Sesamol: A powerful functional food ingredient from sesame oil for cardioprotection
Phytophenols are important bioactive food based chemical entities, largely present in several natural sources. Among them, sesamol is one of the key natural phenols found in sesame seeds and piper cubeba etc. Several studies have reported that sesame oil is a potent cardioprotective functional food. Papers on the utility of sesamol in sesame oil (Chemical name of sesamol is methylenedioxyphenol-MDP) have appeared in the literature, though, there is no single concise review on the usefulness of seamol in sesame oil in CVD is available in the literature. Cardiovascular disease (CVD) is the most challenging health problems encountered by global population. There has been an increasing interest in the growth of effective cardiovascular therapeutics, specifically of natural origin. Among various natural sources of chemicals, phytochemicals are micronutrients and bio-compatible scaffolds having extraordinary efficacy at the multiple disease targets with minimal or no adverse effect. This review offers a perspective on the existing literature on functional food in sesame oil with particular focus on sesamol and its derivatives having nutritional and cardioprotective properties. This is demonstrated to have shown specifically modulating oxidative enzyme, myeloperoxidase (MPO), and other proteins which are detrimental to human well-being. The molecular mechanism of cardioprotection by this food ingredient, primarily attributed to methylenedioxy group present in sesamol component.