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Issue 32, 2013
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Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

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Abstract

The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been shown to affect this aggregation. A combination of EXAFS, NMR, and AFM experiments shows that the influence of zinc is most likely due to the stabilization of prefibrillar aggregates of hIAPP.

Graphical abstract: Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

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Publication details

The article was received on 16 Jan 2013, accepted on 06 Mar 2013 and first published on 06 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40383A
Citation: Chem. Commun., 2013,49, 3339-3341
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    Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

    J. R. Brender, J. Krishnamoorthy, G. M. L. Messina, A. Deb, S. Vivekanandan, C. La Rosa, J. E. Penner-Hahn and A. Ramamoorthy, Chem. Commun., 2013, 49, 3339
    DOI: 10.1039/C3CC40383A

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