Themed collection 2024 Organic Chemistry Frontiers Review-type Articles

32 items
Accepted Manuscript - Highlight

Strategic convergent synthesis en route to Veratrum steroidal alkaloids

Highlight

Direct C(sp2)–H activation of allenes via hydrogen-atom transfer (HAT) in organic synthesis

The highlighted reports demonstrate the unique application of the direct HAT strategy to unlock new reactivity of allenes. With this novel method, a variety of structurally diverse allenes are efficiently workable.

Graphical abstract: Direct C(sp2)–H activation of allenes via hydrogen-atom transfer (HAT) in organic synthesis
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Highlight

Cycloparaphenylene-based [2]catenanes: interlocking the carbon nanohoops

In this highlight, recent advances in the design and synthesis of novel cycloparaphenylene (CPP)-based [2]catenanes are presented, with an emphasis on the design strategy and further investigations on their attractive properties.

Graphical abstract: Cycloparaphenylene-based [2]catenanes: interlocking the carbon nanohoops
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Precision single-atom editing: new frontiers in nitrogen insertion and substitution for the generation of N-heterocycles

This paper primarily focuses on the editing of nitrogen atoms, encompassing the insertion of N, substitution of C with N, and utilization of 15N in place of 14N for the construction of N-heterocycles.

Graphical abstract: Precision single-atom editing: new frontiers in nitrogen insertion and substitution for the generation of N-heterocycles
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Accepted Manuscript - Review Article

Electroreduction Strategy: A Sustainable Tool for Generation of Aryl Radicals

From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Unleashing the potentiality of metals: synergistic catalysis with light and electricity

This review provides a comprehensive overview of metal catalysis in photo-electrochemical systems, discussing reaction mechanisms and offering prospects for this triadic catalytic mode.

Graphical abstract: Unleashing the potentiality of metals: synergistic catalysis with light and electricity
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Catalytic alkane C–H functionalization by carbene insertion into unactivated C(sp3)–H bonds

This review summarizes the developments in the C–H functionalization of saturated hydrocarbons (CnH2n+2 and CnH2n) through catalytic carbene insertion into their C–H bonds dated up to February 2024, based on the categories of the types of carbenes.

Graphical abstract: Catalytic alkane C–H functionalization by carbene insertion into unactivated C(sp3)–H bonds
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Accepted Manuscript - Review Article

Silanes a Versatile Hydride Source for Ni–H Chemistry: A Promising Tool for π-Hydro Functionalization

From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Open Access Review Article

Unveiling the beauty of cyclopropane formation: a comprehensive survey of enantioselective Michael initiated ring closure (MIRC) reactions

This review presents a comprehensive overview of the synthesis of cyclopropanes using enantioselective Michael Initiated Ring Closure (MIRC) reactions.

Graphical abstract: Unveiling the beauty of cyclopropane formation: a comprehensive survey of enantioselective Michael initiated ring closure (MIRC) reactions
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Open Access Review Article

Advancements in the synthesis of polyoxygenated oxepanes and thiepanes for applications to natural products

Oxepanes and thiepanes are central motifs and tenants of many biologically important molecules. This comprehensive review covers synthetic methods for their preparation and use in the total synthesis of polyoxygenated oxepane natural products.

Graphical abstract: Advancements in the synthesis of polyoxygenated oxepanes and thiepanes for applications to natural products
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Site-selective C(sp3)–H functionalization of primary aliphatic amines

C–H bond functionalization represents one of the most efficient and straightforward strategies for diversifying existing molecules.

Graphical abstract: Site-selective C(sp3)–H functionalization of primary aliphatic amines
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Electrochemical switching in mechanically interlocked molecules (MIMs)

Mechanically interlocked molecules (MIMs) which include rotaxanes and catenanes are formed by the mechanical linking of two or more components and has the ability to switch between different states in the presence of an external stimuli.

Graphical abstract: Electrochemical switching in mechanically interlocked molecules (MIMs)
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Recent advances in the metal-catalyzed asymmetric alkene hydrogenation of cyclic conjugated carbonyl compounds

This review summarizes the recent advances (2016–2023) in the stereoselective metal-catalyzed hydrogenation of cyclic α,β-unsaturated ketones, lactams and lactones since considerable developments were made. Where possible the application of these methodologies in synthesis is outlined.

Graphical abstract: Recent advances in the metal-catalyzed asymmetric alkene hydrogenation of cyclic conjugated carbonyl compounds
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Accepted Manuscript - Review Article

Advances in Organocatalytic Asymmetric [3+3] Cycloadditions: Synthesis of Chiral Six-Membered (Hetero)cyclic Compounds

Review Article

Review of application of the I2 and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations

The synthesis of small molecules and complex scaffolds is one of the most important topics in organic synthesis.

Graphical abstract: Review of application of the I2 and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Recent progress in the synthesis of N-substituted arylamines by reductive cross-coupling of nitroarenes

This review describes the recent advances in different reaction types and catalytic systems for the construction of C–NAr and S–NAr bonds by nitroaromatic reductive cross-coupling.

Graphical abstract: Recent progress in the synthesis of N-substituted arylamines by reductive cross-coupling of nitroarenes
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Catalytic intermolecular hydrofunctionalizations of ynamides

This review carefully summarizes the advances achieved in catalytic hydrofunctionalization of ynamides and is categorized by the bond formation type including C−C, C−X, C−O, C−N, C−S, C−P, C−Si, and C−Ge bonds.

Graphical abstract: Catalytic intermolecular hydrofunctionalizations of ynamides
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Advancement in the C–H bond alkylation of (hetero)arenes catalyzed by the most abundant transition metal–iron

Advancement in the direct C–H bond alkylation of arenes and heteroarenes using the catalysts based on the most abundant transition metal, iron, is summarized.

Graphical abstract: Advancement in the C–H bond alkylation of (hetero)arenes catalyzed by the most abundant transition metal–iron
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Frustrated Lewis pair chemistry of alkynes

This review is focused on the chemistry of frustrated Lewis pairs (FLPs) with alkynes and surveys the range of stoichiometric and catalytic reactions enabled by this concept.

Graphical abstract: Frustrated Lewis pair chemistry of alkynes
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Recent advances in N-heterocyclic carbene (NHC)-catalyzed fluorination and fluoroalkylation

Organofluorine compounds are of high value. NHC-catalyzed fluorination and fluoroalkylation have served as powerful and versatile vehicles for accessing the related organofluorines. This review focuses on the recent developments in this area.

Graphical abstract: Recent advances in N-heterocyclic carbene (NHC)-catalyzed fluorination and fluoroalkylation
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Open Access Review Article

Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

In this review, we briefly summarize the recent research progress in enantioselective higher-order cycloadditions, focusing on the preparation of medium-sized and multicyclic chiral molecules by metal-free catalysis.

Graphical abstract: Recent advances in metal-free catalytic enantioselective higher-order cycloadditions
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Recent advances in nickel-catalyzed propargylic substitution

This work summarizes recent progress in nickel-catalyzed propargylic substitution reactions, categorizing them based on the diverse types of nucleophiles involved, with a specific focus on exploring asymmetric transformations.

Graphical abstract: Recent advances in nickel-catalyzed propargylic substitution
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

Asymmetric gold catalysis enabled by specially designed ligands

This review is planned to provide a comprehensive overview of the progress made in the design and development of chiral ligands for asymmetric gold catalysis.

Graphical abstract: Asymmetric gold catalysis enabled by specially designed ligands
Review Article

Site-selective editing of peptides via backbone modification

The site-selective modifications of peptide backbones have a significant impact on peptide conformation, folding ability, and physicochemical and biological properties. This review discusses the site-selective modifications of peptide backbones and classifies them into four categories.

Graphical abstract: Site-selective editing of peptides via backbone modification
Review Article

Palladium-catalyzed cross-dehydrogenative coupling of (hetero)arenes

A general and authoritative literature overview on Pd-catalyzed cross-dehydrogenative coupling reactions of (hetero)arenes from the origins to 2023, where not only the synthetic aspects were described but also the most relevant mechanistic features.

Graphical abstract: Palladium-catalyzed cross-dehydrogenative coupling of (hetero)arenes
Review Article

Catalyst-free photoarylation reactions promoted by visible light

This review presents significant and selected examples of organic synthesis methods that use visible-light-promoted photoarylation reactions without the need for additional photocatalysts.

Graphical abstract: Catalyst-free photoarylation reactions promoted by visible light
Review Article

Recent advances in hydrogen atom transfer induced C(sp3)–H functionalizations initiated by radical addition to alkynes

Recent advances in HAT-induced C(sp3)–H functionalizations triggered by radical addition to alkynes, including 5-exo-trig, 5-endo-trig, 4-exo-trig and 6-endo-trig cyclization cascades, and intermolecular functionalizations, are summarized.

Graphical abstract: Recent advances in hydrogen atom transfer induced C(sp3)–H functionalizations initiated by radical addition to alkynes
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Open Access Review Article

Enantioselective synthesis of chiral BCPs

This article reviews the methodologies available for the asymmetric synthesis of chiral BCPs via enantioselective transformations of BCPs or direct asymmetric functionalization of [1.1.1]propellane.

Graphical abstract: Enantioselective synthesis of chiral BCPs
Review Article

Advances in photoinduced radical–polar crossover cyclization (RPCC) of bifunctional alkenes

Photoinduced radical–polar crossover cyclization (RPCC) of bifunctional alkenes is of high synthetic utility to produce cyclic products with precise alkene design. This review summarizes the recent representative advances in the field of RPC.

Graphical abstract: Advances in photoinduced radical–polar crossover cyclization (RPCC) of bifunctional alkenes
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
Review Article

C–H borylation: a tool for molecular diversification

Iridium-catalyzed C–H activation and borylation has become as a powerful synthetic tool in the past few decades because of the widespread applicability and versatility of organoboron compounds.

Graphical abstract: C–H borylation: a tool for molecular diversification
Review Article

Harnessing photocatalytic and electrochemical approaches for C–H bond trifluoromethylation and fluoroalkylation

The review summarises various photo- and electrochemical strategies for trifluoromethylation and fluoroalkylation of different C(sp3)–H, C(sp2)–H, and C(sp)–H bonds in several classes of organic molecules.

Graphical abstract: Harnessing photocatalytic and electrochemical approaches for C–H bond trifluoromethylation and fluoroalkylation
Review Article

Nascent developments in main group element-catalyzed hydrosilylation and dehydrogenative silylation of alkenes and alkynes

Nascent developments in the main group element-catalyzed hydrosilylation of alkenes and alkynes.

Graphical abstract: Nascent developments in main group element-catalyzed hydrosilylation and dehydrogenative silylation of alkenes and alkynes
From the themed collection: 2024 Organic Chemistry Frontiers HOT articles
32 items

About this collection

Critical reviews, highlights and chemistry frontiers articles published in Organic Chemistry Frontiers during 2024 are collated as below for the benefit of readers.

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