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Issue 26, 2013
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Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

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Abstract

A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed. Traditional 12C/1H and heavy stable isotope 13C/2H-labeled chelator–amino acid conjugates are used as chelating agents to quantify contaminating transition metals, allowing for determination of effective specific activity of radio-metals.

Graphical abstract: Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

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Publication details

The article was received on 19 Dec 2012, accepted on 13 Feb 2013 and first published on 14 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC39071C
Citation: Chem. Commun., 2013,49, 2697-2699
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    Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

    D. Zeng and C. J. Anderson, Chem. Commun., 2013, 49, 2697
    DOI: 10.1039/C3CC39071C

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