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ATR-FTIR spectroscopy shows changes in ovarian cancer cells after incubation with novel organoamidoplatinum complexes

Abstract

Attenuated Total Reflection Fourier Transform Infrared (ATR- FT-IR ) spectroscopy has been applied to cpmpare the effect of the new organoamidoplatinum(II) complexes [Pt{NH(p-HC6F4)CH2CH2N(p-HC6F4)}(py)(O2CR)] (R = C6F4 or 2,4,6-Me3C6H2) with cisplatin on cells from one cisplatin-sensitive ovarian cancer cell line (A2780) and one cisplatin-resistant ovarian cancer cell line (A2780R). After incubation of the cells with cisplatin, 1 and 2 for 48 hours, distinct changes were found in the ATR- FT-IR spectra. Comparison of the second derivative spectra suggests that 1 and 2 induce similar chemical changes in both cell lines, A2780 and A2780R, while cisplatin had a slight effect on A2780 and A2780R cells. Furthermore, drugs 1 and 2 result in changes to the phosphodiester and polysaccharide bands in the spectra. This work shows how ATR- FT-IR can be applied to monitor the effects of organoamidoplatinum(II) complexes on cisplatin-sensitive and cisplatin-resistant cell lines providing potential information on how drugs affect the cellular metabolism.

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Publication details

The article was received on 12 Aug 2018, accepted on 02 Nov 2018 and first published on 05 Nov 2018


Article type: Paper
DOI: 10.1039/C8AN01558A
Citation: Analyst, 2018, Accepted Manuscript
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    ATR-FTIR spectroscopy shows changes in ovarian cancer cells after incubation with novel organoamidoplatinum complexes

    K. Al-Jorani, A. Ruther, R. Haputhanthri, G. B. Deacon, H. L. Li, C. Cullinane and B. R. Wood, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN01558A

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