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Issue 80, 2013
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Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

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Abstract

The N-terminus of hCTR1 was demonstrated to bind three Cu+ ions tightly (log K = 14.92) and reversibly via its Met-rich motifs. Ag+ binds to the protein with the same stoichiometry but much lower affinities than Cu+. The protein also coordinates two Cu2+ ions through its ATCUN motif and His-rich motif with lower affinity. This study provides an insight into the selectivity of the transporter.

Graphical abstract: Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

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Publication details

The article was received on 16 Jul 2013, accepted on 05 Aug 2013 and first published on 07 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45360J
Citation: Chem. Commun., 2013,49, 9134-9136
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    Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

    X. Du, H. Li, X. Wang, Q. Liu, J. Ni and H. Sun, Chem. Commun., 2013, 49, 9134
    DOI: 10.1039/C3CC45360J

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