Issue 6, 2020

Milk protein complexation enhances post prandial vitamin D3 absorption in rats

Abstract

This study investigated the effect of complexation with whey and casein protein, respectively, on post prandial absorption of vitamin D3. For this purpose, Sprague-Dawley rats (n = 78) were administered 840 IU vitamin D3 dissolved in ethanol and either (i) complexed with whey protein isolate (protein : vitamin ration 2 : 1), (ii) complexed with caseinate (protein : vitamin ration 2 : 1), or (iii) provided in a water solution. Serum concentrations of vitamin D3, 25-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 were measured before and 2, 3, 4, 5, 6, 7, 8, and 10 hours after administration of vitamin D3. Significant effects of complexation on serum concentrations of vitamin D3, 25-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 were demonstrated. Complexation with whey protein isolate resulted in the fastest and highest absorption of vitamin D3 while an effect of complexation with caseinate was evident but more modest and non-significant. In conclusion, the study demonstrates that complexation with milk proteins is an efficient strategy to enhance bioaccessibility of vitamin D3.

Graphical abstract: Milk protein complexation enhances post prandial vitamin D3 absorption in rats

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
23 Apr 2020
Accepted
31 May 2020
First published
01 Jun 2020

Food Funct., 2020,11, 4953-4959

Milk protein complexation enhances post prandial vitamin D3 absorption in rats

I. E. I. Lindahl, M. Danielsen, T. K. Dalsgaard, L. Rejnmark, P. Bollen and H. C. Bertram, Food Funct., 2020, 11, 4953 DOI: 10.1039/D0FO01062F

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