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Issue 21, 2013
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Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

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Abstract

Five Pt(II) complexes were tested for their ability to interfere in Cu(II) or Zn(II) coordination to the Aβ peptide. Two of them induce modifications of the Cu(II) sphere but not the associated Cu(Aβ) ROS production. In contrast, they do completely preclude Zn induced Aβ aggregation.

Graphical abstract: Pt(ii) compounds interplay with Cu(ii) and Zn(ii) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

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Publication details

The article was received on 27 Nov 2012, accepted on 23 Jan 2013 and first published on 23 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC38537J
Citation: Chem. Commun., 2013,49, 2130-2132
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    Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

    F. Collin, I. Sasaki, H. Eury, P. Faller and C. Hureau, Chem. Commun., 2013, 49, 2130
    DOI: 10.1039/C3CC38537J

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