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Issue 32, 2013
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Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

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Abstract

Organometallic RuII, OsII and RhIII complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

Graphical abstract: Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

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Publication details

The article was received on 18 Jan 2013, accepted on 06 Mar 2013 and first published on 06 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40432C
Citation: Chem. Commun., 2013,49, 3348-3350
  • Open access: Creative Commons BY license
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    Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

    W. Kandioller, E. Balsano, S. M. Meier, U. Jungwirth, S. Göschl, A. Roller, M. A. Jakupec, W. Berger, B. K. Keppler and C. G. Hartinger, Chem. Commun., 2013, 49, 3348
    DOI: 10.1039/C3CC40432C

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