Issue 10, 2024

Recent advances in the metal-catalyzed asymmetric alkene hydrogenation of cyclic conjugated carbonyl compounds

Abstract

The transition metal-catalyzed asymmetric hydrogenation of carbon–carbon double bonds is recognized as one of the most straightforward methods for the preparation of stereopure compounds. Chiral cyclic motifs have widespread applications in organic synthesis and can also be prepared via this strategy. This review summarizes the recent advances (2016–2023) in the stereoselective metal-catalyzed hydrogenation of cyclic α,β-unsaturated ketones, lactams and lactones since considerable developments in this regard were made. The applications of these methodologies in synthesis are also outlined where relevant.

Graphical abstract: Recent advances in the metal-catalyzed asymmetric alkene hydrogenation of cyclic conjugated carbonyl compounds

Article information

Article type
Review Article
Submitted
02 Feb 2024
Accepted
26 Mar 2024
First published
27 Mar 2024

Org. Chem. Front., 2024,11, 2934-2953

Recent advances in the metal-catalyzed asymmetric alkene hydrogenation of cyclic conjugated carbonyl compounds

M. Tan, B. B. C. Peters, P. G. Andersson and T. Zhou, Org. Chem. Front., 2024, 11, 2934 DOI: 10.1039/D4QO00227J

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