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Themed collection Clinical spectroscopy

61 items
Editorial

SPEC 2018: International Society of Clinical Spectroscopy

Welcome to the latest themed issue on the topic of Optical Diagnosis in Analyst, guest-edited by Dr. Matthew Baker.

Graphical abstract: SPEC 2018: International Society of Clinical Spectroscopy
From the themed collection: Clinical spectroscopy
Editorial

Optical diagnosis – highlighting the clinical applications of vibrational spectroscopy

Welcome to the latest themed issue on the topic of Optical Diagnosis in Analyst, guest-edited by Kathleen Gough and Frédéric Leblond.

Graphical abstract: Optical diagnosis – highlighting the clinical applications of vibrational spectroscopy
From the themed collection: Clinical spectroscopy
Critical Review

Biomedical applications of mid-infrared quantum cascade lasers – a review

Quantum cascade lasers with high spectral power density and narrow band emission profiles provide novel access to biomedical applications.

Graphical abstract: Biomedical applications of mid-infrared quantum cascade lasers – a review
From the themed collection: Clinical spectroscopy
Critical Review

Clinical applications of infrared and Raman spectroscopy: state of play and future challenges

This review examines the state-of-the-art of clinical applications of infrared absorption and Raman spectroscopy, outstanding challenges, and progress towards translation.

Graphical abstract: Clinical applications of infrared and Raman spectroscopy: state of play and future challenges
From the themed collection: Clinical spectroscopy
Critical Review

Raman spectroscopy for cancer detection and cancer surgery guidance: translation to the clinics

This review summarizes actual clinical needs in oncology that can be addressed by Raman spectroscopy, provides results published in the last 10 years and analyses the current status of translation of these results into clinical practice.

Graphical abstract: Raman spectroscopy for cancer detection and cancer surgery guidance: translation to the clinics
From the themed collection: Clinical spectroscopy
Critical Review

Raman technologies in cancer diagnostics

This review explores Raman technologies with a particular emphasis on their utility for cancer diagnostic applications.

Graphical abstract: Raman technologies in cancer diagnostics
From the themed collection: Clinical spectroscopy
Critical Review

Can mid-infrared biomedical spectroscopy of cells, fluids and tissue aid improvements in cancer survival? A patient paradigm

This review takes a fresh approach from the patient perspective; offering insight into the applications of midinfrared biomedical spectroscopy.

Graphical abstract: Can mid-infrared biomedical spectroscopy of cells, fluids and tissue aid improvements in cancer survival? A patient paradigm
From the themed collection: Clinical spectroscopy
Open Access Communication

Dual purpose fibre – SERS pH sensing and bacterial analysis

A way to incorporate SERS nanosensors on the end of an optical fibre that also allows for the extraction of bacterial samples.

Graphical abstract: Dual purpose fibre – SERS pH sensing and bacterial analysis
From the themed collection: Clinical spectroscopy
Communication

Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell

First IR-SNOM images over the Amide I band taken in the centre of an oesophageal cancer cell.

Graphical abstract: Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell
From the themed collection: Clinical spectroscopy
Communication

Identification of bacterial species by untargeted NMR spectroscopy of the exo-metabolome

Identification of bacterial species is a crucial bottleneck for clinical diagnosis of infectious diseases.

Graphical abstract: Identification of bacterial species by untargeted NMR spectroscopy of the exo-metabolome
From the themed collection: Clinical spectroscopy
Paper

Three-dimensional depth profiling of prostate tissue by micro ATR-FTIR spectroscopic imaging with variable angles of incidence

Variable angle micro ATR-FTIR, via the insertion of circular apertures, was used to measure tissue samples at various penetration depths.

Graphical abstract: Three-dimensional depth profiling of prostate tissue by micro ATR-FTIR spectroscopic imaging with variable angles of incidence
From the themed collection: Clinical spectroscopy
Paper

Raman spectroscopy for the evaluation of the radiobiological sensitivity of normal human breast cells at different time points after irradiation by a clinical proton beam

Radiobiological effects occurring in normal human breast cells exposed to a low dose of a clinical proton beam are detectable by means of Raman spectra and the ratiometric analysis of Raman peak intensities.

Graphical abstract: Raman spectroscopy for the evaluation of the radiobiological sensitivity of normal human breast cells at different time points after irradiation by a clinical proton beam
From the themed collection: Clinical spectroscopy
Paper

Detection of leucine aminopeptidase activity in serum using surface-enhanced Raman spectroscopy

A specific reaction-based SERS approach was developed for the selective and sensitive detection of leucine aminopeptidase activity in serum.

Graphical abstract: Detection of leucine aminopeptidase activity in serum using surface-enhanced Raman spectroscopy
From the themed collection: Clinical spectroscopy
Open Access Paper

In-line whole blood fractionation for Raman analysis of blood plasma

Raman studies of dynamically expanded cell-free plasma domains in microfluidic blood flow.

Graphical abstract: In-line whole blood fractionation for Raman analysis of blood plasma
From the themed collection: Clinical spectroscopy
Open Access Paper

Tandem fluorescence and Raman (fluoRaman) characterisation of a novel photosensitiser in colorectal cancer cell line SW480

A novel photosensitiser, DC473, designed with solvatochromatic fluorescence and distinct Raman signal, is detected with tandem fluoRaman in SW480 cells.

Graphical abstract: Tandem fluorescence and Raman (fluoRaman) characterisation of a novel photosensitiser in colorectal cancer cell line SW480
From the themed collection: Clinical spectroscopy
Open Access Paper

Characterization of inflammatory breast cancer: a vibrational microspectroscopy and imaging approach at the cellular and tissue level

Inflammatory breast cancer (IBC) has a poor prognosis because of the lack of specific biomarkers and its late diagnosis.

Graphical abstract: Characterization of inflammatory breast cancer: a vibrational microspectroscopy and imaging approach at the cellular and tissue level
From the themed collection: Clinical spectroscopy
Open Access Paper

Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer's disease brains

Non-negative factorization analysis applied to spontaneous Brillouin microscopy maps of amyloid-beta plaques in a transgenic mouse model enables to resolve spatially distinct components with specific mechanical properties.

Graphical abstract: Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer's disease brains
From the themed collection: Clinical spectroscopy
Paper

Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy

Pre-processing is an essential step in the analysis of spectral data.

Graphical abstract: Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy
From the themed collection: Clinical spectroscopy
Paper

Exploring the efficacy and cellular uptake of sorafenib in colon cancer cells by Raman micro-spectroscopy

This study demonstrates the efficacy and distribution of sorafenib in colon cancer cells by label-free Raman microscopy.

Graphical abstract: Exploring the efficacy and cellular uptake of sorafenib in colon cancer cells by Raman micro-spectroscopy
From the themed collection: Clinical spectroscopy
Paper

Different binding sites of serum albumins in the protein corona of gold nanoparticles

Binding sites of albumins on gold nanoparticles were characterized by surface-enhanced Raman scattering.

Graphical abstract: Different binding sites of serum albumins in the protein corona of gold nanoparticles
From the themed collection: Clinical spectroscopy
Paper

Raman spectroscopic features of primary cardiac microvascular endothelial cells (CMECs) isolated from the murine heart

Gaining knowledge on the biochemical profile of primary endothelial cells on a subcellular level can contribute to better understanding of cardiovascular disease.

Graphical abstract: Raman spectroscopic features of primary cardiac microvascular endothelial cells (CMECs) isolated from the murine heart
From the themed collection: Clinical spectroscopy
Paper

ATR-FTIR spectroscopy shows changes in ovarian cancer cells after incubation with novel organoamidoplatinum(II) complexes

ATR-FTIR spectroscopy has been applied to compare the effect of new organoamidoplatinum(II) complexes with cisplatin on cells from a cisplatin-sensitive and a cisplatin-resistant ovarian cancer cell line.

Graphical abstract: ATR-FTIR spectroscopy shows changes in ovarian cancer cells after incubation with novel organoamidoplatinum(ii) complexes
From the themed collection: Clinical spectroscopy
Paper

A high-throughput serum Raman spectroscopy platform and methodology for colorectal cancer diagnostics

Translating Raman spectroscopy for colorectal cancer diagnosis with a focus on high-throughput design, inter-user variability and sample handling considerations.

Graphical abstract: A high-throughput serum Raman spectroscopy platform and methodology for colorectal cancer diagnostics
From the themed collection: Clinical spectroscopy
Paper

Dual excitation wavelength system for combined fingerprint and high wavenumber Raman spectroscopy

A probe-based Raman spectroscopy system using a single laser module with two excitation wavelengths has been developed for measuring the fingerprint and high wavenumber regions with a single detector.

Graphical abstract: Dual excitation wavelength system for combined fingerprint and high wavenumber Raman spectroscopy
From the themed collection: Clinical spectroscopy
Paper

New insights of Raman spectroscopy for oral clinical applications

Oral injuries are currently diagnosed by histopathological analysis of biopsy, which is an invasive procedure and does not give immediate results.

Graphical abstract: New insights of Raman spectroscopy for oral clinical applications
From the themed collection: Clinical spectroscopy
Paper

Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags

Spectral information relevant to the quality of stored blood can be obtained in situ through sealed blood transfusion bags using a commercially available instrument.

Graphical abstract: Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags
From the themed collection: Clinical spectroscopy
Paper

Near-field infrared nanospectroscopy and super-resolution fluorescence microscopy enable complementary nanoscale analyses of lymphocyte nuclei

First near-field infrared spectroscopy and imaging of lymphocyte nucleus at 30 nm spatial resolution reveals spectrochemically distinct regions in nuclear organization.

Graphical abstract: Near-field infrared nanospectroscopy and super-resolution fluorescence microscopy enable complementary nanoscale analyses of lymphocyte nuclei
From the themed collection: Clinical spectroscopy
Paper

Raman spectroscopic analysis of high molecular weight proteins in solution – considerations for sample analysis and data pre-processing

This study explores the potential of Raman spectroscopy, coupled with multivariate regression techniques and ion exchange chromatography, to quantitatively monitor diagnostically relevant changes in high molecular weight proteins in liquid plasma.

Graphical abstract: Raman spectroscopic analysis of high molecular weight proteins in solution – considerations for sample analysis and data pre-processing
From the themed collection: Clinical spectroscopy
Paper

Raman spectroscopy as a novel tool for fast characterization of the chemical composition of perivascular adipose tissue

One of the new targets of untapped therapeutic potential is perivascular adipose tissue (pVAT). Based on Raman spectroscopy we demonstrated that the lipid unsaturation degree was clearly distinct in various types of adipose tissues, in particular thoracic and abdominal pVATs, and was influenced by the age of animals.

Graphical abstract: Raman spectroscopy as a novel tool for fast characterization of the chemical composition of perivascular adipose tissue
From the themed collection: Clinical spectroscopy
Paper

Diagnosis of pancreatic cancer via1H NMR metabolomics of human plasma

The investigation of blood plasma via1H NMR metabolomics revealed a panel of potential biomarkers of pancreatic cancer.

Graphical abstract: Diagnosis of pancreatic cancer via1H NMR metabolomics of human plasma
From the themed collection: Clinical spectroscopy
Paper

Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model

PCA score of FTIR spectra in fingerprint region for cultured chondrocytes at day 7, 14 and 21 in HA hydrogel showing that the 3D culture drove chondrocytes (CY) to chondron-like (CN) structure dynamically.

Graphical abstract: Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model
From the themed collection: Clinical spectroscopy
Paper

Surface enhanced resonance Raman spectroscopy (SERRS) for probing through plastic and tissue barriers using a handheld spectrometer

Through tissue imaging of a live breast cancer tumour model using handheld surface enhanced resonance Raman spectroscopy (SERRS).

Graphical abstract: Surface enhanced resonance Raman spectroscopy (SERRS) for probing through plastic and tissue barriers using a handheld spectrometer
From the themed collection: Clinical spectroscopy
Paper

Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease

Plasma samples deposited on low-E slides were analysed in transmission mode by using a FT-NIR spectrometer in order to detect Alzheimer's disease using computer-based methods.

Graphical abstract: Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease
From the themed collection: Clinical spectroscopy
Paper

Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy

A method to acquire the Raman spectra of sub-surface components using diffusely focused radiation in a microscope sampling configuration is described.

Graphical abstract: Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy
From the themed collection: Clinical spectroscopy
Paper

In vitro antibacterial activity of oxide and non-oxide bioceramics for arthroplastic devices: I. In situ time-lapse Raman spectroscopy

Raman spectroscopy proved why the antibacterial response of non-oxide Si3N4 bioceramic is superior to those of alumina-based oxide bioceramics.

Graphical abstract: In vitro antibacterial activity of oxide and non-oxide bioceramics for arthroplastic devices: I. In situ time-lapse Raman spectroscopy
From the themed collection: Clinical spectroscopy
Paper

Noninvasive and prospective diagnosis of coronary heart disease with urine using surface-enhanced Raman spectroscopy

The SERS spectra of human urine could provide valuable information for the noninvasive and prospective diagnosis of patients with suspected CHD.

Graphical abstract: Noninvasive and prospective diagnosis of coronary heart disease with urine using surface-enhanced Raman spectroscopy
From the themed collection: Clinical spectroscopy
Paper

An early investigative serum Raman spectroscopy study of meningioma

Serum Raman spectroscopy is explored to classify meningiomas, which are the most frequently reported non-malignant brain and CNS tumors and are often misdiagnosed. We find the technique can be prospectively extended to the screening of high-risk populations and for therapeutic monitoring.

Graphical abstract: An early investigative serum Raman spectroscopy study of meningioma
From the themed collection: Clinical spectroscopy
Paper

FTIR spectroscopy of chronic venous leg ulcer exudates: an approach to spectral healing marker identification

Chronic venous leg ulcer arises as a venous insufficiency complication and is a cause of great morbidity.

Graphical abstract: FTIR spectroscopy of chronic venous leg ulcer exudates: an approach to spectral healing marker identification
From the themed collection: Clinical spectroscopy
Paper

Deciphering the biochemical similarities and differences among mouse embryonic stem cells, somatic and cancer cells using ATR-FTIR spectroscopy

Cellular macromolecules play important roles in cellular behaviors and biological processes.

Graphical abstract: Deciphering the biochemical similarities and differences among mouse embryonic stem cells, somatic and cancer cells using ATR-FTIR spectroscopy
From the themed collection: Clinical spectroscopy
Paper

Selecting optimal features from Fourier transform infrared spectroscopy for discrete-frequency imaging

Augmenting tissue histology with spectral information from mid-IR spectroscopy will benefit a lot. Optimal bands selection needed to do histopathological classification of mid-IR images will help to reduce imaging time and computation complexity. GPU use for feature selection makes it practical.

Graphical abstract: Selecting optimal features from Fourier transform infrared spectroscopy for discrete-frequency imaging
From the themed collection: Clinical spectroscopy
Paper

Detection of antibiotic resistant Escherichia Coli bacteria using infrared microscopy and advanced multivariate analysis

Determining E. coli bacteria susceptibility by analyzing their FTIR spectra using multivariate analysis.

Graphical abstract: Detection of antibiotic resistant Escherichia Coli bacteria using infrared microscopy and advanced multivariate analysis
From the themed collection: Clinical spectroscopy
Paper

Ultrafast laser-probing spectroscopy for studying molecular structure of protein aggregates

We report the development of a new technique to screen protein aggregation based on laser-probing spectroscopy with sub-picosecond resolution.

Graphical abstract: Ultrafast laser-probing spectroscopy for studying molecular structure of protein aggregates
From the themed collection: Clinical spectroscopy
Paper

High definition infrared chemical imaging of colorectal tissue using a Spero QCL microscope

Mid-infrared microscopy has become a key technique in the field of biomedical science and spectroscopy. In this current study, we explore the use of a QCL infrared microscope to produce high definition, high throughput chemical images useful for the screening of biopsied colorectal tissue.

Graphical abstract: High definition infrared chemical imaging of colorectal tissue using a Spero QCL microscope
From the themed collection: Clinical spectroscopy
Paper

Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients

High throughput Raman spectroscopy method for rapid and accurate diagnosis of prostate cancer using liquid plasma samples.

Graphical abstract: Development of a high throughput (HT) Raman spectroscopy method for rapid screening of liquid blood plasma from prostate cancer patients
From the themed collection: Clinical spectroscopy
Paper

Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties

Non-destructive near infrared spectroscopic data can be utilized for assessment of compositional and mechanical properties of engineered cartilage.

Graphical abstract: Near infrared spectroscopic assessment of developing engineered tissues: correlations with compositional and mechanical properties
From the themed collection: Clinical spectroscopy
Paper

Ultra-filtration of human serum for improved quantitative analysis of low molecular weight biomarkers using ATR-IR spectroscopy

Monitoring of changes in the concentrations of the low molecular weight constituents enhanced by abundant proteins depletion.

Graphical abstract: Ultra-filtration of human serum for improved quantitative analysis of low molecular weight biomarkers using ATR-IR spectroscopy
From the themed collection: Clinical spectroscopy
Paper

SIproc: an open-source biomedical data processing platform for large hyperspectral images

There has recently been significant interest within the vibrational spectroscopy community to apply quantitative spectroscopic imaging techniques to histology and clinical diagnosis.

Graphical abstract: SIproc: an open-source biomedical data processing platform for large hyperspectral images
From the themed collection: Clinical spectroscopy
Paper

Early diagnosis of Alzheimer's disease using infrared spectroscopy of isolated blood samples followed by multivariate analyses

A simple blood test for the diagnosis of Alzheimer's disease using FTIR microscopy.

Graphical abstract: Early diagnosis of Alzheimer's disease using infrared spectroscopy of isolated blood samples followed by multivariate analyses
From the themed collection: Clinical spectroscopy
Paper

Virtual staining of colon cancer tissue by label-free Raman micro-spectroscopy

The great capability of virtual staining for label-free classification of colon cancer tissue has been demonstrated via Raman spectral imaging.

Graphical abstract: Virtual staining of colon cancer tissue by label-free Raman micro-spectroscopy
From the themed collection: Clinical spectroscopy
Paper

Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus

The diagnostic performance of Raman spectroscopy for differentiating lichen sclerosus from other vulval conditions in fresh vulval biopsies is demonstrated.

Graphical abstract: Raman spectroscopy and multivariate analysis for the non invasive diagnosis of clinically inconclusive vulval lichen sclerosus
From the themed collection: Clinical spectroscopy
Paper

Raman spectroscopy in microsurgery: impact of operating microscope illumination sources on data quality and tissue classification

A filter system to perform in vivo Raman spectroscopy measurements under microscope lighting for seamless integration into the surgical workflow.

Graphical abstract: Raman spectroscopy in microsurgery: impact of operating microscope illumination sources on data quality and tissue classification
From the themed collection: Clinical spectroscopy
Paper

Feature driven classification of Raman spectra for real-time spectral brain tumour diagnosis using sound

Spectroscopic diagnostics have been shown to be an effective tool for the analysis and discrimination of disease states from human tissue.

Graphical abstract: Feature driven classification of Raman spectra for real-time spectral brain tumour diagnosis using sound
From the themed collection: Clinical spectroscopy
Paper

Computational cell analysis for label-free detection of cell properties in a microfluidic laminar flow

This method utilizes machine learning algorithms and fluid mechanic properties of cells in a microfluidic channel to find the compositions of cell mixtures.

Graphical abstract: Computational cell analysis for label-free detection of cell properties in a microfluidic laminar flow
From the themed collection: Clinical spectroscopy
Paper

Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology

Fourier transform infrared (FTIR) spectroscopy has long been established as an analytical technique for the measurement of vibrational modes of molecular systems.

Graphical abstract: Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology
From the themed collection: Clinical spectroscopy
Paper

Immunoassay for tumor markers in human serum based on Si nanoparticles and SiC@Ag SERS-active substrate

An immunoassay protocol is described to detect tumor markers in human serum based on a sandwich structure consisting of nano-Si immune probes and SiC@Ag SERS-active immune substrate.

Graphical abstract: Immunoassay for tumor markers in human serum based on Si nanoparticles and SiC@Ag SERS-active substrate
From the themed collection: Clinical spectroscopy
Paper

Study of the biochemical effects induced by X-ray irradiations in combination with gadolinium nanoparticles in F98 glioma cells: first FTIR studies at the Emira laboratory of the SESAME synchrotron

One strategy to improve the clinical outcome of radiotherapy is to use nanoparticles as radiosensitizers.

Graphical abstract: Study of the biochemical effects induced by X-ray irradiations in combination with gadolinium nanoparticles in F98 glioma cells: first FTIR studies at the Emira laboratory of the SESAME synchrotron
From the themed collection: Clinical spectroscopy
Open Access Paper

Surface enhanced Raman spectroscopic direct determination of low molecular weight biothiols in umbilical cord whole blood

Biothiols are determined in whole blood samples by Surface Enhanced Raman Spectroscopy (SERS).

Graphical abstract: Surface enhanced Raman spectroscopic direct determination of low molecular weight biothiols in umbilical cord whole blood
From the themed collection: Clinical spectroscopy
Paper

Non-invasive spectroscopy of transfusable red blood cells stored inside sealed plastic blood-bags

Spatially Offset Raman spectroscopy (SORS) has been used to retrieve biochemical information from red blood cell concentrate within sealed PVC bags, demonstrating the potential of SORS to non-invasively assess the condition of the cells prior to transfusion.

Graphical abstract: Non-invasive spectroscopy of transfusable red blood cells stored inside sealed plastic blood-bags
From the themed collection: Clinical spectroscopy
Paper

Naked-eye nanobiosensor for therapeutic drug monitoring of methotrexate

Sensing of methotrexate at clinically-relevant concentrations was achieved with a plasmon-coupling assay.

Graphical abstract: Naked-eye nanobiosensor for therapeutic drug monitoring of methotrexate
From the themed collection: Clinical spectroscopy
Paper

Direct-growth carbon nanotubes on 3D structural microelectrodes for electrophysiological recording

Direct growth of CNTs on 3D microelectrodes could detect distinguished zebrafish ECG resulting from the interfacial improvement analyzed by EIS.

Graphical abstract: Direct-growth carbon nanotubes on 3D structural microelectrodes for electrophysiological recording
From the themed collection: Clinical spectroscopy
Open Access Correction

Correction: Clinical applications of infrared and Raman spectroscopy: state of play and future challenges

From the themed collection: Clinical spectroscopy
61 items

About this collection

This collection of papers highlights fundamental research and applications of clinical spectroscopy published in analyst since 2017. The collection contains selected research and review articles in this field.

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