Themed collection Food & Function Recent HOT articles
Phenolic compounds: current industrial applications, limitations and future challenges
Phenolic compounds (PC) are secondary metabolites with interesting bioactivities that have been explored for industrial application. PC bioactivity depends on their chemical structure integrity, so, methods to increase PC stability have been developed.
Is it scientifically justifiable to exclude wine and/or unfermented grape derivatives from the diet of consumers with or at risk of developing type-2 diabetes?
This narrative review investigates whether low/moderate consumption of wine/grape's derivatives can be part of T2D individuals daily diet.
Melatonin rich foods in our diet: food for thought or wishful thinking?
Plot of the maximum plasma melatonin levels (Cmax) following the oral administration to humans of pure melatonin in various rapid release formulations.
Synergistic potential of nutraceuticals: mechanisms and prospects for futuristic medicine
Synergistic potential of nutraceuticals in chronic disease management.
Insights into the potential benefits of black soybean (Glycine max L.) polyphenols in lifestyle diseases
Black soybean (Glycine max L.), a cultivar containing abundant polyphenols in its seed coat such as anthocyanins and flavan-3-ols, has been reported to possess various health benefits toward lifestyle diseases.
The effect of almond intake on anthropometric indices: a systematic review and meta-analysis
This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of almond intake on anthropometric indices in adult subjects.
An overview and update on the epidemiology of flavonoid intake and cardiovascular disease risk
Higher intakes of flavonoid-rich foods are associated with a lower risk of cardiovascular disease in prospective cohort studies.
The digestion of galactolipids and its ubiquitous function in Nature for the uptake of the essential α-linolenic acid
Galactolipases allow the digestion of galactolipids, the most abundant lipids on Earth and the main source of α-linolenic acid.
Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development
Diet could play a dual role in the production of the TMA/TMAO meta-organismal pathway since it provides TMA precursors, but also other dietary constituents that reduce endogenous TMAO or its damaging effects through different mechanisms.
Anti-stress effects of polyphenols: animal models and human trials
Relationship between “stressors” and “stress responses”, such as hormone secretion. Some polyphenols can prevent stress responses, which subsequently prevent stress-related health problems.
Protection against developing type 2 diabetes by coffee consumption: assessment of the role of chlorogenic acid and metabolites on glycaemic responses
Coffee chlorogenic acids do not affect carbohydrate digestion directly, but modulate glucose absorption/utilisation, the latter through endogenous/gut microbiota metabolites.
Impact of functional foods and nutraceuticals on high blood pressure with a special focus on meta-analysis: review from a public health perspective
In recent times many researchers are expressing immense interest in nutraceuticals and functional foods for combating various diseases or abnormal conditions, especially against hypertension (HT).
Sesamol: a powerful functional food ingredient from sesame oil for cardioprotection
Phytophenols are important bioactive food based chemical entities, largely present in several natural sources.
Rhamnetin decelerates the elimination and enhances the antitumor effect of the molecular-targeting agent sorafenib in hepatocellular carcinoma cells via the miR-148a/PXR axis
The pregnane X receptor (PXR) mediates the resistance of sorafenib in hepatocellular carcinoma (HCC) by promoting the clearance or elimination of sorafenib via the drug resistance-related downstream genes of the PXR. Rhamnetin drepresses the activation of PXR via miR-148a.
Eugenol emerges as an elixir by targeting β-catenin, the central cancer stem cell regulator in lung carcinogenesis: an in vivo and in vitro rationale
The aim of this study was to exploit the inherent properties of eugenol to restrict the growth of cancer cells in a tobacco-related human carcinogen NDEA-induced lung carcinogenesis model in vivo as a chemopreventive agent.
The role of microRNA-33 as a key regulator in hepatic lipogenesis signaling and a potential serological biomarker for NAFLD with excessive dietary fructose consumption in C57BL/6N mice
Fructose-induced hepatic miR-33 suppression lead to fatty liver via upregulation of SREBP1. Additionally, fructose-induced hepatic ferroptosis may cause a spill-over of miR-33 into blood stream, which could be a potential serological biomarker for fructose-induced NAFLD.
Wheat germ glycoprotein regionally modulates immunosuppressed mouse intestinal immunity function from early life to adulthood
Wheat germ glycoprotein (WGP) is widely used due to its nutritional benefits and biological activity.
Chemical compounds with a neuroprotective effect from the seeds of Celosia argentea L.
Compounds isolated from Semen Celosiae are potent inhibitors of neuron injury via inhibition of oxidative stress and apoptosis, and activation of autophagy.
High-internal-phase emulsions (HIPEs) for co-encapsulation of probiotics and curcumin: enhanced survivability and controlled release
Synergistic biological activities of probiotics and curcumin can be achieved based on the gut–brain axis.
Extra virgin olive oil and related by-products (Olea europaea L.) as natural sources of phenolic compounds for abdominal pain relief in gastrointestinal disorders in rats
Olea europaea-derived samples as natural source for abdominal pain relief in gastrointestinal disorders.
Prenatal vitamin D supplementation reduces blood pressure and improves placental angiogenesis in an animal model of preeclampsia
The study demonstrates that prenatal vitamin D supplementation reduces blood pressure and restores angiogenic balance in an animal model of preeclampsia.
Assessment of the effect of lactic acid fermentation on the gastroduodenal digestibility and immunoglobulin E binding capacity of soy proteins via an in vitro dynamic gastrointestinal digestion model
The effect of lactic acid fermentation on the gastroduodenal digestibility and immunoglobulin E-binding capacity of soy proteins was assessed using an in vitro dynamic gastrointestinal digestion model.
Black bean protein concentrate ameliorates hepatic steatosis by decreasing lipogenesis and increasing fatty acid oxidation in rats fed a high fat-sucrose diet
The black bean is a legume widely consumed in Latin America, however its consumption has decreased significantly in recent decades.
Nevadensin relieves food allergic responses and passive cutaneous anaphylaxis in mice through inhibiting the expression of c-Kit receptors
Nevadensin alleviated mice allergic reactions, attenuated passive cutaneous anaphylaxis and suppressed mast cells activation. Nevadensin diminished c-Kit receptor expression, inhibited the proliferation and accelerated the apoptosis of mast cells.
Lactobacillus plantarum relieves diarrhea caused by enterotoxin-producing Escherichia coli through inflammation modulation and gut microbiota regulation
Lactobacillus plantarum can relieve diarrhea caused by enterotoxigenic Escherichia coli (ETEC), but the remission mechanism has not been fully explained.
Modulation of gut homeostasis by exopolysaccharides from Aspergillus cristatus (MK346334), a strain of fungus isolated from Fuzhuan brick tea, contributes to immunomodulatory activity in cyclophosphamide-treated mice
In this study, exopolysaccharides (EPSs) from fungus Aspergillus cristatus (MK346334) isolated from Fuzhuan brick tea maintained gut homeostasis and exhibited immunomodulatory activity in cyclophosphamide-treated mice.
Yeast β-glucan, a potential prebiotic, showed a similar probiotic activity to inulin
β-Glucan, an economical by-product of yeast, showed a similar probiotic activity to inulinw, which is expected to be a potential prebiotic for the modulation of gut microbiota.
Flavonoid-rich extracts from okra flowers exert antitumor activity in colorectal cancer through induction of mitochondrial dysfunction-associated apoptosis, senescence and autophagy
AFE activates p53, acting on apoptosis, autophagy, senescence, and metastasis, and induces mitochondrial dysfunction.
Effects of (−)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice
(−)-Epicatechin reduces neuroinflammation and Tau-hp, improving memory and learning.
Unlocking the potential of minimally processed corn germ oil and high oleic soybean oil to prepare oleogels for bakery application
Minimally processed plant oil used as a novel source to prepare oleogels for cookie making.
Effect of particle size distribution on rheological properties of chocolate
Particle size distribution and particle size ratio have an important effect on rheological properties of model chocolate samples, but also other factors like particle shape, surface roughness and hydrophilicity should be taken into account.
Digestibility, bioactivity and prebiotic potential of phenolics released from whole gold kiwifruit and pomace by in vitro gastrointestinal digestion and colonic fermentation
The aim of this study was to evaluate the release of phenolics, biological activity variation and prebiotic potential of whole gold kiwifruit and pomace by in vitro digestion and colonic fermentation.
The dietary peroxidized lipid, 13-HPODE, promotes intestinal inflammation by mediating granzyme B secretion from natural killer cells
The dietary peroxidized lipid, 13-HPODE, stimulates natural killer cell granzyme B production and secretion, with potential implications for intestinal inflammation.
Interaction of myofibrillar proteins and epigallocatechin gallate in the presence of transglutaminase in solutions
The rheological behavior, assembly measurements, thermal stability, molecular conformation, and molecular interactions of myofibrillar proteins (MP) modified by transglutaminase (TGase) and epigallocatechin-3-gallate (EGCG) were investigated.
Black garlic melanoidins prevent obesity, reduce serum LPS levels and modulate the gut microbiota composition in high-fat diet-induced obese C57BL/6J mice
Black garlic MLDs fermented in the colon, produced SCFAs and modulated gut microbiota composition, thereby protected against hepatic lipid accumulation, insulin resistance, and inflammation partly.
Functional coix seed protein hydrolysates as a novel agent with potential hepatoprotective effect
The aim of this study is to explore the hepatoprotective potential of coix seed protein hydrolysates (CPP) against alcohol-induced liver injury, and investigate the underlying mechanisms.
Combination of dihydroartemisinin and resveratrol effectively inhibits cancer cell migration via regulation of the DLC1/TCTP/Cdc42 pathway
Mechanism of DHA combined with RES in inhibition of cancer cell migration by DLC1/TCTP/Cdc42 signaling.
IRS-1/PI3K/Akt pathway and miRNAs are involved in whole grain highland barley (Hordeum vulgare L.) ameliorating hyperglycemia of db/db mice
The present investigation further unravels the underlying molecular mechanism of WGH on T2DM: IRS-1/PI3K/Akt pathway and related miRNA expression.
Fructooligosaccharides improve growth performance and intestinal epithelium function in weaned pigs exposed to enterotoxigenic Escherichia coli
This study was conducted to explore the protective potential of fructooligosaccharides (FOS) against enterotoxigenic Escherichia coli (ETEC)-induced inflammation and intestinal injury in weaned pigs.
Lactobacillus rhamnosus LRa05 improves lipid accumulation in mice fed with a high fat diet via regulating the intestinal microbiota, reducing glucose content and promoting liver carbohydrate metabolism
LRa05 resists obesity via ameliorating Streptococcus level and glucose metabolism, moreover, the positive correlation between Intestinimonas and palmitoyl ethanolamide and the negative correlation between Enterorhabdus and vitamin B2 are first found.
Peptidomic analysis of pilose antler and its inhibitory effect on triple-negative breast cancer at multiple sites
Pilose antler (PA) is a traditional Chinese functional food and 22 tumor-suppressing polypeptides was detected in its water extract. They inhibit the progression and metastasis of triple-negative 4T1 breast cancer at multiple key sites.
The impact of postharvest storage and cooking time on mineral bioaccessibility in common beans
Postharvest storage negatively influences the common bean mineral bioaccessibility which cannot be counteracted by adapting conventional processing variables. However, dehulling can lead to an improvement of mineral bioaccessibility.
A multi-targeting strategy to ameliorate high-fat-diet- and fructose-induced (western diet-induced) non-alcoholic fatty liver disease (NAFLD) with supplementation of a mixture of legume ethanol extracts
NAFLD (non-alcoholic fatty liver disease) is a multifactorial liver disease related to multiple causes or unhealthy conditions, including obesity and chronic inflammation.
Ubiquinol supplementation modulates energy metabolism and bone turnover during high intensity exercise
Bone and energy metabolism are profoundly influenced by exercise.
Eugenol-loaded chitosan emulsion holds the texture of chilled hairtail (Trichiurus lepturus) better: mechanism exploration by proteomic analysis
Eugenol-loaded chitosan emulsion (ELCE) has been proved to have an excellent antibacterial property.
Contents of key bioactive and detrimental compounds in health performance coffees compared to conventional types of coffees sold in the United States market
The contents of major bioactive compounds in health performance coffees and conventional coffees sold in the U.S. market were compared. Many health claims on the health performance coffee labels were unjustified.
Wheat germ-derived peptide ADWGGPLPH abolishes high glucose-induced oxidative stress via modulation of the PKCζ/AMPK/NOX4 pathway
This study explores the antioxidative effect of a specific wheat germ-derived peptide on high glucose-induced oxidative stress in vascular smooth muscle cells (VSMCs) and the underlying mechanisms.
Roasting carob flour decreases the capacity to bind glycoconjugates of bile acids
Carob is the fruit obtained from Ceratonia siliqua L. and it is a source of bioactive compounds that have been linked to several health promoting effects, including lowering blood cholesterol concentration.
Commercial whey products promote intestinal barrier function with glycomacropeptide enhanced activity in downregulating bacterial endotoxin lipopolysaccharides (LPS)-induced inflammation in vitro
Commercial whey products promote healthy gut by upregulating barrier function related molecules with glycomacropeptide (GMP) having enhanced activity in protecting colon cells against inflammation.
Sacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats
We report that sacha inchi oil with plant-derived ω-3 PUFAs alleviates gut microbiota dysbiosis, prevents bile acid dysmetabolism, and ameliorates hepatic lipid dysmetabolism of glycerolipids, glycerophospholipids, and sphingolipids in HFD rats.
Effectiveness of Vigna unguiculata seed extracts in preventing colorectal cancer
Colorectal cancer (CRC) is one of the most common types of cancer, especially in Western countries, and its incidence rate is increasing every year.
Prebiotic galactooligosaccharides production from lactose and lactulose by Lactobacillus delbrueckii subsp. bulgaricus CRL450
Galactooligosaccharides (GOS) are useful dietary ingredients recognized worldwide as prebiotics.
Effect of mitochondrial quality control on the lycopene antagonizing DEHP-induced mitophagy in spermatogenic cells
This study provides new insights and indicates that LYC prevents DEHP-induced mitophagy of spermatogenic cells via the mitochondrial quality regulation, which may be the target molecule for future DEHP toxicity and the LYC effector mechanism.
Optimization of ergosterol extraction from Pleurotus mushrooms using response surface methodology
In this study, heat-assisted extraction (HAE) was used to optimise the extraction of ergosterol from Pleurotus ostreatus (PO) and Pleurotus eryngii (PE) using response surface methodology (RSM).
Tea polyphenols as a strategy to control starch digestion in bread: the effects of polyphenol type and gluten
Mechanisms to slow down starch digestion – tea polyphenols interact with α-amylase and starch during co-digestion of tea extract and bread.
Theoretical and experimental investigation of the antioxidative activity of monascin
The antioxidant activity of monascin characterized by both theoretical prediction and experimental validation via colorimetric and electron spin resonance (ESR) assays.
Gallic acid reduces the viscosity and water binding capacity of soluble dietary fibers
Water binding capacity and viscosity of soluble dietary fibers are known to be essential drivers of their nutritional benefits.
Lactic acid bacteria reduce diabetes symptoms in mice by alleviating gut microbiota dysbiosis and inflammation in different manners
LAB exhibiting hypoglycaemic effects reduced insulin resistance by contributing to the production of SCFAs and alleviation of inflammation. L. rhamnosus regulated blood lipid more efficiently than Bifidobacterium.
Citrus auraptene induces drug efflux transporter P-glycoprotein expression in human intestinal cells
Citrus phytochemical auraptene activates the drug efflux transporter P-glycoprotein gene (MDR1) promoter in human intestinal LS174T cells. Auraptene increases protein expression of P-glycoprotein. Auraptene can cause food–drug interactions.
Loss of allergy-protective capacity of raw cow's milk after heat treatment coincides with loss of immunologically active whey proteins
Whey proteins denaturing ≤65 °C are important for allergy protection by raw cow's milk.
Influence of type of dairy matrix micro- and macrostructure on in vitro lipid digestion
Recent research indicates that the food matrix can influence digestion kinetics and uptake of nutrients, thus affecting human health.
Milk protein complexation enhances post prandial vitamin D3 absorption in rats
This study investigated the effect of complexation with whey and casein protein, respectively, on post prandial absorption of vitamin D3.
Isolation and identification of cholesterol esterase and pancreatic lipase inhibitory peptides from brewer's spent grain by consecutive chromatography and mass spectrometry
New peptides with cholesterol esterase and pancreatic lipase inhibitory activities were identified from brewer's spent grain hydrolysate, providing added value to this by-product obtained from the beer industry.
Evaluation of the relationship between the peptide profiles and the lipid-lowering properties of olive seed hydrolysates as a tool for tuning hypocholesterolemic functionality
Olive processing generates large amounts of stones with high protein contents.
Systematic bioinformatic analysis of nutrigenomic data of flavanols in cell models of cardiometabolic disease
Flavanol intake positively influences cardiometabolic health in humans – evidence from in vitro nutrigenomic studies.
The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet
In our previous studies, Lactobacillus plantarum Y44 showed antioxidant activity and favorable gastric and intestinal transit tolerance.
Antioxidant and anti-aging effects of a sea cucumber protein hydrolyzate and bioinformatic characterization of its composing peptides
C. elegans-based activity guided and size-based isolation of antioxidant peptide fractions from a sea cucumber protein hydrolyzate and their bioinformatic characterization.
The chemopreventive effect of 5-demethylnobiletin, a unique citrus flavonoid, on colitis-driven colorectal carcinogenesis in mice is associated with its colonic metabolites
The inhibitory effect of dietary 5-demethylnobiletin on colitis-driven colorectal carcinogenesis and the potential roles of its colonic metabolites were reported.
Peptides obtained from edible mushrooms: Hericium erinaceus offers the ability to scavenge free radicals and induce apoptosis in lung cancer cells in humans
This research examined the antioxidant abilities of peptides derived from the Hericium erinaceus mushroom produced via three microbial proteases at varying concentrations.
Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition
Aberrant activation of inflammation and excess accumulation of lipids play pivotal roles in atherosclerosis (AS) progression.
About this collection
This themed collection features articles published in Food & Function marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.