Issue 7, 2020

Anti-stress effects of polyphenols: animal models and human trials

Abstract

Polyphenols, a category of plant compounds that contain multiple phenol structural units, are widely distributed throughout the plant kingdom and have multiple benefits for human health including anti-obesity, anti-hyperglycemic, and anti-hyperlipidemic effects. Additionally, polyphenols have recently gained attention for their anti-stress effects. In this review article, we summarize physiological responses against exposure to stressors and discuss biomarkers for exposure to stressors that are widely used in animal studies and human trials. We also review commonly used animal models for evaluating anti-stress effects. Finally, we discuss recent findings related to the anti-stress effects of polyphenols evaluated in animal models and human trials, and their putative mechanisms. These emerging data require further investigation in scientific studies and human trials to evaluate the anti-stress effects of polyphenols and their potential use for the prevention of stress-related health problems.

Graphical abstract: Anti-stress effects of polyphenols: animal models and human trials

Article information

Article type
Review Article
Submitted
01 May 2020
Accepted
30 Jun 2020
First published
06 Jul 2020

Food Funct., 2020,11, 5702-5717

Anti-stress effects of polyphenols: animal models and human trials

H. Sakakibara and K. Shimoi, Food Funct., 2020, 11, 5702 DOI: 10.1039/D0FO01129K

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