Jump to main content
Jump to site search


Functional coix seed protein hydrolysates as a novel agent with potential hepatoprotective effect

Author affiliations

Abstract

The aim of this study is to explore the hepatoprotective potential of coix seed protein hydrolysates (CPP) against alcohol-induced liver injury, and investigate the underlying mechanisms. The hepatoprotective activity of CPP at 0, 10, 30, 50 mg per kg BW was demonstrated in vivo by using ICR male mice fed with 40% v/v alcohol (5 ml per kg body weight) daily to induce alcoholic liver injury. CPP could significantly improve the alcohol metabolism in liver as evidenced by the enhanced activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The overexpression of serum tumor necrosis factor-α (TNF-α) and interleukin-β (IL-β) by alcohol induced injury was altered by CPP administration. The lipid peroxidation was also retarded by CPP by suppressing malondialdehyde (MDA) level and increasing the activity of liver superoxide dismutase (SOD). The findings from the present study suggested that CPP produced significant hepatoprotection and showed potential to be used as a dietary supplement or the ingredient of functional food.

Graphical abstract: Functional coix seed protein hydrolysates as a novel agent with potential hepatoprotective effect

Back to tab navigation

Article information


Submitted
25 Jun 2020
Accepted
05 Oct 2020
First published
14 Oct 2020

Food Funct., 2020, Advance Article
Article type
Paper

Functional coix seed protein hydrolysates as a novel agent with potential hepatoprotective effect

L. Chen, S. Zhang, Y. Zi, H. Zhao, H. Wang and Y. Zhang, Food Funct., 2020, Advance Article , DOI: 10.1039/D0FO01658F

Social activity

Search articles by author

Spotlight

Advertisements