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Issue 24, 2013
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Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer

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Abstract

The synthesis of a novel pharmacophore comprising a DNA-targeted platinum–acridine hybrid agent and estrogen receptor-targeted 4-hydroxy-N-desmethyltamoxifen (endoxifen) using carbamate coupling chemistry and its evaluation in breast cancer cell lines are described.

Graphical abstract: Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer

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Publication details

The article was received on 14 Dec 2012, accepted on 06 Feb 2013 and first published on 07 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC38957J
Citation: Chem. Commun., 2013,49, 2415-2417
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    Design of a platinum–acridine–endoxifen conjugate targeted at hormone-dependent breast cancer

    S. Ding, X. Qiao, G. L. Kucera and U. Bierbach, Chem. Commun., 2013, 49, 2415
    DOI: 10.1039/C3CC38957J

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