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Issue 21, 2013
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Antimicrobial metallopeptides with broad nuclease and ribonuclease activity

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Abstract

Metallopeptides containing both the complex Cu2+-glycyl-glycyl-histidine (Cu-GGH) and the sequence WRWYCR were shown to possess antimicrobial activity against a variety of pathogenic bacteria, as well as bind to and cleave a variety of nucleic acids, suggesting potential mechanisms for antimicrobial activity that involve binding and/or irreversible cleavage of bacterial nucleic acids.

Graphical abstract: Antimicrobial metallopeptides with broad nuclease and ribonuclease activity

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Publication details

The article was received on 15 Dec 2012, accepted on 24 Jan 2013 and first published on 24 Jan 2013


Article type: Communication
DOI: 10.1039/C3CC38977D
Citation: Chem. Commun., 2013,49, 2118-2120
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    Antimicrobial metallopeptides with broad nuclease and ribonuclease activity

    J. C. Joyner, W. F. Hodnick, A. S. Cowan, D. Tamuly, R. Boyd and J. A. Cowan, Chem. Commun., 2013, 49, 2118
    DOI: 10.1039/C3CC38977D

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