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Issue 62, 2013
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Zinc finger peptide cleavage by a dinuclear platinum compound

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Abstract

Electrospray ionisation mass spectrometry (ESI-MS) and {1H, 15N HSQC} NMR spectroscopy has elucidated the binding of a dinuclear platinum compound to a zinc finger peptide with induced backbone cleavage. Cleavage is selective on the N-terminal side of the cysteine residue following incubation at neutral pH, and is further dependent on structure of dinuclear compound.

Graphical abstract: Zinc finger peptide cleavage by a dinuclear platinum compound

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Publication details

The article was received on 05 Jun 2013, accepted on 18 Jun 2013 and first published on 19 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC44219E
Citation: Chem. Commun., 2013,49, 6986-6988
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    Zinc finger peptide cleavage by a dinuclear platinum compound

    J. B. Mangrum, I. Zgani, S. D. Tsotsoros, Y. Qu and N. P. Farrell, Chem. Commun., 2013, 49, 6986
    DOI: 10.1039/C3CC44219E

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