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Themed collection Medicinal Inorganic Chemistry

21 items
Editorial

Medicinal inorganic chemistry: a web themed issue

Guest editors introduce this web collection celebrating current achievements and future perspectives in medicinal inorganic chemistry, including: metal-based diagnostics and therapeutics, mechanistic studies of metallotherapeutics, the role of metal ions and metal ion homeostasis in disease, chelation therapy, metalloprotein inhibitors, and metal ion sensing.

Graphical abstract: Medicinal inorganic chemistry: a web themed issue
From the themed collection: Medicinal Inorganic Chemistry
Open Access Feature Article

Exploration of the medical periodic table: towards new targets

Exploration of medicinal chemistry of the elements of the periodic table, and especially metals, offers the promise of new drugs and diagnostic agents with novel targets and new mechanisms of action.

Graphical abstract: Exploration of the medical periodic table: towards new targets
From the themed collection: Medicinal Inorganic Chemistry
Feature Article

Tumour targeting with radiometals for diagnosis and therapy

This feature article highlights the field of metallic radionuclides in nuclear oncology for diagnosis with PET or SPECT and treatment with α, β, or Auger electron therapy.

Graphical abstract: Tumour targeting with radiometals for diagnosis and therapy
From the themed collection: Medicinal Inorganic Chemistry
Feature Article

The path for metal complexes to a DNA target

Recent results on a variety of transition metal complexes targeted to DNA are reviewed in order to illustrate many of the issues involved in new therapeutic design.

Graphical abstract: The path for metal complexes to a DNA target
From the themed collection: Medicinal Inorganic Chemistry
Communication

Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

The N-terminus of hCTR1 was demonstrated to bind three Cu+ ions tightly (log K = 14.92) and reversibly via its Met-rich motifs.

Graphical abstract: Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1
From the themed collection: Medicinal Inorganic Chemistry
Communication

Zinc finger peptide cleavage by a dinuclear platinum compound

The platinum-assisted cleavage of the C-terminal HIV NCp7 zinc finger is a novel strategy to inactivate this important biological target.

Graphical abstract: Zinc finger peptide cleavage by a dinuclear platinum compound
From the themed collection: Medicinal Inorganic Chemistry
Communication

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

Simultaneous multi-element imaging using NanoSIMS provides information on the subcellular localisation of both metal and ligands inside tumour cells treated with 15N-labelled Pt drugs.

Graphical abstract: NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound
From the themed collection: Medicinal Inorganic Chemistry
Communication

Dioxygen mediated conversion of {Fe(NO)2}9 dinitrosyl iron complexes to Roussin's red esters

The reaction of S-bound {Fe(NO)2}9 dinitrosyl iron complexes with dioxygen results in the formation of Roussin's red esters and thiolate oxidation.

Graphical abstract: Dioxygen mediated conversion of {Fe(NO)2}9 dinitrosyl iron complexes to Roussin's red esters
From the themed collection: Medicinal Inorganic Chemistry
Communication

Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation

Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed.

Graphical abstract: Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(i) site that is resistant to O2 oxidation
From the themed collection: Medicinal Inorganic Chemistry
Communication

A comparative chemical–biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand

The biological investigation of novel titanium(IV) complexes shows very interesting properties concerning their binding to biomolecules, cellular accumulation and intracellular distribution depending on the ligand system.

Graphical abstract: A comparative chemical–biological evaluation of titanium(iv) complexes with a salan or cyclopentadienyl ligand
From the themed collection: Medicinal Inorganic Chemistry
Communication

A Pt(II)–Dip complex stabilizes parallel c-myc G-quadruplex

[Pt(Dip)2](PF6)2, prepared by the microwave irradiation method, achieves a selective stabilization towards parallel c-myc GQ via aromatic anchors on phenathroline ligands.

Graphical abstract: A Pt(ii)–Dip complex stabilizes parallel c-myc G-quadruplex
From the themed collection: Medicinal Inorganic Chemistry
Communication

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

Zinc alters the aggregation pathway of human islet amyloid polypeptide (hIAPP), an amyloidogenic peptide linked to type II diabetes, to favor nonfibrillar oligomers over amyloid fibers.

Graphical abstract: Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide
From the themed collection: Medicinal Inorganic Chemistry
Open Access Communication

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Organometallic lapachol complexes, in particular a Ru derivative, induce apoptosis in human tumour cell lines by a mode of action involving oxidative stress.

Graphical abstract: Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity
From the themed collection: Medicinal Inorganic Chemistry
Communication

Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase

Tropolone emerged from the screening of a chelator fragment library (CFL) as an inhibitor of the Zn2+-dependent virulence factor, Pseudomonas aeruginosa elastase (LasB).

Graphical abstract: Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase
From the themed collection: Medicinal Inorganic Chemistry
Communication

Detecting and delivering platinum anticancer drugs using fluorescent maghemite nanoparticles

Rhodamine-embedded maghemite nanoparticles provide a novel strategy for tracing and transporting platinum anticancer drugs in vitro and in vivo.

Graphical abstract: Detecting and delivering platinum anticancer drugs using fluorescent maghemite nanoparticles
From the themed collection: Medicinal Inorganic Chemistry
Communication

A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

Conversion of 1 to 2 results in enhanced antioxidant and radical scavenging capacity thus encouraging applications for neurological disorders such as Alzheimer's disease.

Graphical abstract: A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders
From the themed collection: Medicinal Inorganic Chemistry
Communication

Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed.

Graphical abstract: Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides
From the themed collection: Medicinal Inorganic Chemistry
Communication

Light uncages a copper complex to induce nonapoptotic cell death

The cytotoxicity of a copper complex increases in response to UV light, which triggers cleavage of the complex and causes extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.

Graphical abstract: Light uncages a copper complex to induce nonapoptotic cell death
From the themed collection: Medicinal Inorganic Chemistry
Communication

Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer

A multifunctional breast cancer targeted conjugate was synthesized that combines features of an anti-estrogen and a DNA-directed platinating–intercalating hybrid agent.

Graphical abstract: Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer
From the themed collection: Medicinal Inorganic Chemistry
Communication

Antimicrobial metallopeptides with broad nuclease and ribonuclease activity

Metal complexed derivatives of antimicrobial peptides demonstrate enhanced antimicrobial activity against a variety of pathogenic bacteria and mediate irreversible cleavage of nucleic acids, suggesting a likely mechanism of action.

Graphical abstract: Antimicrobial metallopeptides with broad nuclease and ribonuclease activity
From the themed collection: Medicinal Inorganic Chemistry
Communication

Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

A cyclometallated Pt complex able to interact specifically with the amyloid-β peptide, via the Glu11 and His13 side-chains, can preclude Zn induced aggregation of Aβ.

Graphical abstract: Pt(ii) compounds interplay with Cu(ii) and Zn(ii) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease
From the themed collection: Medicinal Inorganic Chemistry
21 items

About this collection

This web themed issue celebrates current achievements and future perspectives in the exciting field of medicinal inorganic chemistry, including, but not limited to: metal-based diagnostics, metal-based therapeutics, mechanistic studies of metallotherapeutics, the role of metal ions and metal ion homeostasis in disease, chelators of medicinal interest (i.e., chelation therapy), inhibitors of medically-relevant metalloproteins, and metal ion sensing.

The guest editors of the issue are Amy Barrios (University of Utah, Salt Lake City, USA), Seth Cohen (University of California, San Diego, USA), and Mi Hee Lim (University of Michigan, Ann Arbor, USA).

Articles in this web themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow

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