fatty acid biosynthesis and tumor necrosis factor-α.
Enhancing the physicochemical stability and digestibility of DHA emulsions by encapsulation of DHA droplets in caseinate/alginate honeycomb-shaped microparticles
DHA was encapsulated in caseinate/alginate microparticles by adjusting the pH based on the electrostatic complexation, in order to improve the physicochemical stability and digestibility of single caseinate-stabilized DHA emulsions.
Study on the therapeutic material basis and effect of Acanthopanax senticosus (Rupr. et Maxim.) Harms leaves in the treatment of ischemic stroke by PK-PD analysis based on online microdialysis–LC-MS/MS method
The therapeutic material basis and effect of ASL in the treatment of ischemic stroke were studied by PK-PD analysis.
The holistico-reductionist Siga classification according to the degree of food processing: an evaluation of ultra-processed foods in French supermarkets
The Siga classification of foods according to degree of processing showed that two-thirds of 24 932 packaged foods collected in French supermarkets are ultra-processed at various degrees.
About this collection
This themed collection features articles published in Food & Function marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.