Nutritive implications of dietary microRNAs: facts, controversies, and perspectives
As a group of non-coding RNA molecules, microRNAs have recently become more well-known due to their pivotal role in gene regulation.
The effects of polyphenols and other bioactives on human health
Consuming polyphenols is associated with benefits to cardiometabolic health and brain function, which are driven by their complex interrelationship with the gut microbiome, their bioactive metabolites, and other phytochemicals.
Inhibition of intestinal glucose transport by polyphenols: a mechanism for indirect attenuation of cholesterol absorption?
Intracellular glucose upregulates NPC1L1 and PCSK9 transcripts, increasing cholesterol and chylomicron output. Inhibition of GLUT2 with polyphenols attenuated this response.
Lycopene alleviates H2O2-induced oxidative stress, inflammation and apoptosis in bovine mammary epithelial cells via the NFE2L2 signaling pathway
LYC against H2O2-induced oxidative damage in bMEC at least partly depended on activation of the NFE2L2 signaling pathway.
Dose–response relationship between cocoa flavanols and human endothelial function: a systematic review and meta-analysis of randomized trials
This systematic review with meta-analysis provides evidence that cocoa flavanols could significantly improve endothelial function, with an optimal effect observed with 710 mg total flavanols, 95 mg (−)-epicatechin or 25 mg (+)-catechin.
Banana flour phenolics inhibit trans-epithelial glucose transport from wheat cakes in a coupled in vitro digestion/Caco-2 cell intestinal model
A 10% replacement of wheat flour with banana flour subjected to different processing conditions resulted in from 45.0 to 54.5% higher glucose transport inhibition.
α-Glucosidase inhibitors: consistency of in silico docking data with in vitro inhibitory data and inhibitory effect prediction of quercetin derivatives
The relationship between in silico and in vitro experiments regarding the inhibitory effects of polyphenols on α-glucosidase was investigated.
Glycation by saccharides of different molecular sizes affected the allergenicity of shrimp tropomyosin via epitope loss and the generation of advanced glycation end products
Greater epitope loss than AGE neoallergen generation resulted in weakened allergenicity, whereas less epitope loss than AGE neoallergen generation led to exacerbated allergenicity.
Artificial intelligence identified peptides modulate inflammation in healthy adults
Dietary bioactive peptides have been, among many functionalities, associated with immune modulation and thereby may improve resolution of inflammation.
The dietary freeze-dried fruit powder of Actinidia arguta ameliorates dextran sulphate sodium-induced ulcerative colitis in mice by inhibiting the activation of MAPKs
Oral administration freeze-dried Actinidia arguta powder could ameliorate ulcerative colitis disease via inhibiting the activation of MAPKs pathway.
Improvement of carotenoid bioaccessibility from spinach by co-ingesting with excipient nanoemulsions: impact of the oil phase composition
This study revealed the impact of the oil phase composition on carotenoid bioaccessibility when they were co-ingested with spinach, using an in vitro model.
Natural alkaloids from lotus plumule ameliorate lipopolysaccharide-induced depression-like behavior: integrating network pharmacology and molecular mechanism evaluation
Alkaloids from lotus plumule regulated BDNF-mediated ER stress and autophagy, subsequently attenuating neuroinflammation in LPS-stimulated BV2 microglia and LPS-induced depressive C56BL/6N mice.
Benefits of blended oil consumption over other sources of lipids on the cardiovascular system in obese rats
High consumption of cooking oils in modern society is believed to be the major cause of cardiovascular disease.
HPLC-DAD-ESI-MS/MS screening of phytochemical compounds and the bioactive properties of different plant parts of Zizyphus lotus (L.) Desf.
Zizyphus lotus L. (Desf.) presented flavonoids and secoiridoids derivatives and revealed to have cytotoxicity, anti-inflammatory and antimicrobial potential.
Urinary and plasmatic metabolomics strategy to explore the holistic mechanism of lignans in S. chinensis in treating Alzheimer's disease using UPLC-Q-TOF-MS
Schisandra chinensis (Turcz.) Baill (S. chinensis), a functional food, is used as a tonic and sedative agent in traditional Chinese medicine.
Challenges of traditional herbal teas: plant infusions and their mixtures with bioactive properties
Five traditional and medicinal plants have been individually characterized and analyzed in terms of bioactivities to determine how these characteristics are modified when preparing blends.
Prediction of new targets and mechanisms for quercetin in the treatment of pancreatic cancer, colon cancer, and rectal cancer
Quercetin has been widely found to exhibit anticancer activity with low toxicity and prevalence in foods.
Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring
Perinatal genistein intake mitigated the harmful effects of high-fat diet on metabolism in both dams and female offspring, and the protective effects were associated with the alterations in gut microbiota.
Food matrix and co-presence of turmeric compounds influence bioavailability of curcumin in healthy humans
Turmeric enhances curcumin bioavailability in healthy men.
Effect of chrysin on changes in intestinal environment and microbiome induced by fructose-feeding in rats
Chrysin is able to interfere with the effects of fructose at the intestinal level, which may contribute to the fructose-induced metabolic syndrome features.
Starch digestion kinetics of extruded reformed rice is changed in different ways with added protein or fiber
Extruded rice with added 20% soy protein isolate or corn bran showed two-phase [(k1/k2) high/low, low/high] kinetic patterns.
Multicompartment emulsion droplets for programmed release of hydrophobic cargoes
Multi-compartmentalized microdroplets composed of a multiple subcompartment shell and single microscale host compartment core were prepared facilely for achieving programmed release of hydrophobic cargoes.
Antioxidant dietary fiber isolated from spent coffee (Coffea arabica L.) grounds improves chronotype and circadian locomotor activity in young adults
This study shows for the first time, the modulation of the circadian rhythm and the positive chronobiotic effects of humans, by a dietary intervention, in daily life, with food or dietary fiber source.
Antidepressant-like effects of dietary gardenia blue pigment derived from genipin and tyrosine
Gardenia blue pigments derived from genipin reacting with amino acids have antidepressant effect.
Effect of low-ratio n-6/n-3 PUFA on blood glucose: a meta-analysis
The aim of this meta-analysis was to investigate the effect of increasing dietary low-ratio n-6/n-3 polyunsaturated fatty acid (PUFA) intake on blood glucose and other related indicators.
Repair activity and crystal adhesion inhibition of polysaccharides with different molecular weights from red algae Porphyra yezoensis against oxalate-induced oxidative damage in renal epithelial cells
Porphyra yezoensis polysaccharide repaired oxalate-injured renal epithelial cells and decreased COM crystal adhesion on the cell surface.
Hepatoprotection of auraptene from the peels of citrus fruits against 17α-ethinylestradiol-induced cholestasis in mice by activating farnesoid X receptor
Auraptene protects against estrogen-induced cholestasis in mice.
Eucalyptus globulus Labill. decoction extract inhibits the growth of NCI-H460 cells by increasing the p53 levels and altering the cell cycle profile
Eucalyptus globulus Labill. extracts exhibit anti-tumor properties in three different cancer cell line models.
Inhibition of bleomycin-induced pulmonary fibrosis in mice by the novel peptide EZY-1 purified from Eucheuma
For the first time, a new 16-amino-acid peptide was isolated from Eucheuma, an edible seaweed, and named EZY-1.
Fructus mori L. polysaccharide-iron chelates formed by self-embedding with iron(III) as the core exhibit good antioxidant activity
Mulberry fruit polysaccharide (MFP) was obtained from Morus alba L. by a hot water extraction method, and mulberry polysaccharide fractions named MFP1, MFP2 and MFP3 were isolated by DEAE cellulose-52 column chromatography.
Chemical characterization and biological activities of two varieties of xoconostle fruits Opuntia joconostle F.A.C. Weber ex Diguet and Opuntia matudae Scheinvar
Xoconostle fruits are a good source of healthy compounds.
Dietary polyphenols rutin, taxifolin and quercetin related compounds target Leishmania amazonensis arginase
Taxifolin, quercetin glucuronide and quercetin glucosides inhibit arginase from Leishmania amazonensis.
Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry
Ocimum basilicum var. purpurascens leaves are a rich source of bioactive compounds with antimicrobial activity, which could be considered as an excellent ingredient for the food industry.
Phenolic profile and effects of acetone fractions obtained from the inflorescences of Calluna vulgaris (L.) Hull on vaginal pathogenic and non-pathogenic bacteria
Fractionated acetone extract of Calluna vulgaris (L.) Hull rich in (−)-epicatechin and (+)-catechin derivatives inhibited vaginal pathogenic bacteria.
Dietary L-tryptophan alleviated LPS-induced intestinal barrier injury by regulating tight junctions in a Caco-2 cell monolayer model
The intestinal epithelial layer forms a barrier through cell–cell tight junctions and breaking or even slightly disrupting this barrier can lead to serious pathological consequences, including infection and inflammation.
Exploiting the bioactive properties of γ-oryzanol from bran of different exotic rice varieties
Analysing nine rice bran extracts with different γ-oryzanol concentrations revealed cytotoxic effects on four human tumour cell lines.
Effects of dietary supplementation with yeast glycoprotein on growth performance, intestinal mucosal morphology, immune response and colonic microbiota in weaned piglets
Antibiotics are commonly provided to weaned piglets; however, this practice has become controversial due to the increased occurrences of microbial resistance, and alternatives are needed.
Potato product form impacts in vitro starch digestibility and glucose transport but only modestly impacts 24 h blood glucose response in humans
Potatoes are rich in phenolic compounds which have been reported to impact starch digestion and intestinal glucose transport in model systems through phenolic–starch interactions.
Soybean germ oil reduces blood cholesterol by inhibiting cholesterol absorption and enhancing bile acid excretion
Soybean germ oil is beneficial in management of hypercholesterolemia in hamsters fed a high cholesterol diet.
Impact of in vitro gastrointestinal digestion on the chemical composition, bioactive properties, and cytotoxicity of Vitis vinifera L. cv. Syrah grape pomace extract
Grape pomace (GP) is a major byproduct worldwide, and it is well known for its bioactive compounds, such as fibers and phenolic compounds, that are popular for their impact upon human health, including in gastrointestinal health.
Fabrication of plant-based vitamin D3-fortified nanoemulsions: influence of carrier oil type on vitamin bioaccessibility
The influence of carrier oil type (corn, fish, or flaxseed oil) on the production, stability, and simulated gastrointestinal behavior of vitamin-fortified nanoemulsions was studied.
Targeted delivery of phycocyanin for the prevention of colon cancer using electrospun fibers
A colonic phycocyanin-loaded delivery system was constructed by coaxial electrospinning for the prevention of colon cancer.
Development of a natural preservative obtained from male chestnut flowers: optimization of a heat-assisted extraction technique
The optimization of phenolic compound extraction from male chestnut flowers has allowed the obtainment of a natural ingredient with potential application in the food industry.
Fabrication of BSA-Pinus koraiensis polyphenol-chitosan nanoparticles and their release characteristics under in vitro simulated gastrointestinal digestion
BSA and chitosan were used to prepare nanoparticles of polyphenols from the pine cones of Pinus koraiensis (PKP-NPs).
Food-borne patulin toxicity is related to gut barrier disruption and can be prevented by docosahexaenoic acid and probiotic supplementation
Patulin toxicity is related to gut barrier disruption and can be prevented by docosahexaenoic acid and probiotic supplementation.
Chemical composition and bioactive properties of Sanguisorba minor Scop. under Mediterranean growing conditions
Sanguisorba minor Scop. is a perennial plant native to the Mediterranean region which exhibits several medicinal activities.
The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities
Curcumin, bisdemethoxycurcumin and demethoxycurcumin are known for their bioactivity.
Agaricus blazei Murrill from Brazil: an ingredient for nutraceutical and cosmeceutical applications
Agaricus blazei bio-residues were explored as a nutraceutical and cosmaceutical ingredient, by evaluating its effect on cell viability using intestinal and skin cell lines, respectively. A. blazei revealed to be a good ingredient for those applications.
Cyanidin inhibits EMT induced by oxaliplatin via targeting the PDK1–PI3K/Akt signaling pathway
Anthocyanins have been shown to exhibit antitumor activity in several cancers in vitro and in vivo.
Lysine-induced swine satellite cell migration is mediated by the FAK pathway
This study demonstrated that the activation of satellite cell migration is dependent on Lysine levels. Furthermore, Lys-dependent satellite cell migration is mediated by the FAK pathway.
Biofunctionalization of selenium nanoparticles with a polysaccharide from Rosa roxburghii fruit and their protective effect against H2O2-induced apoptosis in INS-1 cells
The stable selenium nanoparticles (RP3-SeNPs) have a strong protective effect against H2O2-induced apoptosis in INS-1 cells.
Geographical location specific composition of cultured microbiota and Lactobacillus occurrence in human breast milk in China
Composition of microbiota in human breast milk in China was highly geographical location specific and can be classified into Enterococcus, Streptococcus and Staphylococcus dominant group, respectively. The occurrence rate of Lactobacillus in Northwest and North China is high. Lactobacillus reuteri and Lactobacillus gasseri in Tibetan samples, Gansu Lintan, were the highest.
Dietary wild bitter gourd displays selective androgen receptor modulator like activity and improves the muscle decline of orchidectomized mice
Wild bitter gourd, like selective androgen receptor modulators (SARMs), restored the mass of androgen responsive muscles but not prostate and might improve skeletal muscle function in orchidectomized mice.
Effect of the food form and structure on lipid digestion and postprandial lipaemic response
As the food matrix is a determinant of the rate of fat digestion and absorption, it is important for the modulation of postprandial triglyceridaemia.
Anti-melanogenesis properties of condensed tannins from Vigna angularis seeds with potent antioxidant and DNA damage protection activities
The characterization, anti-tyrosinase activity, cytotoxicity against B16 mouse melanoma cells, antioxidant, and DNA damage protection activities of condensed tannins purified from Vigna angularis seeds were reported.
Evaluation of the bitter components of bamboo shoots using a metabolomics approach
The metabolomics methodology can be more convenient to evaluate the function of food.
Calluna vulgaris (L.) Hull: chemical characterization, evaluation of its bioactive properties and effect on the vaginal microbiota
C. vulgaris inflorescences revealed myricetin derivatives as the main compound and polar extracts revealed higher bioactivities, preserving vaginal microbiota.
Dietary methionine restriction reduces hepatic steatosis and oxidative stress in high-fat-fed mice by promoting H2S production
Dietary methionine restriction reduces hepatic steatosis and oxidative stress in high-fat-fed mice by promoting H2S production.
Algal oil rich in n-3 polyunsaturated fatty acids suppresses B16F10 melanoma lung metastasis by autophagy induction
Melanoma is a malignant tumor that arises from epidermal melanocytes with high morbidity and mortality, and currently, there are no effective conventional genotoxic treatments or systematic treatment.
Spirulina platensis and silicon-enriched spirulina equally improve glucose tolerance and decrease the enzymatic activity of hepatic NADPH oxidase in obesogenic diet-fed rats
The prevalence of metabolic syndrome components, such as obesity, glucose intolerance and hepatic steatosis, is rapidly increasing and becoming a major issue of public health.
The antifungal activity of extracts of Osmundea pinnatifida, an edible seaweed, indicates its usage as a safe environmental fungicide or as a food additive preventing post-harvest fungal food contamination
Extracts of the edible seaweed Osmundea pinnatifida impair Aspergillus fumigatus and Alternaria infectoria conidiation.
Enhancing the antimicrobial and antifungal activities of a coloring extract agent rich in betacyanins obtained from Gomphrena globosa L. flowers
Gomphrena globosa flower extracts were optimized to achieve high antimicrobial and antifungal activities: 10.8 min, 410.5 W, 57.8% of ethanol, and 5 g L−1 solid–liquid ratio.
Licochalcone A inhibits the invasive potential of human glioma cells by targeting the MEK/ERK and ADAM9 signaling pathways
Licochalcone A (LicA) has been reported to possess antitumor properties.
Chlorogenic acid methyl ester exerts strong anti-inflammatory effects via inhibiting the COX-2/NLRP3/NF-κB pathway
In vivo and in vitro studies show that chlorogenic acid methyl ester (CME) has been proven to be a potential nutraceutical for preventing inflammation.
Deoxycholic acid disrupts the intestinal mucosal barrier and promotes intestinal tumorigenesis
Deoxycholic acid (DCA) induced intestinal low grade inflammation and disrupted the mucosal physical and functional barriers, aggravating intestinal tumorigenesis.
Oleogel-structured composite for the stabilization of ω3 fatty acids in fish oil
The fish oil is encapsulated in a multi-compartment system featuring β-cyclodextrin complexation within whey protein isolate (WPI) coated oleogel particles.
The solvation properties and effect of D-fructose on the taste behavior of Citrus aurantium active components in aqueous solutions
The densities and viscosities of synephrine hydrochloride and octopamine hydrochloride aqueous solutions were determined.
Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance
Non-Camellia tea and herbal medicine help prevent the development of diabetes and other metabolic diseases.
Potential of iturins as functional agents: safe, probiotic, and cytotoxic to cancer cells
Iturins are safe for oral administration, increase the abundance of probiotics, and reduce fat intake by regulating the intestinal microflora.
Characterization of transglutaminase from Bacillus subtilis and its cross-linking function with a bovine serum albumin model
The functional properties of bovine serum albumin were significantly improved by Bacillus subtilis transglutaminase with good thermal and pH stability.
About this collection
This themed collection features articles published in Food & Function marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.